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The map label for this gene is proY [H]

Identifier: 16763780

GI number: 16763780

Start: 454652

End: 456022

Strand: Direct

Name: proY [H]

Synonym: STM0400

Alternate gene names: 16763780

Gene position: 454652-456022 (Clockwise)

Preceding gene: 16763779

Following gene: 16763781

Centisome position: 9.36

GC content: 54.12

Gene sequence:

>1371_bases
ATGGAAAGCAATAATAAGCTAAAGCGTGGGCTGAGCACCCGGCACATTCGCTTTATGGCATTAGGTTCGGCAATCGGCAC
CGGCCTGTTTTACGGCTCGGCGGACGCCATCAAAATGGCGGGGCCGAGCGTGCTGTTGGCCTATATTATTGGCGGGGTCG
CGGCATATATCATTATGCGCGCATTGGGGGAAATGTCCGTTCACAACCCTGCCGCCAGCTCATTTTCGCGCTATGCGCAG
GAAAACCTCGGCCCGCTTGCGGGCTACATTACCGGCTGGACCTACTGTTTTGAGATCCTGATCGTCGCCATTGCCGACGT
GACCGCGTTCGGCATTTACATGGGAGTCTGGTTCCCCGCCGTGCCGCACTGGATTTGGGTACTTAGCGTGGTGCTGATCA
TTTGCGCCATCAACCTGATGAGCGTCAAGGTGTTCGGCGAGCTGGAGTTTTGGTTCTCCTTCTTCAAAGTCGCCACCATT
ATTATCATGATTGTCGCGGGTATCGGCATCATTGTGTGGGGAATTGGCAACGGCGGGCAGCCGACCGGCATTCATAACCT
GTGGAGCAACGGCGGCTTCTTCAGCAATGGCTGGTTGGGAATGATCATGTCGCTGCAAATGGTGATGTTCGCTTACGGCG
GGATTGAGATTATCGGTATCACCGCCGGGGAAGCGAAAGACCCGGAGAAATCCATTCCGCGCGCCATTAACTCAGTACCG
ATGCGTATCCTGGTATTTTATGTCGGCACGCTGTTCGTCATTATGTCTATCTATCCGTGGAATCAGGTCGGCACAAACGG
CAGTCCATTTGTGCTGACGTTCCAGCATATGGGGATTACCTTTGCCGCCAGCATTCTGAACTTTGTGGTATTGACCGCCT
CGCTTTCCGCTATCAACTCCGATGTGTTTGGCGTAGGCCGTATGCTGCATGGTATGGCGGAGCAGGGGAGCGCGCCGAAA
GTCTTTGCTAAAACGTCACGCCGTGGTATTCCGTGGGTCACTGTGCTGGTGATGACGATTGCGCTGCTGTTTGCGGTTTA
CCTGAACTACATCATGCCGGAAAACGTCTTCCTGGTGATTGCTTCGCTGGCGACGTTTGCGACGGTATGGGTATGGATTA
TGATCCTGCTGTCGCAAATCGCCTTCCGTCGTCGTTTACCGCCGGAAGAGGTAAAAGCGCTGAAATTTAAGGTGCCGGGC
GGTGTCGTAACGACGATAGCGGGTCTGATTTTCCTGGTCTTCATTATTGCGCTTATCGGCTACCATCCGGATACCCGCAT
CTCACTGTATGTGGGCTTCGCCTGGATAGTTCTGCTGTTGATTGGCTGGATATTTAAACGCCGTCGCGACCGTCAATTGG
CGCAGGCGTAG

Upstream 100 bases:

>100_bases
GGCAGGTGACCTCCAGCGCTCACTAAAATCGCTGACATATGTGTACACCACGGGGCTTAACGCCCCGTGGTTTTTTATTG
TGTTGATAGGTCAGAAATTG

Downstream 100 bases:

>100_bases
TCGTTTTTCTCTGCCTTATCCGGTCTGCAGGCAACGGTAGACCGGATAAGCGGAGCCGCTTCTCCTCCTGGAGCCTCCTC
CCCTAATAAACCCCTGGATG

Product: proline-specific permease

Products: Proton [Cytoplasm]; L-proline [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 456

Protein sequence:

>456_residues
MESNNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMRALGEMSVHNPAASSFSRYAQ
ENLGPLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPAVPHWIWVLSVVLIICAINLMSVKVFGELEFWFSFFKVATI
IIMIVAGIGIIVWGIGNGGQPTGIHNLWSNGGFFSNGWLGMIMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVP
MRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPK
VFAKTSRRGIPWVTVLVMTIALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQIAFRRRLPPEEVKALKFKVPG
GVVTTIAGLIFLVFIIALIGYHPDTRISLYVGFAWIVLLLIGWIFKRRRDRQLAQA

Sequences:

>Translated_456_residues
MESNNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMRALGEMSVHNPAASSFSRYAQ
ENLGPLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPAVPHWIWVLSVVLIICAINLMSVKVFGELEFWFSFFKVATI
IIMIVAGIGIIVWGIGNGGQPTGIHNLWSNGGFFSNGWLGMIMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVP
MRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPK
VFAKTSRRGIPWVTVLVMTIALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQIAFRRRLPPEEVKALKFKVPG
GVVTTIAGLIFLVFIIALIGYHPDTRISLYVGFAWIVLLLIGWIFKRRRDRQLAQA
>Mature_456_residues
MESNNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMRALGEMSVHNPAASSFSRYAQ
ENLGPLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPAVPHWIWVLSVVLIICAINLMSVKVFGELEFWFSFFKVATI
IIMIVAGIGIIVWGIGNGGQPTGIHNLWSNGGFFSNGWLGMIMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVP
MRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITFAASILNFVVLTASLSAINSDVFGVGRMLHGMAEQGSAPK
VFAKTSRRGIPWVTVLVMTIALLFAVYLNYIMPENVFLVIASLATFATVWVWIMILLSQIAFRRRLPPEEVKALKFKVPG
GVVTTIAGLIFLVFIIALIGYHPDTRISLYVGFAWIVLLLIGWIFKRRRDRQLAQA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of proline [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=351, Percent_Identity=24.7863247863248, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI181337167, Length=338, Percent_Identity=25.1479289940828, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI258645169, Length=429, Percent_Identity=21.9114219114219, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI258614005, Length=430, Percent_Identity=21.8604651162791, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI258614003, Length=430, Percent_Identity=21.8604651162791, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI4507047, Length=366, Percent_Identity=23.4972677595628, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI114326544, Length=437, Percent_Identity=21.9679633867277, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI114326550, Length=437, Percent_Identity=21.9679633867277, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI1786602, Length=455, Percent_Identity=95.8241758241758, Blast_Score=826, Evalue=0.0,
Organism=Escherichia coli, GI1786789, Length=453, Percent_Identity=45.916114790287, Blast_Score=384, Evalue=1e-108,
Organism=Escherichia coli, GI1786302, Length=450, Percent_Identity=43.3333333333333, Blast_Score=375, Evalue=1e-105,
Organism=Escherichia coli, GI48994972, Length=451, Percent_Identity=45.2328159645233, Blast_Score=368, Evalue=1e-103,
Organism=Escherichia coli, GI1790653, Length=460, Percent_Identity=41.304347826087, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI87081915, Length=445, Percent_Identity=37.5280898876404, Blast_Score=312, Evalue=3e-86,
Organism=Escherichia coli, GI87081708, Length=457, Percent_Identity=35.6673960612691, Blast_Score=301, Evalue=8e-83,
Organism=Escherichia coli, GI1788480, Length=406, Percent_Identity=37.192118226601, Blast_Score=248, Evalue=4e-67,
Organism=Escherichia coli, GI1789017, Length=386, Percent_Identity=35.4922279792746, Blast_Score=242, Evalue=3e-65,
Organism=Escherichia coli, GI87081869, Length=176, Percent_Identity=27.8409090909091, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87082023, Length=280, Percent_Identity=25.3571428571429, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI2367353, Length=331, Percent_Identity=23.5649546827795, Blast_Score=62, Evalue=6e-11,
Organism=Escherichia coli, GI1786694, Length=467, Percent_Identity=23.7687366167024, Blast_Score=62, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=428, Percent_Identity=23.5981308411215, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17531343, Length=372, Percent_Identity=25, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17533459, Length=401, Percent_Identity=23.6907730673317, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17540018, Length=457, Percent_Identity=23.4135667396061, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=462, Percent_Identity=32.2510822510823, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6320772, Length=466, Percent_Identity=32.1888412017167, Blast_Score=203, Evalue=5e-53,
Organism=Saccharomyces cerevisiae, GI6324990, Length=444, Percent_Identity=32.6576576576577, Blast_Score=197, Evalue=4e-51,
Organism=Saccharomyces cerevisiae, GI6324924, Length=407, Percent_Identity=31.6953316953317, Blast_Score=179, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6319824, Length=432, Percent_Identity=28.4722222222222, Blast_Score=176, Evalue=6e-45,
Organism=Saccharomyces cerevisiae, GI6324059, Length=406, Percent_Identity=32.2660098522167, Blast_Score=173, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6319542, Length=432, Percent_Identity=28.7037037037037, Blast_Score=171, Evalue=3e-43,
Organism=Saccharomyces cerevisiae, GI6322892, Length=474, Percent_Identity=29.535864978903, Blast_Score=169, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6324553, Length=388, Percent_Identity=32.4742268041237, Blast_Score=164, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=434, Percent_Identity=27.4193548387097, Blast_Score=163, Evalue=4e-41,
Organism=Saccharomyces cerevisiae, GI6320717, Length=400, Percent_Identity=27.25, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6321629, Length=431, Percent_Identity=27.6102088167053, Blast_Score=157, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6321053, Length=426, Percent_Identity=26.2910798122066, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319543, Length=399, Percent_Identity=27.5689223057644, Blast_Score=147, Evalue=4e-36,
Organism=Saccharomyces cerevisiae, GI6319608, Length=454, Percent_Identity=25.1101321585903, Blast_Score=135, Evalue=1e-32,
Organism=Saccharomyces cerevisiae, GI6322967, Length=398, Percent_Identity=26.3819095477387, Blast_Score=132, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6324981, Length=426, Percent_Identity=26.056338028169, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320364, Length=505, Percent_Identity=24.3564356435644, Blast_Score=109, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24666159, Length=413, Percent_Identity=22.0338983050847, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI221512776, Length=413, Percent_Identity=22.0338983050847, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI161077963, Length=333, Percent_Identity=25.5255255255255, Blast_Score=69, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50048; Mature: 50048

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MESNNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMR
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHH
ALGEMSVHNPAASSFSRYAQENLGPLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPA
HHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPHWIWVLSVVLIICAINLMSVKVFGELEFWFSFFKVATIIIMIVAGIGIIVWGIGNGGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
PTGIHNLWSNGGFFSNGWLGMIMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVP
CCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHH
MRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITFAASILNFVVLTASLSAINS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
DVFGVGRMLHGMAEQGSAPKVFAKTSRRGIPWVTVLVMTIALLFAVYLNYIMPENVFLVI
HHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ASLATFATVWVWIMILLSQIAFRRRLPPEEVKALKFKVPGGVVTTIAGLIFLVFIIALIG
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHC
YHPDTRISLYVGFAWIVLLLIGWIFKRRRDRQLAQA
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MESNNKLKRGLSTRHIRFMALGSAIGTGLFYGSADAIKMAGPSVLLAYIIGGVAAYIIMR
CCCCCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHHHHHHHHH
ALGEMSVHNPAASSFSRYAQENLGPLAGYITGWTYCFEILIVAIADVTAFGIYMGVWFPA
HHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPHWIWVLSVVLIICAINLMSVKVFGELEFWFSFFKVATIIIMIVAGIGIIVWGIGNGGQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCC
PTGIHNLWSNGGFFSNGWLGMIMSLQMVMFAYGGIEIIGITAGEAKDPEKSIPRAINSVP
CCCHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCHHHHHHHHHHHH
MRILVFYVGTLFVIMSIYPWNQVGTNGSPFVLTFQHMGITFAASILNFVVLTASLSAINS
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHH
DVFGVGRMLHGMAEQGSAPKVFAKTSRRGIPWVTVLVMTIALLFAVYLNYIMPENVFLVI
HHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
ASLATFATVWVWIMILLSQIAFRRRLPPEEVKALKFKVPGGVVTTIAGLIFLVFIIALIG
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHC
YHPDTRISLYVGFAWIVLLLIGWIFKRRRDRQLAQA
CCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-proline [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-proline [Periplasm] = Proton [Cytoplasm] + L-proline [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]