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The map label for this gene is ftsI [H]

Identifier: 218927745

GI number: 218927745

Start: 591889

End: 593652

Strand: Direct

Name: ftsI [H]

Synonym: YPO0549

Alternate gene names: 218927745

Gene position: 591889-593652 (Clockwise)

Preceding gene: 218927744

Following gene: 218927746

Centisome position: 12.72

GC content: 53.17

Gene sequence:

>1764_bases
ATGAAGACAGCGCGCCCCGGGAAGTTAAAGCGTCAGGAAGAACAAGCCAGCTTTATTAGCTGGCGTTTTGCGTTGCTGTG
CGGTTGTATTTTACTGGCATTGGTTGGGCTGATTATGCGTACCGCATACCTGCAAGTGATCAACCCCGATAAGCTGGTGC
GCGAGGGGGATATGCGCTCGCTGCGAGTACAAGAGGTGCCGACGGCGCGTGGCATGATAAGCGATCGCTCTGGCCGCCCT
TTGGCGGTCAGTGTACCCGTCAATGCGGTTTGGGCCGATCCAAAAGAACTGATTGAACAGGGGGGGATCTCTCTGGATAC
CCGCTGGAAAGCCCTGTCGGATGCATTAGAAATCCCTTTAGATCAACTTGCCACGCGCATTAATGCCAATCCAAAAGGCC
GCTTTGTCTATCTGGCCCGTCAGGTGAACCCCGCGATTGGCGACTACATCCGCAAGCTGAAATTACCCGGTATCCATCTA
CGTCAGGAATCCCGTCGCTACTATCCGGCAGGTCAGGTGATGGCTCACATTATTGGTGTGACCAATATCGATGGGCAAGG
GATTGAAGGTGTTGAGAAAAGTTTTGATCGCTGGCTCACCGGCCAACCGGGCGAGCGAACGGTGCGCAAAGACCATTATG
GCCGTGTTATTGAAGATATCTCCTCTGTTGACAGCCAGGCGGCGCATAACCTGGTGCTGAGTGTGGACGAGCGTTTGCAG
GCGTTGGTGTACCGCGAGCTCAATAATGCGGTGGCGTTTAACAAAGCAGAATCGGGCACGGCGGTATTAGTCGATGTGAA
CACCGGTGAAGTCTTGGCGATGGCGAACAGCCCGTCTTACAACCCGAATAACCTAACCGGTACGCCGAAAGACGCGATGC
GTAACCGGGCAATAACCGATATTTTTGAACCCGGCTCGACAGTCAAGCCAATGGTAGTGATGACGGCCTTACAGCATGGT
GTTGTGAAAGAGAACAGTGTGCTGAATACCTTGCCGTACTTTGTTAACGGTCACCAGATTAAAGACGTGGCCCGTTACGC
TGAGCTATCCGTCACTGGGATCTTACAGAAGTCGAGTAACGTCGGTGTTTCTAAACTGGCGTTAGCGATGCCATCCTCAG
CGTTAGTAGATACTTACTCACGGTTTGGGTTTGGGAAAGCGACCAATTTGGGGTTGGTCGGAGAAAGCAGTGGCTTATAT
CCTAAAAAACAACGGTGGTCTGACATAGAGAGGGCCACCTTCTCTTTCGGCTACGGGCTAATGGTAACACCGTTACAACT
AGCGCGAGTCTATGCAACCATCGGCAGCATGGGGGTCTATCGCCCGCTGTCGATAACCCGAGTTGACCCACCTGTCGCCG
GTGAACGCATCTTCCCTGAACCCCTGGTACGCACCGTGGTTCATATGATGGAAAGCGTGGCACTGCCTGGCGGTGGTGGT
ACCAAAGCGGCGATCAAAGGCTACCGTATCGCGATTAAAACCGGTACGGCCAAAAAAGTCGGTCCCGATGGCAAGTATAT
GGATCGATACCTCGCTTACACCGCTGGCGTTGCGCCCGCGAGTAACCCTCGATTTGCTCTGGTTGTGGTGATCAATGACC
CGCAGGCAGGGAAATATTACGGTGGTGCGGTTTCTGCACCGGTATTCGGTGCCATCATGGGCGGCGTTTTACGCACCATG
AACATTGAGCCAGATGCGTTACCCACCGGTGATAAAAGCGAATTAGTGATTAATACAAAAGAGGGTTCAGGTGGCAGATC
GTAA

Upstream 100 bases:

>100_bases
TCGATCCATCACAAGAAAACATTGTGATTAAATAATAGGTTGTTTTTTAACCAGTACAGGAATCAGTGACCATCATGACT
CGCAGTCGCCAAGGTAATAC

Downstream 100 bases:

>100_bases
TTTGCGCGACTTATTCGCTCCTTGGGGGCTAGACGTCCCGGAGCGGGCGCTACGGGAAATGACATTAGACAGCCGTATTG
CAGCTGCCGGCGATTTATTT

Product: penicillin-binding protein 3

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 587; Mature: 587

Protein sequence:

>587_residues
MKTARPGKLKRQEEQASFISWRFALLCGCILLALVGLIMRTAYLQVINPDKLVREGDMRSLRVQEVPTARGMISDRSGRP
LAVSVPVNAVWADPKELIEQGGISLDTRWKALSDALEIPLDQLATRINANPKGRFVYLARQVNPAIGDYIRKLKLPGIHL
RQESRRYYPAGQVMAHIIGVTNIDGQGIEGVEKSFDRWLTGQPGERTVRKDHYGRVIEDISSVDSQAAHNLVLSVDERLQ
ALVYRELNNAVAFNKAESGTAVLVDVNTGEVLAMANSPSYNPNNLTGTPKDAMRNRAITDIFEPGSTVKPMVVMTALQHG
VVKENSVLNTLPYFVNGHQIKDVARYAELSVTGILQKSSNVGVSKLALAMPSSALVDTYSRFGFGKATNLGLVGESSGLY
PKKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSMGVYRPLSITRVDPPVAGERIFPEPLVRTVVHMMESVALPGGGG
TKAAIKGYRIAIKTGTAKKVGPDGKYMDRYLAYTAGVAPASNPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRTM
NIEPDALPTGDKSELVINTKEGSGGRS

Sequences:

>Translated_587_residues
MKTARPGKLKRQEEQASFISWRFALLCGCILLALVGLIMRTAYLQVINPDKLVREGDMRSLRVQEVPTARGMISDRSGRP
LAVSVPVNAVWADPKELIEQGGISLDTRWKALSDALEIPLDQLATRINANPKGRFVYLARQVNPAIGDYIRKLKLPGIHL
RQESRRYYPAGQVMAHIIGVTNIDGQGIEGVEKSFDRWLTGQPGERTVRKDHYGRVIEDISSVDSQAAHNLVLSVDERLQ
ALVYRELNNAVAFNKAESGTAVLVDVNTGEVLAMANSPSYNPNNLTGTPKDAMRNRAITDIFEPGSTVKPMVVMTALQHG
VVKENSVLNTLPYFVNGHQIKDVARYAELSVTGILQKSSNVGVSKLALAMPSSALVDTYSRFGFGKATNLGLVGESSGLY
PKKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSMGVYRPLSITRVDPPVAGERIFPEPLVRTVVHMMESVALPGGGG
TKAAIKGYRIAIKTGTAKKVGPDGKYMDRYLAYTAGVAPASNPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRTM
NIEPDALPTGDKSELVINTKEGSGGRS
>Mature_587_residues
MKTARPGKLKRQEEQASFISWRFALLCGCILLALVGLIMRTAYLQVINPDKLVREGDMRSLRVQEVPTARGMISDRSGRP
LAVSVPVNAVWADPKELIEQGGISLDTRWKALSDALEIPLDQLATRINANPKGRFVYLARQVNPAIGDYIRKLKLPGIHL
RQESRRYYPAGQVMAHIIGVTNIDGQGIEGVEKSFDRWLTGQPGERTVRKDHYGRVIEDISSVDSQAAHNLVLSVDERLQ
ALVYRELNNAVAFNKAESGTAVLVDVNTGEVLAMANSPSYNPNNLTGTPKDAMRNRAITDIFEPGSTVKPMVVMTALQHG
VVKENSVLNTLPYFVNGHQIKDVARYAELSVTGILQKSSNVGVSKLALAMPSSALVDTYSRFGFGKATNLGLVGESSGLY
PKKQRWSDIERATFSFGYGLMVTPLQLARVYATIGSMGVYRPLSITRVDPPVAGERIFPEPLVRTVVHMMESVALPGGGG
TKAAIKGYRIAIKTGTAKKVGPDGKYMDRYLAYTAGVAPASNPRFALVVVINDPQAGKYYGGAVSAPVFGAIMGGVLRTM
NIEPDALPTGDKSELVINTKEGSGGRS

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=584, Percent_Identity=84.5890410958904, Blast_Score=1036, Evalue=0.0,
Organism=Escherichia coli, GI1786854, Length=621, Percent_Identity=25.1207729468599, Blast_Score=142, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 63640; Mature: 63640

Theoretical pI: Translated: 10.03; Mature: 10.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTARPGKLKRQEEQASFISWRFALLCGCILLALVGLIMRTAYLQVINPDKLVREGDMRS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHCCCCCC
LRVQEVPTARGMISDRSGRPLAVSVPVNAVWADPKELIEQGGISLDTRWKALSDALEIPL
EEEECCCCCCCCCCCCCCCCEEEECCCCEEECCHHHHHHHCCCCCCHHHHHHHHHHHCCH
DQLATRINANPKGRFVYLARQVNPAIGDYIRKLKLPGIHLRQESRRYYPAGQVMAHIIGV
HHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCEECHHCCCCCCHHHHHHHHHHC
TNIDGQGIEGVEKSFDRWLTGQPGERTVRKDHYGRVIEDISSVDSQAAHNLVLSVDERLQ
CCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHH
ALVYRELNNAVAFNKAESGTAVLVDVNTGEVLAMANSPSYNPNNLTGTPKDAMRNRAITD
HHHHHHHHCCEEECCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHCCCHHH
IFEPGSTVKPMVVMTALQHGVVKENSVLNTLPYFVNGHQIKDVARYAELSVTGILQKSSN
HHCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCHHCCCHHHHHHHHHHHHHHEEEEECCCC
VGVSKLALAMPSSALVDTYSRFGFGKATNLGLVGESSGLYPKKQRWSDIERATFSFGYGL
CCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCH
MVTPLQLARVYATIGSMGVYRPLSITRVDPPVAGERIFPEPLVRTVVHMMESVALPGGGG
HHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
TKAAIKGYRIAIKTGTAKKVGPDGKYMDRYLAYTAGVAPASNPRFALVVVINDPQAGKYY
CHHEECEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCC
GGAVSAPVFGAIMGGVLRTMNIEPDALPTGDKSELVINTKEGSGGRS
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCC
>Mature Secondary Structure
MKTARPGKLKRQEEQASFISWRFALLCGCILLALVGLIMRTAYLQVINPDKLVREGDMRS
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHCCCCCC
LRVQEVPTARGMISDRSGRPLAVSVPVNAVWADPKELIEQGGISLDTRWKALSDALEIPL
EEEECCCCCCCCCCCCCCCCEEEECCCCEEECCHHHHHHHCCCCCCHHHHHHHHHHHCCH
DQLATRINANPKGRFVYLARQVNPAIGDYIRKLKLPGIHLRQESRRYYPAGQVMAHIIGV
HHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCEECHHCCCCCCHHHHHHHHHHC
TNIDGQGIEGVEKSFDRWLTGQPGERTVRKDHYGRVIEDISSVDSQAAHNLVLSVDERLQ
CCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHH
ALVYRELNNAVAFNKAESGTAVLVDVNTGEVLAMANSPSYNPNNLTGTPKDAMRNRAITD
HHHHHHHHCCEEECCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCHHHHHCCCHHH
IFEPGSTVKPMVVMTALQHGVVKENSVLNTLPYFVNGHQIKDVARYAELSVTGILQKSSN
HHCCCCCCCHHHHHHHHHHCCCCCCCHHHHCCHHCCCHHHHHHHHHHHHHHEEEEECCCC
VGVSKLALAMPSSALVDTYSRFGFGKATNLGLVGESSGLYPKKQRWSDIERATFSFGYGL
CCHHHHHHHCCCHHHHHHHHHHCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHCCCCH
MVTPLQLARVYATIGSMGVYRPLSITRVDPPVAGERIFPEPLVRTVVHMMESVALPGGGG
HHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCC
TKAAIKGYRIAIKTGTAKKVGPDGKYMDRYLAYTAGVAPASNPRFALVVVINDPQAGKYY
CHHEECEEEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCCC
GGAVSAPVFGAIMGGVLRTMNIEPDALPTGDKSELVINTKEGSGGRS
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]