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The map label for this gene is holB [H]

Identifier: 159184783

GI number: 159184783

Start: 1486870

End: 1487895

Strand: Reverse

Name: holB [H]

Synonym: Atu1497

Alternate gene names: 159184783

Gene position: 1487895-1486870 (Counterclockwise)

Preceding gene: 159184784

Following gene: 15888821

Centisome position: 52.36

GC content: 60.62

Gene sequence:

>1026_bases
ATGAGTGAGGTTCAGGGCGTTCTCGACGGCGCGATTGCGCCGCAGCAGAACACGAGGCTTTTCGGGCATGAAGAGGCGGA
GGCGTTCCTTGCGCAATCCTATCGCTCGGGCAAAGGCCATCACGCCATCCTGATCGAAGGACCGGAGGGCATCGGCAAGG
CGACGCTCGCCTTCCGTTTCGCCAATCATGTGCTGACCCATCCCGATCCCGCATCCGCACCGGATTTCCTTGCTGACCCC
GATCCGCAATCGCTCGTCAGCCGGCAGATCACTGCCGGTGCTTCCCATAATCTGCTGCATCTGACGCGTCCGGTGGATGA
GAAGACCGGCCGCGTCAAATCCGCGATCACCGTGGATGAGGTGCGGCGGGCAGGGCATTTCTTTTCCCAGACCTCGGGCA
CCGGCAACTGGCGTATCGTCATCATCGACCCGGCCGACGATCTCAACCGCAATGCCGCGAATGCCATCCTGAAGATTCTG
GAGGAGCCGCCGAAACGGGCGATGTTCCTCGTGCTTTCGCATGCACCGGGAAAATTGCTGCCGACTATCCGCTCGCGCTG
CATGCCGCTACGGCTCCTGCCGCTTTCCGATGCGGCCATGGTCCAAGCGCTCGATCAACTCGACATCAGTCCTGAAGGCG
AAAAGCGCGACGCCCTGCTTACGGCGTCCAAAGGCAGTGTCGCGCAGGCGTTGAAGCTGATGAATTACGGCGGTTCCGAC
ATTGTCGAGGCCTTTGCCGAAGTCATGTCCGCCGAAGGGCCGGGGGCACGCAAGCGCATGCACAAGCTTGCCGAGGTTCT
GGCGCAGAAGGACGGCGACATCGTTCTCGGATTCTTCATGGAACATGTGACGGAAGAATTGATGGAGCGGGCCCGGGCTG
CGGCAATGGCGGGCGATATCGCGGCGGCGGAAAAACATGCGCGGCTTTCCTCGACGCTTTCGGAACGCATCACCGTGGCG
CAGGCCTATAATCTCGACAAGAAGCAGATGGTGCTTTCCATTCTGGAAGATATCCGTTCGGTTTAG

Upstream 100 bases:

>100_bases
ATCGTCAATGCTGACCAGCCGGAAGACAAGGTAACGGAAGACGTCATGTCATTCGTCGAGCCATTGCTCGAGCGTGCGGG
AAACGCTGCGGACGCGGCGC

Downstream 100 bases:

>100_bases
GCGCCGGGATATGAATCATACCCAAAATGGGGAAGTTGTTGTTTCGCTGCTGCGAACAATGGTTTAAGAGCGGTCTATCC
AAAAAACAGCCTGTAAAGTC

Product: DNA polymerase III subunit delta'

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MSEVQGVLDGAIAPQQNTRLFGHEEAEAFLAQSYRSGKGHHAILIEGPEGIGKATLAFRFANHVLTHPDPASAPDFLADP
DPQSLVSRQITAGASHNLLHLTRPVDEKTGRVKSAITVDEVRRAGHFFSQTSGTGNWRIVIIDPADDLNRNAANAILKIL
EEPPKRAMFLVLSHAPGKLLPTIRSRCMPLRLLPLSDAAMVQALDQLDISPEGEKRDALLTASKGSVAQALKLMNYGGSD
IVEAFAEVMSAEGPGARKRMHKLAEVLAQKDGDIVLGFFMEHVTEELMERARAAAMAGDIAAAEKHARLSSTLSERITVA
QAYNLDKKQMVLSILEDIRSV

Sequences:

>Translated_341_residues
MSEVQGVLDGAIAPQQNTRLFGHEEAEAFLAQSYRSGKGHHAILIEGPEGIGKATLAFRFANHVLTHPDPASAPDFLADP
DPQSLVSRQITAGASHNLLHLTRPVDEKTGRVKSAITVDEVRRAGHFFSQTSGTGNWRIVIIDPADDLNRNAANAILKIL
EEPPKRAMFLVLSHAPGKLLPTIRSRCMPLRLLPLSDAAMVQALDQLDISPEGEKRDALLTASKGSVAQALKLMNYGGSD
IVEAFAEVMSAEGPGARKRMHKLAEVLAQKDGDIVLGFFMEHVTEELMERARAAAMAGDIAAAEKHARLSSTLSERITVA
QAYNLDKKQMVLSILEDIRSV
>Mature_340_residues
SEVQGVLDGAIAPQQNTRLFGHEEAEAFLAQSYRSGKGHHAILIEGPEGIGKATLAFRFANHVLTHPDPASAPDFLADPD
PQSLVSRQITAGASHNLLHLTRPVDEKTGRVKSAITVDEVRRAGHFFSQTSGTGNWRIVIIDPADDLNRNAANAILKILE
EPPKRAMFLVLSHAPGKLLPTIRSRCMPLRLLPLSDAAMVQALDQLDISPEGEKRDALLTASKGSVAQALKLMNYGGSDI
VEAFAEVMSAEGPGARKRMHKLAEVLAQKDGDIVLGFFMEHVTEELMERARAAAMAGDIAAAEKHARLSSTLSERITVAQ
AYNLDKKQMVLSILEDIRSV

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity [H]

COG id: COG0470

COG function: function code L; ATPase involved in DNA replication

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1786676, Length=233, Percent_Identity=27.8969957081545, Blast_Score=72, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71986063, Length=221, Percent_Identity=26.6968325791855, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003959
- InterPro:   IPR004622 [H]

Pfam domain/function: PF00004 AAA [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 36927; Mature: 36796

Theoretical pI: Translated: 6.66; Mature: 6.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEVQGVLDGAIAPQQNTRLFGHEEAEAFLAQSYRSGKGHHAILIEGPEGIGKATLAFRF
CCCHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHH
ANHVLTHPDPASAPDFLADPDPQSLVSRQITAGASHNLLHLTRPVDEKTGRVKSAITVDE
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHCCCHHHHHHHHH
VRRAGHFFSQTSGTGNWRIVIIDPADDLNRNAANAILKILEEPPKRAMFLVLSHAPGKLL
HHHHHHHHHCCCCCCCEEEEEECCCHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHH
PTIRSRCMPLRLLPLSDAAMVQALDQLDISPEGEKRDALLTASKGSVAQALKLMNYGGSD
HHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCHH
IVEAFAEVMSAEGPGARKRMHKLAEVLAQKDGDIVLGFFMEHVTEELMERARAAAMAGDI
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
AAAEKHARLSSTLSERITVAQAYNLDKKQMVLSILEDIRSV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SEVQGVLDGAIAPQQNTRLFGHEEAEAFLAQSYRSGKGHHAILIEGPEGIGKATLAFRF
CCHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHH
ANHVLTHPDPASAPDFLADPDPQSLVSRQITAGASHNLLHLTRPVDEKTGRVKSAITVDE
HHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCHHCCCHHHHHHHHH
VRRAGHFFSQTSGTGNWRIVIIDPADDLNRNAANAILKILEEPPKRAMFLVLSHAPGKLL
HHHHHHHHHCCCCCCCEEEEEECCCHHHCCHHHHHHHHHHHCCCCCEEEEEEECCCCCHH
PTIRSRCMPLRLLPLSDAAMVQALDQLDISPEGEKRDALLTASKGSVAQALKLMNYGGSD
HHHHHCCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCHH
IVEAFAEVMSAEGPGARKRMHKLAEVLAQKDGDIVLGFFMEHVTEELMERARAAAMAGDI
HHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHH
AAAEKHARLSSTLSERITVAQAYNLDKKQMVLSILEDIRSV
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550441; 10984043 [H]