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The map label for this gene is purC

Identifier: 15889145

GI number: 15889145

Start: 1824862

End: 1825626

Strand: Direct

Name: purC

Synonym: Atu1843

Alternate gene names: 15889145

Gene position: 1824862-1825626 (Clockwise)

Preceding gene: 159184944

Following gene: 17935734

Centisome position: 64.22

GC content: 58.69

Gene sequence:

>765_bases
ATGAACCGTCGCCGCCGTATTTACGAAGGCAAGGCCAAGATCCTCTACGAAGGTCCGGAGCCAGGCACGCTTATCCAGTT
CTTCAAGGACGATGCGACCGCCTTCAACAAGAAGAAGCACGAAGTCATCGACGGCAAGGGTGTGCTGAACAACCGCATCT
GCGAATATGTCTTCACGCATCTGAACAAGATCGGTATTCCGACCCACTTCATCCGCCGCCTCAACATGCGCGAGCAGTTG
ATCAAGGAAGTGGAGATGATCCCGCTCGAGATCGTCGTGCGCAATGTCGCCGCCGGCTCGCTGTCCAAGCGCCTCGGCAT
CGAGGAAGGCGTGGTGCTGCCGCGCTCCATCATCGAGTTCTATTACAAGTCGGATGAGCTGGAAGACCCGATGGTCTCCG
AAGAGCACATCACGGCTTTCGGCTGGGCCAACCCCGCCGAGCTTGACGACATCATGGCGCTTGCCATCCGCGTCAACGAC
TTCCTGTCCGGCCTCTTCCTCGGCGTCGGCATCCAGCTCGTCGATTTCAAGATCGAATGCGGCCGGCTGTTCGAAGGCGA
CATGATGCGCATCATCCTCGCCGACGAGATTTCGCCCGATAGCTGCCGCCTGTGGGACATCGAGACCCAGAAAAAGATGG
ACAAGGACCTGTTCCGCCGCGATCTGGGCGGGCTTGTGGAAGCCTATTCCGAAGTGGCGCGCCGTCTCGGCATCATCAAT
GAAAACGAACCGATCCGCGGCACCGGCCCAGTCCTCGTAAAGTGA

Upstream 100 bases:

>100_bases
GCGCGCCTCATTGTAGAATGCAGTCTTTTCCTTTAAGGGACCGCTTCAAAGACCAAACTTAACGCCACCCGAATCGGCGT
CAACCAAGAGACCTGCCATT

Downstream 100 bases:

>100_bases
TATCGGCCTCGTAAAGTAATATTGGCTTCGTAGGGTAAATCAGGAGAAGATCAGGTGATCAAGGCACGGGTGACTGTTAC
GCTGAAGAACGGCGTTCTCG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase 1

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVIDGKGVLNNRICEYVFTHLNKIGIPTHFIRRLNMREQL
IKEVEMIPLEIVVRNVAAGSLSKRLGIEEGVVLPRSIIEFYYKSDELEDPMVSEEHITAFGWANPAELDDIMALAIRVND
FLSGLFLGVGIQLVDFKIECGRLFEGDMMRIILADEISPDSCRLWDIETQKKMDKDLFRRDLGGLVEAYSEVARRLGIIN
ENEPIRGTGPVLVK

Sequences:

>Translated_254_residues
MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVIDGKGVLNNRICEYVFTHLNKIGIPTHFIRRLNMREQL
IKEVEMIPLEIVVRNVAAGSLSKRLGIEEGVVLPRSIIEFYYKSDELEDPMVSEEHITAFGWANPAELDDIMALAIRVND
FLSGLFLGVGIQLVDFKIECGRLFEGDMMRIILADEISPDSCRLWDIETQKKMDKDLFRRDLGGLVEAYSEVARRLGIIN
ENEPIRGTGPVLVK
>Mature_254_residues
MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVIDGKGVLNNRICEYVFTHLNKIGIPTHFIRRLNMREQL
IKEVEMIPLEIVVRNVAAGSLSKRLGIEEGVVLPRSIIEFYYKSDELEDPMVSEEHITAFGWANPAELDDIMALAIRVND
FLSGLFLGVGIQLVDFKIECGRLFEGDMMRIILADEISPDSCRLWDIETQKKMDKDLFRRDLGGLVEAYSEVARRLGIIN
ENEPIRGTGPVLVK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family

Homologues:

Organism=Homo sapiens, GI119220557, Length=228, Percent_Identity=33.7719298245614, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI5453539, Length=228, Percent_Identity=33.7719298245614, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI119220559, Length=235, Percent_Identity=32.3404255319149, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI1788820, Length=238, Percent_Identity=45.3781512605042, Blast_Score=211, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17531275, Length=223, Percent_Identity=31.390134529148, Blast_Score=92, Evalue=3e-19,
Organism=Drosophila melanogaster, GI18860083, Length=222, Percent_Identity=32.4324324324324, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24583917, Length=250, Percent_Identity=25.6, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): PUR71_AGRT5 (Q8UEB7)

Other databases:

- EMBL:   AE007869
- PIR:   AI2802
- PIR:   B97582
- RefSeq:   NP_354826.1
- ProteinModelPortal:   Q8UEB7
- SMR:   Q8UEB7
- STRING:   Q8UEB7
- GeneID:   1133881
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1843
- eggNOG:   COG0152
- HOGENOM:   HBG306070
- OMA:   YKDDALG
- PhylomeDB:   Q8UEB7
- ProtClustDB:   PRK09362
- BioCyc:   ATUM176299-1:ATU1843-MONOMER
- HAMAP:   MF_00137
- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236
- Gene3D:   G3DSA:3.30.470.20
- PANTHER:   PTHR11609
- TIGRFAMs:   TIGR00081

Pfam domain/function: PF01259 SAICAR_synt

EC number: =6.3.2.6

Molecular weight: Translated: 29039; Mature: 29039

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: PS01057 SAICAR_SYNTHETASE_1; PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVIDGKGVLNNRICEYVFTH
CCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHH
LNKIGIPTHFIRRLNMREQLIKEVEMIPLEIVVRNVAAGSLSKRLGIEEGVVLPRSIIEF
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
YYKSDELEDPMVSEEHITAFGWANPAELDDIMALAIRVNDFLSGLFLGVGIQLVDFKIEC
HHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEC
GRLFEGDMMRIILADEISPDSCRLWDIETQKKMDKDLFRRDLGGLVEAYSEVARRLGIIN
CCCCCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ENEPIRGTGPVLVK
CCCCCCCCCCEEEC
>Mature Secondary Structure
MNRRRRIYEGKAKILYEGPEPGTLIQFFKDDATAFNKKKHEVIDGKGVLNNRICEYVFTH
CCCCCCEECCCEEEEEECCCCCHHHHHHHHHHHHHCCHHHHHCCCCCCHHHHHHHHHHHH
LNKIGIPTHFIRRLNMREQLIKEVEMIPLEIVVRNVAAGSLSKRLGIEEGVVLPRSIIEF
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
YYKSDELEDPMVSEEHITAFGWANPAELDDIMALAIRVNDFLSGLFLGVGIQLVDFKIEC
HHCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEEC
GRLFEGDMMRIILADEISPDSCRLWDIETQKKMDKDLFRRDLGGLVEAYSEVARRLGIIN
CCCCCCCEEEEEEECCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
ENEPIRGTGPVLVK
CCCCCCCCCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194