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The map label for this gene is panF [H]

Identifier: 218930667

GI number: 218930667

Start: 4075981

End: 4077435

Strand: Reverse

Name: panF [H]

Synonym: YPO3657

Alternate gene names: 218930667

Gene position: 4077435-4075981 (Counterclockwise)

Preceding gene: 218930668

Following gene: 218930666

Centisome position: 87.62

GC content: 52.78

Gene sequence:

>1455_bases
ATGCAAACTGATGTCGTTCTGCCGTTAGTCGGCTATCTGGTGTTGGTCTTTGGCTTATCTATTTATGCTTATACGCGCCG
CCAAACCGGGAATTTTCTCAACGAATATTTTATCGGCAACCGTTCGATGGGCGGTTTTGTATTGGCGATGACCCTGACCG
CCACCTATATCAGCGCCAGCTCGTTTATTGGTGGACCAGGTGCCGCTTATAAATACGGCCTTGGCTGGGTCTTACTGGCG
ATGATCCAATTGCCTGCGGTCTGGCTTTCCCTCGGTGTCTTAGGCAAAAAGTTTGCCATTCTGGCGCGTCGCTATAATGC
CGTGACCCTCAACGATATGTTGTATGCCCGTTATCAGAGCCGTTTACTGGTTTGGCTGGCCAGTATCAGCCTGCTGGTGG
CTTTTGTCGGTGCCATGACCGTGCAATTTATTGGTGGCGCACGGTTGTTAGAAACGGCGGCGGGGATCCCTTACGACACT
GGCTTATTGATTTTTGGTATCAGTATCGCCCTGTACACCTCGTTTGGTGGCTTCCGGGCCAGTGTCTTGAATGATGCCCT
GCAAGGGTTAGTGATGCTGATCGGCACCATTTTACTGTTAGTTGCGGTGATCCACGCGGCAGGTGGCCTACACAAAGCCG
TCGAAACGCTGCAACATATCGATCCGGCGCTGGTTTCCCCCCAAGGCGGCGATCAGATCCTCGACGTGCCATTTATGGCT
TCGTTCTGGATCCTGGTCTGTTTTGGGGTGATTGGTCTGCCACACACCGCCGTACGTTGTATTTCGTATCGTGACAGTAA
AGCGGTTCATCGCGGTATTATCCTCGGCACCATCGTGGTGGCGATCCTAATGTTCGGTATGCACCTGGCTGGCGCACTGG
GGCGGGCGGTGTTACCAGATCTGAAAATTCCAGATCAAGTAATCCCGACACTGATGATCACCGTACTGCCGCCATTTGCT
GCGGGGATATTCCTGGCAGCACCGATGGCGGCGATCATGTCGACCATCAATGCCCAGTTACTGCAATCTTCTGCTACCAT
CGTGAAGGATTTGTATCTCAATCTGTGGCCAGCAGAGTTAAAGAATGAGCGCAAGCTGGCACGTATCTCCAGCTTATCCA
CACTCATTCTTGGGCTATTATTGCTCTTGGCCGCCTGGCGACCACCTGAAATGATTATCTGGTTGAACCTACTGGCCTTT
GGCGGACTGGAAGCGGTATTCCTCTGGCCATTGGTATTGGGATTATACTGGGAGCGAGCCAATGCCCACGGCGCTCTTAG
CGCCATGATCGTCGGTGCGGTATGCTATACGGTATTAGCCAGCTTCGACATCAAGATAGCCGGCCTGCACCCCATTGTGC
CGTCACTTACACTTAATCTGTTGGCGTTTTATATCGGTAATCTGTTTGGCGACAGAGCGCGGGCGCGACACCCCGCCATC
GTCAGTGCCGATTAA

Upstream 100 bases:

>100_bases
TGGTTTGAAGCGGCCTGTATCGCATTACCGCTCCTGTTTATTGTGCTGTGTATTCTGATGGTGCGGCTGATATTCCGCGA
TATTCCACTGGAGGATGACG

Downstream 100 bases:

>100_bases
CATCACTATTACTCTATCAACACATCAGCCGGTATCGTGGTTATGGCCCCGATACCGGCGCTTGAGAGAATTGCTATGCC
TTGGATCCAACTAAAATTAA

Product: sodium/panthothenate symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 484; Mature: 484

Protein sequence:

>484_residues
MQTDVVLPLVGYLVLVFGLSIYAYTRRQTGNFLNEYFIGNRSMGGFVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGVLGKKFAILARRYNAVTLNDMLYARYQSRLLVWLASISLLVAFVGAMTVQFIGGARLLETAAGIPYDT
GLLIFGISIALYTSFGGFRASVLNDALQGLVMLIGTILLLVAVIHAAGGLHKAVETLQHIDPALVSPQGGDQILDVPFMA
SFWILVCFGVIGLPHTAVRCISYRDSKAVHRGIILGTIVVAILMFGMHLAGALGRAVLPDLKIPDQVIPTLMITVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIVKDLYLNLWPAELKNERKLARISSLSTLILGLLLLLAAWRPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAHGALSAMIVGAVCYTVLASFDIKIAGLHPIVPSLTLNLLAFYIGNLFGDRARARHPAI
VSAD

Sequences:

>Translated_484_residues
MQTDVVLPLVGYLVLVFGLSIYAYTRRQTGNFLNEYFIGNRSMGGFVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGVLGKKFAILARRYNAVTLNDMLYARYQSRLLVWLASISLLVAFVGAMTVQFIGGARLLETAAGIPYDT
GLLIFGISIALYTSFGGFRASVLNDALQGLVMLIGTILLLVAVIHAAGGLHKAVETLQHIDPALVSPQGGDQILDVPFMA
SFWILVCFGVIGLPHTAVRCISYRDSKAVHRGIILGTIVVAILMFGMHLAGALGRAVLPDLKIPDQVIPTLMITVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIVKDLYLNLWPAELKNERKLARISSLSTLILGLLLLLAAWRPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAHGALSAMIVGAVCYTVLASFDIKIAGLHPIVPSLTLNLLAFYIGNLFGDRARARHPAI
VSAD
>Mature_484_residues
MQTDVVLPLVGYLVLVFGLSIYAYTRRQTGNFLNEYFIGNRSMGGFVLAMTLTATYISASSFIGGPGAAYKYGLGWVLLA
MIQLPAVWLSLGVLGKKFAILARRYNAVTLNDMLYARYQSRLLVWLASISLLVAFVGAMTVQFIGGARLLETAAGIPYDT
GLLIFGISIALYTSFGGFRASVLNDALQGLVMLIGTILLLVAVIHAAGGLHKAVETLQHIDPALVSPQGGDQILDVPFMA
SFWILVCFGVIGLPHTAVRCISYRDSKAVHRGIILGTIVVAILMFGMHLAGALGRAVLPDLKIPDQVIPTLMITVLPPFA
AGIFLAAPMAAIMSTINAQLLQSSATIVKDLYLNLWPAELKNERKLARISSLSTLILGLLLLLAAWRPPEMIIWLNLLAF
GGLEAVFLWPLVLGLYWERANAHGALSAMIVGAVCYTVLASFDIKIAGLHPIVPSLTLNLLAFYIGNLFGDRARARHPAI
VSAD

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG4145

COG function: function code H; Na+/panthothenate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=466, Percent_Identity=26.8240343347639, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI14140236, Length=477, Percent_Identity=22.8511530398323, Blast_Score=85, Evalue=1e-16,
Organism=Homo sapiens, GI157671931, Length=357, Percent_Identity=20.4481792717087, Blast_Score=73, Evalue=7e-13,
Organism=Homo sapiens, GI4507033, Length=407, Percent_Identity=24.5700245700246, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI109659836, Length=478, Percent_Identity=24.0585774058577, Blast_Score=72, Evalue=2e-12,
Organism=Homo sapiens, GI4507035, Length=377, Percent_Identity=24.9336870026525, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI256985183, Length=442, Percent_Identity=23.0769230769231, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI87082237, Length=470, Percent_Identity=82.7659574468085, Blast_Score=763, Evalue=0.0,
Organism=Escherichia coli, GI1787251, Length=480, Percent_Identity=26.4583333333333, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1790503, Length=451, Percent_Identity=21.2860310421286, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790113, Length=501, Percent_Identity=22.1556886227545, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28573698, Length=461, Percent_Identity=23.644251626898, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 52093; Mature: 52093

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS00456 NA_SOLUT_SYMP_1 ; PS00457 NA_SOLUT_SYMP_2 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTDVVLPLVGYLVLVFGLSIYAYTRRQTGNFLNEYFIGNRSMGGFVLAMTLTATYISAS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
SFIGGPGAAYKYGLGWVLLAMIQLPAVWLSLGVLGKKFAILARRYNAVTLNDMLYARYQS
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEHHHHHHHHHHH
RLLVWLASISLLVAFVGAMTVQFIGGARLLETAAGIPYDTGLLIFGISIALYTSFGGFRA
HHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCHHH
SVLNDALQGLVMLIGTILLLVAVIHAAGGLHKAVETLQHIDPALVSPQGGDQILDVPFMA
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCEECCHHHH
SFWILVCFGVIGLPHTAVRCISYRDSKAVHRGIILGTIVVAILMFGMHLAGALGRAVLPD
HHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
LKIPDQVIPTLMITVLPPFAAGIFLAAPMAAIMSTINAQLLQSSATIVKDLYLNLWPAEL
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
KNERKLARISSLSTLILGLLLLLAAWRPPEMIIWLNLLAFGGLEAVFLWPLVLGLYWERA
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHC
NAHGALSAMIVGAVCYTVLASFDIKIAGLHPIVPSLTLNLLAFYIGNLFGDRARARHPAI
CCCHHHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHHHCCHHHCCCCCE
VSAD
EECC
>Mature Secondary Structure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EECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]