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The map label for this gene is pyrG [H]

Identifier: 15888931

GI number: 15888931

Start: 1602527

End: 1604263

Strand: Reverse

Name: pyrG [H]

Synonym: Atu1618

Alternate gene names: 15888931

Gene position: 1604263-1602527 (Counterclockwise)

Preceding gene: 159184841

Following gene: 15888928

Centisome position: 56.46

GC content: 59.36

Gene sequence:

>1737_bases
TTGTTCGCATTCCGGCTCGCCCCATCGCAGATTCGTCAACAGCGAATTTTCGAAACAATGAAATTTGGGCTGGCGGAATC
AGAGGTAAAAAGGTATCCGGTGAATCCCATGGCGCGATATGTATTCATCACAGGCGGCGTGGTCTCCTCTCTCGGTAAGG
GCATCGCAGCTGCGGCACTCGGAGCTTTGCTGCAATCCCGTGGTTATCGGGTGCGGCTTCGCAAACTCGACCCTTATCTG
AACGTTGATCCCGGCACCATGAGCCCGACACAGCACGGCGAAGTGTTCGTGACGGATGACGGTGCCGAGACGGACCTCGA
CCTTGGCCACTATGAACGCTTTACCGGGCGTTCGGCCACCAAGACCGACAACATCACCACCGGTCGCATTTACAAGAACA
TCATCGACAAGGAACGCCGCGGCGACTATCTCGGCGCGACGGTACAGGTCATTCCGCATGTCACCAACGAGATCAAGGAT
TTCGTGACCGAAGGCAATGACGATTACGACTTCGTCATCTGCGAAATCGGCGGCACGGTGGGTGATATCGAGGCGATGCC
GTTCATGGAGGCGATCCGCCAGCTCGGTAACGACCTGCCGCGCGGCACCGCAATCTATGTTCATCTGACGCTGATGCCTT
ACATTCCGGCGGCCGGCGAATTGAAGACAAAGCCGACCCAGCATTCCGTGAAGGAACTGCAGGCGCTTGGCATTCATCCC
GACATCCTGCTGGTGCGCGCCGACCGGGAAATCCCGGAAGCGGAACGCCGCAAGCTCTCGCTGTTCTGCAACGTGCGTCC
GTCCGCCGTTATTCAGGCGCTGGATGTTGCCAACATCTATGACGTTCCGATCGCCTACCACAATGAAGGTCTCGATTCGG
AAGTGCTGGCCGCCTTCGGCATCGAACCGGCGCCGAAGCCGCGTCTGGAACAGTGGGAAGAGGTCTGCAACCGCATCCGC
ACGCCGGAAGGCGAGGTAACGATTGCGATCGTCGGCAAATATACCGGCCTCAAGGATGCCTACAAGTCGCTGATCGAGGC
GCTGCATCACGGTGGCTTCGCCAACCGCGTCAAGGTTAAGCTGGAGTGGATCGAGTCGGAAGTCTTCGAAAAGGAAGATC
CGACGCCTTATCTCGAAAAGGTCAACGGCATTCTGGTGCCGGGCGGTTTCGGCGAGCGCGGTTCCGAAGGCAAGATCATG
GCGGCGCAGTTCGCCCGTGAGCGCAACGTGCCCTATTTCGGCATCTGCTTCGGCATGCAGATGGCGGTCGTGGAAGCGGC
CCGACATCTCGCCGGCATCGAAAATGCCTCGTCCACCGAATTCGGTCCCACGGCGGAACCCGTCGTTGGCCTGATGACCG
AATGGGTGAAGGGCAACGAGCTGGAGAAGCGCTCCACCAAGGGCGATCTCGGCGGCACCATGCGTCTCGGCGCCTACAAG
GCGGCGCTGAAGAAAGACACCAAGATCGCCGAAATCTATGGCACCACTGATATTTCCGAGCGCCACCGCCACCGCTACGA
GGTGAATGTGGACTACAAGGACCGGCTGGAAGAGTGCGGCTTGGTCTTCTCGGGCATGTCTCCCGATGGTGTCCTGCCGG
AGACGGTGGAATATCCTGACCATCCGTGGTTTATCGGCGTGCAATACCACCCGGAACTGAAGAGCCGCCCGCTCGACCCG
CATCCGCTTTTCGCCAGCTTCGTCGAAGCGGCGGTGGAGCAGAGCCGGCTGGTTTGA

Upstream 100 bases:

>100_bases
GGCCCCGGCGCAGCCCGCCGATCCGAACGCCGTTCCGACCGGTCAATAAGCCCGGTTTTGATTTAACGCTCCGGCAGGCC
AAAAGCCTGCCGGTTTTCTT

Downstream 100 bases:

>100_bases
CGGTTTGAATGATACAAAAAAGGGCCGCGTTTGCGGTCCTTTTTTGTTTGGCGAACAGACTTTCCGTCCTGCAATCATGG
TTTGTCGGGATCGGGATTAC

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase [H]

Number of amino acids: Translated: 578; Mature: 578

Protein sequence:

>578_residues
MFAFRLAPSQIRQQRIFETMKFGLAESEVKRYPVNPMARYVFITGGVVSSLGKGIAAAALGALLQSRGYRVRLRKLDPYL
NVDPGTMSPTQHGEVFVTDDGAETDLDLGHYERFTGRSATKTDNITTGRIYKNIIDKERRGDYLGATVQVIPHVTNEIKD
FVTEGNDDYDFVICEIGGTVGDIEAMPFMEAIRQLGNDLPRGTAIYVHLTLMPYIPAAGELKTKPTQHSVKELQALGIHP
DILLVRADREIPEAERRKLSLFCNVRPSAVIQALDVANIYDVPIAYHNEGLDSEVLAAFGIEPAPKPRLEQWEEVCNRIR
TPEGEVTIAIVGKYTGLKDAYKSLIEALHHGGFANRVKVKLEWIESEVFEKEDPTPYLEKVNGILVPGGFGERGSEGKIM
AAQFARERNVPYFGICFGMQMAVVEAARHLAGIENASSTEFGPTAEPVVGLMTEWVKGNELEKRSTKGDLGGTMRLGAYK
AALKKDTKIAEIYGTTDISERHRHRYEVNVDYKDRLEECGLVFSGMSPDGVLPETVEYPDHPWFIGVQYHPELKSRPLDP
HPLFASFVEAAVEQSRLV

Sequences:

>Translated_578_residues
MFAFRLAPSQIRQQRIFETMKFGLAESEVKRYPVNPMARYVFITGGVVSSLGKGIAAAALGALLQSRGYRVRLRKLDPYL
NVDPGTMSPTQHGEVFVTDDGAETDLDLGHYERFTGRSATKTDNITTGRIYKNIIDKERRGDYLGATVQVIPHVTNEIKD
FVTEGNDDYDFVICEIGGTVGDIEAMPFMEAIRQLGNDLPRGTAIYVHLTLMPYIPAAGELKTKPTQHSVKELQALGIHP
DILLVRADREIPEAERRKLSLFCNVRPSAVIQALDVANIYDVPIAYHNEGLDSEVLAAFGIEPAPKPRLEQWEEVCNRIR
TPEGEVTIAIVGKYTGLKDAYKSLIEALHHGGFANRVKVKLEWIESEVFEKEDPTPYLEKVNGILVPGGFGERGSEGKIM
AAQFARERNVPYFGICFGMQMAVVEAARHLAGIENASSTEFGPTAEPVVGLMTEWVKGNELEKRSTKGDLGGTMRLGAYK
AALKKDTKIAEIYGTTDISERHRHRYEVNVDYKDRLEECGLVFSGMSPDGVLPETVEYPDHPWFIGVQYHPELKSRPLDP
HPLFASFVEAAVEQSRLV
>Mature_578_residues
MFAFRLAPSQIRQQRIFETMKFGLAESEVKRYPVNPMARYVFITGGVVSSLGKGIAAAALGALLQSRGYRVRLRKLDPYL
NVDPGTMSPTQHGEVFVTDDGAETDLDLGHYERFTGRSATKTDNITTGRIYKNIIDKERRGDYLGATVQVIPHVTNEIKD
FVTEGNDDYDFVICEIGGTVGDIEAMPFMEAIRQLGNDLPRGTAIYVHLTLMPYIPAAGELKTKPTQHSVKELQALGIHP
DILLVRADREIPEAERRKLSLFCNVRPSAVIQALDVANIYDVPIAYHNEGLDSEVLAAFGIEPAPKPRLEQWEEVCNRIR
TPEGEVTIAIVGKYTGLKDAYKSLIEALHHGGFANRVKVKLEWIESEVFEKEDPTPYLEKVNGILVPGGFGERGSEGKIM
AAQFARERNVPYFGICFGMQMAVVEAARHLAGIENASSTEFGPTAEPVVGLMTEWVKGNELEKRSTKGDLGGTMRLGAYK
AALKKDTKIAEIYGTTDISERHRHRYEVNVDYKDRLEECGLVFSGMSPDGVLPETVEYPDHPWFIGVQYHPELKSRPLDP
HPLFASFVEAAVEQSRLV

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen [H]

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI148491070, Length=557, Percent_Identity=44.524236983842, Blast_Score=469, Evalue=1e-132,
Organism=Homo sapiens, GI28559085, Length=556, Percent_Identity=42.9856115107914, Blast_Score=454, Evalue=1e-127,
Organism=Homo sapiens, GI28559083, Length=556, Percent_Identity=42.9856115107914, Blast_Score=454, Evalue=1e-127,
Organism=Homo sapiens, GI221316689, Length=556, Percent_Identity=42.9856115107914, Blast_Score=454, Evalue=1e-127,
Organism=Escherichia coli, GI1789142, Length=536, Percent_Identity=56.7164179104478, Blast_Score=601, Evalue=1e-173,
Organism=Caenorhabditis elegans, GI25148299, Length=617, Percent_Identity=36.4667747163695, Blast_Score=393, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6322563, Length=570, Percent_Identity=40.3508771929825, Blast_Score=425, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6319432, Length=567, Percent_Identity=40.3880070546737, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24664469, Length=565, Percent_Identity=44.070796460177, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI21357815, Length=511, Percent_Identity=43.2485322896282, Blast_Score=386, Evalue=1e-107,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase [H]

EC number: =6.3.4.2 [H]

Molecular weight: Translated: 64299; Mature: 64299

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAFRLAPSQIRQQRIFETMKFGLAESEVKRYPVNPMARYVFITGGVVSSLGKGIAAAAL
CCEEECCHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHEEEEEEECHHHHHHCCHHHHHHH
GALLQSRGYRVRLRKLDPYLNVDPGTMSPTQHGEVFVTDDGAETDLDLGHYERFTGRSAT
HHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHCCCCCC
KTDNITTGRIYKNIIDKERRGDYLGATVQVIPHVTNEIKDFVTEGNDDYDFVICEIGGTV
CCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCC
GDIEAMPFMEAIRQLGNDLPRGTAIYVHLTLMPYIPAAGELKTKPTQHSVKELQALGIHP
CCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCC
DILLVRADREIPEAERRKLSLFCNVRPSAVIQALDVANIYDVPIAYHNEGLDSEVLAAFG
CEEEEECCCCCCHHHHCEEEEEEECCHHHHHHHHHHCCEEECCEEECCCCCCHHHHHHHC
IEPAPKPRLEQWEEVCNRIRTPEGEVTIAIVGKYTGLKDAYKSLIEALHHGGFANRVKVK
CCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEE
LEWIESEVFEKEDPTPYLEKVNGILVPGGFGERGSEGKIMAAQFARERNVPYFGICFGMQ
EEEHHHHHHCCCCCCHHHHHCCCEEECCCCCCCCCCCCEEHHHHHHHCCCCEEEHHHHHH
MAVVEAARHLAGIENASSTEFGPTAEPVVGLMTEWVKGNELEKRSTKGDLGGTMRLGAYK
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEHHHHH
AALKKDTKIAEIYGTTDISERHRHRYEVNVDYKDRLEECGLVFSGMSPDGVLPETVEYPD
HHHHCCCEEEEEECCCCHHHHHCCEEEEECCHHHHHHHCCEEEECCCCCCCCCCCCCCCC
HPWFIGVQYHPELKSRPLDPHPLFASFVEAAVEQSRLV
CCEEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFAFRLAPSQIRQQRIFETMKFGLAESEVKRYPVNPMARYVFITGGVVSSLGKGIAAAAL
CCEEECCHHHHHHHHHHHHHHHCCCHHHHHHCCCCHHEEEEEEECHHHHHHCCHHHHHHH
GALLQSRGYRVRLRKLDPYLNVDPGTMSPTQHGEVFVTDDGAETDLDLGHYERFTGRSAT
HHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHHHHCCCCCC
KTDNITTGRIYKNIIDKERRGDYLGATVQVIPHVTNEIKDFVTEGNDDYDFVICEIGGTV
CCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCC
GDIEAMPFMEAIRQLGNDLPRGTAIYVHLTLMPYIPAAGELKTKPTQHSVKELQALGIHP
CCCHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHCCCCC
DILLVRADREIPEAERRKLSLFCNVRPSAVIQALDVANIYDVPIAYHNEGLDSEVLAAFG
CEEEEECCCCCCHHHHCEEEEEEECCHHHHHHHHHHCCEEECCEEECCCCCCHHHHHHHC
IEPAPKPRLEQWEEVCNRIRTPEGEVTIAIVGKYTGLKDAYKSLIEALHHGGFANRVKVK
CCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEE
LEWIESEVFEKEDPTPYLEKVNGILVPGGFGERGSEGKIMAAQFARERNVPYFGICFGMQ
EEEHHHHHHCCCCCCHHHHHCCCEEECCCCCCCCCCCCEEHHHHHHHCCCCEEEHHHHHH
MAVVEAARHLAGIENASSTEFGPTAEPVVGLMTEWVKGNELEKRSTKGDLGGTMRLGAYK
HHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCCCCCCEEEHHHHH
AALKKDTKIAEIYGTTDISERHRHRYEVNVDYKDRLEECGLVFSGMSPDGVLPETVEYPD
HHHHCCCEEEEEECCCCHHHHHCCEEEEECCHHHHHHHCCEEEECCCCCCCCCCCCCCCC
HPWFIGVQYHPELKSRPLDPHPLFASFVEAAVEQSRLV
CCEEEEEEECCCHHCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194 [H]