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The map label for this gene is clpP

Identifier: 15888940

GI number: 15888940

Start: 1613696

End: 1614304

Strand: Reverse

Name: clpP

Synonym: Atu1627

Alternate gene names: 15888940

Gene position: 1614304-1613696 (Counterclockwise)

Preceding gene: 15888941

Following gene: 15888936

Centisome position: 56.81

GC content: 58.29

Gene sequence:

>609_bases
ATGCGCGAAACGATGCAACTCGTCCCTATGGTAGTCGAACAATCCTCAAGGGGAGAACGGTCTTTCGACATTTATTCCCG
CCTGCTGCGGGAAAGGATTATCTTTCTCAACGGGGAGGTCGACGATACGGTCTCAGCGCTGGTGTGCGCGCAATTGCTGT
TTCTCGAAGCGGAAAACCCGAAGAAGCCGATCCACCTCTATATCAACTCGCCGGGTGGCATGGTGACCAGCGGTTTCGCC
ATGTATGACACCATGCGTTACATTCGTGCGCCGGTGCATACGCTCTGCATGGGTACGGCCCGTTCGATGGGGTCATTCCT
GCTGATGGCGGGTGAACCGGGCACGCGGGCGGCGTTGCCCAATGCCAGCATCCTCATTCACCAGCCTTCCGGTGGCTTTC
AGGGGCAGGCGTCGGACATGCTCATCCATGCCGAAGAGATCAGGCAGACGAAACATCGCATGACGCGGCTTTATGCCGAG
CATTGCGGGCGCAGCTACGAAGAATTCGAAACGGCGATGGATCGCGACCGCTTCATGACGGTGCAGGAGGCTCTGGAATG
GGGGCTGATCGACCGCATTCTGGAAGTGCGAGAGGATGCGGCGGCATAG

Upstream 100 bases:

>100_bases
CGGATGACGAAGGCTGCTGCAAACCACAACGGTTCGCCGATCAAGCTCGCGGCCTGATCCGGCACGTTTCCCAACATTTT
CAAACGACAGGAGTTCGCCG

Downstream 100 bases:

>100_bases
GGCCGGCCTATTCGGATTTCCTGCCGATATTGGCGCCGGCCGGCAGCACTTCCAGGCTGCGCCGGGCAAGCTGGGCCAGC
ACTTCATCGGAGCCGAACTG

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp 1

Number of amino acids: Translated: 202; Mature: 202

Protein sequence:

>202_residues
MRETMQLVPMVVEQSSRGERSFDIYSRLLRERIIFLNGEVDDTVSALVCAQLLFLEAENPKKPIHLYINSPGGMVTSGFA
MYDTMRYIRAPVHTLCMGTARSMGSFLLMAGEPGTRAALPNASILIHQPSGGFQGQASDMLIHAEEIRQTKHRMTRLYAE
HCGRSYEEFETAMDRDRFMTVQEALEWGLIDRILEVREDAAA

Sequences:

>Translated_202_residues
MRETMQLVPMVVEQSSRGERSFDIYSRLLRERIIFLNGEVDDTVSALVCAQLLFLEAENPKKPIHLYINSPGGMVTSGFA
MYDTMRYIRAPVHTLCMGTARSMGSFLLMAGEPGTRAALPNASILIHQPSGGFQGQASDMLIHAEEIRQTKHRMTRLYAE
HCGRSYEEFETAMDRDRFMTVQEALEWGLIDRILEVREDAAA
>Mature_202_residues
MRETMQLVPMVVEQSSRGERSFDIYSRLLRERIIFLNGEVDDTVSALVCAQLLFLEAENPKKPIHLYINSPGGMVTSGFA
MYDTMRYIRAPVHTLCMGTARSMGSFLLMAGEPGTRAALPNASILIHQPSGGFQGQASDMLIHAEEIRQTKHRMTRLYAE
HCGRSYEEFETAMDRDRFMTVQEALEWGLIDRILEVREDAAA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=57.8947368421053, Blast_Score=244, Evalue=4e-65,
Organism=Escherichia coli, GI1786641, Length=193, Percent_Identity=60.1036269430052, Blast_Score=252, Evalue=1e-68,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=56.4516129032258, Blast_Score=233, Evalue=7e-62,
Organism=Drosophila melanogaster, GI20129427, Length=192, Percent_Identity=59.8958333333333, Blast_Score=253, Evalue=8e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CLPP1_AGRT5 (Q8UEX6)

Other databases:

- EMBL:   AE007869
- PIR:   AG2776
- PIR:   E97556
- RefSeq:   NP_354621.1
- ProteinModelPortal:   Q8UEX6
- SMR:   Q8UEX6
- STRING:   Q8UEX6
- MEROPS:   S14.001
- GeneID:   1133665
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu1627
- eggNOG:   COG0740
- HOGENOM:   HBG558421
- OMA:   CMGTARS
- ProtClustDB:   PRK00277
- BioCyc:   ATUM176299-1:ATU1627-MONOMER
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00444
- InterPro:   IPR001907
- InterPro:   IPR018215
- PANTHER:   PTHR10381
- PRINTS:   PR00127

Pfam domain/function: PF00574 CLP_protease

EC number: =3.4.21.92

Molecular weight: Translated: 22835; Mature: 22835

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00382 CLP_PROTEASE_HIS; PS00381 CLP_PROTEASE_SER

Important sites: ACT_SITE 102-102 ACT_SITE 127-127

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
6.4 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
6.4 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRETMQLVPMVVEQSSRGERSFDIYSRLLRERIIFLNGEVDDTVSALVCAQLLFLEAENP
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
KKPIHLYINSPGGMVTSGFAMYDTMRYIRAPVHTLCMGTARSMGSFLLMAGEPGTRAALP
CCCEEEEEECCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCC
NASILIHQPSGGFQGQASDMLIHAEEIRQTKHRMTRLYAEHCGRSYEEFETAMDRDRFMT
CCEEEEECCCCCCCCCCHHHEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VQEALEWGLIDRILEVREDAAA
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRETMQLVPMVVEQSSRGERSFDIYSRLLRERIIFLNGEVDDTVSALVCAQLLFLEAENP
CCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCC
KKPIHLYINSPGGMVTSGFAMYDTMRYIRAPVHTLCMGTARSMGSFLLMAGEPGTRAALP
CCCEEEEEECCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCC
NASILIHQPSGGFQGQASDMLIHAEEIRQTKHRMTRLYAEHCGRSYEEFETAMDRDRFMT
CCEEEEECCCCCCCCCCHHHEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VQEALEWGLIDRILEVREDAAA
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194