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The map label for this gene is bioA

Identifier: 16764156

GI number: 16764156

Start: 858794

End: 860083

Strand: Reverse

Name: bioA

Synonym: STM0793

Alternate gene names: 16764156

Gene position: 860083-858794 (Counterclockwise)

Preceding gene: 16764164

Following gene: 16764155

Centisome position: 17.71

GC content: 58.68

Gene sequence:

>1290_bases
ATGACAACGGACGATCTGGCCTTCGATAAACGCCATATTTGGCATCCTTACACTTCCATGACCTCGCCGCTGCCGGTATA
TCCCGTTGAGCGGGCCGAAGGCTGCGAGCTGGTTCTCGCCTCGGGCAAACGCCTGATTGAGGGGATGTCCTCCTGGTGGG
CGGCCATTCATGGTTATAACCACCCGCAATTGAACGCGGCGATGAAAGCGCAAATTGACGCCATGTCGCATGTCATGTTC
GGCGGCATAACCCATCAACCTGCGGTGAATCTGTGCCGTAAGCTGGTCGCGATAACGCCTGAGCCGCTGGAGTGTGTCTT
TCTGGCCGACTCCGGGTCGGTGTCGGTGGAAGTGGCCATGAAGATGGCGCTGCAATACTGGCAGGCGCGCGGCGAATCGC
GTCAGCGTTTTCTGACGTTTCGCCACGGTTATCATGGCGACACGTTCGGCGCGATGTCGGTGTGCGATCCGGATAACTCC
ATGCACAGCTTGTGGAAAGGCTATCTGCCGGAAAATCTGTTCGCGCCGGCGCCGCAAAGCCGGATGGATGGCGAATGGGA
TGAAAGCGACATCGCGCCATTTGCCCGCCTGATGGCCGCGCATCGCCATGAAATAGCCGCCGTGATTCTGGAACCTATCG
TTCAGGGCGCGGGCGGGATGCGCATATATCATCCACAATGGCTCAGGCGTATTCGTAACATGTGCGATCGCGAAGGCATT
CTGCTGATTGCCGATGAAATAGCCACCGGGTTTGGCCGTACCGGCAAACTGTTCGCCTGCGAGCACGCCGGGATCGCGCC
GGATATTCTGTGTCTCGGCAAAGCCTTAACCGGCGGCACCATGACCCTCTCGGCAACGCTCACGACACGCCAGGTTGCAG
AGACTATTAGCAACGGCGAGGCGGGGTGTTTTATGCATGGCCCGACGTTTATGGGGAATCCGCTGGCCTGCGCCGTCGCC
TGCGCCAACCTGACGCTGCTGGAAAGCGGCGAATGGCGTCAGCAGGTGGCGTCTATCGAGTCTCAGTTACGCGCTGAGTT
AGCCCCCGCGCAAAGTTCGCCCTGGGTGGCGGATGTGCGGGTATTGGGCGCGATTGGGGTGGTTGAAACCACGCATCCGG
TCAATATGGCGGCGCTTCAACGCTTCTTCGTCGGGCAAGGCGTCTGGATCAGGCCGTTCGGCAAGCTAATCTACCTGATG
CCGCCCTACATTATTCGTCCGGATCAACTGCGCCGTTTGACCCAGGCGGTCAATGACGCGGTACACAATGAAACATTTTT
TAGCCATTAA

Upstream 100 bases:

>100_bases
GGGTGGCGAGCCATCGGGCTTCTCCAAAATATGTTGTTTGTTTTTGATATGGTGTAGACTCGTAAACCTAAATCTTTTTA
ATTTGGTTTACAAGTCGATT

Downstream 100 bases:

>100_bases
TCAGCGGTAAGCGATGCTGCTTCTGGCTACACTTCTGGTGAGTCAAAAGGAGAGCGCATGAAACTTATCAGCAACGATTT
GCGCGATGGAGATAAACTTC

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MTTDDLAFDKRHIWHPYTSMTSPLPVYPVERAEGCELVLASGKRLIEGMSSWWAAIHGYNHPQLNAAMKAQIDAMSHVMF
GGITHQPAVNLCRKLVAITPEPLECVFLADSGSVSVEVAMKMALQYWQARGESRQRFLTFRHGYHGDTFGAMSVCDPDNS
MHSLWKGYLPENLFAPAPQSRMDGEWDESDIAPFARLMAAHRHEIAAVILEPIVQGAGGMRIYHPQWLRRIRNMCDREGI
LLIADEIATGFGRTGKLFACEHAGIAPDILCLGKALTGGTMTLSATLTTRQVAETISNGEAGCFMHGPTFMGNPLACAVA
CANLTLLESGEWRQQVASIESQLRAELAPAQSSPWVADVRVLGAIGVVETTHPVNMAALQRFFVGQGVWIRPFGKLIYLM
PPYIIRPDQLRRLTQAVNDAVHNETFFSH

Sequences:

>Translated_429_residues
MTTDDLAFDKRHIWHPYTSMTSPLPVYPVERAEGCELVLASGKRLIEGMSSWWAAIHGYNHPQLNAAMKAQIDAMSHVMF
GGITHQPAVNLCRKLVAITPEPLECVFLADSGSVSVEVAMKMALQYWQARGESRQRFLTFRHGYHGDTFGAMSVCDPDNS
MHSLWKGYLPENLFAPAPQSRMDGEWDESDIAPFARLMAAHRHEIAAVILEPIVQGAGGMRIYHPQWLRRIRNMCDREGI
LLIADEIATGFGRTGKLFACEHAGIAPDILCLGKALTGGTMTLSATLTTRQVAETISNGEAGCFMHGPTFMGNPLACAVA
CANLTLLESGEWRQQVASIESQLRAELAPAQSSPWVADVRVLGAIGVVETTHPVNMAALQRFFVGQGVWIRPFGKLIYLM
PPYIIRPDQLRRLTQAVNDAVHNETFFSH
>Mature_428_residues
TTDDLAFDKRHIWHPYTSMTSPLPVYPVERAEGCELVLASGKRLIEGMSSWWAAIHGYNHPQLNAAMKAQIDAMSHVMFG
GITHQPAVNLCRKLVAITPEPLECVFLADSGSVSVEVAMKMALQYWQARGESRQRFLTFRHGYHGDTFGAMSVCDPDNSM
HSLWKGYLPENLFAPAPQSRMDGEWDESDIAPFARLMAAHRHEIAAVILEPIVQGAGGMRIYHPQWLRRIRNMCDREGIL
LIADEIATGFGRTGKLFACEHAGIAPDILCLGKALTGGTMTLSATLTTRQVAETISNGEAGCFMHGPTFMGNPLACAVAC
ANLTLLESGEWRQQVASIESQLRAELAPAQSSPWVADVRVLGAIGVVETTHPVNMAALQRFFVGQGVWIRPFGKLIYLMP
PYIIRPDQLRRLTQAVNDAVHNETFFSH

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=437, Percent_Identity=29.9771167048055, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI284507298, Length=239, Percent_Identity=35.1464435146443, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI13994255, Length=382, Percent_Identity=28.0104712041885, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI37574042, Length=377, Percent_Identity=26.525198938992, Blast_Score=99, Evalue=9e-21,
Organism=Homo sapiens, GI226442709, Length=323, Percent_Identity=27.2445820433437, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI226442705, Length=377, Percent_Identity=26.2599469496021, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI24119277, Length=376, Percent_Identity=25, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1786991, Length=427, Percent_Identity=86.8852459016393, Blast_Score=775, Evalue=0.0,
Organism=Escherichia coli, GI1789016, Length=350, Percent_Identity=30.5714285714286, Blast_Score=157, Evalue=9e-40,
Organism=Escherichia coli, GI145693181, Length=300, Percent_Identity=34.6666666666667, Blast_Score=156, Evalue=3e-39,
Organism=Escherichia coli, GI1789759, Length=413, Percent_Identity=29.5399515738499, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1788044, Length=312, Percent_Identity=33.6538461538462, Blast_Score=136, Evalue=2e-33,
Organism=Escherichia coli, GI1787560, Length=410, Percent_Identity=27.8048780487805, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786349, Length=387, Percent_Identity=26.3565891472868, Blast_Score=98, Evalue=8e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=414, Percent_Identity=26.0869565217391, Blast_Score=125, Evalue=5e-29,
Organism=Caenorhabditis elegans, GI25144274, Length=215, Percent_Identity=32.093023255814, Blast_Score=107, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI32564660, Length=420, Percent_Identity=25.2380952380952, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=327, Percent_Identity=23.5474006116208, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324386, Length=459, Percent_Identity=47.7124183006536, Blast_Score=435, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6323470, Length=415, Percent_Identity=27.4698795180723, Blast_Score=134, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6324432, Length=322, Percent_Identity=27.3291925465839, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI21357415, Length=405, Percent_Identity=28.641975308642, Blast_Score=134, Evalue=8e-32,
Organism=Drosophila melanogaster, GI28574759, Length=363, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI161085790, Length=363, Percent_Identity=27.2727272727273, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI21356575, Length=379, Percent_Identity=25.065963060686, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI281366494, Length=286, Percent_Identity=24.4755244755245, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667139, Length=286, Percent_Identity=24.4755244755245, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24667143, Length=286, Percent_Identity=24.4755244755245, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOA_SALTY (P12677)

Other databases:

- EMBL:   AE006468
- EMBL:   M21923
- RefSeq:   NP_459771.1
- ProteinModelPortal:   P12677
- SMR:   P12677
- PRIDE:   P12677
- GeneID:   1252313
- GenomeReviews:   AE006468_GR
- KEGG:   stm:STM0793
- NMPDR:   fig|99287.1.peg.759
- HOGENOM:   HBG725944
- OMA:   EACDRYD
- ProtClustDB:   PRK07986
- BioCyc:   STYP99287:STM0793-MONOMER
- BRENDA:   2.6.1.62
- GO:   GO:0005737
- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF8
- TIGRFAMs:   TIGR00508

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.62

Molecular weight: Translated: 47353; Mature: 47222

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 17-17 BINDING 245-245 BINDING 274-274 BINDING 307-307 BINDING 309-309 BINDING 391-391

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTDDLAFDKRHIWHPYTSMTSPLPVYPVERAEGCELVLASGKRLIEGMSSWWAAIHGYN
CCCCCCCCCCHHCCCCHHHCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCC
HPQLNAAMKAQIDAMSHVMFGGITHQPAVNLCRKLVAITPEPLECVFLADSGSVSVEVAM
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEHHHHH
KMALQYWQARGESRQRFLTFRHGYHGDTFGAMSVCDPDNSMHSLWKGYLPENLFAPAPQS
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHCCCCCCCCCCCCCC
RMDGEWDESDIAPFARLMAAHRHEIAAVILEPIVQGAGGMRIYHPQWLRRIRNMCDREGI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCCE
LLIADEIATGFGRTGKLFACEHAGIAPDILCLGKALTGGTMTLSATLTTRQVAETISNGE
EEEEHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHCCCC
AGCFMHGPTFMGNPLACAVACANLTLLESGEWRQQVASIESQLRAELAPAQSSPWVADVR
CCEEEECCCCCCCHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
VLGAIGVVETTHPVNMAALQRFFVGQGVWIRPFGKLIYLMPPYIIRPDQLRRLTQAVNDA
HHHHHCEEECCCCCCHHHHHHHHHCCCCEECCCCCEEEECCCCEECHHHHHHHHHHHHHH
VHNETFFSH
HHCCHHCCC
>Mature Secondary Structure 
TTDDLAFDKRHIWHPYTSMTSPLPVYPVERAEGCELVLASGKRLIEGMSSWWAAIHGYN
CCCCCCCCCHHCCCCHHHCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCC
HPQLNAAMKAQIDAMSHVMFGGITHQPAVNLCRKLVAITPEPLECVFLADSGSVSVEVAM
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEHHHHH
KMALQYWQARGESRQRFLTFRHGYHGDTFGAMSVCDPDNSMHSLWKGYLPENLFAPAPQS
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCEECCCCCHHHHHHHCCCCCCCCCCCCCC
RMDGEWDESDIAPFARLMAAHRHEIAAVILEPIVQGAGGMRIYHPQWLRRIRNMCDREGI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCCE
LLIADEIATGFGRTGKLFACEHAGIAPDILCLGKALTGGTMTLSATLTTRQVAETISNGE
EEEEHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHCCCC
AGCFMHGPTFMGNPLACAVACANLTLLESGEWRQQVASIESQLRAELAPAQSSPWVADVR
CCEEEECCCCCCCHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHH
VLGAIGVVETTHPVNMAALQRFFVGQGVWIRPFGKLIYLMPPYIIRPDQLRRLTQAVNDA
HHHHHCEEECCCCCCHHHHHHHHHCCCCEECCCCCEEEECCCCEECHHHHHHHHHHHHHH
VHNETFFSH
HHCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609; 2971595