Click here to switch to the map view.

The map label for this gene is thrC [H]

Identifier: 218927658

GI number: 218927658

Start: 486790

End: 488079

Strand: Direct

Name: thrC [H]

Synonym: YPO0461

Alternate gene names: 218927658

Gene position: 486790-488079 (Clockwise)

Preceding gene: 218927657

Following gene: 218927660

Centisome position: 10.46

GC content: 47.83

Gene sequence:

>1290_bases
ATGAAACTGTATAACCTTAAAGATCATAACGAGCAGGTCAGCTTCGCACAGGCGATCAAACAAGGCTTGGGCAAACAGCA
GGGGCTATTTTTCCCGTTGGAGTTGCCCGAGTTCGAACTGACTGAGATCGATAAACTGCTGGATCTGGATTTTGTGACCC
GTAGTAGCCGCATTCTGTCGGCTTTTATTGGTAGTGAAATTGCACCAGATGTCTTAACCAAACGTGTGCAGGCAGCTTTT
GAATTCCCAGCCCCTGTTGCACAAGTTGAAAATGATATCGCCGTTCTGGAGTTGTTCCACGGCCCGACCTTGGCGTTTAA
AGACTTTGGCGCACGTTTTATGGCACAGATGCTGGCCGAAGTTGCTGGCGATCAACCCGTCACTATTTTAACGGCAACAT
CGGGTGATACTGGTGCGGCGGTGGCTCATGCATTCTACGGGCTGAAAAATGTTCGAGTGGTTATCCTTTATCCACGAGGC
AAGATTAGTCCGCTGCAAGAAAAGCTGTTTTGTACTCTGGGCGGTAATATTCACACGGTGGCGATTGATGGCGATTTTGA
TGCTTGTCAGGCACTGGTTAAGCAAGCTTTTGATGATGAAGAACTGAAAACCGCGCTGAGTTTGAATTCCGCTAACTCAA
TTAATATCAGCCGGTTACTGGCACAAATTTGTTACTACTTTGAAGCTGTAGCCCAGTTACCACAAGAGGCGCGCAACCAA
CTGGTTATCTCTGTACCAAGCGGTAACTTTGGTGATTTGACTGCCGGTTTGTTGGCAAAATCTTTAGGGCTACCGGTGAA
ACGCTTTATTGCTGCCACTAATGCTAACGACACCGTGCCACGCTTTTTGGTTAACGGCCAGTGGCAGCCAAAGCCAACTG
TAGCCACGTTATCGAATGCCATGGATGTCAGTCAGCCAAATAATTGGCCACGTGTGGAAGAGCTATATCGTCGCAAAATC
TGGCAGTTGAAGGATTTAGGGCATGGTGCGGTTAGCGATAAAACCACAAAAGATACGATGCGTGAATTAGCTGGTTTGGG
GTATATCTCTGAGCCTCACGCGGCGATTGCTTACCGTGTATTGCGTGATCAGTTGCAAGATGGTGAATTTGGCTTGTTTA
TCGGAACCGCACATCCCGCGAAATTCAAAGAGAGCGTAGAGGCAATTCTGGGTCAGGAATTACCTTTACCAAAACCACTG
GCCGTGAGAGCGCAATTACCGTTGCTATCCCATGATTTGCCCGCAGACTTTGCACAAATGCGGGCATTTTTGATGGCATT
GCCGAAGTAA

Upstream 100 bases:

>100_bases
CATGGCGGGCTGGCTACAAAATCATTACCTGCAAAACGACGAAGGTTTTGTTCATATTTGCCGTCTGGATACCGCAGGCG
CACGACTACTGGGATAACGC

Downstream 100 bases:

>100_bases
TCGGTTATTAACAAAGCTATTTTTAGCCTCGTGAGTGAAGGGTTGACCGCACCTCGGGGCACTTCGGCGACTTACGTCGC
TACGACCCCAACGGCACGTT

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 429; Mature: 429

Protein sequence:

>429_residues
MKLYNLKDHNEQVSFAQAIKQGLGKQQGLFFPLELPEFELTEIDKLLDLDFVTRSSRILSAFIGSEIAPDVLTKRVQAAF
EFPAPVAQVENDIAVLELFHGPTLAFKDFGARFMAQMLAEVAGDQPVTILTATSGDTGAAVAHAFYGLKNVRVVILYPRG
KISPLQEKLFCTLGGNIHTVAIDGDFDACQALVKQAFDDEELKTALSLNSANSINISRLLAQICYYFEAVAQLPQEARNQ
LVISVPSGNFGDLTAGLLAKSLGLPVKRFIAATNANDTVPRFLVNGQWQPKPTVATLSNAMDVSQPNNWPRVEELYRRKI
WQLKDLGHGAVSDKTTKDTMRELAGLGYISEPHAAIAYRVLRDQLQDGEFGLFIGTAHPAKFKESVEAILGQELPLPKPL
AVRAQLPLLSHDLPADFAQMRAFLMALPK

Sequences:

>Translated_429_residues
MKLYNLKDHNEQVSFAQAIKQGLGKQQGLFFPLELPEFELTEIDKLLDLDFVTRSSRILSAFIGSEIAPDVLTKRVQAAF
EFPAPVAQVENDIAVLELFHGPTLAFKDFGARFMAQMLAEVAGDQPVTILTATSGDTGAAVAHAFYGLKNVRVVILYPRG
KISPLQEKLFCTLGGNIHTVAIDGDFDACQALVKQAFDDEELKTALSLNSANSINISRLLAQICYYFEAVAQLPQEARNQ
LVISVPSGNFGDLTAGLLAKSLGLPVKRFIAATNANDTVPRFLVNGQWQPKPTVATLSNAMDVSQPNNWPRVEELYRRKI
WQLKDLGHGAVSDKTTKDTMRELAGLGYISEPHAAIAYRVLRDQLQDGEFGLFIGTAHPAKFKESVEAILGQELPLPKPL
AVRAQLPLLSHDLPADFAQMRAFLMALPK
>Mature_429_residues
MKLYNLKDHNEQVSFAQAIKQGLGKQQGLFFPLELPEFELTEIDKLLDLDFVTRSSRILSAFIGSEIAPDVLTKRVQAAF
EFPAPVAQVENDIAVLELFHGPTLAFKDFGARFMAQMLAEVAGDQPVTILTATSGDTGAAVAHAFYGLKNVRVVILYPRG
KISPLQEKLFCTLGGNIHTVAIDGDFDACQALVKQAFDDEELKTALSLNSANSINISRLLAQICYYFEAVAQLPQEARNQ
LVISVPSGNFGDLTAGLLAKSLGLPVKRFIAATNANDTVPRFLVNGQWQPKPTVATLSNAMDVSQPNNWPRVEELYRRKI
WQLKDLGHGAVSDKTTKDTMRELAGLGYISEPHAAIAYRVLRDQLQDGEFGLFIGTAHPAKFKESVEAILGQELPLPKPL
AVRAQLPLLSHDLPADFAQMRAFLMALPK

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Homo sapiens, GI153792148, Length=437, Percent_Identity=29.9771167048055, Blast_Score=165, Evalue=9e-41,
Organism=Homo sapiens, GI149193323, Length=420, Percent_Identity=30, Blast_Score=159, Evalue=7e-39,
Organism=Escherichia coli, GI1786185, Length=425, Percent_Identity=83.0588235294118, Blast_Score=713, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319901, Length=447, Percent_Identity=33.1096196868009, Blast_Score=212, Evalue=9e-56,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 47069; Mature: 47069

Theoretical pI: Translated: 6.12; Mature: 6.12

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLYNLKDHNEQVSFAQAIKQGLGKQQGLFFPLELPEFELTEIDKLLDLDFVTRSSRILS
CCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
AFIGSEIAPDVLTKRVQAAFEFPAPVAQVENDIAVLELFHGPTLAFKDFGARFMAQMLAE
HHHCCCCCHHHHHHHHHHHHCCCCCHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHH
VAGDQPVTILTATSGDTGAAVAHAFYGLKNVRVVILYPRGKISPLQEKLFCTLGGNIHTV
HCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHEEEEECCCEEEE
AIDGDFDACQALVKQAFDDEELKTALSLNSANSINISRLLAQICYYFEAVAQLPQEARNQ
EECCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
LVISVPSGNFGDLTAGLLAKSLGLPVKRFIAATNANDTVPRFLVNGQWQPKPTVATLSNA
EEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHEECCCCCCCCHHHHHHHH
MDVSQPNNWPRVEELYRRKIWQLKDLGHGAVSDKTTKDTMRELAGLGYISEPHAAIAYRV
HCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHH
LRDQLQDGEFGLFIGTAHPAKFKESVEAILGQELPLPKPLAVRAQLPLLSHDLPADFAQM
HHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCEECCCHHCCCCCHHHHHH
RAFLMALPK
HHHHHHCCC
>Mature Secondary Structure
MKLYNLKDHNEQVSFAQAIKQGLGKQQGLFFPLELPEFELTEIDKLLDLDFVTRSSRILS
CCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
AFIGSEIAPDVLTKRVQAAFEFPAPVAQVENDIAVLELFHGPTLAFKDFGARFMAQMLAE
HHHCCCCCHHHHHHHHHHHHCCCCCHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHHH
VAGDQPVTILTATSGDTGAAVAHAFYGLKNVRVVILYPRGKISPLQEKLFCTLGGNIHTV
HCCCCCEEEEEECCCCCHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHEEEEECCCEEEE
AIDGDFDACQALVKQAFDDEELKTALSLNSANSINISRLLAQICYYFEAVAQLPQEARNQ
EECCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
LVISVPSGNFGDLTAGLLAKSLGLPVKRFIAATNANDTVPRFLVNGQWQPKPTVATLSNA
EEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHEECCCCCCCCHHHHHHHH
MDVSQPNNWPRVEELYRRKIWQLKDLGHGAVSDKTTKDTMRELAGLGYISEPHAAIAYRV
HCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHH
LRDQLQDGEFGLFIGTAHPAKFKESVEAILGQELPLPKPLAVRAQLPLLSHDLPADFAQM
HHHHHCCCCEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCEECCCHHCCCCCHHHHHH
RAFLMALPK
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8423151 [H]