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The map label for this gene is yisK [H]

Identifier: 16763711

GI number: 16763711

Start: 374837

End: 375715

Strand: Direct

Name: yisK [H]

Synonym: STM0331

Alternate gene names: 16763711

Gene position: 374837-375715 (Clockwise)

Preceding gene: 16763710

Following gene: 16763712

Centisome position: 7.72

GC content: 49.83

Gene sequence:

>879_bases
ATGAAACTGGTTCAATATCTTGTGAACGGTGGCAAACGCTACGGCATTATGCAGGAAACCGGAATAATTGATCTCTCGCA
GCGGCTTGGCGACAAATATCCCACTTTGAAATCTCTCCTGTGCGCTAATGCGCTGACGGATGCGGCGTTATGGTGTGATG
AGCCGGCGGATTATTACTACCAGGAAGTCACTTTTCTGCCGGTGATTGACGATCCGCAGAAGATCATCTGTGTCGGAATG
AATTATGCCGATAAGCGTATTGAGTTTAATGAAACCAACCCGGCCCCAACCCTTTTTGTCCGCTTTGCGGATTCTCAGAC
CGGGCATAATGGCCTGCTGCTGAAGCCTGAAAATACCAATGAGTTCGACTACGAAGGTGAATTAGCCGTAGTGATTGGGC
GGCGATGCTCCCGGGTCAGCGCTGAGGATGCTTTAGATTATGTCGCCGGATACAGCTGCTATATGGATGGTTCAGTGAGG
GACTGGCAGCATAGCTGGTTTACGGCTGGAAAAAACTGGCCTTCGACAGGATCATTCGGTCCGTGTCTGGTGACCACAGA
CGACATTCCCGATCCCCAGATGCTACGTTTACTGACACGACTAAACGGGCGGGAGGTGCAGAACGAATCTACGGCAAATA
TGATCCATCCTATCGCTTCACTCATTGCTTATATAAGCACATTTACTCTGCTTTCCCCTGGCGACACGATCCTCACAGGG
TCGCCTGGTGGAGTGGGCAAAAAACGCGTTCCACCGCTGTTTTTACACGATGGTGATGTTATTGAAGTTGAGATTGAACA
TATTGGAACCCTGCGCAATGTCGTCCGGGATAGCCGTTATTTAACATCCTCTGTTAGCTGGCATGACGGGAGAAAGTGA

Upstream 100 bases:

>100_bases
AATACTTGCCGGAGATTGAAAATTTTGAGGTTGCGCATTATTCACGGCGGCCGTGGCTAAAACGCCCTGCATCCCCGCGC
GGTTAAGGAAGAAGACTGCA

Downstream 100 bases:

>100_bases
TGAGTACACTGATTGAATGCGGCGCCTCTCCGTTTATTCCGGGGTTTGCGCTCAAGGATGTTCGTCTGGAAAATGGTCTG
ACGGTAAGAGTGGCTATCGG

Product: fumarylacetoacetate hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MKLVQYLVNGGKRYGIMQETGIIDLSQRLGDKYPTLKSLLCANALTDAALWCDEPADYYYQEVTFLPVIDDPQKIICVGM
NYADKRIEFNETNPAPTLFVRFADSQTGHNGLLLKPENTNEFDYEGELAVVIGRRCSRVSAEDALDYVAGYSCYMDGSVR
DWQHSWFTAGKNWPSTGSFGPCLVTTDDIPDPQMLRLLTRLNGREVQNESTANMIHPIASLIAYISTFTLLSPGDTILTG
SPGGVGKKRVPPLFLHDGDVIEVEIEHIGTLRNVVRDSRYLTSSVSWHDGRK

Sequences:

>Translated_292_residues
MKLVQYLVNGGKRYGIMQETGIIDLSQRLGDKYPTLKSLLCANALTDAALWCDEPADYYYQEVTFLPVIDDPQKIICVGM
NYADKRIEFNETNPAPTLFVRFADSQTGHNGLLLKPENTNEFDYEGELAVVIGRRCSRVSAEDALDYVAGYSCYMDGSVR
DWQHSWFTAGKNWPSTGSFGPCLVTTDDIPDPQMLRLLTRLNGREVQNESTANMIHPIASLIAYISTFTLLSPGDTILTG
SPGGVGKKRVPPLFLHDGDVIEVEIEHIGTLRNVVRDSRYLTSSVSWHDGRK
>Mature_292_residues
MKLVQYLVNGGKRYGIMQETGIIDLSQRLGDKYPTLKSLLCANALTDAALWCDEPADYYYQEVTFLPVIDDPQKIICVGM
NYADKRIEFNETNPAPTLFVRFADSQTGHNGLLLKPENTNEFDYEGELAVVIGRRCSRVSAEDALDYVAGYSCYMDGSVR
DWQHSWFTAGKNWPSTGSFGPCLVTTDDIPDPQMLRLLTRLNGREVQNESTANMIHPIASLIAYISTFTLLSPGDTILTG
SPGGVGKKRVPPLFLHDGDVIEVEIEHIGTLRNVVRDSRYLTSSVSWHDGRK

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAH family [H]

Homologues:

Organism=Homo sapiens, GI156231349, Length=220, Percent_Identity=42.7272727272727, Blast_Score=174, Evalue=6e-44,
Organism=Homo sapiens, GI40786394, Length=222, Percent_Identity=41.8918918918919, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI13654274, Length=214, Percent_Identity=34.1121495327103, Blast_Score=115, Evalue=4e-26,
Organism=Homo sapiens, GI215422413, Length=180, Percent_Identity=37.2222222222222, Blast_Score=115, Evalue=7e-26,
Organism=Homo sapiens, GI66348062, Length=180, Percent_Identity=37.2222222222222, Blast_Score=114, Evalue=1e-25,
Organism=Escherichia coli, GI1787428, Length=180, Percent_Identity=35.5555555555556, Blast_Score=104, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17557057, Length=195, Percent_Identity=36.9230769230769, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6324161, Length=233, Percent_Identity=26.1802575107296, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28572127, Length=287, Percent_Identity=36.2369337979094, Blast_Score=157, Evalue=8e-39,
Organism=Drosophila melanogaster, GI24663695, Length=274, Percent_Identity=35.4014598540146, Blast_Score=139, Evalue=3e-33,
Organism=Drosophila melanogaster, GI28571789, Length=207, Percent_Identity=31.4009661835749, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002529
- InterPro:   IPR011234 [H]

Pfam domain/function: PF01557 FAA_hydrolase [H]

EC number: NA

Molecular weight: Translated: 32563; Mature: 32563

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLVQYLVNGGKRYGIMQETGIIDLSQRLGDKYPTLKSLLCANALTDAALWCDEPADYYY
CHHHHHHHCCCCEECEECCCCCEEHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHE
QEVTFLPVIDDPQKIICVGMNYADKRIEFNETNPAPTLFVRFADSQTGHNGLLLKPENTN
EEEEEEEEECCCCEEEEEECCCCCCEEEECCCCCCCEEEEEEECCCCCCCCEEECCCCCC
EFDYEGELAVVIGRRCSRVSAEDALDYVAGYSCYMDGSVRDWQHSWFTAGKNWPSTGSFG
CCCCCCCEEEEECCCCCCCCHHHHHHHHHCCEEEECCCCCCCCHHHEECCCCCCCCCCCC
PCLVTTDDIPDPQMLRLLTRLNGREVQNESTANMIHPIASLIAYISTFTLLSPGDTILTG
CEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCEEEEC
SPGGVGKKRVPPLFLHDGDVIEVEIEHIGTLRNVVRDSRYLTSSVSWHDGRK
CCCCCCCCCCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MKLVQYLVNGGKRYGIMQETGIIDLSQRLGDKYPTLKSLLCANALTDAALWCDEPADYYY
CHHHHHHHCCCCEECEECCCCCEEHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHE
QEVTFLPVIDDPQKIICVGMNYADKRIEFNETNPAPTLFVRFADSQTGHNGLLLKPENTN
EEEEEEEEECCCCEEEEEECCCCCCEEEECCCCCCCEEEEEEECCCCCCCCEEECCCCCC
EFDYEGELAVVIGRRCSRVSAEDALDYVAGYSCYMDGSVRDWQHSWFTAGKNWPSTGSFG
CCCCCCCEEEEECCCCCCCCHHHHHHHHHCCEEEECCCCCCCCHHHEECCCCCCCCCCCC
PCLVTTDDIPDPQMLRLLTRLNGREVQNESTANMIHPIASLIAYISTFTLLSPGDTILTG
CEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEECCCCEEEEC
SPGGVGKKRVPPLFLHDGDVIEVEIEHIGTLRNVVRDSRYLTSSVSWHDGRK
CCCCCCCCCCCEEEEECCCEEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9353931; 9384377 [H]