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The map label for this gene is bisC [C]

Identifier: 218927974

GI number: 218927974

Start: 871777

End: 874038

Strand: Reverse

Name: bisC [C]

Synonym: YPO0794

Alternate gene names: 218927974

Gene position: 874038-871777 (Counterclockwise)

Preceding gene: 218927976

Following gene: 218927973

Centisome position: 18.78

GC content: 51.99

Gene sequence:

>2262_bases
ATGTCCATCATCCGTTACCCCCAACTTGCCCATTGGGGCGCTTATACCGCAGTTGTTGAAGATGGCAAGCTGATCCGCTG
CGAGCCATTTGCCGATGATCCCGATCCCTCGCCGCTACTGAACTCAATTGTTCCGATGGTTTACTCCGATAAACGTATCC
GTAAACCCGCCATCCGCCGTTCTTGGTTAAAGCGGCGGGAGAAGAGTGACCGGACTCTACGCGGGCAGGAGGATTTTGTT
GAAGTCGACTGGGATGTGGCGCTGGATTTAGTGGCCGAAGAGAATCGCCGGGTTAGGGACCAATACGGGCCTGCTGGGTT
ATTTACCGGCTCTTATGGCTGGTCTTCTGCGGGGCGTTTACATCATGCCCGCTCATTAGTTCGGCGTTTCTATTTCAGTG
GCGGTGGCGGTGTCGATCAATTAGGTAATTACAGTTGGGGGGCTGCACAATTTTTCCTGCCTTATGTCATTGGGACCTTT
AGCCCATTGACCGGGCGGGTGACGTCATGGCCCAGTGTGGTGGAACACTGTGAATTGTTCATTGCTTTTGGTGGGCTGGC
ACTGAAAAATGCGCAAGTCTCCTCCGGTGGGTCGGCTGAACATTCCCTTAAACTCTGGCTAGAGAAACTGGCACAAAAAG
GGACGCCAGTCATTAATATCAGCCCGATGCGTGATGATTGCCCCGCATTTGTTAACGCGGAATGGATACCCATTCGTCCG
AATACAGACGTCGCGCTGATGTTGGCGTTGGCTTATGAAATTCAGCGCCTTGATGGTCATGATGAGGCATTCCTTGCAAC
CCATTGTGTGGGTTATGGTCAATTGGCTGATTATATTCGTGGGGCCAATGACGGGATAGCGAAAACTCCAGACTGGGCGA
GCAGCATTACCGGTATTCCTGCGGCCAGAATCGCACAGTTAGCGCAACAACTTATCGGTGTGCGCAGTTTTATGACCTGT
TCGTATTCGGTGCAACGTGCGCATCGTGGTGAGCAACCGTATTGGATGGTGATTGCATTATCAGCCATGTTGGGGCAAGT
CGGGCTACCGGGTGGGGGTTTTTCATTCGGTCATGGTTCGATGAATGGTGTGGGTAACCCGCGCATTGATACACCGGGGC
CAGCCATGCCAGTGGGTAAGAACCCCGCCGGATTGGCTATTCCTGTGGCACGGATTTGCGACATGTTGTTACAACCGGGG
CAACCATATCAATTTCAGGGTGAAACACATACCTACCCGGATATTCATTTGGTGCACTGGGCGGGTGGGAACCCGTTCCA
TCATCATCAGCAGTTGAATCGGTTGGTTGAGGGGTGGCAAAAACCGGATACCGTGATCGTACAGGACATTTGGTGGACGC
CCGTAGCAAAAATGGCCGATATCGTCCTGCCAGTCACCAGTTCACTGGAGCGTAATGATATCGGTGGATCATCCAGGGAT
CGCTATGTCTTGGCGATGCATCAGGCGATTGCACCACAGCATCAGGCGCGCCACGATTTTGATATTTTCGCCGACTTGGC
TGACCGATTGGGCTACCGTGAAACCTTTACCGAGGGTCGTGATGAAATGGCGTGGATCAGGCATATTTATCAGGAGTGTG
GTGCGGCACAGCGCTCTCATGATGTTGAATGGCCAGATTTTGAGACTTTTTGGCAACAAGGGTATGTCGGTTTACCTGCT
CCCTCCAAAGCATTTGTGTTCTTTGATTCTTTCCGTGAAGACCCACAGGCTAATCCATTACAGACCCCGAGTGGCAAAAT
TGAATTATTTAGTGAAAAAATTGCCAGCTACCAATACAACGATTTTGCACCTCATGCAGAGTGGAAACCTCCGGTCGAAT
GGCTGGGCGCTCCGCTGGCTGAACAGTGGCCGCTACATTTAATCTCTATTCAACCGGGAGATCGCTTACACAGTCAGCTC
GATCCCGCCCCATTGGCTCAGAGCAATAAAACCGCAGGTCGTGAAACGCTGTATATGCATCCGCTGGATGCGGCCAGCCG
TGATATTACCGAAGGTAGTCAGGTCCAGGTTAGCAACTTACGCGGTCACTGTCTGGCGGGGGTCAGTATTACTGATGGGG
TTACCCGTGGGGTGGTATTGATGGCAACCGGAGCCTGGTTTGATCCTGGTTTTGGGGGCACGCAGCATAAAATTGAACAA
TCCGGTAACCCAAATGTATTGACGCTGGATATTGGGACATCTCGATTGACTCAAGGCCCAAATGCGATGAGCTGTTTGGT
CGAGGTGGCGCTTTATGAGTAG

Upstream 100 bases:

>100_bases
GTGTATCGCCCCAAATGACTATGTTTAGTCGAAATGGTGCTTTGAGTATGTGCGGTGGCGAATGTTACCTTGATGTTTTA
TTTCATTGCCTGAGAGAGCC

Downstream 100 bases:

>100_bases
ATTATCTTTCGTTTGCCGCCTTCCTGTAGCTCGAATTATTTAGGGTCTATTCGCCAAACAGCCACTTGGGAATGTATTTC
TCTGGTGGCTGAAATGCGAT

Product: putative biotin sulfoxide reductas2

Products: Biotin [C]

Alternate protein names: BDS reductase; BSO reductase [H]

Number of amino acids: Translated: 753; Mature: 752

Protein sequence:

>753_residues
MSIIRYPQLAHWGAYTAVVEDGKLIRCEPFADDPDPSPLLNSIVPMVYSDKRIRKPAIRRSWLKRREKSDRTLRGQEDFV
EVDWDVALDLVAEENRRVRDQYGPAGLFTGSYGWSSAGRLHHARSLVRRFYFSGGGGVDQLGNYSWGAAQFFLPYVIGTF
SPLTGRVTSWPSVVEHCELFIAFGGLALKNAQVSSGGSAEHSLKLWLEKLAQKGTPVINISPMRDDCPAFVNAEWIPIRP
NTDVALMLALAYEIQRLDGHDEAFLATHCVGYGQLADYIRGANDGIAKTPDWASSITGIPAARIAQLAQQLIGVRSFMTC
SYSVQRAHRGEQPYWMVIALSAMLGQVGLPGGGFSFGHGSMNGVGNPRIDTPGPAMPVGKNPAGLAIPVARICDMLLQPG
QPYQFQGETHTYPDIHLVHWAGGNPFHHHQQLNRLVEGWQKPDTVIVQDIWWTPVAKMADIVLPVTSSLERNDIGGSSRD
RYVLAMHQAIAPQHQARHDFDIFADLADRLGYRETFTEGRDEMAWIRHIYQECGAAQRSHDVEWPDFETFWQQGYVGLPA
PSKAFVFFDSFREDPQANPLQTPSGKIELFSEKIASYQYNDFAPHAEWKPPVEWLGAPLAEQWPLHLISIQPGDRLHSQL
DPAPLAQSNKTAGRETLYMHPLDAASRDITEGSQVQVSNLRGHCLAGVSITDGVTRGVVLMATGAWFDPGFGGTQHKIEQ
SGNPNVLTLDIGTSRLTQGPNAMSCLVEVALYE

Sequences:

>Translated_753_residues
MSIIRYPQLAHWGAYTAVVEDGKLIRCEPFADDPDPSPLLNSIVPMVYSDKRIRKPAIRRSWLKRREKSDRTLRGQEDFV
EVDWDVALDLVAEENRRVRDQYGPAGLFTGSYGWSSAGRLHHARSLVRRFYFSGGGGVDQLGNYSWGAAQFFLPYVIGTF
SPLTGRVTSWPSVVEHCELFIAFGGLALKNAQVSSGGSAEHSLKLWLEKLAQKGTPVINISPMRDDCPAFVNAEWIPIRP
NTDVALMLALAYEIQRLDGHDEAFLATHCVGYGQLADYIRGANDGIAKTPDWASSITGIPAARIAQLAQQLIGVRSFMTC
SYSVQRAHRGEQPYWMVIALSAMLGQVGLPGGGFSFGHGSMNGVGNPRIDTPGPAMPVGKNPAGLAIPVARICDMLLQPG
QPYQFQGETHTYPDIHLVHWAGGNPFHHHQQLNRLVEGWQKPDTVIVQDIWWTPVAKMADIVLPVTSSLERNDIGGSSRD
RYVLAMHQAIAPQHQARHDFDIFADLADRLGYRETFTEGRDEMAWIRHIYQECGAAQRSHDVEWPDFETFWQQGYVGLPA
PSKAFVFFDSFREDPQANPLQTPSGKIELFSEKIASYQYNDFAPHAEWKPPVEWLGAPLAEQWPLHLISIQPGDRLHSQL
DPAPLAQSNKTAGRETLYMHPLDAASRDITEGSQVQVSNLRGHCLAGVSITDGVTRGVVLMATGAWFDPGFGGTQHKIEQ
SGNPNVLTLDIGTSRLTQGPNAMSCLVEVALYE
>Mature_752_residues
SIIRYPQLAHWGAYTAVVEDGKLIRCEPFADDPDPSPLLNSIVPMVYSDKRIRKPAIRRSWLKRREKSDRTLRGQEDFVE
VDWDVALDLVAEENRRVRDQYGPAGLFTGSYGWSSAGRLHHARSLVRRFYFSGGGGVDQLGNYSWGAAQFFLPYVIGTFS
PLTGRVTSWPSVVEHCELFIAFGGLALKNAQVSSGGSAEHSLKLWLEKLAQKGTPVINISPMRDDCPAFVNAEWIPIRPN
TDVALMLALAYEIQRLDGHDEAFLATHCVGYGQLADYIRGANDGIAKTPDWASSITGIPAARIAQLAQQLIGVRSFMTCS
YSVQRAHRGEQPYWMVIALSAMLGQVGLPGGGFSFGHGSMNGVGNPRIDTPGPAMPVGKNPAGLAIPVARICDMLLQPGQ
PYQFQGETHTYPDIHLVHWAGGNPFHHHQQLNRLVEGWQKPDTVIVQDIWWTPVAKMADIVLPVTSSLERNDIGGSSRDR
YVLAMHQAIAPQHQARHDFDIFADLADRLGYRETFTEGRDEMAWIRHIYQECGAAQRSHDVEWPDFETFWQQGYVGLPAP
SKAFVFFDSFREDPQANPLQTPSGKIELFSEKIASYQYNDFAPHAEWKPPVEWLGAPLAEQWPLHLISIQPGDRLHSQLD
PAPLAQSNKTAGRETLYMHPLDAASRDITEGSQVQVSNLRGHCLAGVSITDGVTRGVVLMATGAWFDPGFGGTQHKIEQS
GNPNVLTLDIGTSRLTQGPNAMSCLVEVALYE

Specific function: This enzyme may serve as a scavenger, allowing the cell to utilize biotin sulfoxide as a biotin source. It reduces a spontaneous oxidation product of biotin, D-biotin D-sulfoxide (BSO or BDS), back to biotin [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081994, Length=760, Percent_Identity=38.9473684210526, Blast_Score=548, Evalue=1e-157,
Organism=Escherichia coli, GI145693196, Length=763, Percent_Identity=39.4495412844037, Blast_Score=524, Evalue=1e-149,
Organism=Escherichia coli, GI1787231, Length=767, Percent_Identity=39.374185136897, Blast_Score=517, Evalue=1e-148,
Organism=Escherichia coli, GI87081797, Length=713, Percent_Identity=30.8555399719495, Blast_Score=286, Evalue=4e-78,
Organism=Escherichia coli, GI1787870, Length=748, Percent_Identity=28.2085561497326, Blast_Score=250, Evalue=3e-67,
Organism=Escherichia coli, GI171474008, Length=746, Percent_Identity=28.1501340482574, Blast_Score=246, Evalue=4e-66,
Organism=Escherichia coli, GI3868721, Length=768, Percent_Identity=20.3125, Blast_Score=102, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.7.2.3 [C]

Molecular weight: Translated: 83350; Mature: 83219

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIIRYPQLAHWGAYTAVVEDGKLIRCEPFADDPDPSPLLNSIVPMVYSDKRIRKPAIRR
CCCCCCCCHHHCCCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCHHCCHHHHH
SWLKRREKSDRTLRGQEDFVEVDWDVALDLVAEENRRVRDQYGPAGLFTGSYGWSSAGRL
HHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHCCHHHHHHCCCCEEEECCCCCCCCCHH
HHARSLVRRFYFSGGGGVDQLGNYSWGAAQFFLPYVIGTFSPLTGRVTSWPSVVEHCELF
HHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
IAFGGLALKNAQVSSGGSAEHSLKLWLEKLAQKGTPVINISPMRDDCPAFVNAEWIPIRP
HHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEECC
NTDVALMLALAYEIQRLDGHDEAFLATHCVGYGQLADYIRGANDGIAKTPDWASSITGIP
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHCCCCC
AARIAQLAQQLIGVRSFMTCSYSVQRAHRGEQPYWMVIALSAMLGQVGLPGGGFSFGHGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCC
MNGVGNPRIDTPGPAMPVGKNPAGLAIPVARICDMLLQPGQPYQFQGETHTYPDIHLVHW
CCCCCCCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEE
AGGNPFHHHQQLNRLVEGWQKPDTVIVQDIWWTPVAKMADIVLPVTSSLERNDIGGSSRD
CCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
RYVLAMHQAIAPQHQARHDFDIFADLADRLGYRETFTEGRDEMAWIRHIYQECGAAQRSH
CEEEEEHHHHCCHHHCCCCHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHCCHHHCC
DVEWPDFETFWQQGYVGLPAPSKAFVFFDSFREDPQANPLQTPSGKIELFSEKIASYQYN
CCCCCCHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
DFAPHAEWKPPVEWLGAPLAEQWPLHLISIQPGDRLHSQLDPAPLAQSNKTAGRETLYMH
CCCCCCCCCCCHHHHCCCCCCCCCEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCEEEEC
PLDAASRDITEGSQVQVSNLRGHCLAGVSITDGVTRGVVLMATGAWFDPGFGGTQHKIEQ
CCCCCCCCCCCCCEEEEECCCCEEEECCEECCCCCCCEEEEEECCCCCCCCCCCHHHHHC
SGNPNVLTLDIGTSRLTQGPNAMSCLVEVALYE
CCCCCEEEEECCHHHHCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SIIRYPQLAHWGAYTAVVEDGKLIRCEPFADDPDPSPLLNSIVPMVYSDKRIRKPAIRR
CCCCCCCHHHCCCEEEEECCCCEEEEECCCCCCCCCHHHHHHHHHHCCCCHHCCHHHHH
SWLKRREKSDRTLRGQEDFVEVDWDVALDLVAEENRRVRDQYGPAGLFTGSYGWSSAGRL
HHHHHHHHCCCCCCCCCCEEEECHHHHHHHHHHCCHHHHHHCCCCEEEECCCCCCCCCHH
HHARSLVRRFYFSGGGGVDQLGNYSWGAAQFFLPYVIGTFSPLTGRVTSWPSVVEHCELF
HHHHHHHHHHHHCCCCCHHHCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
IAFGGLALKNAQVSSGGSAEHSLKLWLEKLAQKGTPVINISPMRDDCPAFVNAEWIPIRP
HHHCCEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCEEEECC
NTDVALMLALAYEIQRLDGHDEAFLATHCVGYGQLADYIRGANDGIAKTPDWASSITGIP
CCCHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHCCCCCCCCCCCCHHHHCCCCC
AARIAQLAQQLIGVRSFMTCSYSVQRAHRGEQPYWMVIALSAMLGQVGLPGGGFSFGHGS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCC
MNGVGNPRIDTPGPAMPVGKNPAGLAIPVARICDMLLQPGQPYQFQGETHTYPDIHLVHW
CCCCCCCCCCCCCCCCCCCCCCCCCEECHHHHHHHHHCCCCCEEECCCCCCCCCEEEEEE
AGGNPFHHHQQLNRLVEGWQKPDTVIVQDIWWTPVAKMADIVLPVTSSLERNDIGGSSRD
CCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
RYVLAMHQAIAPQHQARHDFDIFADLADRLGYRETFTEGRDEMAWIRHIYQECGAAQRSH
CEEEEEHHHHCCHHHCCCCHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHCCHHHCC
DVEWPDFETFWQQGYVGLPAPSKAFVFFDSFREDPQANPLQTPSGKIELFSEKIASYQYN
CCCCCCHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
DFAPHAEWKPPVEWLGAPLAEQWPLHLISIQPGDRLHSQLDPAPLAQSNKTAGRETLYMH
CCCCCCCCCCCHHHHCCCCCCCCCEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCEEEEC
PLDAASRDITEGSQVQVSNLRGHCLAGVSITDGVTRGVVLMATGAWFDPGFGGTQHKIEQ
CCCCCCCCCCCCCEEEEECCCCEEEECCEECCCCCCCEEEEEECCCCCCCCCCCHHHHHC
SGNPNVLTLDIGTSRLTQGPNAMSCLVEVALYE
CCCCCEEEEECCHHHHCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds) [C]

Specific reaction: Reduces A Spontaneous Oxidation Product Of Biotin, D-Biotin D-Sulfoxide (Bso Or Bds), Back To Biotin. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7733660 [H]