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The map label for this gene is folB [H]

Identifier: 218927841

GI number: 218927841

Start: 705730

End: 706089

Strand: Direct

Name: folB [H]

Synonym: YPO0648

Alternate gene names: 218927841

Gene position: 705730-706089 (Clockwise)

Preceding gene: 218927839

Following gene: 218927842

Centisome position: 15.16

GC content: 50.0

Gene sequence:

>360_bases
ATGGACATCGTATTTATTGAGGAACTCAGTGTCATAACCACCATCGGGGTTTATGACTGGGAGCAGACCATCCAGCAGAA
GCTGGTGTTCGATATCGAAATGGGCTGGGATAACCGTAAAGCGGCGGGCAGTGATGATGTCAATGACTGCCTGAGTTACG
CTGATATCAGTGAGGCGGTGATACAACATGTCGGCTCACAGCGTTTTGCATTGGTAGAGCGGGTCGCTGAAGAGGTAGCC
GAGTTGTTATTACGACGCTTTAATTCGCCGTGGGTACGCATCAAAGTTAGCAAGCCGGGGGCTGTTGCCCAAGCCAAAAA
TGTTGGTGTAATTATTGAACGTGGCCAACGGCTAAGCTGA

Upstream 100 bases:

>100_bases
CCCCGTTGAATAATGGTCGTTTTAATCGCAACATCAGTGGATAATACGCATATTCGGCTGGAAGTGGTATCCGGCAGGCA
CAAAAACAGAGAATGACGTG

Downstream 100 bases:

>100_bases
CCTTTTGTCGCCATATGACATAAAAATATCATTCTGCATTGATAATGTTGTCTGATTGTGTCGAGGTTCGTGATAAATTT
TCTGTATCCTTCTTAACTTG

Product: bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase

Products: NA

Alternate protein names: DHNA [H]

Number of amino acids: Translated: 119; Mature: 119

Protein sequence:

>119_residues
MDIVFIEELSVITTIGVYDWEQTIQQKLVFDIEMGWDNRKAAGSDDVNDCLSYADISEAVIQHVGSQRFALVERVAEEVA
ELLLRRFNSPWVRIKVSKPGAVAQAKNVGVIIERGQRLS

Sequences:

>Translated_119_residues
MDIVFIEELSVITTIGVYDWEQTIQQKLVFDIEMGWDNRKAAGSDDVNDCLSYADISEAVIQHVGSQRFALVERVAEEVA
ELLLRRFNSPWVRIKVSKPGAVAQAKNVGVIIERGQRLS
>Mature_119_residues
MDIVFIEELSVITTIGVYDWEQTIQQKLVFDIEMGWDNRKAAGSDDVNDCLSYADISEAVIQHVGSQRFALVERVAEEVA
ELLLRRFNSPWVRIKVSKPGAVAQAKNVGVIIERGQRLS

Specific function: Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. Can use L-threo-dihydroneopterin and D-erythro-dihydroneopterin as substrates for the formation of 6-hydroxymethyldihydropterin, but it can also catalyze the epimeriza

COG id: COG1539

COG function: function code H; Dihydroneopterin aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHNA family [H]

Homologues:

Organism=Escherichia coli, GI87082204, Length=118, Percent_Identity=84.7457627118644, Blast_Score=205, Evalue=6e-55,
Organism=Escherichia coli, GI1788641, Length=110, Percent_Identity=27.2727272727273, Blast_Score=60, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006156
- InterPro:   IPR006157 [H]

Pfam domain/function: PF02152 FolB [H]

EC number: =4.1.2.25 [H]

Molecular weight: Translated: 13391; Mature: 13391

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIVFIEELSVITTIGVYDWEQTIQQKLVFDIEMGWDNRKAAGSDDVNDCLSYADISEAV
CCEEEEEHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
IQHVGSQRFALVERVAEEVAELLLRRFNSPWVRIKVSKPGAVAQAKNVGVIIERGQRLS
HHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHCCCCCEEEECCCCCC
>Mature Secondary Structure
MDIVFIEELSVITTIGVYDWEQTIQQKLVFDIEMGWDNRKAAGSDDVNDCLSYADISEAV
CCEEEEEHHHHHHHHCCCCHHHHHHHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHHH
IQHVGSQRFALVERVAEEVAELLLRRFNSPWVRIKVSKPGAVAQAKNVGVIIERGQRLS
HHHCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHCCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]