Click here to switch to the map view.

The map label for this gene is tmk [H]

Identifier: 159184784

GI number: 159184784

Start: 1487888

End: 1488454

Strand: Reverse

Name: tmk [H]

Synonym: Atu1498

Alternate gene names: 159184784

Gene position: 1488454-1487888 (Counterclockwise)

Preceding gene: 159184785

Following gene: 159184783

Centisome position: 52.38

GC content: 62.26

Gene sequence:

>567_bases
GTGGTCGTCACGCGTGAGCCGGGTGGTTCGCCGGGCGCCGAGGCGGTCCGACACGTCATTCTGTCAGGTGCGGCCGAATC
GTTCGGCGTGCGCATGGAGGCGATCCTGTTTGCGGCGGCGCGTAACGACCATGTCGAGGAGGTCATTCGCCCGGCGCTTG
CGCGCGGCGAGATCGTGCTCTGCGACCGTTTCCTTGACTCCTCGCGTGTCTATCAGGGCACGACCGGCAATCTGGAGCCT
GATTTCATTGAGACGCTGCAACGGATAGCCATTGATGGCGTTGTGCCCGAGTTGACGCTGATCTTCGATATCGCTGCCGA
AAAGGGCCTGGCCCGCGCCAGAAAACGTGCAGATGAGGGAGCGACCCCCGACCGCTTCGAAAAAGAGGAAATCGAGACCC
ACGAGAAGCGGCGCGAGGCCTATCTGGATATTGCGCTGGCCGAACCGCGTCGCTGCCGTATCGTCAATGCTGACCAGCCG
GAAGACAAGGTAACGGAAGACGTCATGTCATTCGTCGAGCCATTGCTCGAGCGTGCGGGAAACGCTGCGGACGCGGCGCA
TGAGTGA

Upstream 100 bases:

>100_bases
AAAGACCGGATTGTTCATCAGCTTCGAGGGCGGCGAAGGCGCTGGCAAGTCGACGCAGATTCGCACGCTTGCCGAGGCGC
TTCGCGGCCGTGGTTTCGAG

Downstream 100 bases:

>100_bases
GGTTCAGGGCGTTCTCGACGGCGCGATTGCGCCGCAGCAGAACACGAGGCTTTTCGGGCATGAAGAGGCGGAGGCGTTCC
TTGCGCAATCCTATCGCTCG

Product: thymydilate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MVVTREPGGSPGAEAVRHVILSGAAESFGVRMEAILFAAARNDHVEEVIRPALARGEIVLCDRFLDSSRVYQGTTGNLEP
DFIETLQRIAIDGVVPELTLIFDIAAEKGLARARKRADEGATPDRFEKEEIETHEKRREAYLDIALAEPRRCRIVNADQP
EDKVTEDVMSFVEPLLERAGNAADAAHE

Sequences:

>Translated_188_residues
MVVTREPGGSPGAEAVRHVILSGAAESFGVRMEAILFAAARNDHVEEVIRPALARGEIVLCDRFLDSSRVYQGTTGNLEP
DFIETLQRIAIDGVVPELTLIFDIAAEKGLARARKRADEGATPDRFEKEEIETHEKRREAYLDIALAEPRRCRIVNADQP
EDKVTEDVMSFVEPLLERAGNAADAAHE
>Mature_188_residues
MVVTREPGGSPGAEAVRHVILSGAAESFGVRMEAILFAAARNDHVEEVIRPALARGEIVLCDRFLDSSRVYQGTTGNLEP
DFIETLQRIAIDGVVPELTLIFDIAAEKGLARARKRADEGATPDRFEKEEIETHEKRREAYLDIALAEPRRCRIVNADQP
EDKVTEDVMSFVEPLLERAGNAADAAHE

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=175, Percent_Identity=36, Blast_Score=97, Evalue=7e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 20735; Mature: 20735

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVTREPGGSPGAEAVRHVILSGAAESFGVRMEAILFAAARNDHVEEVIRPALARGEIVL
CEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEE
CDRFLDSSRVYQGTTGNLEPDFIETLQRIAIDGVVPELTLIFDIAAEKGLARARKRADEG
EHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
ATPDRFEKEEIETHEKRREAYLDIALAEPRRCRIVNADQPEDKVTEDVMSFVEPLLERAG
CCCCCCCHHHHHHHHHHHHHHHHHEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
NAADAAHE
CCCCCCCC
>Mature Secondary Structure
MVVTREPGGSPGAEAVRHVILSGAAESFGVRMEAILFAAARNDHVEEVIRPALARGEIVL
CEEECCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCEEE
CDRFLDSSRVYQGTTGNLEPDFIETLQRIAIDGVVPELTLIFDIAAEKGLARARKRADEG
EHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCC
ATPDRFEKEEIETHEKRREAYLDIALAEPRRCRIVNADQPEDKVTEDVMSFVEPLLERAG
CCCCCCCHHHHHHHHHHHHHHHHHEECCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCC
NAADAAHE
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]