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The map label for this gene is msrA

Identifier: 218930539

GI number: 218930539

Start: 3937294

End: 3937932

Strand: Direct

Name: msrA

Synonym: YPO3525

Alternate gene names: 218930539

Gene position: 3937294-3937932 (Clockwise)

Preceding gene: 218930535

Following gene: 218930540

Centisome position: 84.61

GC content: 53.21

Gene sequence:

>639_bases
ATGCAAAACGTTGATAATACCGCCGTCATTGATGCGGCGAATGCCTTGCCGGGGCGACTGACATCAATACCGGTCTCTCC
TCTCCATGCCGTTCATGGTCATTCCATGACGTATATACCGGAGGGGATGGACCTAGCCTTCTTCGCCATGGGCTGCTTCT
GGGGAGCCGAACGCTTGTTCTGGCAACAGCCTGGCGTCTATAGCACCGCAGCAGGTTACAGCGGTGGTCACACGCCTAAT
CCAACCTATCATGAAGTTTGCAGTGGTCGTACAGGCCATGCGGAGGTGGTTCGTGTTGTTTTTGATCCCGCCGTCATCAG
CTATCAGCAGCTATTGCAGATTTTCTGGGAAAATCACGATCCAGCACAAGGGATGCGTCAGGGCGGTGATGTCGGGACAC
AATACCGCTCGGCTATTTATGTCCTGACCCCCGAGCAGGAAGAACAAGCTCACAAGAGCCGGGAGCGGTTCCAACAAGCC
ATGGAAAAAGCCGGTGATCAACGGGTGATTACCAGCGAAATTACGGTTGCCCTGCCGTTTTACTATGCCGAGGATGACCA
CCAGCAATATTTGCACAAAAATCCTCATGGATACTGTGGTCTTGGGGGTATTGGCGTTTGTCTGCCGCCTAACGTGTAA

Upstream 100 bases:

>100_bases
ACAATCAGATACAACTATCTATAGTGATTCACTGTAAACATCTTGTTATCCATTTACTGTAAAAATCTAATTTACTGTCA
ACCTCGGAGTCTGTTTTTTT

Downstream 100 bases:

>100_bases
GGCTGGCAGTGCGCTCATCGCTGCTGCTATCTCCCATCGCTGCTGCTATACTGTCCGGGCTGTTCACTCAGCCCAATAAC
CACTTTCTGCCATTAGCTTG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MQNVDNTAVIDAANALPGRLTSIPVSPLHAVHGHSMTYIPEGMDLAFFAMGCFWGAERLFWQQPGVYSTAAGYSGGHTPN
PTYHEVCSGRTGHAEVVRVVFDPAVISYQQLLQIFWENHDPAQGMRQGGDVGTQYRSAIYVLTPEQEEQAHKSRERFQQA
MEKAGDQRVITSEITVALPFYYAEDDHQQYLHKNPHGYCGLGGIGVCLPPNV

Sequences:

>Translated_212_residues
MQNVDNTAVIDAANALPGRLTSIPVSPLHAVHGHSMTYIPEGMDLAFFAMGCFWGAERLFWQQPGVYSTAAGYSGGHTPN
PTYHEVCSGRTGHAEVVRVVFDPAVISYQQLLQIFWENHDPAQGMRQGGDVGTQYRSAIYVLTPEQEEQAHKSRERFQQA
MEKAGDQRVITSEITVALPFYYAEDDHQQYLHKNPHGYCGLGGIGVCLPPNV
>Mature_212_residues
MQNVDNTAVIDAANALPGRLTSIPVSPLHAVHGHSMTYIPEGMDLAFFAMGCFWGAERLFWQQPGVYSTAAGYSGGHTPN
PTYHEVCSGRTGHAEVVRVVFDPAVISYQQLLQIFWENHDPAQGMRQGGDVGTQYRSAIYVLTPEQEEQAHKSRERFQQA
MEKAGDQRVITSEITVALPFYYAEDDHQQYLHKNPHGYCGLGGIGVCLPPNV

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family

Homologues:

Organism=Homo sapiens, GI6912516, Length=204, Percent_Identity=55.8823529411765, Blast_Score=234, Evalue=3e-62,
Organism=Homo sapiens, GI208609995, Length=187, Percent_Identity=57.7540106951872, Blast_Score=221, Evalue=3e-58,
Organism=Homo sapiens, GI208609993, Length=204, Percent_Identity=42.156862745098, Blast_Score=153, Evalue=1e-37,
Organism=Escherichia coli, GI1790665, Length=210, Percent_Identity=73.3333333333333, Blast_Score=308, Evalue=1e-85,
Organism=Caenorhabditis elegans, GI17533973, Length=148, Percent_Identity=37.1621621621622, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320881, Length=179, Percent_Identity=32.9608938547486, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24664627, Length=168, Percent_Identity=36.9047619047619, Blast_Score=99, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24664631, Length=168, Percent_Identity=36.3095238095238, Blast_Score=94, Evalue=5e-20,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=39.0070921985816, Blast_Score=92, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MSRA_YERP3 (A7FMV2)

Other databases:

- EMBL:   CP000720
- RefSeq:   YP_001402580.1
- ProteinModelPortal:   A7FMV2
- SMR:   A7FMV2
- STRING:   A7FMV2
- GeneID:   5385789
- GenomeReviews:   CP000720_GR
- KEGG:   ypi:YpsIP31758_3626
- eggNOG:   COG0225
- HOGENOM:   HBG748152
- OMA:   SAIYCTT
- ProtClustDB:   PRK00058
- BioCyc:   YPSE349747:YPSIP31758_3626-MONOMER
- HAMAP:   MF_01401
- InterPro:   IPR002569
- Gene3D:   G3DSA:3.30.1060.10
- TIGRFAMs:   TIGR00401

Pfam domain/function: PF01625 PMSR; SSF55068 MsrA

EC number: =1.8.4.11

Molecular weight: Translated: 23434; Mature: 23434

Theoretical pI: Translated: 5.91; Mature: 5.91

Prosite motif: NA

Important sites: ACT_SITE 52-52

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNVDNTAVIDAANALPGRLTSIPVSPLHAVHGHSMTYIPEGMDLAFFAMGCFWGAERLF
CCCCCCCEEEECCCCCCCCCEECCCCHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHH
WQQPGVYSTAAGYSGGHTPNPTYHEVCSGRTGHAEVVRVVFDPAVISYQQLLQIFWENHD
HCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCC
PAQGMRQGGDVGTQYRSAIYVLTPEQEEQAHKSRERFQQAMEKAGDQRVITSEITVALPF
HHHHHHCCCCCCCHHHCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEE
YYAEDDHQQYLHKNPHGYCGLGGIGVCLPPNV
EECCCHHHHHHHCCCCCEECCCCCCEECCCCC
>Mature Secondary Structure
MQNVDNTAVIDAANALPGRLTSIPVSPLHAVHGHSMTYIPEGMDLAFFAMGCFWGAERLF
CCCCCCCEEEECCCCCCCCCEECCCCHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHH
WQQPGVYSTAAGYSGGHTPNPTYHEVCSGRTGHAEVVRVVFDPAVISYQQLLQIFWENHD
HCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHCCCC
PAQGMRQGGDVGTQYRSAIYVLTPEQEEQAHKSRERFQQAMEKAGDQRVITSEITVALPF
HHHHHHCCCCCCCHHHCEEEEECCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEEE
YYAEDDHQQYLHKNPHGYCGLGGIGVCLPPNV
EECCCHHHHHHHCCCCCEECCCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA