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The map label for this gene is basR [H]

Identifier: 218930521

GI number: 218930521

Start: 3917555

End: 3918217

Strand: Direct

Name: basR [H]

Synonym: YPO3507

Alternate gene names: 218930521

Gene position: 3917555-3918217 (Clockwise)

Preceding gene: 218930520

Following gene: 218930522

Centisome position: 84.18

GC content: 49.32

Gene sequence:

>663_bases
ATGAAATTACTGATTGTTGAAGATGATGAACTGCTACAACGCGGTATAGCCATGGCGCTGACCAGTGAAGGCTATGTCTG
CGACTGCGCAGCTACCGCCGCCGAGGCTCACAGTTTGCTGCAAACCAGTCAGTACAGCATGATTATTCTTGATCTCGGCC
TGCCGGATCAGGATGGTACTCTGTTATTACGTCAATGGCGTCGCCAACATGTCACCCTGCCAGTACTCATCCTCACCGCA
CGTGATGCGCTTGAAGACAGGGTTGACGGGCTGGATGCCGGTGCTGACGATTATCTTGTCAAACCTTTTGCCTTGGCTGA
ATTACTGGCCCGGGTACGTGCTCTCATCCGCCGTTATCAGGGGCAGAGTGACAACCTGGTACAGCAAGATGACCTGAGCC
TTAACTTGTCGACACAACAAGTCTGTTTACAAGGGCAGCCATTAGAGATAACCCCTAAAGAGTTTGCGATCCTCTCACGT
CTAATCATGCGAGCTGGGCAAACAGTTAACCGCGAGTTGTTACAACAGGATCTATATACCTGGAATGACGACCTTAGCTC
TAATACGCTGGAAGTTCATATTCATAATTTGCGACGCAAACTGGGTAAAGATCGTATCCGAACCGTTCGAGGTATTGGTT
ATCGATTGGAAGCCTTATCATGA

Upstream 100 bases:

>100_bases
GCTATGCCGTTCCACCTGAAGACCAAAAAAATCGCCGAGCCCCCTTGGTTCGATTTGAGAGCCGCCTCTATAAAGATATT
TATCAGAATAACTGAGAGCT

Downstream 100 bases:

>100_bases
TCAGCATGCGCCGTCGTTTGCTGTTAATGCTGGCGCTGATTTTACTGGTGACCCAGTTGATCAGCGCATTCTGGCTATGG
CATGAAAGTCAGGAACAAAT

Product: DNA-binding transcriptional regulator BasR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 220; Mature: 220

Protein sequence:

>220_residues
MKLLIVEDDELLQRGIAMALTSEGYVCDCAATAAEAHSLLQTSQYSMIILDLGLPDQDGTLLLRQWRRQHVTLPVLILTA
RDALEDRVDGLDAGADDYLVKPFALAELLARVRALIRRYQGQSDNLVQQDDLSLNLSTQQVCLQGQPLEITPKEFAILSR
LIMRAGQTVNRELLQQDLYTWNDDLSSNTLEVHIHNLRRKLGKDRIRTVRGIGYRLEALS

Sequences:

>Translated_220_residues
MKLLIVEDDELLQRGIAMALTSEGYVCDCAATAAEAHSLLQTSQYSMIILDLGLPDQDGTLLLRQWRRQHVTLPVLILTA
RDALEDRVDGLDAGADDYLVKPFALAELLARVRALIRRYQGQSDNLVQQDDLSLNLSTQQVCLQGQPLEITPKEFAILSR
LIMRAGQTVNRELLQQDLYTWNDDLSSNTLEVHIHNLRRKLGKDRIRTVRGIGYRLEALS
>Mature_220_residues
MKLLIVEDDELLQRGIAMALTSEGYVCDCAATAAEAHSLLQTSQYSMIILDLGLPDQDGTLLLRQWRRQHVTLPVLILTA
RDALEDRVDGLDAGADDYLVKPFALAELLARVRALIRRYQGQSDNLVQQDDLSLNLSTQQVCLQGQPLEITPKEFAILSR
LIMRAGQTVNRELLQQDLYTWNDDLSSNTLEVHIHNLRRKLGKDRIRTVRGIGYRLEALS

Specific function: Member of the two-component regulatory system pmrB/pmrA involved in regulation of virulence. Unphosphorylated pmrA represses extracellular enzyme genes. Phosphorylation of pmrA by pmrB relieves such repression, which leads to activation of extracellular e

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=56.4220183486239, Blast_Score=253, Evalue=5e-69,
Organism=Escherichia coli, GI1789402, Length=216, Percent_Identity=47.6851851851852, Blast_Score=212, Evalue=1e-56,
Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=40.3587443946188, Blast_Score=156, Evalue=9e-40,
Organism=Escherichia coli, GI1787375, Length=221, Percent_Identity=36.6515837104072, Blast_Score=150, Evalue=7e-38,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=37.6681614349776, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=34.2342342342342, Blast_Score=130, Evalue=9e-32,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=36.036036036036, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=32.4444444444444, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1788394, Length=225, Percent_Identity=35.1111111111111, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=38.0530973451327, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=34.070796460177, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=34.2342342342342, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=27.1929824561404, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790299, Length=159, Percent_Identity=30.8176100628931, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=31.7757009345794, Blast_Score=70, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24820; Mature: 24820

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLLIVEDDELLQRGIAMALTSEGYVCDCAATAAEAHSLLQTSQYSMIILDLGLPDQDGT
CEEEEECCHHHHHCCHHHEECCCCCEEEHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCH
LLLRQWRRQHVTLPVLILTARDALEDRVDGLDAGADDYLVKPFALAELLARVRALIRRYQ
HHHHHHHHHCCCEEEEEEEHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHC
GQSDNLVQQDDLSLNLSTQQVCLQGQPLEITPKEFAILSRLIMRAGQTVNRELLQQDLYT
CCCCCCEECCCCEEECCHHHHHHCCCCCEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
WNDDLSSNTLEVHIHNLRRKLGKDRIRTVRGIGYRLEALS
CCCCCCCCEEEEHHHHHHHHHCHHHHHHHHHCCEEEEECC
>Mature Secondary Structure
MKLLIVEDDELLQRGIAMALTSEGYVCDCAATAAEAHSLLQTSQYSMIILDLGLPDQDGT
CEEEEECCHHHHHCCHHHEECCCCCEEEHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCH
LLLRQWRRQHVTLPVLILTARDALEDRVDGLDAGADDYLVKPFALAELLARVRALIRRYQ
HHHHHHHHHCCCEEEEEEEHHHHHHHHHCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHC
GQSDNLVQQDDLSLNLSTQQVCLQGQPLEITPKEFAILSRLIMRAGQTVNRELLQQDLYT
CCCCCCEECCCCEEECCHHHHHHCCCCCEECHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
WNDDLSSNTLEVHIHNLRRKLGKDRIRTVRGIGYRLEALS
CCCCCCCCEEEEHHHHHHHHHCHHHHHHHHHCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14617142 [H]