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The map label for this gene is obgE [H]

Identifier: 218930523

GI number: 218930523

Start: 3919376

End: 3920548

Strand: Reverse

Name: obgE [H]

Synonym: YPO3509

Alternate gene names: 218930523

Gene position: 3920548-3919376 (Counterclockwise)

Preceding gene: 218930524

Following gene: 218930519

Centisome position: 84.25

GC content: 48.93

Gene sequence:

>1173_bases
ATGAAGTTTGTAGATGAAGCTGCAATCCTGGTTGTAGCAGGTGATGGTGGTAACGGTTGTGTCAGTTTCCGCCGTGAAAA
GTATATCCCTAACGGTGGCCCTGACGGTGGTGACGGTGGTGACGGTGGCGATATTTACCTGCTGGCTGATGAAAACCTCA
ACACACTGATTGATTACCGTTTTGTAAAATCTTTCCGGGCTGAGCGTGGGCAGAATGGTCAGAGCCGCGACTGTACAGGC
AAACGCGGTAAAGATATCACCATCAAAGTCCCGGTTGGTACGCGGGTGCTGGATCAAGGCACTGGTGAAATTGTCGGTGA
TATGGTCCGTCATGGCCAGCGGCTGATGGTGGCCAAAGGCGGTTTTCACGGGTTGGGTAACAGCCGTTTCAAATCCTCGG
TTAACCGGGCTCCGCGCCAAAAAACCATGGGAACTGAAGGTGAAACACGTGAGCTGATGCTGGAACTGCTGTTATTGGCC
GATGTGGGTATGTTGGGCCTACCTAATGCCGGTAAATCGACATTTATCCGCGCGGTTTCCGCCGCTAAACCTAAAGTTGC
TGATTATCCATTTACTACCCTGATTCCAAGTCTGGGCGTAGTGCGAATGGATTACGAACAGAGCTTTGTGATTGCCGATA
TTCCAGGTTTGATTGAAGGTGCTTCAGATGGTGCAGGGCTTGGTATTCGCTTCCTGAAACATCTTGAGCGTTGCCGGGTA
TTATTGCACTTGGTGGATTTGGCGCCTATTGATGAATCAGACCCCGCTGAAAATGCCAAAGTAATTGTTAATGAGTTGCA
GCAGTACAGCGAGAACCTTGCTGAGAAGCCTCGCTGGCTTGTTTTCAATAAGATTGACCTGATAGACCCAGAAGAAGCTG
AAAAACGTGCTAAGGCCATTGTAGAAACGCTAGGATGGGAAGGTAAGTACTACATGATCTCTGCCGCGAATCGCGACAAT
GTGAATGCATTGTGCTGGGATGTCATGAGTTTCCTTAATTCTCAACCTAAAGCCATGGCTATTGCAGAAAGCGTGCCAGA
GAAAGTTGAGTTCATGTGGGACGATTACCACCGTGAGCAACTGGCGGAAGTTGAAGCGGAAGCTGAAGACGACTGGGATG
ATGATTGGGATGAAGAAGATGATGACGGCGTAGAAATTATCTACGAACGTTAA

Upstream 100 bases:

>100_bases
AATGTTTTCCGCAATTGGTCACCGTTGGTGGCCACGTCGGACAGAAATAAACCTGGTTGCTTTGCAAAAGCAGCCGGTGA
ATGATTTACGGAGAAAGTAA

Downstream 100 bases:

>100_bases
ATTCTCCAGTTATTCTTTGAATAAGGGCTGCCATTTTTTCGTGGTGGCCCTTATTTTTTGGCAGGGTGGCCCTTATTGGG
GGCGGTGAGCATATCTATTT

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKFVDEAAILVVAGDGGNGCVSFRREKYIPNGGPDGGDGGDGGDIYLLADENLNTLIDYRFVKSFRAERGQNGQSRDCTG
KRGKDITIKVPVGTRVLDQGTGEIVGDMVRHGQRLMVAKGGFHGLGNSRFKSSVNRAPRQKTMGTEGETRELMLELLLLA
DVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLIPSLGVVRMDYEQSFVIADIPGLIEGASDGAGLGIRFLKHLERCRV
LLHLVDLAPIDESDPAENAKVIVNELQQYSENLAEKPRWLVFNKIDLIDPEEAEKRAKAIVETLGWEGKYYMISAANRDN
VNALCWDVMSFLNSQPKAMAIAESVPEKVEFMWDDYHREQLAEVEAEAEDDWDDDWDEEDDDGVEIIYER

Sequences:

>Translated_390_residues
MKFVDEAAILVVAGDGGNGCVSFRREKYIPNGGPDGGDGGDGGDIYLLADENLNTLIDYRFVKSFRAERGQNGQSRDCTG
KRGKDITIKVPVGTRVLDQGTGEIVGDMVRHGQRLMVAKGGFHGLGNSRFKSSVNRAPRQKTMGTEGETRELMLELLLLA
DVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLIPSLGVVRMDYEQSFVIADIPGLIEGASDGAGLGIRFLKHLERCRV
LLHLVDLAPIDESDPAENAKVIVNELQQYSENLAEKPRWLVFNKIDLIDPEEAEKRAKAIVETLGWEGKYYMISAANRDN
VNALCWDVMSFLNSQPKAMAIAESVPEKVEFMWDDYHREQLAEVEAEAEDDWDDDWDEEDDDGVEIIYER
>Mature_390_residues
MKFVDEAAILVVAGDGGNGCVSFRREKYIPNGGPDGGDGGDGGDIYLLADENLNTLIDYRFVKSFRAERGQNGQSRDCTG
KRGKDITIKVPVGTRVLDQGTGEIVGDMVRHGQRLMVAKGGFHGLGNSRFKSSVNRAPRQKTMGTEGETRELMLELLLLA
DVGMLGLPNAGKSTFIRAVSAAKPKVADYPFTTLIPSLGVVRMDYEQSFVIADIPGLIEGASDGAGLGIRFLKHLERCRV
LLHLVDLAPIDESDPAENAKVIVNELQQYSENLAEKPRWLVFNKIDLIDPEEAEKRAKAIVETLGWEGKYYMISAANRDN
VNALCWDVMSFLNSQPKAMAIAESVPEKVEFMWDDYHREQLAEVEAEAEDDWDDDWDEEDDDGVEIIYER

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain [H]

Homologues:

Organism=Homo sapiens, GI24308117, Length=322, Percent_Identity=40.6832298136646, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI111955139, Length=277, Percent_Identity=39.3501805054152, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI111955063, Length=133, Percent_Identity=45.1127819548872, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI4758796, Length=128, Percent_Identity=35.15625, Blast_Score=72, Evalue=8e-13,
Organism=Homo sapiens, GI58761500, Length=135, Percent_Identity=31.1111111111111, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1789574, Length=390, Percent_Identity=77.6923076923077, Blast_Score=562, Evalue=1e-161,
Organism=Escherichia coli, GI1787454, Length=128, Percent_Identity=34.375, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17508313, Length=325, Percent_Identity=38.4615384615385, Blast_Score=158, Evalue=4e-39,
Organism=Caenorhabditis elegans, GI17552324, Length=308, Percent_Identity=32.4675324675325, Blast_Score=140, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17509631, Length=128, Percent_Identity=35.9375, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17555344, Length=119, Percent_Identity=32.7731092436975, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321962, Length=175, Percent_Identity=38.2857142857143, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319281, Length=232, Percent_Identity=24.1379310344828, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20129375, Length=286, Percent_Identity=42.6573426573427, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24585318, Length=311, Percent_Identity=35.6913183279743, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24640873, Length=136, Percent_Identity=31.6176470588235, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24640877, Length=136, Percent_Identity=31.6176470588235, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24640875, Length=136, Percent_Identity=31.6176470588235, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917 [H]

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 43148; Mature: 43148

Theoretical pI: Translated: 4.43; Mature: 4.43

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFVDEAAILVVAGDGGNGCVSFRREKYIPNGGPDGGDGGDGGDIYLLADENLNTLIDYR
CCCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHH
FVKSFRAERGQNGQSRDCTGKRGKDITIKVPVGTRVLDQGTGEIVGDMVRHGQRLMVAKG
HHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHCCCHHHHHHHHHCCCEEEEECC
GFHGLGNSRFKSSVNRAPRQKTMGTEGETRELMLELLLLADVGMLGLPNAGKSTFIRAVS
CCCCCCCHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLIPSLGVVRMDYEQSFVIADIPGLIEGASDGAGLGIRFLKHLERCRV
HCCCCCCCCCHHHHHCCCCEEEECCCCCEEEEECCHHHCCCCCCCCHHHHHHHHHHHHHH
LLHLVDLAPIDESDPAENAKVIVNELQQYSENLAEKPRWLVFNKIDLIDPEEAEKRAKAI
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHH
VETLGWEGKYYMISAANRDNVNALCWDVMSFLNSQPKAMAIAESVPEKVEFMWDDYHREQ
HHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHH
LAEVEAEAEDDWDDDWDEEDDDGVEIIYER
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MKFVDEAAILVVAGDGGNGCVSFRREKYIPNGGPDGGDGGDGGDIYLLADENLNTLIDYR
CCCCCCEEEEEEECCCCCCCCHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHHH
FVKSFRAERGQNGQSRDCTGKRGKDITIKVPVGTRVLDQGTGEIVGDMVRHGQRLMVAKG
HHHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCHHHCCCHHHHHHHHHCCCEEEEECC
GFHGLGNSRFKSSVNRAPRQKTMGTEGETRELMLELLLLADVGMLGLPNAGKSTFIRAVS
CCCCCCCHHHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHH
AAKPKVADYPFTTLIPSLGVVRMDYEQSFVIADIPGLIEGASDGAGLGIRFLKHLERCRV
HCCCCCCCCCHHHHHCCCCEEEECCCCCEEEEECCHHHCCCCCCCCHHHHHHHHHHHHHH
LLHLVDLAPIDESDPAENAKVIVNELQQYSENLAEKPRWLVFNKIDLIDPEEAEKRAKAI
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHH
VETLGWEGKYYMISAANRDNVNALCWDVMSFLNSQPKAMAIAESVPEKVEFMWDDYHREQ
HHHHCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHCHHHHHHHHHHHHHHH
LAEVEAEAEDDWDDDWDEEDDDGVEIIYER
HHHHHHCCCCCCCCCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA