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The map label for this gene is lig [H]

Identifier: 159184491

GI number: 159184491

Start: 839733

End: 841358

Strand: Direct

Name: lig [H]

Synonym: Atu0840

Alternate gene names: 159184491

Gene position: 839733-841358 (Clockwise)

Preceding gene: 159184490

Following gene: 15888182

Centisome position: 29.55

GC content: 61.87

Gene sequence:

>1626_bases
ATGAAAGCCTTCGCCACCCTTCTCGACCGCCTTGTCCTCACGCCGTCGCGCAACGGCAAGCTGAAGCTGCTCACCGATTA
TTTCCGCGATACGCCCGATCCCGACCGGGGCTACGGGTTGGCGGCCATTGCCGGCACGCTGGACCTCAAAAGCGTTAAAC
CGGCCATGCTGCGCGAGCTGGTTATGGAGCGCATGGACGAGGTGCTGTTCCGTTATTCCTACGATTATGTCGGCGATCTG
GCCGAGACCATTTCGCTGGTCTGGGGCAATATCGGCGGCGTGGATGATGCGGAGGCGCAGGATCCGCGCCTCGGCGAAGT
CGTGACGCTGATGAACTCGCTGGGGCGTACCGAGGTGCGCGGCGCGGTGCGCGATCTGCTTGACCGGCTCGATACCTCCT
CCCGTTTCGCTTTCCTCAAACTCGCCACCGGCAGCCTGCGTATCGGCGTTTCGGCGCGGCTGGCGCGGCAGGCGCTGGCG
GATTTCGCGGATAAGGACATCACTGAAATCGAGACCCTTTGGCATGGTCTGACGCCCCCCTACACCACGCTATTCTCCTG
GCTGGAGGGCAACTCCGACCGCCCGCTGCTGGCAACGCCCGCCATCTTCCATTCGGTGATGCTGGCGACACCGGTCGCCG
ATGGCGATCTCGATGCGCTGGATCCCGCCGACTATGCAGCAGAGTGGAAATGGGACGGTATCCGTGTGCAATTGTCCCGG
GCCGGCGAAACGCGAAAGCTCTATTCCCGCTCCGGCGACGATATTTCCGGTGCTTTCCCGGATGTGCTTGACGCCATCGA
ATTCGAAGGCGTGATGGATGGCGAATTGCTGGTCGGTGGCACCGCGCGATCCAACAATCTCACCCGCACCTTCTCGGATT
TGCAGCAGCGGCTGAACCGCAAGACGGTAACGGCGAAGATGCGGGATGACTATCCCGCTTTCATCCGCGCTTATGACCTG
CTGTTCGAGGGCGAGAGCGACATTCGCGCGCAAACCTACCTGGAGCGCCGCAACCGGCTGTCTGACATCATCGAGCGCGC
GCCGCATGATCGCTTCGACCTCTCGCCGTTGATCGGCTTCTCCAGCTGGTCGGAACTCGACACTTTGCGCGCCGCACCGC
CCGATCCTGTCATCGAAGGGGTGATGATCAAGCGCCGCGACAGCACCTATCAGGCCGGGCGCGCCAAGGGGCCCTGGTTC
AAGTGGAAACGCGATCCCTACAATATCGACGCCGTTATGATGTATGCCCAGCGTGGCCACGGCAAAAGATCGAGCTATTA
TTCCGATTTCACCTTCGGTGTCTGGGCGGAAGGCGAGGATGGTGAACAGCTCGTGCCTGTCGGAAAGGCCTATTTCGGTT
TCACCGATGCCGAACTGGAAGTGCTGGACAAGTTCGTGCGCGACAATACGGTCGAGCGTTTCGGCCCGGTGCGGGCGGTG
CGCGCCACACCGGATTTCGGTTTCGTGCTGGAGGTGGCCTTCGAAGGCATCAACCGCTCCACCCGCCACAAGTCAGGCGT
TGCCATGCGGTTTCCGCGTATTGCAAGGTTGCGCGCCGACAAGCTGCCAGCCGAGGCCGACAGGCTCTCGACGCTGGTGG
CGATGATCGATGGTGTGGAAGGTTAG

Upstream 100 bases:

>100_bases
ACCCATGGCCGCGAGGAGGCGCTGGTACGCTGGTGCGAATTGCAGGGCATTGCCGCCAAGCCGCTGCATCTCGTCGGTTA
CGAGGATGAGGGGGACTGAA

Downstream 100 bases:

>100_bases
GGAAATGAGGCAGCTTCGCGATCGTAAACCTTACCCGGTCCAGAAATTGCCATGATGGCTGCGAATACATTGTTGTCATT
CGCGAATCCGTGATTGGACA

Product: ATP-dependent DNA ligase

Products: NA

Alternate protein names: Polydeoxyribonucleotide synthase [ATP] [H]

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MKAFATLLDRLVLTPSRNGKLKLLTDYFRDTPDPDRGYGLAAIAGTLDLKSVKPAMLRELVMERMDEVLFRYSYDYVGDL
AETISLVWGNIGGVDDAEAQDPRLGEVVTLMNSLGRTEVRGAVRDLLDRLDTSSRFAFLKLATGSLRIGVSARLARQALA
DFADKDITEIETLWHGLTPPYTTLFSWLEGNSDRPLLATPAIFHSVMLATPVADGDLDALDPADYAAEWKWDGIRVQLSR
AGETRKLYSRSGDDISGAFPDVLDAIEFEGVMDGELLVGGTARSNNLTRTFSDLQQRLNRKTVTAKMRDDYPAFIRAYDL
LFEGESDIRAQTYLERRNRLSDIIERAPHDRFDLSPLIGFSSWSELDTLRAAPPDPVIEGVMIKRRDSTYQAGRAKGPWF
KWKRDPYNIDAVMMYAQRGHGKRSSYYSDFTFGVWAEGEDGEQLVPVGKAYFGFTDAELEVLDKFVRDNTVERFGPVRAV
RATPDFGFVLEVAFEGINRSTRHKSGVAMRFPRIARLRADKLPAEADRLSTLVAMIDGVEG

Sequences:

>Translated_541_residues
MKAFATLLDRLVLTPSRNGKLKLLTDYFRDTPDPDRGYGLAAIAGTLDLKSVKPAMLRELVMERMDEVLFRYSYDYVGDL
AETISLVWGNIGGVDDAEAQDPRLGEVVTLMNSLGRTEVRGAVRDLLDRLDTSSRFAFLKLATGSLRIGVSARLARQALA
DFADKDITEIETLWHGLTPPYTTLFSWLEGNSDRPLLATPAIFHSVMLATPVADGDLDALDPADYAAEWKWDGIRVQLSR
AGETRKLYSRSGDDISGAFPDVLDAIEFEGVMDGELLVGGTARSNNLTRTFSDLQQRLNRKTVTAKMRDDYPAFIRAYDL
LFEGESDIRAQTYLERRNRLSDIIERAPHDRFDLSPLIGFSSWSELDTLRAAPPDPVIEGVMIKRRDSTYQAGRAKGPWF
KWKRDPYNIDAVMMYAQRGHGKRSSYYSDFTFGVWAEGEDGEQLVPVGKAYFGFTDAELEVLDKFVRDNTVERFGPVRAV
RATPDFGFVLEVAFEGINRSTRHKSGVAMRFPRIARLRADKLPAEADRLSTLVAMIDGVEG
>Mature_541_residues
MKAFATLLDRLVLTPSRNGKLKLLTDYFRDTPDPDRGYGLAAIAGTLDLKSVKPAMLRELVMERMDEVLFRYSYDYVGDL
AETISLVWGNIGGVDDAEAQDPRLGEVVTLMNSLGRTEVRGAVRDLLDRLDTSSRFAFLKLATGSLRIGVSARLARQALA
DFADKDITEIETLWHGLTPPYTTLFSWLEGNSDRPLLATPAIFHSVMLATPVADGDLDALDPADYAAEWKWDGIRVQLSR
AGETRKLYSRSGDDISGAFPDVLDAIEFEGVMDGELLVGGTARSNNLTRTFSDLQQRLNRKTVTAKMRDDYPAFIRAYDL
LFEGESDIRAQTYLERRNRLSDIIERAPHDRFDLSPLIGFSSWSELDTLRAAPPDPVIEGVMIKRRDSTYQAGRAKGPWF
KWKRDPYNIDAVMMYAQRGHGKRSSYYSDFTFGVWAEGEDGEQLVPVGKAYFGFTDAELEVLDKFVRDNTVERFGPVRAV
RATPDFGFVLEVAFEGINRSTRHKSGVAMRFPRIARLRADKLPAEADRLSTLVAMIDGVEG

Specific function: DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair [H]

COG id: COG1793

COG function: function code L; ATP-dependent DNA ligase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent DNA ligase family [H]

Homologues:

Organism=Caenorhabditis elegans, GI71985269, Length=379, Percent_Identity=27.1767810026385, Blast_Score=84, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6320038, Length=488, Percent_Identity=23.5655737704918, Blast_Score=84, Evalue=7e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022865
- InterPro:   IPR000977
- InterPro:   IPR012309
- InterPro:   IPR012310
- InterPro:   IPR016059
- InterPro:   IPR012308
- InterPro:   IPR012340
- InterPro:   IPR016027 [H]

Pfam domain/function: PF04679 DNA_ligase_A_C; PF01068 DNA_ligase_A_M; PF04675 DNA_ligase_A_N [H]

EC number: =6.5.1.1 [H]

Molecular weight: Translated: 60588; Mature: 60588

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: PS00697 DNA_LIGASE_A1 ; PS50160 DNA_LIGASE_A3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAFATLLDRLVLTPSRNGKLKLLTDYFRDTPDPDRGYGLAAIAGTLDLKSVKPAMLREL
CCHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCCCCCCCHHHHHHHCCHHCCCHHHHHHH
VMERMDEVLFRYSYDYVGDLAETISLVWGNIGGVDDAEAQDPRLGEVVTLMNSLGRTEVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHH
GAVRDLLDRLDTSSRFAFLKLATGSLRIGVSARLARQALADFADKDITEIETLWHGLTPP
HHHHHHHHHCCCCCCEEEEEEECCCEEECHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCH
YTTLFSWLEGNSDRPLLATPAIFHSVMLATPVADGDLDALDPADYAAEWKWDGIRVQLSR
HHHHHHHHCCCCCCCEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEC
AGETRKLYSRSGDDISGAFPDVLDAIEFEGVMDGELLVGGTARSNNLTRTFSDLQQRLNR
CCCHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHH
KTVTAKMRDDYPAFIRAYDLLFEGESDIRAQTYLERRNRLSDIIERAPHDRFDLSPLIGF
HHEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCC
SSWSELDTLRAAPPDPVIEGVMIKRRDSTYQAGRAKGPWFKWKRDPYNIDAVMMYAQRGH
CCHHHHHHHCCCCCCHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHEEEEHHHCC
GKRSSYYSDFTFGVWAEGEDGEQLVPVGKAYFGFTDAELEVLDKFVRDNTVERFGPVRAV
CCCCCCCCCCEEEEEECCCCCCEEEECCHHHHCCCCHHHHHHHHHHHCCCHHHHCCCEEE
RATPDFGFVLEVAFEGINRSTRHKSGVAMRFPRIARLRADKLPAEADRLSTLVAMIDGVE
EECCCCCHHHHHHHHHCCCCHHCCCCCEECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCC
G
C
>Mature Secondary Structure
MKAFATLLDRLVLTPSRNGKLKLLTDYFRDTPDPDRGYGLAAIAGTLDLKSVKPAMLREL
CCHHHHHHHHHHCCCCCCCCEEEEEHHHCCCCCCCCCCCHHHHHHHCCHHCCCHHHHHHH
VMERMDEVLFRYSYDYVGDLAETISLVWGNIGGVDDAEAQDPRLGEVVTLMNSLGRTEVR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHH
GAVRDLLDRLDTSSRFAFLKLATGSLRIGVSARLARQALADFADKDITEIETLWHGLTPP
HHHHHHHHHCCCCCCEEEEEEECCCEEECHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCH
YTTLFSWLEGNSDRPLLATPAIFHSVMLATPVADGDLDALDPADYAAEWKWDGIRVQLSR
HHHHHHHHCCCCCCCEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEC
AGETRKLYSRSGDDISGAFPDVLDAIEFEGVMDGELLVGGTARSNNLTRTFSDLQQRLNR
CCCHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHH
KTVTAKMRDDYPAFIRAYDLLFEGESDIRAQTYLERRNRLSDIIERAPHDRFDLSPLIGF
HHEEEECCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHCCC
SSWSELDTLRAAPPDPVIEGVMIKRRDSTYQAGRAKGPWFKWKRDPYNIDAVMMYAQRGH
CCHHHHHHHCCCCCCHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHEEEEHHHCC
GKRSSYYSDFTFGVWAEGEDGEQLVPVGKAYFGFTDAELEVLDKFVRDNTVERFGPVRAV
CCCCCCCCCCEEEEEECCCCCCEEEECCHHHHCCCCHHHHHHHHHHHCCCHHHHCCCEEE
RATPDFGFVLEVAFEGINRSTRHKSGVAMRFPRIARLRADKLPAEADRLSTLVAMIDGVE
EECCCCCHHHHHHHHHCCCCHHCCCCCEECCCHHHHHHHHCCCCHHHHHHHHHHHHHCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA