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The map label for this gene is thrB [H]

Identifier: 218927657

GI number: 218927657

Start: 485857

End: 486786

Strand: Direct

Name: thrB [H]

Synonym: YPO0460

Alternate gene names: 218927657

Gene position: 485857-486786 (Clockwise)

Preceding gene: 218927656

Following gene: 218927658

Centisome position: 10.44

GC content: 52.58

Gene sequence:

>930_bases
ATGGTTAAAATCTATGCTCCGGCATCAATTGGCAATGTCAGCGTCGGCTTCGATGTATTAGGTGCGGCGGTCTCGCCAAT
AGATGGCACATTGCTCGGTGATTGTGTCAGCGTAACAGCCGCAGAGCGTTTTAGCCTGCATAATGAAGGCCGTTTTGTCA
GCAAGCTGCCTGATGATCCCAAACAGAATATCGTTTATCAGTGTTGGGAACGCTTTTGCCAGGAAATGGGCAAAGAGATC
CCCGTCGCTATGGTGCTGGAAAAGAATATGCCGATCGGTTCAGGGCTGGGTTCCAGCGCCTGTTCAGTGGTTGCCGGCCT
GATGGCGATGAATGAGTTCTGCGGCCAACCGTTGGATAAAGTCACATTACTCGGCATGATGGGGGAACTGGAAGGGCGGG
TCTCGGGCAGTATTCATTTCGATAATGTCGCGCCTTGTTATTTAGGGGGCATGCAGCTGATCCTTGAGCAGGAAGGTTAT
ATCAGTCAGGATGTTCCTGGTTTTAGCGATTGGTTATGGGTGATGGCCTATCCGGGGATCAAAGTGTCTACCGCCGAAGC
GCGGGCGATTTTACCGGCGCAGTATCGCCGTCAGGATTGCATCACTCATGGGCGTAATTTGGCGGGGTTCATTCACGCTT
GTCACACTCAGCAGCCAGATTTAGCCGCTAAAATGATGAAGGATGTTATCGCGGAACCTTACCGCACTCAATTGCTGCCA
GGCTTTGCTGCTGCACGACAAGCGGCACAGGATATCGGTGCGCTGGCCTGTGGTATTTCCGGATCCGGCCCCACGTTGTT
TGCCGTCTGTAACGACCAGGCAACCGCACAACGCATGGCGGGCTGGCTACAAAATCATTACCTGCAAAACGACGAAGGTT
TTGTTCATATTTGCCGTCTGGATACCGCAGGCGCACGACTACTGGGATAA

Upstream 100 bases:

>100_bases
CGTTGGTGCTACGCGGTTATGGCGCAGGCAATGATGTGACTGCCGCTGGGGTGTTTGCCGATCTTTTACGCACATTATCA
TGGAAGTTGGGAGTTTAAAT

Downstream 100 bases:

>100_bases
CGCATGAAACTGTATAACCTTAAAGATCATAACGAGCAGGTCAGCTTCGCACAGGCGATCAAACAAGGCTTGGGCAAACA
GCAGGGGCTATTTTTCCCGT

Product: homoserine kinase

Products: NA

Alternate protein names: HK; HSK [H]

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MVKIYAPASIGNVSVGFDVLGAAVSPIDGTLLGDCVSVTAAERFSLHNEGRFVSKLPDDPKQNIVYQCWERFCQEMGKEI
PVAMVLEKNMPIGSGLGSSACSVVAGLMAMNEFCGQPLDKVTLLGMMGELEGRVSGSIHFDNVAPCYLGGMQLILEQEGY
ISQDVPGFSDWLWVMAYPGIKVSTAEARAILPAQYRRQDCITHGRNLAGFIHACHTQQPDLAAKMMKDVIAEPYRTQLLP
GFAAARQAAQDIGALACGISGSGPTLFAVCNDQATAQRMAGWLQNHYLQNDEGFVHICRLDTAGARLLG

Sequences:

>Translated_309_residues
MVKIYAPASIGNVSVGFDVLGAAVSPIDGTLLGDCVSVTAAERFSLHNEGRFVSKLPDDPKQNIVYQCWERFCQEMGKEI
PVAMVLEKNMPIGSGLGSSACSVVAGLMAMNEFCGQPLDKVTLLGMMGELEGRVSGSIHFDNVAPCYLGGMQLILEQEGY
ISQDVPGFSDWLWVMAYPGIKVSTAEARAILPAQYRRQDCITHGRNLAGFIHACHTQQPDLAAKMMKDVIAEPYRTQLLP
GFAAARQAAQDIGALACGISGSGPTLFAVCNDQATAQRMAGWLQNHYLQNDEGFVHICRLDTAGARLLG
>Mature_309_residues
MVKIYAPASIGNVSVGFDVLGAAVSPIDGTLLGDCVSVTAAERFSLHNEGRFVSKLPDDPKQNIVYQCWERFCQEMGKEI
PVAMVLEKNMPIGSGLGSSACSVVAGLMAMNEFCGQPLDKVTLLGMMGELEGRVSGSIHFDNVAPCYLGGMQLILEQEGY
ISQDVPGFSDWLWVMAYPGIKVSTAEARAILPAQYRRQDCITHGRNLAGFIHACHTQQPDLAAKMMKDVIAEPYRTQLLP
GFAAARQAAQDIGALACGISGSGPTLFAVCNDQATAQRMAGWLQNHYLQNDEGFVHICRLDTAGARLLG

Specific function: Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate [H]

COG id: COG0083

COG function: function code E; Homoserine kinase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. Homoserine kinase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786184, Length=308, Percent_Identity=76.6233766233766, Blast_Score=508, Evalue=1e-145,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR006203
- InterPro:   IPR000870
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N [H]

EC number: =2.7.1.39 [H]

Molecular weight: Translated: 33232; Mature: 33232

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00627 GHMP_KINASES_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
7.8 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
7.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKIYAPASIGNVSVGFDVLGAAVSPIDGTLLGDCVSVTAAERFSLHNEGRFVSKLPDDP
CEEEEECCCCCCCEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCH
KQNIVYQCWERFCQEMGKEIPVAMVLEKNMPIGSGLGSSACSVVAGLMAMNEFCGQPLDK
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
VTLLGMMGELEGRVSGSIHFDNVAPCYLGGMQLILEQEGYISQDVPGFSDWLWVMAYPGI
HHHHHHHHHHCCCCCCCEEECCCCHHHHCCHHHEEECCCCCCCCCCCHHHHHHHEECCCE
KVSTAEARAILPAQYRRQDCITHGRNLAGFIHACHTQQPDLAAKMMKDVIAEPYRTQLLP
EEECCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHCC
GFAAARQAAQDIGALACGISGSGPTLFAVCNDQATAQRMAGWLQNHYLQNDEGFVHICRL
CHHHHHHHHHHHHHEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEEE
DTAGARLLG
CCCCHHCCC
>Mature Secondary Structure
MVKIYAPASIGNVSVGFDVLGAAVSPIDGTLLGDCVSVTAAERFSLHNEGRFVSKLPDDP
CEEEEECCCCCCCEECHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCH
KQNIVYQCWERFCQEMGKEIPVAMVLEKNMPIGSGLGSSACSVVAGLMAMNEFCGQPLDK
HHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHH
VTLLGMMGELEGRVSGSIHFDNVAPCYLGGMQLILEQEGYISQDVPGFSDWLWVMAYPGI
HHHHHHHHHHCCCCCCCEEECCCCHHHHCCHHHEEECCCCCCCCCCCHHHHHHHEECCCE
KVSTAEARAILPAQYRRQDCITHGRNLAGFIHACHTQQPDLAAKMMKDVIAEPYRTQLLP
EEECCHHHHHCCHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCHHHHHCC
GFAAARQAAQDIGALACGISGSGPTLFAVCNDQATAQRMAGWLQNHYLQNDEGFVHICRL
CHHHHHHHHHHHHHEEECCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCEEEEEEE
DTAGARLLG
CCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA