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The map label for this gene is ampR [H]

Identifier: 218929547

GI number: 218929547

Start: 2755992

End: 2756972

Strand: Reverse

Name: ampR [H]

Synonym: YPO2458

Alternate gene names: 218929547

Gene position: 2756972-2755992 (Counterclockwise)

Preceding gene: 218929551

Following gene: 218929546

Centisome position: 59.24

GC content: 50.05

Gene sequence:

>981_bases
TTGTGGTTTTTGCGCCAGGCAATATTTCATCGTTGGTATGGAGACGGTATTCCTATGAGAAAACTCCCATCACTCCGTAT
GTTGCGTGTGTTTGAAGAGGCCTGCCACACGCTGAGTTTCAGTAAAGCAGCGGAGGCGTTATTTATGACGCAAAGCGCCG
CCAGTCGTCAGATTAAGCAACTGGAAAATTTTCTGGGGAAATCGCTATTTATACGCGGACACAGAGGGTTAGAGTTGACC
CAAGATGAGATGACTATGTTACCTATCGTCAGACAGTCGTTGGATTTACTGGAGGAGGGGGTGAAACATGTCCAGTTAAG
TAATCCACTGCAACATCTGCGCTTACAGGTCGCGCCGACATTTGCCACCCGCTGGTTGGCCCCCCGGTTGGTTACGTTAC
TGCAACGTAATAGTCAGCTACAAATTGCCCTGATCAGTGAGATTCGTCAGAAGTATTGTGATTTTGACAGCGCGATCCGC
TTTGGTGATATTCGTCGGGACCTGTCGAATGGGCACCTGCTCTGCTACGAACAGCTCTGTTTAGTCGCCAGCCCTCTGGT
GATGCAACAGGGGCGTTTTCCCCCACTGACCGCTTTACCACAGTTGCATATTCTTAATGGCGATAGTCGTCTGACAAACT
GGCAGCAATGGCTGGATGCGGCACAGATAACCGTAGCCGCAGGGCATAACGCGCTTGAGTTCAGTACTCAAGACCAGGTG
ATCAGTGCCTGCACTACTGGTGCCGGTTACGCAGTGTTAGATATTCTGATGATTAGCCATGAACTGGATAATGGGTTATT
GAGACAGGTTTTGCCGCTGACGGTGACCAGCACTCATGGCTACTGGCTAGAGATCCCACAGGATAAAGGCCATTCGCCAA
GGGTGATTATTTTTCAGGAGTGGTTACAGCGGGAGTTGAAGCGTGATATTGCCAAGCGCTACTCAAAAGGGGAAGCCAAA
CCTCTACCGGCTGTGCTTTAG

Upstream 100 bases:

>100_bases
GAAAAAGGTACGTGACCCGCCTCTGAATTCTTATAAATAAACGGGCCTGCCCACATGTAAAATGCGCATATTGGCAACAT
AAAATTAACGATTTTCTGGG

Downstream 100 bases:

>100_bases
CAGCCCAATGGCGATTGAATTAAGATATTGGCCGGAATGTGGCTCCTGCGGTTCAGTAAGACAAGGCACCAAATGTGAGC
GCTGAGAAGAGAAGCAGGGG

Product: putative LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MWFLRQAIFHRWYGDGIPMRKLPSLRMLRVFEEACHTLSFSKAAEALFMTQSAASRQIKQLENFLGKSLFIRGHRGLELT
QDEMTMLPIVRQSLDLLEEGVKHVQLSNPLQHLRLQVAPTFATRWLAPRLVTLLQRNSQLQIALISEIRQKYCDFDSAIR
FGDIRRDLSNGHLLCYEQLCLVASPLVMQQGRFPPLTALPQLHILNGDSRLTNWQQWLDAAQITVAAGHNALEFSTQDQV
ISACTTGAGYAVLDILMISHELDNGLLRQVLPLTVTSTHGYWLEIPQDKGHSPRVIIFQEWLQRELKRDIAKRYSKGEAK
PLPAVL

Sequences:

>Translated_326_residues
MWFLRQAIFHRWYGDGIPMRKLPSLRMLRVFEEACHTLSFSKAAEALFMTQSAASRQIKQLENFLGKSLFIRGHRGLELT
QDEMTMLPIVRQSLDLLEEGVKHVQLSNPLQHLRLQVAPTFATRWLAPRLVTLLQRNSQLQIALISEIRQKYCDFDSAIR
FGDIRRDLSNGHLLCYEQLCLVASPLVMQQGRFPPLTALPQLHILNGDSRLTNWQQWLDAAQITVAAGHNALEFSTQDQV
ISACTTGAGYAVLDILMISHELDNGLLRQVLPLTVTSTHGYWLEIPQDKGHSPRVIIFQEWLQRELKRDIAKRYSKGEAK
PLPAVL
>Mature_326_residues
MWFLRQAIFHRWYGDGIPMRKLPSLRMLRVFEEACHTLSFSKAAEALFMTQSAASRQIKQLENFLGKSLFIRGHRGLELT
QDEMTMLPIVRQSLDLLEEGVKHVQLSNPLQHLRLQVAPTFATRWLAPRLVTLLQRNSQLQIALISEIRQKYCDFDSAIR
FGDIRRDLSNGHLLCYEQLCLVASPLVMQQGRFPPLTALPQLHILNGDSRLTNWQQWLDAAQITVAAGHNALEFSTQDQV
ISACTTGAGYAVLDILMISHELDNGLLRQVLPLTVTSTHGYWLEIPQDKGHSPRVIIFQEWLQRELKRDIAKRYSKGEAK
PLPAVL

Specific function: This protein is a positive regulator of gene expression of beta-lactamase (AmpC) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786448, Length=290, Percent_Identity=29.6551724137931, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1789173, Length=293, Percent_Identity=30.7167235494881, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1788706, Length=293, Percent_Identity=24.5733788395904, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI145693193, Length=297, Percent_Identity=25.9259259259259, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1786401, Length=298, Percent_Identity=26.510067114094, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 37226; Mature: 37226

Theoretical pI: Translated: 8.97; Mature: 8.97

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWFLRQAIFHRWYGDGIPMRKLPSLRMLRVFEEACHTLSFSKAAEALFMTQSAASRQIKQ
CHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LENFLGKSLFIRGHRGLELTQDEMTMLPIVRQSLDLLEEGVKHVQLSNPLQHLRLQVAPT
HHHHHCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHH
FATRWLAPRLVTLLQRNSQLQIALISEIRQKYCDFDSAIRFGDIRRDLSNGHLLCYEQLC
HHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEHHHHHH
LVASPLVMQQGRFPPLTALPQLHILNGDSRLTNWQQWLDAAQITVAAGHNALEFSTQDQV
HHHCHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHEEEECCCCCEECCCHHHH
ISACTTGAGYAVLDILMISHELDNGLLRQVLPLTVTSTHGYWLEIPQDKGHSPRVIIFQE
HHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHEEEECCCEEEECCCCCCCCCEEEEHHH
WLQRELKRDIAKRYSKGEAKPLPAVL
HHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MWFLRQAIFHRWYGDGIPMRKLPSLRMLRVFEEACHTLSFSKAAEALFMTQSAASRQIKQ
CHHHHHHHHHHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LENFLGKSLFIRGHRGLELTQDEMTMLPIVRQSLDLLEEGVKHVQLSNPLQHLRLQVAPT
HHHHHCCCEEEECCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCHH
FATRWLAPRLVTLLQRNSQLQIALISEIRQKYCDFDSAIRFGDIRRDLSNGHLLCYEQLC
HHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEHHHHHH
LVASPLVMQQGRFPPLTALPQLHILNGDSRLTNWQQWLDAAQITVAAGHNALEFSTQDQV
HHHCHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHEEEECCCCCEECCCHHHH
ISACTTGAGYAVLDILMISHELDNGLLRQVLPLTVTSTHGYWLEIPQDKGHSPRVIIFQE
HHHHHCCCCHHHHHHHHHHHHHCHHHHHHHHHHEEEECCCEEEECCCCCCCCCEEEEHHH
WLQRELKRDIAKRYSKGEAKPLPAVL
HHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1510392 [H]