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The map label for this gene is glpA [H]

Identifier: 218930829

GI number: 218930829

Start: 4292206

End: 4293861

Strand: Reverse

Name: glpA [H]

Synonym: YPO3826

Alternate gene names: 218930829

Gene position: 4293861-4292206 (Counterclockwise)

Preceding gene: 218930831

Following gene: 218930828

Centisome position: 92.27

GC content: 53.99

Gene sequence:

>1656_bases
ATGACGAACAGTTCTCCTTATCTAGAAACGGATGTCATCATTATCGGTGGCGGAGCAACCGGTGCCGGAATCGCTCGCGA
CTGCGCCCGCCGTGGTTTGGCTTGTACTTTATTGGAAAGGCATGACATCGCTACTGGGGCCACGGGGCGTAATCATGGTC
TCCTGCACAGTGGCGCTCGCTATGCGGTAACCGACGGTGAGTCAGCCCGTGAGTGCATTGAAGAAAACCGCATTCTCAAA
CGGATTGCTCGCCACTGCATTGAACAAACGGATGGCTTGTTCATCACCTTGCCGGAAGACTCTCTGGCGTATCAGCTACA
ATTTATCGCCCGTTGTCGGGATGCGGGCATTGAGGCTGAAGCCATTGATCCGGCACAGGCACTGCGCTTGGAGCCTGCCG
TCAACCCCGCGCTGATTGCCGCGGTCCGGGTCCCTGATGGTACTGTCGATCCTTTCCGTTTAACCGCGGCTAACATGTTG
GATGCCCGCGAACATGGCGCGAATATTCTGACATATCATGAAGTTATCGGTTTGTTGCGGCAGGGTTCCCGAATCAATGG
TGTGTGCGTTTTCGACCATAAAAATCAGCGAAAATACGACATTCATGCGCAGATTGTGGTGAATGCTGCTGGGATCTGGG
GACAACATATTGCTGAATATGCCGATCTGCGTATCCGCATGTTCCCCGCCAAAGGCGCGTTGCTGATCCTCGGGCATCGG
ATCAATAACATGGTGATCAACCGTTGTCGTAAGCCTGCGGATGCCGATATTTTGGTGCCGGGCGATACCATTTCATTGAT
CGGTACCACGTCAACCCACATCAATTACGATCAAATAGACAATATGGTAGTAACGGCACAAGAGGTGGATACATTAATTC
GTGAAGGTGCCAAACTTTCGCCGCAACTGGCGCAAACCCGTATTTTGCGTGCCTACGCGGGAGTGCGGCCGCTGGTTGCC
AGCGATGATGATCCATCAGGGCGTAATGTCAGCCGTGGCATCGTATTACTGGATCATGCCAGCCGGGATGGGGTGGAGGG
TTTTATCACGATCACCGGTGGCAAGCTGATGACCTACCGGCTGATGGCGGAATGGGCAACCGATAAAGTGTGCGAAAAGT
TGGGTATCAGCGCAGCTTGTACCACAGCGCAAGTGCCATTACCCGGCTCACGGCAATCCGCAGAACAGACTTTAAGCAAA
GTGATCTCTTTGCCTGCCAGCATTCGCGGTTCGGCGGTTTATCGCCATGGTGATCGTGCCACGCAGTTGTTGGTGGGAAA
CCGGCTGGATAACAGCCTGGTGTGTGAATGTGAGGCGGTCACCGCCGGTGAAGTTCGCTACGCGGTTGAATCTTTATCGG
TCAATAACCTGTTGGATTTACGCCGTCGTACCCGTGTGGGGATGGGCACTTGCCAGGGAGAACTGTGCGCTTGCCGTGCA
GCGGGCCTACTCAGCCGCTTTAAGGTGACCACACCGCAGCAATCCCGTGAGCAACTGACACAATTTCTCAACGAGCGCTG
GAAAGGTGTACGCCCAATTGCTTGGGGTGATGCATTGCGTGAGAGTGAGTTTACCCAGTGGGTCTATCAGGGACTCTGTG
GTTTGGATGAGATTCCAGCCACCGTGAATGCGCGGGAGAAACACGATGAAATTTGA

Upstream 100 bases:

>100_bases
GGTTCGTTTTTGTTTCTTATCAATCAATATCTATAAAGACTGTGGCTCAATAGGGACATAACTCGCCAGCAGGCGGCTGT
CTGATAATCTGGGGTCTTTC

Downstream 100 bases:

>100_bases
TGTGATCATCATTGGCGGTGGCTTGGCCGGGTTGGCCTGTGGTATTCGTTTGGCCGAACAAGGTAAATATTGTGCGATTG
TCAGTTCCGGACAAAATGCA

Product: sn-glycerol-3-phosphate dehydrogenase subunit A

Products: NA

Alternate protein names: G-3-P dehydrogenase [H]

Number of amino acids: Translated: 551; Mature: 550

Protein sequence:

>551_residues
MTNSSPYLETDVIIIGGGATGAGIARDCARRGLACTLLERHDIATGATGRNHGLLHSGARYAVTDGESARECIEENRILK
RIARHCIEQTDGLFITLPEDSLAYQLQFIARCRDAGIEAEAIDPAQALRLEPAVNPALIAAVRVPDGTVDPFRLTAANML
DAREHGANILTYHEVIGLLRQGSRINGVCVFDHKNQRKYDIHAQIVVNAAGIWGQHIAEYADLRIRMFPAKGALLILGHR
INNMVINRCRKPADADILVPGDTISLIGTTSTHINYDQIDNMVVTAQEVDTLIREGAKLSPQLAQTRILRAYAGVRPLVA
SDDDPSGRNVSRGIVLLDHASRDGVEGFITITGGKLMTYRLMAEWATDKVCEKLGISAACTTAQVPLPGSRQSAEQTLSK
VISLPASIRGSAVYRHGDRATQLLVGNRLDNSLVCECEAVTAGEVRYAVESLSVNNLLDLRRRTRVGMGTCQGELCACRA
AGLLSRFKVTTPQQSREQLTQFLNERWKGVRPIAWGDALRESEFTQWVYQGLCGLDEIPATVNAREKHDEI

Sequences:

>Translated_551_residues
MTNSSPYLETDVIIIGGGATGAGIARDCARRGLACTLLERHDIATGATGRNHGLLHSGARYAVTDGESARECIEENRILK
RIARHCIEQTDGLFITLPEDSLAYQLQFIARCRDAGIEAEAIDPAQALRLEPAVNPALIAAVRVPDGTVDPFRLTAANML
DAREHGANILTYHEVIGLLRQGSRINGVCVFDHKNQRKYDIHAQIVVNAAGIWGQHIAEYADLRIRMFPAKGALLILGHR
INNMVINRCRKPADADILVPGDTISLIGTTSTHINYDQIDNMVVTAQEVDTLIREGAKLSPQLAQTRILRAYAGVRPLVA
SDDDPSGRNVSRGIVLLDHASRDGVEGFITITGGKLMTYRLMAEWATDKVCEKLGISAACTTAQVPLPGSRQSAEQTLSK
VISLPASIRGSAVYRHGDRATQLLVGNRLDNSLVCECEAVTAGEVRYAVESLSVNNLLDLRRRTRVGMGTCQGELCACRA
AGLLSRFKVTTPQQSREQLTQFLNERWKGVRPIAWGDALRESEFTQWVYQGLCGLDEIPATVNAREKHDEI
>Mature_550_residues
TNSSPYLETDVIIIGGGATGAGIARDCARRGLACTLLERHDIATGATGRNHGLLHSGARYAVTDGESARECIEENRILKR
IARHCIEQTDGLFITLPEDSLAYQLQFIARCRDAGIEAEAIDPAQALRLEPAVNPALIAAVRVPDGTVDPFRLTAANMLD
AREHGANILTYHEVIGLLRQGSRINGVCVFDHKNQRKYDIHAQIVVNAAGIWGQHIAEYADLRIRMFPAKGALLILGHRI
NNMVINRCRKPADADILVPGDTISLIGTTSTHINYDQIDNMVVTAQEVDTLIREGAKLSPQLAQTRILRAYAGVRPLVAS
DDDPSGRNVSRGIVLLDHASRDGVEGFITITGGKLMTYRLMAEWATDKVCEKLGISAACTTAQVPLPGSRQSAEQTLSKV
ISLPASIRGSAVYRHGDRATQLLVGNRLDNSLVCECEAVTAGEVRYAVESLSVNNLLDLRRRTRVGMGTCQGELCACRAA
GLLSRFKVTTPQQSREQLTQFLNERWKGVRPIAWGDALRESEFTQWVYQGLCGLDEIPATVNAREKHDEI

Specific function: Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor [H]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=533, Percent_Identity=24.202626641651, Blast_Score=117, Evalue=3e-26,
Organism=Homo sapiens, GI285002231, Length=533, Percent_Identity=24.202626641651, Blast_Score=117, Evalue=3e-26,
Organism=Escherichia coli, GI1788574, Length=512, Percent_Identity=77.34375, Blast_Score=811, Evalue=0.0,
Organism=Escherichia coli, GI2367226, Length=462, Percent_Identity=24.6753246753247, Blast_Score=85, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI115534726, Length=507, Percent_Identity=25.0493096646943, Blast_Score=104, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17509253, Length=521, Percent_Identity=27.6391554702495, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI161077125, Length=514, Percent_Identity=27.0428015564202, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24653942, Length=514, Percent_Identity=27.0428015564202, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24653944, Length=514, Percent_Identity=27.0428015564202, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI20130025, Length=514, Percent_Identity=27.0428015564202, Blast_Score=94, Evalue=3e-19,
Organism=Drosophila melanogaster, GI20130091, Length=242, Percent_Identity=28.5123966942149, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24586295, Length=386, Percent_Identity=22.5388601036269, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007419
- InterPro:   IPR006076
- InterPro:   IPR017752
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO; PF04324 Fer2_BFD [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 60153; Mature: 60022

Theoretical pI: Translated: 7.14; Mature: 7.14

Prosite motif: PS00977 FAD_G3PDH_1 ; PS00978 FAD_G3PDH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNSSPYLETDVIIIGGGATGAGIARDCARRGLACTLLERHDIATGATGRNHGLLHSGAR
CCCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCEEEEEHHCCCCCCCCCCCCCCEECCCE
YAVTDGESARECIEENRILKRIARHCIEQTDGLFITLPEDSLAYQLQFIARCRDAGIEAE
EEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCC
AIDPAQALRLEPAVNPALIAAVRVPDGTVDPFRLTAANMLDAREHGANILTYHEVIGLLR
CCCHHHHHCCCCCCCCEEEEEEECCCCCCCCCEEHHHHHHHHHHHCCCEEEHHHHHHHHH
QGSRINGVCVFDHKNQRKYDIHAQIVVNAAGIWGQHIAEYADLRIRMFPAKGALLILGHR
CCCCCCCEEEEECCCCCEEEEEEEEEEEECCHHHHHHHHHHCCEEEEECCCCEEEEEECH
INNMVINRCRKPADADILVPGDTISLIGTTSTHINYDQIDNMVVTAQEVDTLIREGAKLS
HHHHHHHHCCCCCCCEEEECCCEEEEEECCCCCCCHHHHCCEEEEHHHHHHHHHCCCCCC
PQLAQTRILRAYAGVRPLVASDDDPSGRNVSRGIVLLDHASRDGVEGFITITGGKLMTYR
HHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEEHH
LMAEWATDKVCEKLGISAACTTAQVPLPGSRQSAEQTLSKVISLPASIRGSAVYRHGDRA
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCH
TQLLVGNRLDNSLVCECEAVTAGEVRYAVESLSVNNLLDLRRRTRVGMGTCQGELCACRA
HEEEECCCCCCCEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
AGLLSRFKVTTPQQSREQLTQFLNERWKGVRPIAWGDALRESEFTQWVYQGLCGLDEIPA
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
TVNAREKHDEI
CCCCCHHCCCC
>Mature Secondary Structure 
TNSSPYLETDVIIIGGGATGAGIARDCARRGLACTLLERHDIATGATGRNHGLLHSGAR
CCCCCCEEEEEEEEECCCCCCHHHHHHHHCCCEEEEEHHCCCCCCCCCCCCCCEECCCE
YAVTDGESARECIEENRILKRIARHCIEQTDGLFITLPEDSLAYQLQFIARCRDAGIEAE
EEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHCCCCCC
AIDPAQALRLEPAVNPALIAAVRVPDGTVDPFRLTAANMLDAREHGANILTYHEVIGLLR
CCCHHHHHCCCCCCCCEEEEEEECCCCCCCCCEEHHHHHHHHHHHCCCEEEHHHHHHHHH
QGSRINGVCVFDHKNQRKYDIHAQIVVNAAGIWGQHIAEYADLRIRMFPAKGALLILGHR
CCCCCCCEEEEECCCCCEEEEEEEEEEEECCHHHHHHHHHHCCEEEEECCCCEEEEEECH
INNMVINRCRKPADADILVPGDTISLIGTTSTHINYDQIDNMVVTAQEVDTLIREGAKLS
HHHHHHHHCCCCCCCEEEECCCEEEEEECCCCCCCHHHHCCEEEEHHHHHHHHHCCCCCC
PQLAQTRILRAYAGVRPLVASDDDPSGRNVSRGIVLLDHASRDGVEGFITITGGKLMTYR
HHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEEECCCEEEHH
LMAEWATDKVCEKLGISAACTTAQVPLPGSRQSAEQTLSKVISLPASIRGSAVYRHGDRA
HHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCH
TQLLVGNRLDNSLVCECEAVTAGEVRYAVESLSVNNLLDLRRRTRVGMGTCQGELCACRA
HEEEECCCCCCCEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
AGLLSRFKVTTPQQSREQLTQFLNERWKGVRPIAWGDALRESEFTQWVYQGLCGLDEIPA
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCC
TVNAREKHDEI
CCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]