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The map label for this gene is kdsD

Identifier: 218930589

GI number: 218930589

Start: 3988782

End: 3989768

Strand: Direct

Name: kdsD

Synonym: YPO3577

Alternate gene names: 218930589

Gene position: 3988782-3989768 (Clockwise)

Preceding gene: 218930588

Following gene: 218930590

Centisome position: 85.71

GC content: 50.96

Gene sequence:

>987_bases
ATGTCTACTTTTGATTTACAGCCGGGCGTGGATTTCCAGCAGGCAGGTAAGCAGGTACTTCAGATTGAACGCGAAGGGCT
GGCTCAACTCGATCAATACATAAACGAGGATTTCTCCAGAGCCTGTGAGGCCATTTTTCGTTGCCACGGCAAAGTCGTCG
TGATGGGAATGGGCAAATCTGGTCATATTGGCTGCAAAATTGCAGCCACATTCGCCAGCACGGGCACACCTGCATTTTTT
GTCCATCCTGGTGAAGCCAGCCATGGCGATTTGGGCATGATCACGCCACAAGATATTGTATTAGCTATCTCTAACTCTGG
GGAATCCAACGAAATCCTCACGTTGATCCCCGTGCTTAAGCGCCAGAAAATTCTGTTGATTTGCATGAGCAGTAACCCTG
AGAGCACCATGGGTAAAGCGGCCGATATTCACTTGTGCATTAATGTGCCACAAGAGGCCTGTCCGCTGGGGCTAGCGCCA
ACCACCAGTACGACTGCAACACTGGTTATGGGGGATGCGTTGGCGGTAGCCTTGCTCAAAGCACGGGGTTTCACGCAGGA
AGATTTCGCACTCTCTCACCCAGGTGGCGCGCTGGGGCGTAAGTTGCTGCTGCGGATCAGCGATATTATGCATACGGGTA
CGGAGATCCCCACCGTCAGCCCTGATGCATCATTACGTGATGCCTTGCTAGAAATTACTCGGAAAAGTCTGGGTTTGACC
GTTATTTGTGACGATTCAATGAGGATTAAAGGTATCTTTACCGACGGTGACTTGCGCCGGGTATTTGATATGGGCATTGA
TCTGAATAATGCAAAAATTGCTGACGTCATGACTCGCGGGGGTATTCGAGTCCCTCCGAACATATTGGCGGTGGACGCGC
TCAATCTGATGGAGTCACGCCATATCACTGCGTTGCTCGTCGCTGATGGTGACCAATTACTGGGTGTCGTACATATGCAC
GATATGCTGAGAGCCGGTGTTGTCTGA

Upstream 100 bases:

>100_bases
CCTATAAATTTCAATGCTCAGGAAGGCTTGGAGCGAAAGCAACCAACACACCTACAGCGTGAAAGATGACGGTAATACCA
ACATTGGGCGGATATTAAGT

Downstream 100 bases:

>100_bases
CAGTTTAGTTGAGTCAATGAGCGCCGCGAACAATGCTATCAGTCAGTGATTCGGGTGAGTGAGTGCCGCTACCAATGTTG
TAACTTCAAGAACGCTGCAA

Product: D-arabinose 5-phosphate isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 328; Mature: 327

Protein sequence:

>328_residues
MSTFDLQPGVDFQQAGKQVLQIEREGLAQLDQYINEDFSRACEAIFRCHGKVVVMGMGKSGHIGCKIAATFASTGTPAFF
VHPGEASHGDLGMITPQDIVLAISNSGESNEILTLIPVLKRQKILLICMSSNPESTMGKAADIHLCINVPQEACPLGLAP
TTSTTATLVMGDALAVALLKARGFTQEDFALSHPGGALGRKLLLRISDIMHTGTEIPTVSPDASLRDALLEITRKSLGLT
VICDDSMRIKGIFTDGDLRRVFDMGIDLNNAKIADVMTRGGIRVPPNILAVDALNLMESRHITALLVADGDQLLGVVHMH
DMLRAGVV

Sequences:

>Translated_328_residues
MSTFDLQPGVDFQQAGKQVLQIEREGLAQLDQYINEDFSRACEAIFRCHGKVVVMGMGKSGHIGCKIAATFASTGTPAFF
VHPGEASHGDLGMITPQDIVLAISNSGESNEILTLIPVLKRQKILLICMSSNPESTMGKAADIHLCINVPQEACPLGLAP
TTSTTATLVMGDALAVALLKARGFTQEDFALSHPGGALGRKLLLRISDIMHTGTEIPTVSPDASLRDALLEITRKSLGLT
VICDDSMRIKGIFTDGDLRRVFDMGIDLNNAKIADVMTRGGIRVPPNILAVDALNLMESRHITALLVADGDQLLGVVHMH
DMLRAGVV
>Mature_327_residues
STFDLQPGVDFQQAGKQVLQIEREGLAQLDQYINEDFSRACEAIFRCHGKVVVMGMGKSGHIGCKIAATFASTGTPAFFV
HPGEASHGDLGMITPQDIVLAISNSGESNEILTLIPVLKRQKILLICMSSNPESTMGKAADIHLCINVPQEACPLGLAPT
TSTTATLVMGDALAVALLKARGFTQEDFALSHPGGALGRKLLLRISDIMHTGTEIPTVSPDASLRDALLEITRKSLGLTV
ICDDSMRIKGIFTDGDLRRVFDMGIDLNNAKIADVMTRGGIRVPPNILAVDALNLMESRHITALLVADGDQLLGVVHMHD
MLRAGVV

Specific function: Catalyzes the interconversion of D-arabinose 5-phosphate and D-ribulose 5-phosphate

COG id: COG0794

COG function: function code M; Predicted sugar phosphate isomerase involved in capsule formation

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1789588, Length=328, Percent_Identity=77.4390243902439, Blast_Score=530, Evalue=1e-152,
Organism=Escherichia coli, GI87082151, Length=316, Percent_Identity=48.4177215189873, Blast_Score=291, Evalue=3e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDSD_YERPE (Q8D1Q8)

Other databases:

- EMBL:   AL590842
- EMBL:   AE009952
- EMBL:   AE017042
- PIR:   AB0435
- RefSeq:   NP_667491.1
- RefSeq:   NP_995102.1
- RefSeq:   YP_002348464.1
- ProteinModelPortal:   Q8D1Q8
- GeneID:   1145095
- GeneID:   1176397
- GeneID:   2764370
- GenomeReviews:   AE009952_GR
- GenomeReviews:   AE017042_GR
- GenomeReviews:   AL590842_GR
- KEGG:   ype:YPO3577
- KEGG:   ypk:y0149
- KEGG:   ypm:YP_3832
- HOGENOM:   HBG754974
- OMA:   MLAMGDA
- ProtClustDB:   PRK10892
- BioCyc:   YPES187410:Y0149-MONOMER
- BioCyc:   YPES214092:YPO3577-MONOMER
- BRENDA:   5.3.1.13
- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR004800
- InterPro:   IPR001347
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00116
- TIGRFAMs:   TIGR00393

Pfam domain/function: PF00571 CBS; PF01380 SIS

EC number: =5.3.1.13

Molecular weight: Translated: 35062; Mature: 34931

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS51371 CBS; PS51464 SIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTFDLQPGVDFQQAGKQVLQIEREGLAQLDQYINEDFSRACEAIFRCHGKVVVMGMGKS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
GHIGCKIAATFASTGTPAFFVHPGEASHGDLGMITPQDIVLAISNSGESNEILTLIPVLK
CCEEEEEEEEEECCCCCEEEEECCCCCCCCEECCCCCEEEEEEECCCCCCCEEEEEEHHC
RQKILLICMSSNPESTMGKAADIHLCINVPQEACPLGLAPTTSTTATLVMGDALAVALLK
CCEEEEEEECCCCCHHCCCCEEEEEEEECCHHHCCCCCCCCCCCEEEEEEHHHHHHHHHH
ARGFTQEDFALSHPGGALGRKLLLRISDIMHTGTEIPTVSPDASLRDALLEITRKSLGLT
HCCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEE
VICDDSMRIKGIFTDGDLRRVFDMGIDLNNAKIADVMTRGGIRVPPNILAVDALNLMESR
EEECCCEEEEEEECCCHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCEEEHHHHHHHHCC
HITALLVADGDQLLGVVHMHDMLRAGVV
CEEEEEEECCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
STFDLQPGVDFQQAGKQVLQIEREGLAQLDQYINEDFSRACEAIFRCHGKVVVMGMGKS
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCC
GHIGCKIAATFASTGTPAFFVHPGEASHGDLGMITPQDIVLAISNSGESNEILTLIPVLK
CCEEEEEEEEEECCCCCEEEEECCCCCCCCEECCCCCEEEEEEECCCCCCCEEEEEEHHC
RQKILLICMSSNPESTMGKAADIHLCINVPQEACPLGLAPTTSTTATLVMGDALAVALLK
CCEEEEEEECCCCCHHCCCCEEEEEEEECCHHHCCCCCCCCCCCEEEEEEHHHHHHHHHH
ARGFTQEDFALSHPGGALGRKLLLRISDIMHTGTEIPTVSPDASLRDALLEITRKSLGLT
HCCCCCCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCEE
VICDDSMRIKGIFTDGDLRRVFDMGIDLNNAKIADVMTRGGIRVPPNILAVDALNLMESR
EEECCCEEEEEEECCCHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCCEEEHHHHHHHHCC
HITALLVADGDQLLGVVHMHDMLRAGVV
CEEEEEEECCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430