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The map label for this gene is trxC [H]

Identifier: 218930295

GI number: 218930295

Start: 3642614

End: 3643051

Strand: Direct

Name: trxC [H]

Synonym: YPO3270

Alternate gene names: 218930295

Gene position: 3642614-3643051 (Clockwise)

Preceding gene: 218930293

Following gene: 218930296

Centisome position: 78.27

GC content: 50.23

Gene sequence:

>438_bases
ATGAATACGGTATGTACAGCTTGTATGGCGACGAATCGCCTACCGGAAGAACGTATTGATGACGGCGCAAAATGTGGGCG
CTGTGGCCACTCTTTATTTGATGGCGAAGTCATTAATGCCACCGCTGAAACACTGGATAAGCTGCTGCAAGATGACCTGC
CAATGGTTATCGATTTCTGGGCGCCTTGGTGTGGGCCGTGCCGCAGCTTCGCGCCCATCTTTGCAGAGACCGCAGCCGAA
CGCGCCGGAAAAGTTCGTTTCGTTAAAGTGAACACCGAAGCCGAACCTGCACTCAGCACCCGTTTTCGCATCCGTAGCAT
CCCGACCATCATGTTGTATCGCAACGGCAAAATGATCGATATGCTAAATGGCGCTGTACCCAAAGCGCCCTTTGATAATT
GGTTAGATGAACAATTATCAAGAGATCCAAACAGTTAA

Upstream 100 bases:

>100_bases
AAACAATTCAGTGAATTCTTGGCTGTCTGGCTTCTCTTATATCTACTTAAAAATAAAGGCTAATGTATGATAAAGGCTAA
CATATGATAAAGGCTAATGT

Downstream 100 bases:

>100_bases
CAAAATAACCAAATAATTAGCCAGAGAGCCACTAGCCCGATAAGTGAGTTTAACGCATTTATCGCCTTTAAGGGCTGTTC
AGGCCCTTGATAAATCCCCA

Product: thioredoxin 2

Products: NA

Alternate protein names: Trx-2; Protein-disulfide reductase [H]

Number of amino acids: Translated: 145; Mature: 145

Protein sequence:

>145_residues
MNTVCTACMATNRLPEERIDDGAKCGRCGHSLFDGEVINATAETLDKLLQDDLPMVIDFWAPWCGPCRSFAPIFAETAAE
RAGKVRFVKVNTEAEPALSTRFRIRSIPTIMLYRNGKMIDMLNGAVPKAPFDNWLDEQLSRDPNS

Sequences:

>Translated_145_residues
MNTVCTACMATNRLPEERIDDGAKCGRCGHSLFDGEVINATAETLDKLLQDDLPMVIDFWAPWCGPCRSFAPIFAETAAE
RAGKVRFVKVNTEAEPALSTRFRIRSIPTIMLYRNGKMIDMLNGAVPKAPFDNWLDEQLSRDPNS
>Mature_145_residues
MNTVCTACMATNRLPEERIDDGAKCGRCGHSLFDGEVINATAETLDKLLQDDLPMVIDFWAPWCGPCRSFAPIFAETAAE
RAGKVRFVKVNTEAEPALSTRFRIRSIPTIMLYRNGKMIDMLNGAVPKAPFDNWLDEQLSRDPNS

Specific function: Efficient electron donor for the essential enzyme ribonucleotide reductase. Is also able to reduce the interchain disulfide bridges of insulin [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=79, Percent_Identity=31.6455696202532, Blast_Score=67, Evalue=5e-12,
Organism=Homo sapiens, GI4758304, Length=101, Percent_Identity=32.6732673267327, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788936, Length=139, Percent_Identity=77.6978417266187, Blast_Score=239, Evalue=6e-65,
Organism=Escherichia coli, GI87082331, Length=106, Percent_Identity=36.7924528301887, Blast_Score=88, Evalue=2e-19,
Organism=Escherichia coli, GI87081747, Length=108, Percent_Identity=27.7777777777778, Blast_Score=64, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI212646193, Length=112, Percent_Identity=29.4642857142857, Blast_Score=80, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI115532380, Length=87, Percent_Identity=36.7816091954023, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI115532378, Length=87, Percent_Identity=36.7816091954023, Blast_Score=71, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17544108, Length=102, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17507705, Length=75, Percent_Identity=40, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI193209454, Length=84, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=84, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI32566189, Length=84, Percent_Identity=33.3333333333333, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25144092, Length=106, Percent_Identity=30.188679245283, Blast_Score=66, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6323072, Length=89, Percent_Identity=32.5842696629214, Blast_Score=64, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6321648, Length=92, Percent_Identity=31.5217391304348, Blast_Score=62, Evalue=5e-11,
Organism=Drosophila melanogaster, GI28573567, Length=98, Percent_Identity=27.5510204081633, Blast_Score=70, Evalue=6e-13,
Organism=Drosophila melanogaster, GI17647799, Length=91, Percent_Identity=30.7692307692308, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921434, Length=104, Percent_Identity=35.5769230769231, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 16168; Mature: 16168

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.1 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
8.3 %Cys+Met (Translated Protein)
4.1 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
8.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTVCTACMATNRLPEERIDDGAKCGRCGHSLFDGEVINATAETLDKLLQDDLPMVIDFW
CCHHHHHHHHHCCCCHHHCCCCHHHHHHCCHHCCCHHHHHHHHHHHHHHHCCCCEEHHHH
APWCGPCRSFAPIFAETAAERAGKVRFVKVNTEAEPALSTRFRIRSIPTIMLYRNGKMID
CCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCEEE
MLNGAVPKAPFDNWLDEQLSRDPNS
HHCCCCCCCCCHHHHHHHHHCCCCC
>Mature Secondary Structure
MNTVCTACMATNRLPEERIDDGAKCGRCGHSLFDGEVINATAETLDKLLQDDLPMVIDFW
CCHHHHHHHHHCCCCHHHCCCCHHHHHHCCHHCCCHHHHHHHHHHHHHHHCCCCEEHHHH
APWCGPCRSFAPIFAETAAERAGKVRFVKVNTEAEPALSTRFRIRSIPTIMLYRNGKMID
CCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCEEE
MLNGAVPKAPFDNWLDEQLSRDPNS
HHCCCCCCCCCHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]