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The map label for this gene is serS

Identifier: 159184878

GI number: 159184878

Start: 1688355

End: 1689638

Strand: Reverse

Name: serS

Synonym: Atu1703

Alternate gene names: 159184878

Gene position: 1689638-1688355 (Counterclockwise)

Preceding gene: 15889011

Following gene: 15889009

Centisome position: 59.46

GC content: 61.21

Gene sequence:

>1284_bases
ATGCACGACATTAAATGGATACGCGAAAACCCCGAAGCTTTTGATGCGGCCCTTGCACGGCGCAGCGTAGAGCCCGCTGC
CGCAGGTCTGATCGCTCTCGATGAAAAGCGCCGTTCCGTCATCCAGTCCCTGCAGGACATGCAGTCCCGCCGCAATGCCG
CCTCCAAGGAAATCGGCGCCGCCATGGCGCAGAAGAACATGGAACTGGCGGAAAAGCTGAAAGCCGAAGTCGCTGATATC
AAGGAAAACATGCCGCGCGCCGAGGAGGAGGACCGTCAGGTCTCCGCCGAGCTGAACGACGCCCTGTCGCGCCTGCCGAA
CATGCCCTTCGACGATGTGCCTGACGGCAAGGACGAGCACGACAATGTGGTGGCCCGCGTCACCGGCCAGAAGCCCGGCT
GGAACCACGCGGCAAAGGAGCACTTCGAGATTGGCGAAGCGCTCGGTTATATGGATTTCGAGCGGGCTGCCAAGCTCTCC
GGTTCGCGTTTCACGGTGCTGACCAGCCAGCTGGCGCGTCTGGAACGGGCGCTCGGCCAGTTCATGATCGACCTGCACAC
CTCGGAACATGGTTATACCGAAGTCTCTTCGCCGCTGATGGTGCGTGACGAGGCGATGTTCGGCACGGGGCAATTGCCGA
AATTCGCCGAGGACCTGTTCAGGACCACCGATGGCCGCTGGTTGATCCCGACGGCGGAAGTGACGTTGACCAACCTCGTT
TCCGGCGAAATTCTCGAGCAGGAAAAACTGCCGTTGCGCTTCACGGCGCTCACACCTTCCTTCCGTTCGGAAGCGGGCTC
TGCCGGACGTGATACGCGCGGCATGCTGCGCCAGCACCAGTTCTGGAAATGCGAGCTTGTCTCCATCACCGATGCGGAAA
GTGCCGTTGCCGAGCATGAGCGCATGACGGCCTGCGCCGAAGAAGTGCTGAAGCGTCTGGGCTTACATTTCCGCACCCTG
ACGCTCTGCACCGGCGATATGGGCTTCAGCGCCCGCAAGACCTATGATCTGGAAGTGTGGCTGCCCGGCCAGAACACCTA
TCGTGAAATTTCTTCCTGCTCGGTCTGCGGCGATTTCCAGGCGCGGCGCATGAATGCGCGTTATCGCGGCAAGGACGACA
AGGCGACGAAGTTCGTGCACACGCTGAACGGCTCCGGCACCGCCGTCGGCCGCTGCCTGATCGCCGTTCTCGAAAATTAC
CTGAACGACGATGGTTCCGTCACAATTCCGGACGTGCTGCTGCCGTATATGGGCGGGCTGACGCGGATCGAGAAGGCGGC
TTGA

Upstream 100 bases:

>100_bases
ATTTTTCTGAAGGTCTCACCGCTCAAAAAATCCTCGCGCCGGGTTCATGCCCGGCGTTTTGCTGTAAAACGCGACGATGC
AACAACGGTCTGGAACGACG

Downstream 100 bases:

>100_bases
GAGAGCGCGGCGTCGTGCTGTTGGAAGGTGAGTCTGCCAATTGCGCCGATGTCATCCTCGGGCTTGTCCCGAGGATCGGC
AACCTATCGATTTATTTGGA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MHDIKWIRENPEAFDAALARRSVEPAAAGLIALDEKRRSVIQSLQDMQSRRNAASKEIGAAMAQKNMELAEKLKAEVADI
KENMPRAEEEDRQVSAELNDALSRLPNMPFDDVPDGKDEHDNVVARVTGQKPGWNHAAKEHFEIGEALGYMDFERAAKLS
GSRFTVLTSQLARLERALGQFMIDLHTSEHGYTEVSSPLMVRDEAMFGTGQLPKFAEDLFRTTDGRWLIPTAEVTLTNLV
SGEILEQEKLPLRFTALTPSFRSEAGSAGRDTRGMLRQHQFWKCELVSITDAESAVAEHERMTACAEEVLKRLGLHFRTL
TLCTGDMGFSARKTYDLEVWLPGQNTYREISSCSVCGDFQARRMNARYRGKDDKATKFVHTLNGSGTAVGRCLIAVLENY
LNDDGSVTIPDVLLPYMGGLTRIEKAA

Sequences:

>Translated_427_residues
MHDIKWIRENPEAFDAALARRSVEPAAAGLIALDEKRRSVIQSLQDMQSRRNAASKEIGAAMAQKNMELAEKLKAEVADI
KENMPRAEEEDRQVSAELNDALSRLPNMPFDDVPDGKDEHDNVVARVTGQKPGWNHAAKEHFEIGEALGYMDFERAAKLS
GSRFTVLTSQLARLERALGQFMIDLHTSEHGYTEVSSPLMVRDEAMFGTGQLPKFAEDLFRTTDGRWLIPTAEVTLTNLV
SGEILEQEKLPLRFTALTPSFRSEAGSAGRDTRGMLRQHQFWKCELVSITDAESAVAEHERMTACAEEVLKRLGLHFRTL
TLCTGDMGFSARKTYDLEVWLPGQNTYREISSCSVCGDFQARRMNARYRGKDDKATKFVHTLNGSGTAVGRCLIAVLENY
LNDDGSVTIPDVLLPYMGGLTRIEKAA
>Mature_427_residues
MHDIKWIRENPEAFDAALARRSVEPAAAGLIALDEKRRSVIQSLQDMQSRRNAASKEIGAAMAQKNMELAEKLKAEVADI
KENMPRAEEEDRQVSAELNDALSRLPNMPFDDVPDGKDEHDNVVARVTGQKPGWNHAAKEHFEIGEALGYMDFERAAKLS
GSRFTVLTSQLARLERALGQFMIDLHTSEHGYTEVSSPLMVRDEAMFGTGQLPKFAEDLFRTTDGRWLIPTAEVTLTNLV
SGEILEQEKLPLRFTALTPSFRSEAGSAGRDTRGMLRQHQFWKCELVSITDAESAVAEHERMTACAEEVLKRLGLHFRTL
TLCTGDMGFSARKTYDLEVWLPGQNTYREISSCSVCGDFQARRMNARYRGKDDKATKFVHTLNGSGTAVGRCLIAVLENY
LNDDGSVTIPDVLLPYMGGLTRIEKAA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=384, Percent_Identity=32.5520833333333, Blast_Score=183, Evalue=3e-46,
Organism=Homo sapiens, GI8923421, Length=432, Percent_Identity=28.4722222222222, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI225579074, Length=438, Percent_Identity=29.4520547945205, Blast_Score=169, Evalue=5e-42,
Organism=Escherichia coli, GI1787120, Length=431, Percent_Identity=51.2761020881671, Blast_Score=424, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17539260, Length=452, Percent_Identity=28.5398230088496, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI17542084, Length=349, Percent_Identity=29.512893982808, Blast_Score=154, Evalue=1e-37,
Organism=Saccharomyces cerevisiae, GI6320226, Length=398, Percent_Identity=33.1658291457286, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6321799, Length=430, Percent_Identity=25.8139534883721, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17737985, Length=327, Percent_Identity=34.2507645259939, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24581334, Length=432, Percent_Identity=29.6296296296296, Blast_Score=173, Evalue=2e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_AGRT5 (Q8UEQ2)

Other databases:

- EMBL:   AE007869
- PIR:   AI2785
- PIR:   C97565
- RefSeq:   NP_354691.2
- ProteinModelPortal:   Q8UEQ2
- SMR:   Q8UEQ2
- STRING:   Q8UEQ2
- GeneID:   1133741
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1703
- eggNOG:   COG0172
- HOGENOM:   HBG629391
- OMA:   PKFADDM
- PhylomeDB:   Q8UEQ2
- ProtClustDB:   PRK05431
- BioCyc:   ATUM176299-1:ATU1703-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 47600; Mature: 47600

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 285-285 BINDING 385-385

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIKWIRENPEAFDAALARRSVEPAAAGLIALDEKRRSVIQSLQDMQSRRNAASKEIGA
CCCCCHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMAQKNMELAEKLKAEVADIKENMPRAEEEDRQVSAELNDALSRLPNMPFDDVPDGKDEH
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DNVVARVTGQKPGWNHAAKEHFEIGEALGYMDFERAAKLSGSRFTVLTSQLARLERALGQ
CCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
FMIDLHTSEHGYTEVSSPLMVRDEAMFGTGQLPKFAEDLFRTTDGRWLIPTAEVTLTNLV
HHEEEECCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCEEECCHHHHHHHHH
SGEILEQEKLPLRFTALTPSFRSEAGSAGRDTRGMLRQHQFWKCELVSITDAESAVAEHE
HHHHHHHCCCCEEEEEECCHHHHHCCCCCCCHHHHHHHCCCCEEEEEEECCHHHHHHHHH
RMTACAEEVLKRLGLHFRTLTLCTGDMGFSARKTYDLEVWLPGQNTYREISSCSVCGDFQ
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHCCCCCCHH
ARRMNARYRGKDDKATKFVHTLNGSGTAVGRCLIAVLENYLNDDGSVTIPDVLLPYMGGL
HHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCH
TRIEKAA
HHHHHCC
>Mature Secondary Structure
MHDIKWIRENPEAFDAALARRSVEPAAAGLIALDEKRRSVIQSLQDMQSRRNAASKEIGA
CCCCCHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AMAQKNMELAEKLKAEVADIKENMPRAEEEDRQVSAELNDALSRLPNMPFDDVPDGKDEH
HHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
DNVVARVTGQKPGWNHAAKEHFEIGEALGYMDFERAAKLSGSRFTVLTSQLARLERALGQ
CCEEEEEECCCCCCCHHHHHHHHHHHHHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
FMIDLHTSEHGYTEVSSPLMVRDEAMFGTGQLPKFAEDLFRTTDGRWLIPTAEVTLTNLV
HHEEEECCCCCCCCCCCCEEEECCCCCCCCCCHHHHHHHHHCCCCCEEECCHHHHHHHHH
SGEILEQEKLPLRFTALTPSFRSEAGSAGRDTRGMLRQHQFWKCELVSITDAESAVAEHE
HHHHHHHCCCCEEEEEECCHHHHHCCCCCCCHHHHHHHCCCCEEEEEEECCHHHHHHHHH
RMTACAEEVLKRLGLHFRTLTLCTGDMGFSARKTYDLEVWLPGQNTYREISSCSVCGDFQ
HHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCEEEEEEEEECCCHHHHHHHHCCCCCCHH
ARRMNARYRGKDDKATKFVHTLNGSGTAVGRCLIAVLENYLNDDGSVTIPDVLLPYMGGL
HHHCCCCCCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCH
TRIEKAA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194