Click here to switch to the map view.

The map label for this gene is mltC [H]

Identifier: 218928125

GI number: 218928125

Start: 1052323

End: 1053399

Strand: Direct

Name: mltC [H]

Synonym: YPO0954

Alternate gene names: 218928125

Gene position: 1052323-1053399 (Clockwise)

Preceding gene: 218928124

Following gene: 284987067

Centisome position: 22.61

GC content: 46.24

Gene sequence:

>1077_bases
ATGAAGAAAATTTTAGCTTTGCTGGTAATCGCCCCCTTATTAGTGTCTTGTTCGGGCAACAAAAATCAGGTAGAAAACGA
AGTTTTTGTCAAAGACACCAATGGTTTTGAGATTTTAATGGGCCAATTTGCCCATAACATTGAAAATATTTGGGGCTTAA
AAGAAGTCTTAATCGCTGGTCCAAAAGATTACGTTAAGTACACGGATCAATATCAAACCCGCAGCCATATCAATTTTGAT
GCTGGTACCATTACGATAGAGACGATCGCCACGACCAATCCGGCGGCACATTTACGTCAGGCGATCATCACAACGCTACT
GATGGGTGATGATCCAGGCTCGATCGACCTCTATTCTGATGTAAACGATATTCAGATCAGTAAAGAGCCGTTCCTCTATG
GCCAGGTGCTGGACAACAATGGCGAACCAATCCGTTGGGAATGGCGGGCAGCCCATTTTGCTGATTATTTGCTACAAAAC
AAAATGCAAACACGGACTTCCGGTTTGCATGTGATCTCGTTCGTTACCATACAGTTAGTGCCAAACCATCTGGACAAACG
GGCGCATAAATACCTGCCATTGGTACGGAAATCAGCAGCACGTTACGGCGTGGAAGAGTCTTTGATTCTCGCCATTATGC
AAACCGAATCGAGCTTCAACCCCTATGCCGTCAGCCGTTCTGATGCGCTCGGTCTGATGCAGGTGGTTCAACATACTGCA
GGAAAAGATGTATTCAAACTGAAAGGCAAAAGTGGCCAACCAAGCCGCAGCTATCTGTTTGATCCTGAAAATAATATCGA
CGCAGGCACCGCATATTTATCTATTCTGCAAAATACCTATTTGGGGGGGATTCAAAATGCCACCTCACGGCGTTATGCCG
TGATCACCTCCTACAACGGCGGCGCAGGTAGCGTATTGCGCGTGTTCCACAGCGATAAAAATAAGGCAGTGGGTATCATT
AACACGATGTCACCAGGGGATGTGTTCCAAACACTCACGACCAAGCATCCATCAGGTGAATCCCGCCGTTATCTGGTGAA
AGTGAACAGCGCACAGAAGAACTATCGCCGCTATTAG

Upstream 100 bases:

>100_bases
GAGCTTACATCAGTAAGTGACTGGGGTGAGCGAAGGCAGCCAACGCACTGGTAGCTTGAAATATGACGGGTAAATTCCTC
ATCAAGATATGGCTTGTAAG

Downstream 100 bases:

>100_bases
TGGTTAATAAGTAAATAGTGGTTAATAAGTAAATAGTGGTTAATAGGCAAATAGTGGTTAGCAGGCAAATAATGGTTAGC
AAACCGATAGTGATTAGTCA

Product: murein transglycosylase C

Products: N-Acetylmuramic Acid Residues; N-Acetylglucosamine Residues [C]

Alternate protein names: Murein hydrolase C [H]

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MKKILALLVIAPLLVSCSGNKNQVENEVFVKDTNGFEILMGQFAHNIENIWGLKEVLIAGPKDYVKYTDQYQTRSHINFD
AGTITIETIATTNPAAHLRQAIITTLLMGDDPGSIDLYSDVNDIQISKEPFLYGQVLDNNGEPIRWEWRAAHFADYLLQN
KMQTRTSGLHVISFVTIQLVPNHLDKRAHKYLPLVRKSAARYGVEESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTA
GKDVFKLKGKSGQPSRSYLFDPENNIDAGTAYLSILQNTYLGGIQNATSRRYAVITSYNGGAGSVLRVFHSDKNKAVGII
NTMSPGDVFQTLTTKHPSGESRRYLVKVNSAQKNYRRY

Sequences:

>Translated_358_residues
MKKILALLVIAPLLVSCSGNKNQVENEVFVKDTNGFEILMGQFAHNIENIWGLKEVLIAGPKDYVKYTDQYQTRSHINFD
AGTITIETIATTNPAAHLRQAIITTLLMGDDPGSIDLYSDVNDIQISKEPFLYGQVLDNNGEPIRWEWRAAHFADYLLQN
KMQTRTSGLHVISFVTIQLVPNHLDKRAHKYLPLVRKSAARYGVEESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTA
GKDVFKLKGKSGQPSRSYLFDPENNIDAGTAYLSILQNTYLGGIQNATSRRYAVITSYNGGAGSVLRVFHSDKNKAVGII
NTMSPGDVFQTLTTKHPSGESRRYLVKVNSAQKNYRRY
>Mature_358_residues
MKKILALLVIAPLLVSCSGNKNQVENEVFVKDTNGFEILMGQFAHNIENIWGLKEVLIAGPKDYVKYTDQYQTRSHINFD
AGTITIETIATTNPAAHLRQAIITTLLMGDDPGSIDLYSDVNDIQISKEPFLYGQVLDNNGEPIRWEWRAAHFADYLLQN
KMQTRTSGLHVISFVTIQLVPNHLDKRAHKYLPLVRKSAARYGVEESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTA
GKDVFKLKGKSGQPSRSYLFDPENNIDAGTAYLSILQNTYLGGIQNATSRRYAVITSYNGGAGSVLRVFHSDKNKAVGII
NTMSPGDVFQTLTTKHPSGESRRYLVKVNSAQKNYRRY

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082191, Length=358, Percent_Identity=77.6536312849162, Blast_Score=568, Evalue=1e-163,
Organism=Escherichia coli, GI87081855, Length=166, Percent_Identity=41.566265060241, Blast_Score=145, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 39948; Mature: 39948

Theoretical pI: Translated: 9.48; Mature: 9.48

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKILALLVIAPLLVSCSGNKNQVENEVFVKDTNGFEILMGQFAHNIENIWGLKEVLIAG
CHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCHHHHHHCC
PKDYVKYTDQYQTRSHINFDAGTITIETIATTNPAAHLRQAIITTLLMGDDPGSIDLYSD
CHHHHHHCCCCCCCCCCEECCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEECC
VNDIQISKEPFLYGQVLDNNGEPIRWEWRAAHFADYLLQNKMQTRTSGLHVISFVTIQLV
CCCEEECCCCEEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEC
PNHLDKRAHKYLPLVRKSAARYGVEESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTA
HHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEECCCCCCCEEECCCHHHHHHHHHHHHC
GKDVFKLKGKSGQPSRSYLFDPENNIDAGTAYLSILQNTYLGGIQNATSRRYAVITSYNG
CCCEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCC
GAGSVLRVFHSDKNKAVGIINTMSPGDVFQTLTTKHPSGESRRYLVKVNSAQKNYRRY
CCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEEECCCCHHHCCC
>Mature Secondary Structure
MKKILALLVIAPLLVSCSGNKNQVENEVFVKDTNGFEILMGQFAHNIENIWGLKEVLIAG
CHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHCHHHHHHCC
PKDYVKYTDQYQTRSHINFDAGTITIETIATTNPAAHLRQAIITTLLMGDDPGSIDLYSD
CHHHHHHCCCCCCCCCCEECCCEEEEEEEECCCHHHHHHHHHHHHHHCCCCCCCEEEECC
VNDIQISKEPFLYGQVLDNNGEPIRWEWRAAHFADYLLQNKMQTRTSGLHVISFVTIQLV
CCCEEECCCCEEEEEEECCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCEEEEEEEEEEEC
PNHLDKRAHKYLPLVRKSAARYGVEESLILAIMQTESSFNPYAVSRSDALGLMQVVQHTA
HHHHHHHHHHHHHHHHHHHHHCCCCHHEEEEEEECCCCCCCEEECCCHHHHHHHHHHHHC
GKDVFKLKGKSGQPSRSYLFDPENNIDAGTAYLSILQNTYLGGIQNATSRRYAVITSYNG
CCCEEEECCCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCC
GAGSVLRVFHSDKNKAVGIINTMSPGDVFQTLTTKHPSGESRRYLVKVNSAQKNYRRY
CCCCEEEEEECCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEEECCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA