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The map label for this gene is kdsC

Identifier: 218930590

GI number: 218930590

Start: 3990017

End: 3990580

Strand: Direct

Name: kdsC

Synonym: YPO3578

Alternate gene names: 218930590

Gene position: 3990017-3990580 (Clockwise)

Preceding gene: 218930589

Following gene: 218930591

Centisome position: 85.74

GC content: 49.11

Gene sequence:

>564_bases
ATGAGCAACACCGCATATATAGACACATGCTACGGGCCAGTGGCCGATGACGTAATACAACGTGCAGCAAACATTCGTCT
ACTGATTTGTGATGTCGACGGTGTTATGTCCGATGGCCTGATTTATATGGGCAATCAAGGCGAAGAGCTGAAAGCGTTCA
ACGTGCGTGATGGCTATGGTATCCGCTGCCTGATAACCTCAGACATTGACGTCGCTATCATTACTGGCCGCCGGGCAAAA
TTATTGGAAGACCGAGCCAACACCTTAGGCATTACCCACCTTTATCAAGGACAATCTGATAAGCTGGTGGCCTACCACGA
ATTATTAGCTACCTTACAGTGTCAACCCGAGCAGGTCGCTTATATTGGTGATGACTTGATTGATTGGCCCGTAATGGCGC
AAGTTGGGTTATCTGTTGCGGTGGCAGATGCCCATCCGTTACTGTTACCCAAGGCGCATTATGTGACTCGAATCAAGGGG
GGCCGGGGGGCGGTACGTGAAGTATGTGATTTGATATTATTGGCCCAAGACAAGCTCGAAGGGGCCACAGGATTATCAAT
ATGA

Upstream 100 bases:

>100_bases
AGCAAACGAATGAATCCCGATGAGCTGACACCAGTCAGTGATTCGGGTGAATGAGTGCCGCTAACAACGCTGCAACTTCA
AGTAAGAAGGGTAAGAGTTA

Downstream 100 bases:

>100_bases
GCAAGACAAGACGCTGGATAACACTGGTACTGGCACTGATTGCGTTAGCCTTGATTGGCTGGAATATGTCAGGTTTTAAT
CAACAAGGTGCGCCAGTAGT

Product: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase

Products: NA

Alternate protein names: KDO 8-P phosphatase

Number of amino acids: Translated: 187; Mature: 186

Protein sequence:

>187_residues
MSNTAYIDTCYGPVADDVIQRAANIRLLICDVDGVMSDGLIYMGNQGEELKAFNVRDGYGIRCLITSDIDVAIITGRRAK
LLEDRANTLGITHLYQGQSDKLVAYHELLATLQCQPEQVAYIGDDLIDWPVMAQVGLSVAVADAHPLLLPKAHYVTRIKG
GRGAVREVCDLILLAQDKLEGATGLSI

Sequences:

>Translated_187_residues
MSNTAYIDTCYGPVADDVIQRAANIRLLICDVDGVMSDGLIYMGNQGEELKAFNVRDGYGIRCLITSDIDVAIITGRRAK
LLEDRANTLGITHLYQGQSDKLVAYHELLATLQCQPEQVAYIGDDLIDWPVMAQVGLSVAVADAHPLLLPKAHYVTRIKG
GRGAVREVCDLILLAQDKLEGATGLSI
>Mature_186_residues
SNTAYIDTCYGPVADDVIQRAANIRLLICDVDGVMSDGLIYMGNQGEELKAFNVRDGYGIRCLITSDIDVAIITGRRAKL
LEDRANTLGITHLYQGQSDKLVAYHELLATLQCQPEQVAYIGDDLIDWPVMAQVGLSVAVADAHPLLLPKAHYVTRIKGG
RGAVREVCDLILLAQDKLEGATGLSI

Specific function: Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate

COG id: COG1778

COG function: function code R; Low specificity phosphatase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsC family

Homologues:

Organism=Homo sapiens, GI8923900, Length=164, Percent_Identity=30.4878048780488, Blast_Score=81, Evalue=5e-16,
Organism=Escherichia coli, GI2367202, Length=183, Percent_Identity=77.0491803278689, Blast_Score=289, Evalue=6e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDSC_YERPE (Q8ZB47)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AC0435
- RefSeq:   NP_667493.1
- RefSeq:   NP_995103.1
- RefSeq:   YP_002348465.1
- PDB:   3IJ5
- PDBsum:   3IJ5
- ProteinModelPortal:   Q8ZB47
- SMR:   Q8ZB47
- GeneID:   1145097
- GeneID:   1176398
- GeneID:   2764371
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO3578
- KEGG:   ypk:y0150
- KEGG:   ypm:YP_3833
- HOGENOM:   HBG471796
- OMA:   KTFNTLD
- ProtClustDB:   PRK09484
- BioCyc:   YPES187410:Y0150-MONOMER
- BioCyc:   YPES214092:YPO3578-MONOMER
- BRENDA:   3.1.3.45
- InterPro:   IPR023214
- InterPro:   IPR013200
- InterPro:   IPR006549
- InterPro:   IPR010023
- Gene3D:   G3DSA:3.40.50.1000
- PIRSF:   PIRSF006118
- TIGRFAMs:   TIGR01662
- TIGRFAMs:   TIGR01670

Pfam domain/function: PF08282 Hydrolase_3; SSF56784 SSF56784

EC number: =3.1.3.45

Molecular weight: Translated: 20300; Mature: 20168

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTAYIDTCYGPVADDVIQRAANIRLLICDVDGVMSDGLIYMGNQGEELKAFNVRDGYG
CCCCEEEEECCCCHHHHHHHHHCCEEEEEEECCCCCCCCEEEECCCCCCEEEEECCCCCC
IRCLITSDIDVAIITGRRAKLLEDRANTLGITHLYQGQSDKLVAYHELLATLQCQPEQVA
EEEEEECCCCEEEEECCCHHHHHHHCHHEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEE
YIGDDLIDWPVMAQVGLSVAVADAHPLLLPKAHYVTRIKGGRGAVREVCDLILLAQDKLE
EECCCCCCCHHHHHCCCEEEEECCCCEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHCC
GATGLSI
CCCCCCC
>Mature Secondary Structure 
SNTAYIDTCYGPVADDVIQRAANIRLLICDVDGVMSDGLIYMGNQGEELKAFNVRDGYG
CCCEEEEECCCCHHHHHHHHHCCEEEEEEECCCCCCCCEEEECCCCCCEEEEECCCCCC
IRCLITSDIDVAIITGRRAKLLEDRANTLGITHLYQGQSDKLVAYHELLATLQCQPEQVA
EEEEEECCCCEEEEECCCHHHHHHHCHHEEEEEEECCCCCCCHHHHHHHHHHCCCCCCEE
YIGDDLIDWPVMAQVGLSVAVADAHPLLLPKAHYVTRIKGGRGAVREVCDLILLAQDKLE
EECCCCCCCHHHHHCCCEEEEECCCCEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHCC
GATGLSI
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430