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The map label for this gene is aas [H]

Identifier: 218927973

GI number: 218927973

Start: 869172

End: 871328

Strand: Reverse

Name: aas [H]

Synonym: YPO0793

Alternate gene names: 218927973

Gene position: 871328-869172 (Counterclockwise)

Preceding gene: 218927974

Following gene: 218927972

Centisome position: 18.72

GC content: 51.0

Gene sequence:

>2157_bases
ATGGCTTATCGCTTATTGCGTGCTCTTTTTCGTGGGTTATTCCGTGTCACCATTGATGGTGTCACCGACCAATTTAAGCA
TGAAAAATTAATTATTACGCCCAATCACGTCTCTTTCCTCGATGGGGCTTTATTAGCGCTATTTCTACCGATCAAGCCAG
TATTTGCTGTCTATACCAGTATTACTGACACCTGGTATATGCGTTGGCTAAAGCCTTATGTGGATTTTGTTGCGCTGGAT
CCGACCAACCCGATGGCCATCAAACATCTGGTCAGAATGGTCGAACAGGGCAGGCCAGTAGTCATTTTCCCTGAAGGGCG
CATCACTGTGACCGGCTCCTTGATGAAAATTTATGATGGGGCGGCATTTGTTGCGGCAAAATCAGGTGCGGCGGTGGTCC
CTATCCGTTTAGATGGCCCTGAATTTACTCATTTTGGGCGATTGCAGGGCGTGCTAAAAACACGCTGGTTCCCAAAAATC
AGTATTCATGTGTTACCGGCCACCACCATTCCTATGCCACAAGCGCCACGCTCGCGCGAACGGCGAGTTCTGGCCGGTGA
GCACCTGCATACCATTATGATGGCGGCCCGCATGGCCACGGTGCCACGGGAAACGCTGTTTGAAGCGTTGCTATCGGCAC
AAACCCGTTATGGTCGCTTTAAACCTTGCATTGAAGATGTCTCATTTAAAGAGGACAGCTACCAGACGCTACTGAAGAAA
ACGCTCGGTGTGAGCCGTATTTTGCAACGCTTTACCGTGCCGGGTGAGCATGTCGGGATGTTGCTGCCCAATGCCACCAT
TACTGCGGCTGCTATTTTTGGCGCATCGTTACGTGGACGAATTCCGGCACTGCTCAACTACACCTCGGGTGCTAAAGGGC
TACAGAGCGCTATCATTGCGGCTTCACTTAAAACCATCGTCACCTCGCGCCAGTTTTTGGAAAAAGGCAAACTGACGCAC
CTGCCGGAACAGGTCAATGAGGTGAACTGGGTCTATCTGGAAGATTTAAAAGACACGGTGACACTGACGGATAAGCTGTG
GATCTTATTCCACTTGTGTTTCCCGCGTAGGGCGATGTTGCCGCAGCAGGCTGATGGCAGCGCGTTAATCTTGTTTACCT
CTGGATCGGAAGGCAACCCTAAAGGCGTGGTGCATTCTCATGCCAGTTTGTTGGCTAACGTCGAACAAATCCGAACCATT
GCTGACTTCACGCCACGTGATCGCTTCATGTCATCATTGCCGCTGTTTCATGCTTTTGGTCTGACGGTGGGATTATTCAC
ACCACTGATGACCGGTAGCCGAGTATTCCTTTACCCTAGTCCGCTGCATTACCGCGTGGTACCTGAACTGGTATATGACC
GTAACTGTACCGTGCTCTTTGGGACCTCAACATTCTTGGGGAATTATGCGCGCTTTGCTCATCCATATGATTTCGCCCGC
GTGCGTTATGTGGTTGCTGGCGCTGAAAAGTTGGCTGAAAGCACCAAACAGATTTGGCAGGATAAATTTGGTATCCGTAT
TCTGGAAGGGTATGGCGTAACCGAGTGCGCGCCCGTTGTGGCGATTAACGTACCGATGGCGGCTAAAGTGAACACGGTAG
GGCGCATTTTACCGGGGATGGAAGCCCGATTGATTAACGTACCGGGGATTGCTCAAGGTGGCCGCTTACAATTACGCGGC
CCTAATATTATGCGTGGTTACTTACGGGTAGAGAATCCCGGTGTATTGGAGCAGCCATCAGCAGAAAATGCTCAGGGTGA
ACTTGACGCTAATTGGTATGACACCGGTGATATTGTGACCCTCGACGAACAAGGGTTCTGCGCGATCCGTGGCCGGGTGA
AACGTTTTGCTAAGTTGGCTGGGGAGATGGTATCACTGGAGAGCGTTGAACAATTGGCAATAAGCCTTTCACCGGAAGGG
CAACATGCAGCAGCGGCTAAAACTGACAGTGCGAAAGGTGAAGCATTGGTGCTGTTTACCACTGACAGTGAGATAACCCG
TGAACGGTTAATCAAAGTGGCACGGGAAAATGGTGTGCCTGAACTGGCGGTGCCGCGCGATATCCGGGTCGTGAAAGCTC
TCCCCTTATTAGGCAGCGGTAAACCTGACTTCGTCACGTTGGGCAAAATGGCACAAGATCCGGAGATGAGCGTATGA

Upstream 100 bases:

>100_bases
CGCTCTCCTAACCATATTGTTAGTGTGCTATTAACGACACACCCGCCATTATTATAGTATTCTCTATTTTTCAAATTCAT
TGAGTTATAGGGATATAGAC

Downstream 100 bases:

>100_bases
GTCAGGACGTATTAGCAGATAAGCCTTTGTTATCTCGGAGCATGGTCGCGGTACTCTGTGCTCAGTTTTTCTCCGCTTTC
GGGGATAATGCCCTGCTGTT

Product: bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase

Products: NA

Alternate protein names: 2-acylglycerophosphoethanolamine acyltransferase; 2-acyl-GPE acyltransferase; Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase; Acyl-[acyl-carrier-protein] synthetase; Acyl-ACP synthetase; Long-chain-fatty-acid--[acyl-carrier-protein] ligase [H]

Number of amino acids: Translated: 718; Mature: 717

Protein sequence:

>718_residues
MAYRLLRALFRGLFRVTIDGVTDQFKHEKLIITPNHVSFLDGALLALFLPIKPVFAVYTSITDTWYMRWLKPYVDFVALD
PTNPMAIKHLVRMVEQGRPVVIFPEGRITVTGSLMKIYDGAAFVAAKSGAAVVPIRLDGPEFTHFGRLQGVLKTRWFPKI
SIHVLPATTIPMPQAPRSRERRVLAGEHLHTIMMAARMATVPRETLFEALLSAQTRYGRFKPCIEDVSFKEDSYQTLLKK
TLGVSRILQRFTVPGEHVGMLLPNATITAAAIFGASLRGRIPALLNYTSGAKGLQSAIIAASLKTIVTSRQFLEKGKLTH
LPEQVNEVNWVYLEDLKDTVTLTDKLWILFHLCFPRRAMLPQQADGSALILFTSGSEGNPKGVVHSHASLLANVEQIRTI
ADFTPRDRFMSSLPLFHAFGLTVGLFTPLMTGSRVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLGNYARFAHPYDFAR
VRYVVAGAEKLAESTKQIWQDKFGIRILEGYGVTECAPVVAINVPMAAKVNTVGRILPGMEARLINVPGIAQGGRLQLRG
PNIMRGYLRVENPGVLEQPSAENAQGELDANWYDTGDIVTLDEQGFCAIRGRVKRFAKLAGEMVSLESVEQLAISLSPEG
QHAAAAKTDSAKGEALVLFTTDSEITRERLIKVARENGVPELAVPRDIRVVKALPLLGSGKPDFVTLGKMAQDPEMSV

Sequences:

>Translated_718_residues
MAYRLLRALFRGLFRVTIDGVTDQFKHEKLIITPNHVSFLDGALLALFLPIKPVFAVYTSITDTWYMRWLKPYVDFVALD
PTNPMAIKHLVRMVEQGRPVVIFPEGRITVTGSLMKIYDGAAFVAAKSGAAVVPIRLDGPEFTHFGRLQGVLKTRWFPKI
SIHVLPATTIPMPQAPRSRERRVLAGEHLHTIMMAARMATVPRETLFEALLSAQTRYGRFKPCIEDVSFKEDSYQTLLKK
TLGVSRILQRFTVPGEHVGMLLPNATITAAAIFGASLRGRIPALLNYTSGAKGLQSAIIAASLKTIVTSRQFLEKGKLTH
LPEQVNEVNWVYLEDLKDTVTLTDKLWILFHLCFPRRAMLPQQADGSALILFTSGSEGNPKGVVHSHASLLANVEQIRTI
ADFTPRDRFMSSLPLFHAFGLTVGLFTPLMTGSRVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLGNYARFAHPYDFAR
VRYVVAGAEKLAESTKQIWQDKFGIRILEGYGVTECAPVVAINVPMAAKVNTVGRILPGMEARLINVPGIAQGGRLQLRG
PNIMRGYLRVENPGVLEQPSAENAQGELDANWYDTGDIVTLDEQGFCAIRGRVKRFAKLAGEMVSLESVEQLAISLSPEG
QHAAAAKTDSAKGEALVLFTTDSEITRERLIKVARENGVPELAVPRDIRVVKALPLLGSGKPDFVTLGKMAQDPEMSV
>Mature_717_residues
AYRLLRALFRGLFRVTIDGVTDQFKHEKLIITPNHVSFLDGALLALFLPIKPVFAVYTSITDTWYMRWLKPYVDFVALDP
TNPMAIKHLVRMVEQGRPVVIFPEGRITVTGSLMKIYDGAAFVAAKSGAAVVPIRLDGPEFTHFGRLQGVLKTRWFPKIS
IHVLPATTIPMPQAPRSRERRVLAGEHLHTIMMAARMATVPRETLFEALLSAQTRYGRFKPCIEDVSFKEDSYQTLLKKT
LGVSRILQRFTVPGEHVGMLLPNATITAAAIFGASLRGRIPALLNYTSGAKGLQSAIIAASLKTIVTSRQFLEKGKLTHL
PEQVNEVNWVYLEDLKDTVTLTDKLWILFHLCFPRRAMLPQQADGSALILFTSGSEGNPKGVVHSHASLLANVEQIRTIA
DFTPRDRFMSSLPLFHAFGLTVGLFTPLMTGSRVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLGNYARFAHPYDFARV
RYVVAGAEKLAESTKQIWQDKFGIRILEGYGVTECAPVVAINVPMAAKVNTVGRILPGMEARLINVPGIAQGGRLQLRGP
NIMRGYLRVENPGVLEQPSAENAQGELDANWYDTGDIVTLDEQGFCAIRGRVKRFAKLAGEMVSLESVEQLAISLSPEGQ
HAAAAKTDSAKGEALVLFTTDSEITRERLIKVARENGVPELAVPRDIRVVKALPLLGSGKPDFVTLGKMAQDPEMSV

Specific function: Plays a role in lysophospholipid acylation. Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-

COG id: COG0318

COG function: function code IQ; Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the ATP- dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI156151445, Length=351, Percent_Identity=28.4900284900285, Blast_Score=108, Evalue=3e-23,
Organism=Homo sapiens, GI187761345, Length=402, Percent_Identity=26.1194029850746, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI187761343, Length=402, Percent_Identity=26.1194029850746, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI57165410, Length=407, Percent_Identity=26.044226044226, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI57165412, Length=407, Percent_Identity=26.2899262899263, Blast_Score=87, Evalue=4e-17,
Organism=Escherichia coli, GI1789201, Length=715, Percent_Identity=70.7692307692308, Blast_Score=1070, Evalue=0.0,
Organism=Escherichia coli, GI1788107, Length=514, Percent_Identity=25.0972762645914, Blast_Score=129, Evalue=8e-31,
Organism=Escherichia coli, GI145693145, Length=355, Percent_Identity=27.887323943662, Blast_Score=124, Evalue=2e-29,
Organism=Escherichia coli, GI1786810, Length=355, Percent_Identity=23.6619718309859, Blast_Score=89, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17558820, Length=344, Percent_Identity=27.6162790697674, Blast_Score=122, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI32563687, Length=340, Percent_Identity=28.2352941176471, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI71994694, Length=508, Percent_Identity=24.8031496062992, Blast_Score=106, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71994703, Length=508, Percent_Identity=24.8031496062992, Blast_Score=106, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI71994690, Length=508, Percent_Identity=24.8031496062992, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17560308, Length=368, Percent_Identity=26.0869565217391, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71985884, Length=315, Percent_Identity=26.031746031746, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17531443, Length=321, Percent_Identity=23.98753894081, Blast_Score=75, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538037, Length=389, Percent_Identity=23.6503856041131, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17559526, Length=521, Percent_Identity=23.0326295585413, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17557194, Length=329, Percent_Identity=23.7082066869301, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6319699, Length=347, Percent_Identity=25.6484149855908, Blast_Score=99, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6320852, Length=349, Percent_Identity=25.5014326647564, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI18859661, Length=281, Percent_Identity=27.7580071174377, Blast_Score=96, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21355181, Length=547, Percent_Identity=24.1316270566728, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24581924, Length=548, Percent_Identity=21.3503649635036, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19922652, Length=282, Percent_Identity=24.468085106383, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002123
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF01553 Acyltransferase; PF00501 AMP-binding [H]

EC number: =2.3.1.40; =6.2.1.20 [H]

Molecular weight: Translated: 79388; Mature: 79256

Theoretical pI: Translated: 9.88; Mature: 9.88

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYRLLRALFRGLFRVTIDGVTDQFKHEKLIITPNHVSFLDGALLALFLPIKPVFAVYTS
CHHHHHHHHHHHHHEEEECCHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
ITDTWYMRWLKPYVDFVALDPTNPMAIKHLVRMVEQGRPVVIFPEGRITVTGSLMKIYDG
HHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEEEEHHHHCC
AAFVAAKSGAAVVPIRLDGPEFTHFGRLQGVLKTRWFPKISIHVLPATTIPMPQAPRSRE
EEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCC
RRVLAGEHLHTIMMAARMATVPRETLFEALLSAQTRYGRFKPCIEDVSFKEDSYQTLLKK
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHH
TLGVSRILQRFTVPGEHVGMLLPNATITAAAIFGASLRGRIPALLNYTSGAKGLQSAIIA
HHCHHHHHHHHCCCCHHHEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHH
ASLKTIVTSRQFLEKGKLTHLPEQVNEVNWVYLEDLKDTVTLTDKLWILFHLCFPRRAML
HHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEEEECCCCCEEHHHHHHHHHHHHCCHHHCC
PQQADGSALILFTSGSEGNPKGVVHSHASLLANVEQIRTIADFTPRDRFMSSLPLFHAFG
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHH
LTVGLFTPLMTGSRVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLGNYARFAHPYDFAR
HHHHHHHHHHCCCEEEEECCCCCEEECHHHHHCCCCEEEEECHHHHHCHHHHCCCCHHHH
VRYVVAGAEKLAESTKQIWQDKFGIRILEGYGVTECAPVVAINVPMAAKVNTVGRILPGM
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHCCCC
EARLINVPGIAQGGRLQLRGPNIMRGYLRVENPGVLEQPSAENAQGELDANWYDTGDIVT
CEEEEECCCCCCCCEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEECCCCEEE
LDEQGFCAIRGRVKRFAKLAGEMVSLESVEQLAISLSPEGQHAAAAKTDSAKGEALVLFT
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCEEEEEE
TDSEITRERLIKVARENGVPELAVPRDIRVVKALPLLGSGKPDFVTLGKMAQDPEMSV
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHEECCCCCCCCCCEEEECCCCCCCCCCC
>Mature Secondary Structure 
AYRLLRALFRGLFRVTIDGVTDQFKHEKLIITPNHVSFLDGALLALFLPIKPVFAVYTS
HHHHHHHHHHHHHEEEECCHHHHHCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
ITDTWYMRWLKPYVDFVALDPTNPMAIKHLVRMVEQGRPVVIFPEGRITVTGSLMKIYDG
HHHHHHHHHHHHHHCEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCEEEEEEEHHHHCC
AAFVAAKSGAAVVPIRLDGPEFTHFGRLQGVLKTRWFPKISIHVLPATTIPMPQAPRSRE
EEEEEECCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCC
RRVLAGEHLHTIMMAARMATVPRETLFEALLSAQTRYGRFKPCIEDVSFKEDSYQTLLKK
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHCCCCCHHHHHHHHH
TLGVSRILQRFTVPGEHVGMLLPNATITAAAIFGASLRGRIPALLNYTSGAKGLQSAIIA
HHCHHHHHHHHCCCCHHHEEECCCCHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHH
ASLKTIVTSRQFLEKGKLTHLPEQVNEVNWVYLEDLKDTVTLTDKLWILFHLCFPRRAML
HHHHHHHHHHHHHHCCCCCCCCHHHCCCCEEEEECCCCCEEHHHHHHHHHHHHCCHHHCC
PQQADGSALILFTSGSEGNPKGVVHSHASLLANVEQIRTIADFTPRDRFMSSLPLFHAFG
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCHHHHHH
LTVGLFTPLMTGSRVFLYPSPLHYRVVPELVYDRNCTVLFGTSTFLGNYARFAHPYDFAR
HHHHHHHHHHCCCEEEEECCCCCEEECHHHHHCCCCEEEEECHHHHHCHHHHCCCCHHHH
VRYVVAGAEKLAESTKQIWQDKFGIRILEGYGVTECAPVVAINVPMAAKVNTVGRILPGM
HHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEECCCCCCHHHHHHHCCCC
EARLINVPGIAQGGRLQLRGPNIMRGYLRVENPGVLEQPSAENAQGELDANWYDTGDIVT
CEEEEECCCCCCCCEEEECCCCEEEEEEEECCCCCCCCCCCCCCCCCCCCCEECCCCEEE
LDEQGFCAIRGRVKRFAKLAGEMVSLESVEQLAISLSPEGQHAAAAKTDSAKGEALVLFT
ECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCCCCCCEEEEEE
TDSEITRERLIKVARENGVPELAVPRDIRVVKALPLLGSGKPDFVTLGKMAQDPEMSV
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHEECCCCCCCCCCEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA