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The map label for this gene is cusR [H]

Identifier: 159184556

GI number: 159184556

Start: 958852

End: 959523

Strand: Direct

Name: cusR [H]

Synonym: Atu0970

Alternate gene names: 159184556

Gene position: 958852-959523 (Clockwise)

Preceding gene: 15888312

Following gene: 15888314

Centisome position: 33.74

GC content: 59.97

Gene sequence:

>672_bases
ATGCGTATTCTCGTTGTTGAGGACGATGCCAATCTCAATCGTCAGCTGACCGACGCCCTGAAAGAGGCCGGTTATGTCGT
CGATCAGGCATTCGACGGCGAAGAGGGGCATTACCTCGGCGACACCGAGCCCTATGACGCCATCGTCCTCGATATCGGCC
TGCCGCAACTGGATGGCATTACCGTCGTTGAAAAATGGCGTGCCGCCGGCAAGGCCATGCCGGTCCTCATCCTTACCGCC
CGCGACCGCTGGAGCGACAAGGTGGCGGGCATCGATGCCGGTGCCGATGACTACGTGACCAAGCCTTTCCATGTCGAAGA
AGTGCTTGCCCGCGTGCGCGCGCTCATCCGCCGCGCCGCTGGCCATGCCTCTTCCGAACTGGTCTGCGGCCCGGTCCGGC
TCGACACCAAATCCTCCAAGGCGACCGTCAACGGCACGACGCTGAAACTCACCTCGCATGAGTTCCGGCTCCTGTCCTAT
CTCATGCATCACATGGGCGAGGTCGTTTCGCGCACGGAGCTGGTCGAACATATGTACGATCAGGATTTCGACCGCGATTC
CAACACGATCGAGGTGTTTGTCGGACGTTTGCGCAAGAAGATCGGAGTTGATCTGATCGAGACGATCCGCGGTCTCGGTT
ACCGGATGCAAGCGCCGGCAGATGCGAAGTAA

Upstream 100 bases:

>100_bases
GATGTAGCTTGCCCGCATCGCCGAAATATCGGAAAACAACCCGACACATGTAGCATGACCGGCCACCTGCGTGGGCCGGG
ACGGAAGGAAAGGGCGGACA

Downstream 100 bases:

>100_bases
CTCTCTCACCGCCCGCGTTCTGCTGCTCGCCTCTGCCTGGTCGGCGCTGGCGCTTGTCGTGATCGCCGTCGTGATTTCGA
CGCTTTACCGCCAGGGCGTG

Product: two component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 223; Mature: 223

Protein sequence:

>223_residues
MRILVVEDDANLNRQLTDALKEAGYVVDQAFDGEEGHYLGDTEPYDAIVLDIGLPQLDGITVVEKWRAAGKAMPVLILTA
RDRWSDKVAGIDAGADDYVTKPFHVEEVLARVRALIRRAAGHASSELVCGPVRLDTKSSKATVNGTTLKLTSHEFRLLSY
LMHHMGEVVSRTELVEHMYDQDFDRDSNTIEVFVGRLRKKIGVDLIETIRGLGYRMQAPADAK

Sequences:

>Translated_223_residues
MRILVVEDDANLNRQLTDALKEAGYVVDQAFDGEEGHYLGDTEPYDAIVLDIGLPQLDGITVVEKWRAAGKAMPVLILTA
RDRWSDKVAGIDAGADDYVTKPFHVEEVLARVRALIRRAAGHASSELVCGPVRLDTKSSKATVNGTTLKLTSHEFRLLSY
LMHHMGEVVSRTELVEHMYDQDFDRDSNTIEVFVGRLRKKIGVDLIETIRGLGYRMQAPADAK
>Mature_223_residues
MRILVVEDDANLNRQLTDALKEAGYVVDQAFDGEEGHYLGDTEPYDAIVLDIGLPQLDGITVVEKWRAAGKAMPVLILTA
RDRWSDKVAGIDAGADDYVTKPFHVEEVLARVRALIRRAAGHASSELVCGPVRLDTKSSKATVNGTTLKLTSHEFRLLSY
LMHHMGEVVSRTELVEHMYDQDFDRDSNTIEVFVGRLRKKIGVDLIETIRGLGYRMQAPADAK

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1787375, Length=218, Percent_Identity=42.6605504587156, Blast_Score=187, Evalue=5e-49,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=44.6428571428571, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1789402, Length=216, Percent_Identity=43.9814814814815, Blast_Score=177, Evalue=4e-46,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=40.990990990991, Blast_Score=166, Evalue=1e-42,
Organism=Escherichia coli, GI1790552, Length=218, Percent_Identity=41.2844036697248, Blast_Score=161, Evalue=4e-41,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=33.3333333333333, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=34.9775784753363, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=34.070796460177, Blast_Score=123, Evalue=9e-30,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=35.4260089686099, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=33.7837837837838, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=34.6491228070175, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=31.5789473684211, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=28.5087719298246, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI1788550, Length=108, Percent_Identity=34.2592592592593, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=25.764192139738, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788191, Length=118, Percent_Identity=33.0508474576271, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24807; Mature: 24807

Theoretical pI: Translated: 5.37; Mature: 5.37

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILVVEDDANLNRQLTDALKEAGYVVDQAFDGEEGHYLGDTEPYDAIVLDIGLPQLDGI
CEEEEEECCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCH
TVVEKWRAAGKAMPVLILTARDRWSDKVAGIDAGADDYVTKPFHVEEVLARVRALIRRAA
HHHHHHHHCCCCCCEEEEECCCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GHASSELVCGPVRLDTKSSKATVNGTTLKLTSHEFRLLSYLMHHMGEVVSRTELVEHMYD
CCCCCCEEECCEEECCCCCCEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFVGRLRKKIGVDLIETIRGLGYRMQAPADAK
CCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure
MRILVVEDDANLNRQLTDALKEAGYVVDQAFDGEEGHYLGDTEPYDAIVLDIGLPQLDGI
CEEEEEECCCCCCHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCH
TVVEKWRAAGKAMPVLILTARDRWSDKVAGIDAGADDYVTKPFHVEEVLARVRALIRRAA
HHHHHHHHCCCCCCEEEEECCCCCCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
GHASSELVCGPVRLDTKSSKATVNGTTLKLTSHEFRLLSYLMHHMGEVVSRTELVEHMYD
CCCCCCEEECCEEECCCCCCEEECCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QDFDRDSNTIEVFVGRLRKKIGVDLIETIRGLGYRMQAPADAK
CCCCCCCCHHHHHHHHHHHHHCHHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]