Click here to switch to the map view.

The map label for this gene is lyx [H]

Identifier: 218930355

GI number: 218930355

Start: 3719480

End: 3720976

Strand: Direct

Name: lyx [H]

Synonym: YPO3334

Alternate gene names: 218930355

Gene position: 3719480-3720976 (Clockwise)

Preceding gene: 218930354

Following gene: 218930356

Centisome position: 79.92

GC content: 51.84

Gene sequence:

>1497_bases
ATGAGCCACTATTTTCTCGGCATTGATCTGGGCGGTACCGTGACCAAAGCCGGTATTTATACCGCCGACGGCAGCGAAAT
TGCCGTTACTGAACAGGCGCTCCCGGTACTTAGCCCACAAGCGGGATTCTGTGAGCGCGATATGGAGGCCCTGTGGATCG
CCACCTGTCAGGTGATCCGCCAAACGCTGAACAAGGCATGTGCTTTATCGGAATATCATATTGCGGCAGAGAACATCGGT
GGCATCAGTTTCTCTGCCCATGGCAAAGGGTTATATCTGGTGGATAAACAGGGGCTGCCGGTACGTAACGGAATTGTTTC
CTCCGATTCCCGTGCACAGAAACTGGTTAACCGTTGGCAGCAAGAAGGTAAAGATCACGCCGCCTATGAACGTAGCCTGC
AACAACTGTGGCCATCCCATCCCGCAGCCCTCTTGCGTTGGTTAAAGGAAAACGAGCCAGAAAACTATCAGCGCAGCGGT
TATGTGCTCATGGTCCATGACTATATCCGTTACCGTCTAACGGGTGAGTTTACTATTGAAGAAACCAATATTTCTGGCAG
CAATCTTTATAATCAATACAACGGCAGTTTTGATCCGCAACTAATGGCGATTTTTGCCATTGAGGAAGTCATGGAGAAAA
CCGCGCCGATTATCGGTTCAGCCGATTTAGCAGGTCATGTCAGTGAAGATGCGGCTAACGCCTGTGGGCTGAAAGCAGGA
ACACCAGTGTTCGGCGGCATGTTTGATGTGGTCGGTGCGGCACTGACTTCTGGTTTACACGACAGCCGCCAACTCAGTGC
GGTGGCGGGCACTTGGTCAATCGCCACCCGTATTTTTGAGGCGATCACCCCCTCCGAATACCCCTATGTTTGGGGGAAAT
ATTGCATCCCCGGCACCTACTTCGTACATGAAGGCAGCCCAACCTCGGCCAGTAACCTTGCCTGGTTCGTGAAACAATTT
CTCCCTGAACTGCCAAATAGCTACCAGACCCTGAATCAGTGGGCGGCTTTGGGCTATGAAAAATCTGAAGATATTCTGTT
TTTCCCTTGGCTATACGGCTCCAACCACAGTGCTAATCTTAGCGGAGGCCTGCTTGGGTTAAGTGGGCATCACAATATCG
AAGACATTGTGTACGCCATTTATCAGGGAGTGGTTTTTTCACATCTTCTGCATCAGGACAAGATTTTGGCGTTGGATGAC
ACCATCGACTGTATCCGCTTTACCGGTGGCCCGACACATTCCGCTATTTGGATGCAGATGTTCTGCGATGCCAGTAATTT
GCCACTGGAAATTGTCGATATTCAGCAATCCGGCTGCCGGGCAGCGGCGCTGTGTGCGGCGGTGGGGAGCCACTATTACC
ACGGGTTTGAAGAGGCGATCCGCGCCTGCCCGCCCCCTATCACCCGCCTGCTCCCCAATGCTGAAAAACATCAGCGATTA
CGGGCGCGTTTTGACAAATTCAAACAGGTCGCTGAAGCGCTCAGCACGGTAATGTAA

Upstream 100 bases:

>100_bases
TTGCTGGAAATTATCCATGCCCGCCACTGGATCGAAGACAAAATGCGGTTGGCTGGCTGGGATAACGAATCCGGCCAGTT
AACCCGCTAAGGAGCCACAC

Downstream 100 bases:

>100_bases
GCCTCATACATCACATTCAGTGATCGATAAAACCATCATGTCACCAGGCCAGCACACGGTGAGATCGATGACCGTCGGTC
AGTGCCCCACTCCCCTACTG

Product: putative L-xylulose kinase

Products: NA

Alternate protein names: L-xylulokinase; 3-dehydro-L-gulonate kinase [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MSHYFLGIDLGGTVTKAGIYTADGSEIAVTEQALPVLSPQAGFCERDMEALWIATCQVIRQTLNKACALSEYHIAAENIG
GISFSAHGKGLYLVDKQGLPVRNGIVSSDSRAQKLVNRWQQEGKDHAAYERSLQQLWPSHPAALLRWLKENEPENYQRSG
YVLMVHDYIRYRLTGEFTIEETNISGSNLYNQYNGSFDPQLMAIFAIEEVMEKTAPIIGSADLAGHVSEDAANACGLKAG
TPVFGGMFDVVGAALTSGLHDSRQLSAVAGTWSIATRIFEAITPSEYPYVWGKYCIPGTYFVHEGSPTSASNLAWFVKQF
LPELPNSYQTLNQWAALGYEKSEDILFFPWLYGSNHSANLSGGLLGLSGHHNIEDIVYAIYQGVVFSHLLHQDKILALDD
TIDCIRFTGGPTHSAIWMQMFCDASNLPLEIVDIQQSGCRAAALCAAVGSHYYHGFEEAIRACPPPITRLLPNAEKHQRL
RARFDKFKQVAEALSTVM

Sequences:

>Translated_498_residues
MSHYFLGIDLGGTVTKAGIYTADGSEIAVTEQALPVLSPQAGFCERDMEALWIATCQVIRQTLNKACALSEYHIAAENIG
GISFSAHGKGLYLVDKQGLPVRNGIVSSDSRAQKLVNRWQQEGKDHAAYERSLQQLWPSHPAALLRWLKENEPENYQRSG
YVLMVHDYIRYRLTGEFTIEETNISGSNLYNQYNGSFDPQLMAIFAIEEVMEKTAPIIGSADLAGHVSEDAANACGLKAG
TPVFGGMFDVVGAALTSGLHDSRQLSAVAGTWSIATRIFEAITPSEYPYVWGKYCIPGTYFVHEGSPTSASNLAWFVKQF
LPELPNSYQTLNQWAALGYEKSEDILFFPWLYGSNHSANLSGGLLGLSGHHNIEDIVYAIYQGVVFSHLLHQDKILALDD
TIDCIRFTGGPTHSAIWMQMFCDASNLPLEIVDIQQSGCRAAALCAAVGSHYYHGFEEAIRACPPPITRLLPNAEKHQRL
RARFDKFKQVAEALSTVM
>Mature_497_residues
SHYFLGIDLGGTVTKAGIYTADGSEIAVTEQALPVLSPQAGFCERDMEALWIATCQVIRQTLNKACALSEYHIAAENIGG
ISFSAHGKGLYLVDKQGLPVRNGIVSSDSRAQKLVNRWQQEGKDHAAYERSLQQLWPSHPAALLRWLKENEPENYQRSGY
VLMVHDYIRYRLTGEFTIEETNISGSNLYNQYNGSFDPQLMAIFAIEEVMEKTAPIIGSADLAGHVSEDAANACGLKAGT
PVFGGMFDVVGAALTSGLHDSRQLSAVAGTWSIATRIFEAITPSEYPYVWGKYCIPGTYFVHEGSPTSASNLAWFVKQFL
PELPNSYQTLNQWAALGYEKSEDILFFPWLYGSNHSANLSGGLLGLSGHHNIEDIVYAIYQGVVFSHLLHQDKILALDDT
IDCIRFTGGPTHSAIWMQMFCDASNLPLEIVDIQQSGCRAAALCAAVGSHYYHGFEEAIRACPPPITRLLPNAEKHQRLR
ARFDKFKQVAEALSTVM

Specific function: Catalyzes the phosphorylation of L-xylulose and 3-keto- L-gulonate. Is involved in L-lyxose utilization via xylulose, and may also be involved in the utilization of 2,3-diketo-L-gulonate [H]

COG id: COG1070

COG function: function code G; Sugar (pentulose and hexulose) kinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI164663828, Length=545, Percent_Identity=22.5688073394495, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI164663830, Length=568, Percent_Identity=21.830985915493, Blast_Score=79, Evalue=9e-15,
Organism=Escherichia coli, GI1790005, Length=495, Percent_Identity=42.8282828282828, Blast_Score=414, Evalue=1e-117,
Organism=Escherichia coli, GI1787789, Length=515, Percent_Identity=23.495145631068, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1789987, Length=502, Percent_Identity=23.3067729083665, Blast_Score=105, Evalue=9e-24,
Organism=Escherichia coli, GI1790338, Length=251, Percent_Identity=30.2788844621514, Blast_Score=76, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24657106, Length=545, Percent_Identity=23.4862385321101, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24657102, Length=545, Percent_Identity=23.4862385321101, Blast_Score=97, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.53 [H]

Molecular weight: Translated: 54883; Mature: 54751

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHYFLGIDLGGTVTKAGIYTADGSEIAVTEQALPVLSPQAGFCERDMEALWIATCQVIR
CCEEEEEEECCCCEEECEEEECCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
QTLNKACALSEYHIAAENIGGISFSAHGKGLYLVDKQGLPVRNGIVSSDSRAQKLVNRWQ
HHHHHHHHHHHHEEHHHCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
QEGKDHAAYERSLQQLWPSHPAALLRWLKENEPENYQRSGYVLMVHDYIRYRLTGEFTIE
HCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECEEEEEEEEEEEE
ETNISGSNLYNQYNGSFDPQLMAIFAIEEVMEKTAPIIGSADLAGHVSEDAANACGLKAG
ECCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHCCCCCC
TPVFGGMFDVVGAALTSGLHDSRQLSAVAGTWSIATRIFEAITPSEYPYVWGKYCIPGTY
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCEE
FVHEGSPTSASNLAWFVKQFLPELPNSYQTLNQWAALGYEKSEDILFFPWLYGSNHSANL
EEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCC
SGGLLGLSGHHNIEDIVYAIYQGVVFSHLLHQDKILALDDTIDCIRFTGGPTHSAIWMQM
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCCCHHHHHHHH
FCDASNLPLEIVDIQQSGCRAAALCAAVGSHYYHGFEEAIRACPPPITRLLPNAEKHQRL
HCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHCCCHHHHHHH
RARFDKFKQVAEALSTVM
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SHYFLGIDLGGTVTKAGIYTADGSEIAVTEQALPVLSPQAGFCERDMEALWIATCQVIR
CEEEEEEECCCCEEECEEEECCCCEEEEEHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
QTLNKACALSEYHIAAENIGGISFSAHGKGLYLVDKQGLPVRNGIVSSDSRAQKLVNRWQ
HHHHHHHHHHHHEEHHHCCCCEEEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHH
QEGKDHAAYERSLQQLWPSHPAALLRWLKENEPENYQRSGYVLMVHDYIRYRLTGEFTIE
HCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEEEECEEEEEEEEEEEE
ETNISGSNLYNQYNGSFDPQLMAIFAIEEVMEKTAPIIGSADLAGHVSEDAANACGLKAG
ECCCCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCHHHHHHCCCCCC
TPVFGGMFDVVGAALTSGLHDSRQLSAVAGTWSIATRIFEAITPSEYPYVWGKYCIPGTY
CCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCEE
FVHEGSPTSASNLAWFVKQFLPELPNSYQTLNQWAALGYEKSEDILFFPWLYGSNHSANL
EEECCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCC
SGGLLGLSGHHNIEDIVYAIYQGVVFSHLLHQDKILALDDTIDCIRFTGGPTHSAIWMQM
CCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCEEEEEECCCCCHHHHHHHH
FCDASNLPLEIVDIQQSGCRAAALCAAVGSHYYHGFEEAIRACPPPITRLLPNAEKHQRL
HCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHCCCHHHHHHH
RARFDKFKQVAEALSTVM
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7961955; 11741871 [H]