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The map label for this gene is argC

Identifier: 218930925

GI number: 218930925

Start: 4411401

End: 4412405

Strand: Reverse

Name: argC

Synonym: YPO3927

Alternate gene names: 218930925

Gene position: 4412405-4411401 (Counterclockwise)

Preceding gene: 218930930

Following gene: 218930924

Centisome position: 94.81

GC content: 50.45

Gene sequence:

>1005_bases
ATGTTAAATACGTTGATTGTTGGTGCCAGTGGCTATGCCGGCGCGGAGCTTACGGCTTACCTTAATCGTCACCCACATAT
GAACATAACCGGTTTAGCGGTTTCAGCGCAAAGTGCAGATGCAGGAAAATTACTTTCCGATCTGCATCCACAGTTAAAAG
GCATTCTTGACCTCCCGCTACAGCCCTTGGTAGATGTGGCTCAGGCGGCTAAAGGTATCGATGTGGTTTTCCTCGCTACC
GCTCATGAGGTCAGCCATGATTTGGCACCACAATTTTTAGCCGCTGGCTGTGTGGTATTTGATCTTTCCGGTGCATTCCG
TGTGCGTGATGCGGCGTTTTACAGCCAATATTACGGTTTTGAACACCAACATCCCGATTGGCTCGATAAGGCGGTTTATG
GCCTGGCAGAATGGCAATCAGAAGACATTAAGCAAGCTCAATTGATTGCTGTTCCTGGTTGTTATCCAACCGCATCACAA
CTGGCGCTTAAACCGTTGGTTGATGGGCAATTACTGAACGATGCACAGTGGCCAGTCATTAATGCCGTCAGTGGTGTCAG
CGGTGCAGGGCGTAAAGCCAGCATGGGCAACAGCTTCTGTGAAGTTAGCTTGCAGCCATATGGCCTATTTACCCACCGTC
ACCAGCCAGAAATTGTTACCCATCTTGGCACCCCCGTCATTTTTACACCGCATCTGGGGAATTTTGCCCGAGGGATCTTG
GCGACGATTACCTGCCGCCTGAAAGCTGGGGTCACGGCGCAAAACATCGCCGATGCCTATCACCATGCTTATCAGAATAA
GCCACTGGTGCGGTTGTATCAACAAGGTGTCCCGGCGCTGAAAGCCGTGGTCGGCCTACCTTTCTGTGATATTGGTTTCT
CGGTACAAGGCGAGCATTTAATTATTGTTGCCACCGAAGATAACCTGCTGAAAGGTGCTGCGGCTCAGGCCGTACAATGT
ATGAATATCCGTTTTGGCTTCCCGGAAACGCAGTCCCTGTTGTAG

Upstream 100 bases:

>100_bases
CCTTGCTGAGAACCCGAATACCAGTTTTGACTATTTATGTTTTTATATGCATAGGCTTTTATTGACATAAATAAAAATAC
TCAGAAGGTGAACTGAACCC

Downstream 100 bases:

>100_bases
CGTTCGGTTGCAAGCAATAGATTGTAAGTGATTGATTGTAATTAATGGATTGCAAGAAATAGATTGCAGTAAACAGATTG
TGAGCCATAAATTGTGAGCA

Product: N-acetyl-gamma-glutamyl-phosphate reductase

Products: NA

Alternate protein names: AGPR; N-acetyl-glutamate semialdehyde dehydrogenase; NAGSA dehydrogenase

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MLNTLIVGASGYAGAELTAYLNRHPHMNITGLAVSAQSADAGKLLSDLHPQLKGILDLPLQPLVDVAQAAKGIDVVFLAT
AHEVSHDLAPQFLAAGCVVFDLSGAFRVRDAAFYSQYYGFEHQHPDWLDKAVYGLAEWQSEDIKQAQLIAVPGCYPTASQ
LALKPLVDGQLLNDAQWPVINAVSGVSGAGRKASMGNSFCEVSLQPYGLFTHRHQPEIVTHLGTPVIFTPHLGNFARGIL
ATITCRLKAGVTAQNIADAYHHAYQNKPLVRLYQQGVPALKAVVGLPFCDIGFSVQGEHLIIVATEDNLLKGAAAQAVQC
MNIRFGFPETQSLL

Sequences:

>Translated_334_residues
MLNTLIVGASGYAGAELTAYLNRHPHMNITGLAVSAQSADAGKLLSDLHPQLKGILDLPLQPLVDVAQAAKGIDVVFLAT
AHEVSHDLAPQFLAAGCVVFDLSGAFRVRDAAFYSQYYGFEHQHPDWLDKAVYGLAEWQSEDIKQAQLIAVPGCYPTASQ
LALKPLVDGQLLNDAQWPVINAVSGVSGAGRKASMGNSFCEVSLQPYGLFTHRHQPEIVTHLGTPVIFTPHLGNFARGIL
ATITCRLKAGVTAQNIADAYHHAYQNKPLVRLYQQGVPALKAVVGLPFCDIGFSVQGEHLIIVATEDNLLKGAAAQAVQC
MNIRFGFPETQSLL
>Mature_334_residues
MLNTLIVGASGYAGAELTAYLNRHPHMNITGLAVSAQSADAGKLLSDLHPQLKGILDLPLQPLVDVAQAAKGIDVVFLAT
AHEVSHDLAPQFLAAGCVVFDLSGAFRVRDAAFYSQYYGFEHQHPDWLDKAVYGLAEWQSEDIKQAQLIAVPGCYPTASQ
LALKPLVDGQLLNDAQWPVINAVSGVSGAGRKASMGNSFCEVSLQPYGLFTHRHQPEIVTHLGTPVIFTPHLGNFARGIL
ATITCRLKAGVTAQNIADAYHHAYQNKPLVRLYQQGVPALKAVVGLPFCDIGFSVQGEHLIIVATEDNLLKGAAAQAVQC
MNIRFGFPETQSLL

Specific function: Arginine biosynthesis; third step. [C]

COG id: COG0002

COG function: function code E; Acetylglutamate semialdehyde dehydrogenase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAGSA dehydrogenase family. Type 1 subfamily

Homologues:

Organism=Escherichia coli, GI1790396, Length=334, Percent_Identity=78.1437125748503, Blast_Score=543, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6320913, Length=333, Percent_Identity=30.03003003003, Blast_Score=115, Evalue=7e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGC_YERPE (Q8ZA86)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AC0478
- RefSeq:   NP_667650.1
- RefSeq:   NP_994416.1
- RefSeq:   YP_002348800.1
- ProteinModelPortal:   Q8ZA86
- SMR:   Q8ZA86
- GeneID:   1145257
- GeneID:   1176768
- GeneID:   2763912
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO3927
- KEGG:   ypk:y0310
- KEGG:   ypm:YP_3123
- HOGENOM:   HBG294213
- OMA:   VCRIAVH
- ProtClustDB:   PRK00436
- BioCyc:   YPES187410:Y0310-MONOMER
- BioCyc:   YPES214092:YPO3927-MONOMER
- BRENDA:   1.2.1.38
- GO:   GO:0005737
- HAMAP:   MF_00150
- InterPro:   IPR023013
- InterPro:   IPR000706
- InterPro:   IPR016040
- InterPro:   IPR000534
- InterPro:   IPR012280
- Gene3D:   G3DSA:3.40.50.720
- SMART:   SM00859
- TIGRFAMs:   TIGR01850

Pfam domain/function: PF01118 Semialdhyde_dh; PF02774 Semialdhyde_dhC

EC number: =1.2.1.38

Molecular weight: Translated: 35871; Mature: 35871

Theoretical pI: Translated: 6.62; Mature: 6.62

Prosite motif: PS01224 ARGC; PS00142 ZINC_PROTEASE

Important sites: ACT_SITE 154-154

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNTLIVGASGYAGAELTAYLNRHPHMNITGLAVSAQSADAGKLLSDLHPQLKGILDLPL
CCCEEEEECCCCCCCHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHCHHHHHHHCCCC
QPLVDVAQAAKGIDVVFLATAHEVSHDLAPQFLAAGCVVFDLSGAFRVRDAAFYSQYYGF
HHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHCCEEEEECCCCEEHHHHHHHHHHCCC
EHQHPDWLDKAVYGLAEWQSEDIKQAQLIAVPGCYPTASQLALKPLVDGQLLNDAQWPVI
CCCCCHHHHHHHHHHHHHCHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCHH
NAVSGVSGAGRKASMGNSFCEVSLQPYGLFTHRHQPEIVTHLGTPVIFTPHLGNFARGIL
HHHCCCCCCCCCCCCCCCEEEEEECCEEEECCCCCCHHHHHCCCCEEECCCCCHHHHHHH
ATITCRLKAGVTAQNIADAYHHAYQNKPLVRLYQQGVPALKAVVGLPFCDIGFSVQGEHL
HHHEEHHCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHCCCEECCCCEECCCEE
IIVATEDNLLKGAAAQAVQCMNIRFGFPETQSLL
EEEECCCCHHHHHHHHHHHHEEEEECCCCHHHCC
>Mature Secondary Structure
MLNTLIVGASGYAGAELTAYLNRHPHMNITGLAVSAQSADAGKLLSDLHPQLKGILDLPL
CCCEEEEECCCCCCCHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHCHHHHHHHCCCC
QPLVDVAQAAKGIDVVFLATAHEVSHDLAPQFLAAGCVVFDLSGAFRVRDAAFYSQYYGF
HHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHCCEEEEECCCCEEHHHHHHHHHHCCC
EHQHPDWLDKAVYGLAEWQSEDIKQAQLIAVPGCYPTASQLALKPLVDGQLLNDAQWPVI
CCCCCHHHHHHHHHHHHHCHHCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCCCCCCCHH
NAVSGVSGAGRKASMGNSFCEVSLQPYGLFTHRHQPEIVTHLGTPVIFTPHLGNFARGIL
HHHCCCCCCCCCCCCCCCEEEEEECCEEEECCCCCCHHHHHCCCCEEECCCCCHHHHHHH
ATITCRLKAGVTAQNIADAYHHAYQNKPLVRLYQQGVPALKAVVGLPFCDIGFSVQGEHL
HHHEEHHCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHCCCEECCCCEECCCEE
IIVATEDNLLKGAAAQAVQCMNIRFGFPETQSLL
EEEECCCCHHHHHHHHHHHHEEEEECCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430