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The map label for this gene is bioA [H]

Identifier: 218928314

GI number: 218928314

Start: 1295706

End: 1296974

Strand: Reverse

Name: bioA [H]

Synonym: YPO1150

Alternate gene names: 218928314

Gene position: 1296974-1295706 (Counterclockwise)

Preceding gene: 218928319

Following gene: 218928312

Centisome position: 27.87

GC content: 53.11

Gene sequence:

>1269_bases
ATGACACCTTCTGACTTAGTTTTTGATCAACAGCATATCTGGCATCCCTACACCTCAATGACTGAGCCACTGCCCTGTTA
CCCCGTGGTGGGCGCTGAAGGTGTTGAATTGCAATTGGCTGATGGTCGGCGGCTGATCGATGGTATGTCATCTTGGTGGG
CAGCCATTCATGGCTATAACCACCCGGTACTGAATTTCGCCGCGCATCAGCAACTGGATAAAATGTCGCACGTGATGTTC
GGGGGCATTACCCATCCGCCCGCAGTAAAGCTGTGCCGACAACTGGTCGCGATGACACCGCCGCCGCTGGAATGCGTTTT
TTTGGCCGATTCCGGCTCGGTGAGCGTTGAGGTCGCACTGAAAATGGCGTTGCAATACTGGCAAGCGAAGGGCGAGCGGC
GGCAGCGTATTTTGACCTTGCGCCATGGTTACCACGGCGATACGTTCGGTGCGATGTCCGTCTGTGACCCACAGAATTCA
ATGCACAGTTTGTATCAGGGCTATTTAGCCGAGAATCTGTTTGCCAATGCGCCACAGTGCGGCTTTGATGACCCGTGGGA
TCCGCAAGATATCGCTAATTTTGTCGCGCTGATAACCCAGCACGCCAATGAGATTGCCGCCGTAATCCTGGAACCCGTGG
TGCAAGGGGCGGGCGGGATGCGAATTTATCACCCCAGCTATCTGCGTGAAGTCAGGGCGTTATGTGATAAACATCAAATT
TTATTGATTGCCGATGAGATAGCCACTGGGTTTGGCCGAACAGGCAAACTGTTTGCCTGTGAACATGCGCAGATCGTGCC
GGATATTTTATGTTTAGGTAAAGCGCTCACCGGAGGTTATCTCACCTTATCCGCCACGCTGACCACCCGTGCAGTGGCAG
AAACCATCAGTAAAGGGGATGCGGGCTGCTTTATGCATGGGCCAACCTTTATGGCGAATCCGCTGGCTTGCGCAGTCGCC
TCTGCGAACCTGAGTTTATTAGCAGAGAATTCGTGGCAACAGCAGGTGAGTAAAATAGAAGATCAGTTAAAAAGGGAATT
ACTGCCGCTGGCTCAGGAAGATACCGTGGCCGATGTGCGGGTACTTGGGGCCATCGGGGTGGTAGAGATGAAAAAACCCG
TTAATGTCGCCCGCCTGCAACGCAGTTTTGTCGAACAGGGGGTGTGGATCAGGCCCTTTGGCAAACTGATTTATCTGATG
CCGCCTTATATTATCTCTCAACACGCCTTAACCCGGCTCACTGCGGCCGTGGTAGATCGCGGAAGCTAA

Upstream 100 bases:

>100_bases
ATGATGGCCTCTCAAAAGAAGAGAAAAAGTTTCGTCAGTGTAAATAAACTCGATATACTGTCAACCATTCTATTGATATT
TTGGTTTACAACGGTACCTA

Downstream 100 bases:

>100_bases
ATGCCTATCTTCACCGTTTAAGGTAACGGCATCGCGGTTTTTCCGCCGTCTGGTGTAAAGATCTCTGCGACATCAGCGCC
ACAGTCGCCGTCAATTTAGA

Product: adenosylmethionine--8-amino-7-oxononanoate transaminase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 422; Mature: 421

Protein sequence:

>422_residues
MTPSDLVFDQQHIWHPYTSMTEPLPCYPVVGAEGVELQLADGRRLIDGMSSWWAAIHGYNHPVLNFAAHQQLDKMSHVMF
GGITHPPAVKLCRQLVAMTPPPLECVFLADSGSVSVEVALKMALQYWQAKGERRQRILTLRHGYHGDTFGAMSVCDPQNS
MHSLYQGYLAENLFANAPQCGFDDPWDPQDIANFVALITQHANEIAAVILEPVVQGAGGMRIYHPSYLREVRALCDKHQI
LLIADEIATGFGRTGKLFACEHAQIVPDILCLGKALTGGYLTLSATLTTRAVAETISKGDAGCFMHGPTFMANPLACAVA
SANLSLLAENSWQQQVSKIEDQLKRELLPLAQEDTVADVRVLGAIGVVEMKKPVNVARLQRSFVEQGVWIRPFGKLIYLM
PPYIISQHALTRLTAAVVDRGS

Sequences:

>Translated_422_residues
MTPSDLVFDQQHIWHPYTSMTEPLPCYPVVGAEGVELQLADGRRLIDGMSSWWAAIHGYNHPVLNFAAHQQLDKMSHVMF
GGITHPPAVKLCRQLVAMTPPPLECVFLADSGSVSVEVALKMALQYWQAKGERRQRILTLRHGYHGDTFGAMSVCDPQNS
MHSLYQGYLAENLFANAPQCGFDDPWDPQDIANFVALITQHANEIAAVILEPVVQGAGGMRIYHPSYLREVRALCDKHQI
LLIADEIATGFGRTGKLFACEHAQIVPDILCLGKALTGGYLTLSATLTTRAVAETISKGDAGCFMHGPTFMANPLACAVA
SANLSLLAENSWQQQVSKIEDQLKRELLPLAQEDTVADVRVLGAIGVVEMKKPVNVARLQRSFVEQGVWIRPFGKLIYLM
PPYIISQHALTRLTAAVVDRGS
>Mature_421_residues
TPSDLVFDQQHIWHPYTSMTEPLPCYPVVGAEGVELQLADGRRLIDGMSSWWAAIHGYNHPVLNFAAHQQLDKMSHVMFG
GITHPPAVKLCRQLVAMTPPPLECVFLADSGSVSVEVALKMALQYWQAKGERRQRILTLRHGYHGDTFGAMSVCDPQNSM
HSLYQGYLAENLFANAPQCGFDDPWDPQDIANFVALITQHANEIAAVILEPVVQGAGGMRIYHPSYLREVRALCDKHQIL
LIADEIATGFGRTGKLFACEHAQIVPDILCLGKALTGGYLTLSATLTTRAVAETISKGDAGCFMHGPTFMANPLACAVAS
ANLSLLAENSWQQQVSKIEDQLKRELLPLAQEDTVADVRVLGAIGVVEMKKPVNVARLQRSFVEQGVWIRPFGKLIYLMP
PYIISQHALTRLTAAVVDRGS

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=429, Percent_Identity=29.3706293706294, Blast_Score=143, Evalue=4e-34,
Organism=Homo sapiens, GI284507298, Length=209, Percent_Identity=36.8421052631579, Blast_Score=125, Evalue=6e-29,
Organism=Homo sapiens, GI13994255, Length=377, Percent_Identity=29.4429708222812, Blast_Score=125, Evalue=7e-29,
Organism=Homo sapiens, GI226442709, Length=323, Percent_Identity=27.2445820433437, Blast_Score=89, Evalue=9e-18,
Organism=Homo sapiens, GI37574042, Length=323, Percent_Identity=27.2445820433437, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI226442705, Length=296, Percent_Identity=27.7027027027027, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI24119277, Length=392, Percent_Identity=26.530612244898, Blast_Score=79, Evalue=8e-15,
Organism=Escherichia coli, GI1786991, Length=417, Percent_Identity=74.5803357314149, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI145693181, Length=337, Percent_Identity=34.1246290801187, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789016, Length=347, Percent_Identity=29.971181556196, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789759, Length=394, Percent_Identity=29.9492385786802, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI1788044, Length=423, Percent_Identity=29.3144208037825, Blast_Score=131, Evalue=7e-32,
Organism=Escherichia coli, GI1787560, Length=397, Percent_Identity=27.2040302267003, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786349, Length=387, Percent_Identity=28.1653746770026, Blast_Score=105, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25144271, Length=424, Percent_Identity=26.1792452830189, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI25144274, Length=216, Percent_Identity=33.7962962962963, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI32564660, Length=407, Percent_Identity=26.7813267813268, Blast_Score=114, Evalue=7e-26,
Organism=Caenorhabditis elegans, GI71992977, Length=363, Percent_Identity=22.038567493113, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17541228, Length=292, Percent_Identity=25.3424657534247, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324386, Length=456, Percent_Identity=47.5877192982456, Blast_Score=429, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6323470, Length=407, Percent_Identity=28.7469287469287, Blast_Score=131, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324432, Length=380, Percent_Identity=28.1578947368421, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6321456, Length=369, Percent_Identity=24.1192411924119, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21357415, Length=414, Percent_Identity=29.7101449275362, Blast_Score=144, Evalue=1e-34,
Organism=Drosophila melanogaster, GI28574759, Length=406, Percent_Identity=26.8472906403941, Blast_Score=105, Evalue=7e-23,
Organism=Drosophila melanogaster, GI161085790, Length=358, Percent_Identity=27.9329608938547, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21356575, Length=362, Percent_Identity=28.1767955801105, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI281366494, Length=287, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24667139, Length=287, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI24667143, Length=287, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 46349; Mature: 46218

Theoretical pI: Translated: 6.60; Mature: 6.60

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSDLVFDQQHIWHPYTSMTEPLPCYPVVGAEGVELQLADGRRLIDGMSSWWAAIHGYN
CCCCCCEECHHHHCCCHHCCCCCCCCEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCCC
HPVLNFAAHQQLDKMSHVMFGGITHPPAVKLCRQLVAMTPPPLECVFLADSGSVSVEVAL
CCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEHHHHH
KMALQYWQAKGERRQRILTLRHGYHGDTFGAMSVCDPQNSMHSLYQGYLAENLFANAPQC
HHHHHHHHHCCHHHHHEEHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCC
GFDDPWDPQDIANFVALITQHANEIAAVILEPVVQGAGGMRIYHPSYLREVRALCDKHQI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCCE
LLIADEIATGFGRTGKLFACEHAQIVPDILCLGKALTGGYLTLSATLTTRAVAETISKGD
EEEEHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCC
AGCFMHGPTFMANPLACAVASANLSLLAENSWQQQVSKIEDQLKRELLPLAQEDTVADVR
CCEEEECCCHHCCCHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
VLGAIGVVEMKKPVNVARLQRSFVEQGVWIRPFGKLIYLMPPYIISQHALTRLTAAVVDR
HHHHHCCEECCCCCHHHHHHHHHHHCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHCC
GS
CC
>Mature Secondary Structure 
TPSDLVFDQQHIWHPYTSMTEPLPCYPVVGAEGVELQLADGRRLIDGMSSWWAAIHGYN
CCCCCEECHHHHCCCHHCCCCCCCCEEECCCCCCEEEECCCHHHHHHHHHHHHHHCCCC
HPVLNFAAHQQLDKMSHVMFGGITHPPAVKLCRQLVAMTPPPLECVFLADSGSVSVEVAL
CCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEHHHHH
KMALQYWQAKGERRQRILTLRHGYHGDTFGAMSVCDPQNSMHSLYQGYLAENLFANAPQC
HHHHHHHHHCCHHHHHEEHHHCCCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHCCCCCC
GFDDPWDPQDIANFVALITQHANEIAAVILEPVVQGAGGMRIYHPSYLREVRALCDKHQI
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHCCCCE
LLIADEIATGFGRTGKLFACEHAQIVPDILCLGKALTGGYLTLSATLTTRAVAETISKGD
EEEEHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHCCC
AGCFMHGPTFMANPLACAVASANLSLLAENSWQQQVSKIEDQLKRELLPLAQEDTVADVR
CCEEEECCCHHCCCHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
VLGAIGVVEMKKPVNVARLQRSFVEQGVWIRPFGKLIYLMPPYIISQHALTRLTAAVVDR
HHHHHCCEECCCCCHHHHHHHHHHHCCCEEECCCCEEEECCCHHHHHHHHHHHHHHHHCC
GS
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8250549 [H]