| Definition | Salmonella enterica subsp. enterica serovar Typhimurium str. LT2 chromosome, complete genome. |
|---|---|
| Accession | NC_003197 |
| Length | 4,857,432 |
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The map label for this gene is kduD [H]
Identifier: 16766319
GI number: 16766319
Start: 3177574
End: 3178335
Strand: Reverse
Name: kduD [H]
Synonym: STM3017
Alternate gene names: 16766319
Gene position: 3178335-3177574 (Counterclockwise)
Preceding gene: 16766320
Following gene: 16766318
Centisome position: 65.43
GC content: 51.84
Gene sequence:
>762_bases ATGATTTTGAATGCATTTTCTCTTGAAGGTAAAGTCGCGGTTGTGACGGGGTGCGATACCGGATTGGGGCAGGGGATGGC GTTAGGGCTGGCGGAAGCGGGCTGTGACATTGTTGGTATTAACATTGTTGAACCGACGGAAACTATTGCGCGCGTCACCG CTCTGGGACGTCGTTTTTTAAGCCTGACAGCCGATCTGCGTCAAATCGATGGCATTCCGGCATTACTGGAACGGGCGGTG GCGGAATACGGTCATATTGATATTCTGGTGAATAACGCGGGTTTGATCCGTCGTGAAGATGCGATTGATTTCACGGAAAA AGACTGGGATGACGTTATGAACCTGAACATCAAGAGCGTGTTCTTTATGTCTCAGGCGGCGGCAAAACATTTTATTGCCC AGGGCAACGGCGGCAAAATTATTAATATCGCGTCTATGCTCTCCTTCCAGGGCGGCATTCGCGTTCCGTCTTATACCGCG TCGAAAAGCGGCGTAATGGGAATAACACGTCTGATGGCGAACGAGTGGGCGAAACACAATATCAATGTGAACGCCATCGC ACCGGGCTATATGTCCACGAATAATACCCAGCAATTGCGCGCTGATGCACAACGTAGCGCCGAAATTCTCGACCGTATTC CGGCTGGACGTTGGGGGCTACCGGGCGATTTAATGGGGCCGGTAGTCTTCCTGGCATCCAGCGCCGCTGATTATATTAAC GGCTATACCATAGCGGTAGATGGCGGTTGGCTGGCGCGTTAA
Upstream 100 bases:
>100_bases TCTTCGATGACATGGATCACGTTGCGGTACAAGATCTGCGCTAGTCGCGACCGGTGATAACGCCTGTGCGTGACAGGCAT GACAAAAATAAGGATTAACA
Downstream 100 bases:
>100_bases TCCGCTACTGACAAATGCGTTTCTGGGAAAATCGACGCTTTGGCCGAAAAAACTGATAAAGCCCTGTCCTCGTACAGGGT TTTTTTATGATCTCATTAGC
Product: 2-deoxy-D-gluconate 3-dehydrogenase
Products: NA
Alternate protein names: 2-keto-3-deoxygluconate 5-dehydrogenase; 2-keto-3-deoxygluconate oxidoreductase; KDG oxidoreductase [H]
Number of amino acids: Translated: 253; Mature: 253
Protein sequence:
>253_residues MILNAFSLEGKVAVVTGCDTGLGQGMALGLAEAGCDIVGINIVEPTETIARVTALGRRFLSLTADLRQIDGIPALLERAV AEYGHIDILVNNAGLIRREDAIDFTEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTA SKSGVMGITRLMANEWAKHNINVNAIAPGYMSTNNTQQLRADAQRSAEILDRIPAGRWGLPGDLMGPVVFLASSAADYIN GYTIAVDGGWLAR
Sequences:
>Translated_253_residues MILNAFSLEGKVAVVTGCDTGLGQGMALGLAEAGCDIVGINIVEPTETIARVTALGRRFLSLTADLRQIDGIPALLERAV AEYGHIDILVNNAGLIRREDAIDFTEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTA SKSGVMGITRLMANEWAKHNINVNAIAPGYMSTNNTQQLRADAQRSAEILDRIPAGRWGLPGDLMGPVVFLASSAADYIN GYTIAVDGGWLAR >Mature_253_residues MILNAFSLEGKVAVVTGCDTGLGQGMALGLAEAGCDIVGINIVEPTETIARVTALGRRFLSLTADLRQIDGIPALLERAV AEYGHIDILVNNAGLIRREDAIDFTEKDWDDVMNLNIKSVFFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTA SKSGVMGITRLMANEWAKHNINVNAIAPGYMSTNNTQQLRADAQRSAEILDRIPAGRWGLPGDLMGPVVFLASSAADYIN GYTIAVDGGWLAR
Specific function: Catalyzes the reduction of 2,5-diketo-3-deoxygluconate (DKII or 4,6-dihydroxy-2,5-dioxohexanoate) into 2-keto-3- deoxygluconate (KDG or 2-dehydro-3-deoxygluconate) with a concomitant oxidation of NADH [H]
COG id: NA
COG function: NA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI15277342, Length=255, Percent_Identity=31.3725490196078, Blast_Score=127, Evalue=7e-30, Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=32, Blast_Score=114, Evalue=9e-26, Organism=Homo sapiens, GI66933014, Length=249, Percent_Identity=30.9236947791165, Blast_Score=113, Evalue=1e-25, Organism=Homo sapiens, GI7705925, Length=254, Percent_Identity=28.740157480315, Blast_Score=112, Evalue=5e-25, Organism=Homo sapiens, GI19923817, Length=257, Percent_Identity=28.7937743190661, Blast_Score=105, Evalue=4e-23, Organism=Homo sapiens, GI10190704, Length=253, Percent_Identity=32.4110671936759, Blast_Score=101, Evalue=7e-22, Organism=Homo sapiens, GI40254992, Length=242, Percent_Identity=29.3388429752066, Blast_Score=100, Evalue=2e-21, Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=28.4584980237154, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI4504505, Length=254, Percent_Identity=26.3779527559055, Blast_Score=87, Evalue=1e-17, Organism=Homo sapiens, GI5031737, Length=245, Percent_Identity=26.9387755102041, Blast_Score=86, Evalue=3e-17, Organism=Homo sapiens, GI4503301, Length=250, Percent_Identity=29.6, Blast_Score=84, Evalue=1e-16, Organism=Homo sapiens, GI31542939, Length=197, Percent_Identity=30.4568527918782, Blast_Score=75, Evalue=5e-14, Organism=Homo sapiens, GI40254986, Length=199, Percent_Identity=29.6482412060301, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI59889578, Length=191, Percent_Identity=27.2251308900524, Blast_Score=72, Evalue=5e-13, Organism=Homo sapiens, GI4758504, Length=255, Percent_Identity=27.4509803921569, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI33667109, Length=196, Percent_Identity=25, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI209862901, Length=200, Percent_Identity=29.5, Blast_Score=68, Evalue=8e-12, Organism=Homo sapiens, GI19923983, Length=200, Percent_Identity=29.5, Blast_Score=68, Evalue=8e-12, Organism=Homo sapiens, GI20149619, Length=211, Percent_Identity=29.8578199052133, Blast_Score=68, Evalue=9e-12, Organism=Homo sapiens, GI109715829, Length=240, Percent_Identity=24.1666666666667, Blast_Score=68, Evalue=9e-12, Organism=Homo sapiens, GI224922801, Length=174, Percent_Identity=30.4597701149425, Blast_Score=66, Evalue=2e-11, Organism=Homo sapiens, GI126723191, Length=183, Percent_Identity=28.9617486338798, Blast_Score=66, Evalue=3e-11, Organism=Escherichia coli, GI1789208, Length=253, Percent_Identity=93.2806324110672, Blast_Score=492, Evalue=1e-140, Organism=Escherichia coli, GI87082160, Length=257, Percent_Identity=41.6342412451362, Blast_Score=195, Evalue=3e-51, Organism=Escherichia coli, GI1790717, Length=248, Percent_Identity=39.9193548387097, Blast_Score=174, Evalue=4e-45, Organism=Escherichia coli, GI1787335, Length=246, Percent_Identity=36.1788617886179, Blast_Score=144, Evalue=4e-36, Organism=Escherichia coli, GI1788459, Length=245, Percent_Identity=34.6938775510204, Blast_Score=133, Evalue=9e-33, Organism=Escherichia coli, GI87082100, Length=254, Percent_Identity=31.1023622047244, Blast_Score=118, Evalue=3e-28, Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=31.9672131147541, Blast_Score=103, Evalue=1e-23, Organism=Escherichia coli, GI1786812, Length=250, Percent_Identity=27.2, Blast_Score=88, Evalue=5e-19, Organism=Escherichia coli, GI1789378, Length=248, Percent_Identity=26.6129032258064, Blast_Score=82, Evalue=3e-17, Organism=Escherichia coli, GI2367175, Length=245, Percent_Identity=26.9387755102041, Blast_Score=75, Evalue=3e-15, Organism=Escherichia coli, GI1789057, Length=259, Percent_Identity=27.027027027027, Blast_Score=69, Evalue=2e-13, Organism=Escherichia coli, GI2367365, Length=176, Percent_Identity=28.4090909090909, Blast_Score=66, Evalue=3e-12, Organism=Escherichia coli, GI1787526, Length=192, Percent_Identity=26.0416666666667, Blast_Score=63, Evalue=2e-11, Organism=Caenorhabditis elegans, GI25147288, Length=245, Percent_Identity=32.6530612244898, Blast_Score=123, Evalue=7e-29, Organism=Caenorhabditis elegans, GI17555706, Length=245, Percent_Identity=31.0204081632653, Blast_Score=122, Evalue=2e-28, Organism=Caenorhabditis elegans, GI17561402, Length=260, Percent_Identity=32.6923076923077, Blast_Score=116, Evalue=1e-26, Organism=Caenorhabditis elegans, GI17560676, Length=249, Percent_Identity=29.718875502008, Blast_Score=110, Evalue=6e-25, Organism=Caenorhabditis elegans, GI71994600, Length=255, Percent_Identity=29.4117647058824, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI115534694, Length=247, Percent_Identity=26.7206477732794, Blast_Score=103, Evalue=1e-22, Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=30.2681992337165, Blast_Score=100, Evalue=1e-21, Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=29.1497975708502, Blast_Score=99, Evalue=1e-21, Organism=Caenorhabditis elegans, GI17544670, Length=269, Percent_Identity=29.7397769516729, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17559104, Length=257, Percent_Identity=29.5719844357977, Blast_Score=99, Evalue=3e-21, Organism=Caenorhabditis elegans, GI17560220, Length=260, Percent_Identity=29.2307692307692, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI17551412, Length=258, Percent_Identity=30.2325581395349, Blast_Score=97, Evalue=1e-20, Organism=Caenorhabditis elegans, GI17562906, Length=260, Percent_Identity=29.2307692307692, Blast_Score=96, Evalue=2e-20, Organism=Caenorhabditis elegans, GI17562908, Length=266, Percent_Identity=29.3233082706767, Blast_Score=95, Evalue=3e-20, Organism=Caenorhabditis elegans, GI17531453, Length=260, Percent_Identity=30.3846153846154, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17538480, Length=261, Percent_Identity=27.9693486590038, Blast_Score=92, Evalue=3e-19, Organism=Caenorhabditis elegans, GI17560150, Length=258, Percent_Identity=27.5193798449612, Blast_Score=91, Evalue=5e-19, Organism=Caenorhabditis elegans, GI17568967, Length=192, Percent_Identity=28.125, Blast_Score=90, Evalue=1e-18, Organism=Caenorhabditis elegans, GI193204405, Length=263, Percent_Identity=29.277566539924, Blast_Score=89, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17563726, Length=261, Percent_Identity=27.9693486590038, Blast_Score=87, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17560332, Length=258, Percent_Identity=29.0697674418605, Blast_Score=87, Evalue=6e-18, Organism=Caenorhabditis elegans, GI17562990, Length=262, Percent_Identity=26.7175572519084, Blast_Score=87, Evalue=8e-18, Organism=Caenorhabditis elegans, GI17562904, Length=261, Percent_Identity=26.8199233716475, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI72000259, Length=263, Percent_Identity=27.3764258555133, Blast_Score=85, Evalue=4e-17, Organism=Caenorhabditis elegans, GI17565030, Length=260, Percent_Identity=30.7692307692308, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17564282, Length=195, Percent_Identity=29.2307692307692, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17536025, Length=255, Percent_Identity=25.8823529411765, Blast_Score=82, Evalue=4e-16, Organism=Caenorhabditis elegans, GI17538486, Length=258, Percent_Identity=27.1317829457364, Blast_Score=81, Evalue=5e-16, Organism=Caenorhabditis elegans, GI17538182, Length=254, Percent_Identity=31.1023622047244, Blast_Score=80, Evalue=9e-16, Organism=Caenorhabditis elegans, GI17536651, Length=258, Percent_Identity=25.1937984496124, Blast_Score=77, Evalue=7e-15, Organism=Caenorhabditis elegans, GI17561272, Length=251, Percent_Identity=27.0916334661355, Blast_Score=76, Evalue=1e-14, Organism=Caenorhabditis elegans, GI193203117, Length=195, Percent_Identity=28.2051282051282, Blast_Score=76, Evalue=2e-14, Organism=Caenorhabditis elegans, GI193203115, Length=193, Percent_Identity=28.4974093264249, Blast_Score=75, Evalue=2e-14, Organism=Caenorhabditis elegans, GI32563809, Length=208, Percent_Identity=25.4807692307692, Blast_Score=71, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17507613, Length=210, Percent_Identity=24.7619047619048, Blast_Score=71, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17555612, Length=221, Percent_Identity=28.9592760180996, Blast_Score=71, Evalue=5e-13, Organism=Caenorhabditis elegans, GI71982365, Length=201, Percent_Identity=26.865671641791, Blast_Score=68, Evalue=5e-12, Organism=Caenorhabditis elegans, GI17508651, Length=160, Percent_Identity=30.625, Blast_Score=65, Evalue=4e-11, Organism=Saccharomyces cerevisiae, GI6322861, Length=200, Percent_Identity=31.5, Blast_Score=85, Evalue=1e-17, Organism=Saccharomyces cerevisiae, GI6324126, Length=251, Percent_Identity=25.8964143426295, Blast_Score=70, Evalue=4e-13, Organism=Drosophila melanogaster, GI24639444, Length=247, Percent_Identity=31.5789473684211, Blast_Score=127, Evalue=6e-30, Organism=Drosophila melanogaster, GI21355319, Length=249, Percent_Identity=29.718875502008, Blast_Score=110, Evalue=7e-25, Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=29.6, Blast_Score=106, Evalue=2e-23, Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=29.6442687747036, Blast_Score=106, Evalue=2e-23, Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=30.4347826086957, Blast_Score=103, Evalue=9e-23, Organism=Drosophila melanogaster, GI24644339, Length=254, Percent_Identity=27.5590551181102, Blast_Score=96, Evalue=2e-20, Organism=Drosophila melanogaster, GI24643142, Length=244, Percent_Identity=28.6885245901639, Blast_Score=94, Evalue=1e-19, Organism=Drosophila melanogaster, GI18859837, Length=258, Percent_Identity=30.6201550387597, Blast_Score=88, Evalue=7e-18, Organism=Drosophila melanogaster, GI21358495, Length=202, Percent_Identity=30.6930693069307, Blast_Score=84, Evalue=1e-16, Organism=Drosophila melanogaster, GI24644337, Length=206, Percent_Identity=27.1844660194175, Blast_Score=83, Evalue=2e-16, Organism=Drosophila melanogaster, GI24649181, Length=198, Percent_Identity=29.2929292929293, Blast_Score=77, Evalue=1e-14, Organism=Drosophila melanogaster, GI21357673, Length=198, Percent_Identity=28.2828282828283, Blast_Score=76, Evalue=2e-14, Organism=Drosophila melanogaster, GI221331218, Length=220, Percent_Identity=27.7272727272727, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI24665243, Length=221, Percent_Identity=27.6018099547511, Blast_Score=75, Evalue=5e-14, Organism=Drosophila melanogaster, GI17737361, Length=264, Percent_Identity=28.7878787878788, Blast_Score=75, Evalue=6e-14, Organism=Drosophila melanogaster, GI24584748, Length=253, Percent_Identity=26.4822134387352, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI161076933, Length=253, Percent_Identity=26.4822134387352, Blast_Score=72, Evalue=3e-13, Organism=Drosophila melanogaster, GI221331216, Length=221, Percent_Identity=28.0542986425339, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI24665247, Length=222, Percent_Identity=27.9279279279279, Blast_Score=71, Evalue=5e-13, Organism=Drosophila melanogaster, GI24640492, Length=214, Percent_Identity=25.2336448598131, Blast_Score=70, Evalue=1e-12, Organism=Drosophila melanogaster, GI24648944, Length=203, Percent_Identity=28.0788177339901, Blast_Score=65, Evalue=4e-11, Organism=Drosophila melanogaster, GI24580925, Length=255, Percent_Identity=24.7058823529412, Blast_Score=65, Evalue=6e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR011286 - InterPro: IPR002198 - InterPro: IPR002347 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.1.1.127 [H]
Molecular weight: Translated: 27024; Mature: 27024
Theoretical pI: Translated: 5.30; Mature: 5.30
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.6 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.6 %Met (Mature Protein) 4.3 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MILNAFSLEGKVAVVTGCDTGLGQGMALGLAEAGCDIVGINIVEPTETIARVTALGRRFL CEEEEEECCCCEEEEEECCCCCCCCCEEEHHHCCCCEEEEEEECHHHHHHHHHHHHHHHH SLTADLRQIDGIPALLERAVAEYGHIDILVNNAGLIRREDAIDFTEKDWDDVMNLNIKSV HHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCCCCCHHHHHCCCHHHH FFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTASKSGVMGITRLMANEWAKHN HHHHHHHHHHHEEECCCCCEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC INVNAIAPGYMSTNNTQQLRADAQRSAEILDRIPAGRWGLPGDLMGPVVFLASSAADYIN CCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC GYTIAVDGGWLAR CEEEEECCCEECC >Mature Secondary Structure MILNAFSLEGKVAVVTGCDTGLGQGMALGLAEAGCDIVGINIVEPTETIARVTALGRRFL CEEEEEECCCCEEEEEECCCCCCCCCEEEHHHCCCCEEEEEEECHHHHHHHHHHHHHHHH SLTADLRQIDGIPALLERAVAEYGHIDILVNNAGLIRREDAIDFTEKDWDDVMNLNIKSV HHHHHHHHHCCCHHHHHHHHHHCCCEEEEECCCCCEEECCCCCCCCCCHHHHHCCCHHHH FFMSQAAAKHFIAQGNGGKIINIASMLSFQGGIRVPSYTASKSGVMGITRLMANEWAKHN HHHHHHHHHHHEEECCCCCEEEHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCC INVNAIAPGYMSTNNTQQLRADAQRSAEILDRIPAGRWGLPGDLMGPVVFLASSAADYIN CCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHC GYTIAVDGGWLAR CEEEEECCCEECC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9278503; 2836407; 1766386 [H]