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The map label for this gene is lysN [H]

Identifier: 15889303

GI number: 15889303

Start: 1977360

End: 1978604

Strand: Reverse

Name: lysN [H]

Synonym: Atu2015

Alternate gene names: 15889303

Gene position: 1978604-1977360 (Counterclockwise)

Preceding gene: 15889305

Following gene: 15889302

Centisome position: 69.63

GC content: 60.72

Gene sequence:

>1245_bases
ATGCTTGATTGGGAACAAATTTTCGCCACGCGCTCTTCGCGCATGAAAGCGTCTGAAATCCGCGAGCTGCTGAAGCTGCT
CGAACAGCCCGATATCATCTCCTTTGCCGGCGGCATTCCGGATCCGGCTCTCTTCCCCGCAGAGGAGTTCCAGCAGGCTT
ATGCGGAAATTTTTTCCGGCGCGCAGGTCAACGCCGCCCTGCAATATTCTGTCAGCGAGGGTTACAAGCCGCTGCGCGAA
TGGCTGGCGGGCGAAATGGACAAGATCGGCATCGACTGCACCGCCGATAACGTCTTCATCGTTTCCGGTTCGCAGCAGGG
TCTCGATTATCTCGGCAAGCTGTTCCTGTCGCCGAAGGATACGGCGCTGGTGACATGGCCGACCTATCTCGGCGCGCTTT
CCGCTTTCAACGCCTATGAGCCGAATTACGACCAGCTTAATCCGGGTGGCAACCGCACGCCTGAAGCTTACCGCGAAACA
GCGGCCAAGCTCGGGGGCGCGGTGAAGTTCGCCTATCTTTCGGCTGATTTCTCCAATCCGACCGGCGAAACCGTCGATCT
TGCCGGCCGCGAAAAGGTTCTGGCGCTGGCCGACGAGCTTGACATCGCCGTCATCGAAGACGCTGCCTATCAGTCGCTGC
GTTACGACGGCGAAGCGGTTCCGCCCATCATGGCGCTCGACATTGCCCGTTCGGGCGGCATCGAGAACACCCGCACCATC
TACTGCGGCAGCTTTTCGAAGACGCTCGCCCCCGGCCTCCGCGTCGGGTACATCGTCGCCTCCGCGCCTGTCATCCGCAA
GCTGGTGCTGATGAAGCAGGCCGCCGACTTGCATTCCTCCACCATCAACCAGATCGCCATCGAACGCGTCGCCGCGCGCG
GTTTCGATAAGCAGGTGGCCAAGATCAAGGCGGCCTACAGCGCACGGCGGGATGCGATGCTCTCCGCGCTCGAGAAGTAC
ATGCCGAAGACCACCAGCTGGACCAAGCCGGAAGGTGGCATGTTCATCTGGGTGACATTGCCTGAGGGCATGGATGGTGC
CGCGCTGCTGGCAAAATCCATCGCTACGGAAAAGGTGGCCTTTGTTCCCGGCCGCGCGTTCTTTGCGGATGGTTCGGGTA
CGAACACGCTGCGCATCAGCTTCTCCTGCGCCAACGAGGCGATGATCGAGGAAGGCATGAAGCGGCTTGGCCGGTTGATT
ACGACGGCGCAGGCGGAGACGACTGAGGTGCTTGCGGCGATTTGA

Upstream 100 bases:

>100_bases
AGGCAGAAATAATTCGAAAAACTGATAAGTCAGTATTGCTGACATATCGACATTTCTGTAAAGATGCGCGCATAAAAACG
ACACAAGAGGAAACGTACCC

Downstream 100 bases:

>100_bases
TGTCGGGGGCTTACGGCAGCGACGGAGGTTGCGGCTTACCCCCCTCTGCCCTGCCGGGCATCTCCCCCACAAGGGGGGAG
ATCGACTCGAGGTGATGTTT

Product: aminotransferase

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 414; Mature: 414

Protein sequence:

>414_residues
MLDWEQIFATRSSRMKASEIRELLKLLEQPDIISFAGGIPDPALFPAEEFQQAYAEIFSGAQVNAALQYSVSEGYKPLRE
WLAGEMDKIGIDCTADNVFIVSGSQQGLDYLGKLFLSPKDTALVTWPTYLGALSAFNAYEPNYDQLNPGGNRTPEAYRET
AAKLGGAVKFAYLSADFSNPTGETVDLAGREKVLALADELDIAVIEDAAYQSLRYDGEAVPPIMALDIARSGGIENTRTI
YCGSFSKTLAPGLRVGYIVASAPVIRKLVLMKQAADLHSSTINQIAIERVAARGFDKQVAKIKAAYSARRDAMLSALEKY
MPKTTSWTKPEGGMFIWVTLPEGMDGAALLAKSIATEKVAFVPGRAFFADGSGTNTLRISFSCANEAMIEEGMKRLGRLI
TTAQAETTEVLAAI

Sequences:

>Translated_414_residues
MLDWEQIFATRSSRMKASEIRELLKLLEQPDIISFAGGIPDPALFPAEEFQQAYAEIFSGAQVNAALQYSVSEGYKPLRE
WLAGEMDKIGIDCTADNVFIVSGSQQGLDYLGKLFLSPKDTALVTWPTYLGALSAFNAYEPNYDQLNPGGNRTPEAYRET
AAKLGGAVKFAYLSADFSNPTGETVDLAGREKVLALADELDIAVIEDAAYQSLRYDGEAVPPIMALDIARSGGIENTRTI
YCGSFSKTLAPGLRVGYIVASAPVIRKLVLMKQAADLHSSTINQIAIERVAARGFDKQVAKIKAAYSARRDAMLSALEKY
MPKTTSWTKPEGGMFIWVTLPEGMDGAALLAKSIATEKVAFVPGRAFFADGSGTNTLRISFSCANEAMIEEGMKRLGRLI
TTAQAETTEVLAAI
>Mature_414_residues
MLDWEQIFATRSSRMKASEIRELLKLLEQPDIISFAGGIPDPALFPAEEFQQAYAEIFSGAQVNAALQYSVSEGYKPLRE
WLAGEMDKIGIDCTADNVFIVSGSQQGLDYLGKLFLSPKDTALVTWPTYLGALSAFNAYEPNYDQLNPGGNRTPEAYRET
AAKLGGAVKFAYLSADFSNPTGETVDLAGREKVLALADELDIAVIEDAAYQSLRYDGEAVPPIMALDIARSGGIENTRTI
YCGSFSKTLAPGLRVGYIVASAPVIRKLVLMKQAADLHSSTINQIAIERVAARGFDKQVAKIKAAYSARRDAMLSALEKY
MPKTTSWTKPEGGMFIWVTLPEGMDGAALLAKSIATEKVAFVPGRAFFADGSGTNTLRISFSCANEAMIEEGMKRLGRLI
TTAQAETTEVLAAI

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=433, Percent_Identity=27.7136258660508, Blast_Score=175, Evalue=9e-44,
Organism=Homo sapiens, GI33469970, Length=433, Percent_Identity=27.7136258660508, Blast_Score=175, Evalue=9e-44,
Organism=Escherichia coli, GI1787710, Length=382, Percent_Identity=25.3926701570681, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1790797, Length=390, Percent_Identity=26.1538461538462, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1788722, Length=353, Percent_Identity=30.5949008498584, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI48994949, Length=405, Percent_Identity=25.9259259259259, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6321000, Length=246, Percent_Identity=30.8943089430894, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6321236, Length=493, Percent_Identity=21.2981744421907, Blast_Score=75, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21356535, Length=420, Percent_Identity=24.2857142857143, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 44837; Mature: 44837

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDWEQIFATRSSRMKASEIRELLKLLEQPDIISFAGGIPDPALFPAEEFQQAYAEIFSG
CCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCC
AQVNAALQYSVSEGYKPLREWLAGEMDKIGIDCTADNVFIVSGSQQGLDYLGKLFLSPKD
CEECCEEEECHHHCHHHHHHHHCCCHHHCCEEEECCCEEEEECCCHHHHHHHHHHCCCCC
TALVTWPTYLGALSAFNAYEPNYDQLNPGGNRTPEAYRETAAKLGGAVKFAYLSADFSNP
CEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCC
TGETVDLAGREKVLALADELDIAVIEDAAYQSLRYDGEAVPPIMALDIARSGGIENTRTI
CCCEEECCCCCHHHHHHCCCCEEEECHHHHHHHCCCCCCCCCHHEEEEHHCCCCCCCCEE
YCGSFSKTLAPGLRVGYIVASAPVIRKLVLMKQAADLHSSTINQIAIERVAARGFDKQVA
EECCCHHHHCCCCCEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
KIKAAYSARRDAMLSALEKYMPKTTSWTKPEGGMFIWVTLPEGMDGAALLAKSIATEKVA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHEE
FVPGRAFFADGSGTNTLRISFSCANEAMIEEGMKRLGRLITTAQAETTEVLAAI
EECCCEEEECCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCC
>Mature Secondary Structure
MLDWEQIFATRSSRMKASEIRELLKLLEQPDIISFAGGIPDPALFPAEEFQQAYAEIFSG
CCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCC
AQVNAALQYSVSEGYKPLREWLAGEMDKIGIDCTADNVFIVSGSQQGLDYLGKLFLSPKD
CEECCEEEECHHHCHHHHHHHHCCCHHHCCEEEECCCEEEEECCCHHHHHHHHHHCCCCC
TALVTWPTYLGALSAFNAYEPNYDQLNPGGNRTPEAYRETAAKLGGAVKFAYLSADFSNP
CEEEECHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEECCCCCC
TGETVDLAGREKVLALADELDIAVIEDAAYQSLRYDGEAVPPIMALDIARSGGIENTRTI
CCCEEECCCCCHHHHHHCCCCEEEECHHHHHHHCCCCCCCCCHHEEEEHHCCCCCCCCEE
YCGSFSKTLAPGLRVGYIVASAPVIRKLVLMKQAADLHSSTINQIAIERVAARGFDKQVA
EECCCHHHHCCCCCEEHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
KIKAAYSARRDAMLSALEKYMPKTTSWTKPEGGMFIWVTLPEGMDGAALLAKSIATEKVA
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHEE
FVPGRAFFADGSGTNTLRISFSCANEAMIEEGMKRLGRLITTAQAETTEVLAAI
EECCCEEEECCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA