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The map label for this gene is phoQ [H]

Identifier: 15888314

GI number: 15888314

Start: 959513

End: 960913

Strand: Direct

Name: phoQ [H]

Synonym: Atu0971

Alternate gene names: 15888314

Gene position: 959513-960913 (Clockwise)

Preceding gene: 159184556

Following gene: 159184557

Centisome position: 33.77

GC content: 63.53

Gene sequence:

>1401_bases
ATGCGAAGTAACTCTCTCACCGCCCGCGTTCTGCTGCTCGCCTCTGCCTGGTCGGCGCTGGCGCTTGTCGTGATCGCCGT
CGTGATTTCGACGCTTTACCGCCAGGGCGTGGAGCGCAGCTTCACCGATCTTCTGCGGGCGCAGCTCTATAACGTCATCA
ACTCAGTGACGATTTCCAACGAAAATACGCTGGCCGGCAGCCCGCAGCTTGGCGATCTCCGGTTCTCGCAGCCGGATACC
GGCTGGTACTGGGTGGTGGAGCCGCTCGGTAATTTCCAGACCGCGCCGCTGGTGTCCTCCTCGCTCGGTGTCTCGACGCT
GCCGGTGCCGAGCATTATCGATGCTCCCTTCGACAACAGATACGAGCGATTTTATGCCGTGACCGACGAGGCCGGCAATC
AGGTGCGCGTGGCGGAAACGGAAGTCGTGCTGGATGGCGAAGGCCGGGCCGCGCGTTTTCGTGTTTCCGGCAATCTGAAC
GTCGTGGAAGACGATGTGCGCGACTTCTCCAACAGCCTTTATCTGGCGCTTGCCGTCTTCGGTGTCGGCAGTCTGGTCGT
CAACGGTCTTGCCATTCTCTACAGTCTGCGGCCTCTCGATCAGGCCCGCCGGGCACTCGGCAAGATCAGAGGCGGGGAGG
CGGAAAGCCTCGAAGGCGAATTCCCGCGCGAAATCCAGCCGCTCGCCAATGAGGTCAATGCGCTGATCGACAGCAATCGC
CGCCTTGTGGAGCGCGCCCGCATGCAGGTCGGCAATCTCGCGCATTCGCTGAAAACGCCGATCGCCGTACTCCTCAACGA
GGCCCGCACGCTGGAACCGCAACATGGTGATCTGGTGCGGGCGCAGGCGGATGCCATGCAGGCGCAGGTGCAATCCTATC
TCTCCCGCGCCCGCATTGCCGCCCAGCGCGGCTCGATCCTTGCCCGCGTGGAAGCGGAGCCGGCGCTGGAACGGCTGGTG
CGGGTGATGCGCCGCCTGAACCCCGACAAGCAGTTCGTGCTGAATTTCGAACAGCCGGGCGCGGTGCTCGGGATGGAACA
GCAGGATCTCGAAGAGGTCGTCGGCAATCTCCTGGAAAATGCGGCGCGTTTTGCCGAAACCAGAGTGGTCGTCACGCTTG
CCACCGGCACGCATCCTTCTTCCGACGCCGAAATCGGCCGCCGCTCCTGGGTGGAGCTGACCGTGGAGGACGACGGCCCG
GGGCTGGAGCCGGGACAGATCAGCGAAGCGATGAAACGCGGCCGCCGGCTGGACGAGAGCCGGCCGGGCACGGGCCTCGG
CCTGTCGATCGTTTCTGAAGTGGTGTCTGAATACCACGGTCGCTTTTCGCTGTCGCGCAGCGCCATTGGCGGCCTGAAGG
CCGATCTGATTTTGCCGGGTCTTTCGAAAGAGCTTGCGTGA

Upstream 100 bases:

>100_bases
AACACGATCGAGGTGTTTGTCGGACGTTTGCGCAAGAAGATCGGAGTTGATCTGATCGAGACGATCCGCGGTCTCGGTTA
CCGGATGCAAGCGCCGGCAG

Downstream 100 bases:

>100_bases
GCCGCGAAAAAAGGCAAGAAATTCAATACCGGTACATGACAGCGTTTCCAGGGAAAGTGGACCCCGGTTTCCCGTCAGGA
AATGCGGAAGAACAAAAATC

Product: two component sensor kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 466; Mature: 466

Protein sequence:

>466_residues
MRSNSLTARVLLLASAWSALALVVIAVVISTLYRQGVERSFTDLLRAQLYNVINSVTISNENTLAGSPQLGDLRFSQPDT
GWYWVVEPLGNFQTAPLVSSSLGVSTLPVPSIIDAPFDNRYERFYAVTDEAGNQVRVAETEVVLDGEGRAARFRVSGNLN
VVEDDVRDFSNSLYLALAVFGVGSLVVNGLAILYSLRPLDQARRALGKIRGGEAESLEGEFPREIQPLANEVNALIDSNR
RLVERARMQVGNLAHSLKTPIAVLLNEARTLEPQHGDLVRAQADAMQAQVQSYLSRARIAAQRGSILARVEAEPALERLV
RVMRRLNPDKQFVLNFEQPGAVLGMEQQDLEEVVGNLLENAARFAETRVVVTLATGTHPSSDAEIGRRSWVELTVEDDGP
GLEPGQISEAMKRGRRLDESRPGTGLGLSIVSEVVSEYHGRFSLSRSAIGGLKADLILPGLSKELA

Sequences:

>Translated_466_residues
MRSNSLTARVLLLASAWSALALVVIAVVISTLYRQGVERSFTDLLRAQLYNVINSVTISNENTLAGSPQLGDLRFSQPDT
GWYWVVEPLGNFQTAPLVSSSLGVSTLPVPSIIDAPFDNRYERFYAVTDEAGNQVRVAETEVVLDGEGRAARFRVSGNLN
VVEDDVRDFSNSLYLALAVFGVGSLVVNGLAILYSLRPLDQARRALGKIRGGEAESLEGEFPREIQPLANEVNALIDSNR
RLVERARMQVGNLAHSLKTPIAVLLNEARTLEPQHGDLVRAQADAMQAQVQSYLSRARIAAQRGSILARVEAEPALERLV
RVMRRLNPDKQFVLNFEQPGAVLGMEQQDLEEVVGNLLENAARFAETRVVVTLATGTHPSSDAEIGRRSWVELTVEDDGP
GLEPGQISEAMKRGRRLDESRPGTGLGLSIVSEVVSEYHGRFSLSRSAIGGLKADLILPGLSKELA
>Mature_466_residues
MRSNSLTARVLLLASAWSALALVVIAVVISTLYRQGVERSFTDLLRAQLYNVINSVTISNENTLAGSPQLGDLRFSQPDT
GWYWVVEPLGNFQTAPLVSSSLGVSTLPVPSIIDAPFDNRYERFYAVTDEAGNQVRVAETEVVLDGEGRAARFRVSGNLN
VVEDDVRDFSNSLYLALAVFGVGSLVVNGLAILYSLRPLDQARRALGKIRGGEAESLEGEFPREIQPLANEVNALIDSNR
RLVERARMQVGNLAHSLKTPIAVLLNEARTLEPQHGDLVRAQADAMQAQVQSYLSRARIAAQRGSILARVEAEPALERLV
RVMRRLNPDKQFVLNFEQPGAVLGMEQQDLEEVVGNLLENAARFAETRVVVTLATGTHPSSDAEIGRRSWVELTVEDDGP
GLEPGQISEAMKRGRRLDESRPGTGLGLSIVSEVVSEYHGRFSLSRSAIGGLKADLILPGLSKELA

Specific function: Member of the two-component regulatory system phoQ/phoP which regulates the expression of genes involved in virulence and resistance to host defense antimicrobial peptides. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=279, Percent_Identity=28.3154121863799, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1787894, Length=240, Percent_Identity=26.25, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=27.3542600896861, Blast_Score=70, Evalue=4e-13,
Organism=Escherichia coli, GI1789808, Length=312, Percent_Identity=26.6025641025641, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790346, Length=249, Percent_Identity=22.4899598393574, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788393, Length=253, Percent_Identity=25.296442687747, Blast_Score=66, Evalue=6e-12,
Organism=Escherichia coli, GI1786912, Length=251, Percent_Identity=27.8884462151394, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 50785; Mature: 50785

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSNSLTARVLLLASAWSALALVVIAVVISTLYRQGVERSFTDLLRAQLYNVINSVTISN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
ENTLAGSPQLGDLRFSQPDTGWYWVVEPLGNFQTAPLVSSSLGVSTLPVPSIIDAPFDNR
CCCCCCCCCCCCEECCCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCCCHHHCCCCCCC
YERFYAVTDEAGNQVRVAETEVVLDGEGRAARFRVSGNLNVVEDDVRDFSNSLYLALAVF
CCEEEEEECCCCCEEEEEEEEEEECCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHH
GVGSLVVNGLAILYSLRPLDQARRALGKIRGGEAESLEGEFPREIQPLANEVNALIDSNR
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCH
RLVERARMQVGNLAHSLKTPIAVLLNEARTLEPQHGDLVRAQADAMQAQVQSYLSRARIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AQRGSILARVEAEPALERLVRVMRRLNPDKQFVLNFEQPGAVLGMEQQDLEEVVGNLLEN
HHCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEECCCHHHHHHHHHHHHHH
AARFAETRVVVTLATGTHPSSDAEIGRRSWVELTVEDDGPGLEPGQISEAMKRGRRLDES
HHHHHHCEEEEEEECCCCCCCCHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCC
RPGTGLGLSIVSEVVSEYHGRFSLSRSAIGGLKADLILPGLSKELA
CCCCCCHHHHHHHHHHHHCCCEEECHHHHCCCCHHEECCCCHHCCC
>Mature Secondary Structure
MRSNSLTARVLLLASAWSALALVVIAVVISTLYRQGVERSFTDLLRAQLYNVINSVTISN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECC
ENTLAGSPQLGDLRFSQPDTGWYWVVEPLGNFQTAPLVSSSLGVSTLPVPSIIDAPFDNR
CCCCCCCCCCCCEECCCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCCCHHHCCCCCCC
YERFYAVTDEAGNQVRVAETEVVLDGEGRAARFRVSGNLNVVEDDVRDFSNSLYLALAVF
CCEEEEEECCCCCEEEEEEEEEEECCCCCEEEEEECCCCCEEHHHHHHHHHHHHHHHHHH
GVGSLVVNGLAILYSLRPLDQARRALGKIRGGEAESLEGEFPREIQPLANEVNALIDSNR
HHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCH
RLVERARMQVGNLAHSLKTPIAVLLNEARTLEPQHGDLVRAQADAMQAQVQSYLSRARIA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
AQRGSILARVEAEPALERLVRVMRRLNPDKQFVLNFEQPGAVLGMEQQDLEEVVGNLLEN
HHCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEECCCCCEECCCHHHHHHHHHHHHHH
AARFAETRVVVTLATGTHPSSDAEIGRRSWVELTVEDDGPGLEPGQISEAMKRGRRLDES
HHHHHHCEEEEEEECCCCCCCCHHCCCCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCC
RPGTGLGLSIVSEVVSEYHGRFSLSRSAIGGLKADLILPGLSKELA
CCCCCCHHHHHHHHHHHHCCCEEECHHHHCCCCHHEECCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA