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The map label for this gene is phr [H]

Identifier: 15888554

GI number: 15888554

Start: 1212113

End: 1213552

Strand: Reverse

Name: phr [H]

Synonym: Atu1218

Alternate gene names: 15888554

Gene position: 1213552-1212113 (Counterclockwise)

Preceding gene: 159184674

Following gene: 15888553

Centisome position: 42.71

GC content: 59.24

Gene sequence:

>1440_bases
ATGTCGCTAAAAACCGCCCCCGTCATCGTCTGGTTCCGCAAGGATCTGCGTCTTTCTGACAATCTTGCTTTGCTCGCCGC
AGTGGAGCATGGCGGGCCAGTTATTCCGGTCTATATCAGGGAAAAATCCGCCGGTCCCTTAGGGGGTGCGCAGGAATGGT
GGCTCCACCATTCGCTTGCCGCTCTCTCCTCCTCGCTTGAAAAAGCCGGCGGCCGCCTCGTGCTCGCAAGCGGCGATGCA
GAGAGGATACTGCGTGACCTGATATCCGAAACCGGGGCAGACACCGTGGTCTGGAACCGCCGTTATGATCCGACCGGCAT
GGCCACCGACAAGGCGCTCAAACAGAAGCTCCGGGACGACGGGCTGACGGTTCGAAGCTTCTCCGGCCAGCTGCTGCATG
AGCCATCGCGGCTGCAGACGAAATCGGGCGGGCCTTACCGCGTCTATACGCCCTTCTGGCGGGCGCTGGAGGGGAGCGAC
GAGCCCCATGCGCCGGCGGATCCGCCAAAGAGCCTGACAGCACCGAAAGTATGGCCGAAGTCCGAGAAACTCTCCAACTG
GAAGCTGCTACCCACCAAGCCGGACTGGGCAAAGGATTTCAGCGATATCTGGACCCCCGGCGAAACCGGTGCGTTGGACA
AACTCGATGATTTCATCGATGGCGCCCTGAAAGGTTATGAAGAAGGCCGGGATTTTCCGGCAAAACCCGCGACGTCGCTG
CTTTCACCGCATCTTGCCGCGGGTGAGATATCGCCGGCGGCCGTCTGGCACGCCACGAAAGGGCTTTCGCGACATATCGC
CTCCAATGATATCAGCCGTTTCCGCAAGGAAATCGTCTGGCGGGAATTCTGCTACCATTTGCTGTTCCATTTCCCGGAGC
TGGGCGAAAAGAACTGGAACGACAGTTTCGACGCCTTTTCCTGGCGGGACGATGAAAAATCCTTCAAGGCCTGGACGCGC
GGCATGACGGGTTACCCGATCGTCGATGCCGGCATGCGGCAATTGTGGCAACATGGCACCATGCATAACCGGGTGCGCAT
GATCGTGGCGTCCTTCCTCATCAAACATCTGCTGATCGACTGGCGGAAGGGCGAGAAGTGGTTTCGCGATACGCTCGTCG
ATGCGGACCCGGCGTCCAATGCCGCCAACTGGCAATGGGTGGCAGGTTCAGGGGCGGACGCCTCGCCGTTCTTCCGCATC
TTCAACCCCATATTGCAGGGAGAGAAATTCGACGGCGATGGGGATTATGTGCGCAGGTTCGTGCCCGAGCTTGAAAAGCT
CGAGCGGAAATACATCCACAAGCCGTTCGAAGCGCCCAAAGATGCGCTGAAAAAGGCGGGCGTCGAACTCGGCAAGACCT
ATCCGCTACCGATCGTTGACCATGGAAAAGCGCGGGAAAGAGCGCTTGCCGCCTATGCCGCAGTGAAGAAGACCACATAA

Upstream 100 bases:

>100_bases
TAACCCTCGAAAAACCATGTGCCCCATCTTCTCATTGTAGCCGATTTGCGGAACAAAGCGGTTCAACACTCGTTCAAGCG
GAAGTGAACCGGGACCTCTC

Downstream 100 bases:

>100_bases
AACTGGGTATCGGCAAAATTTTGCGTGGCTAAGCCCGAGCCGGGAAGATAATTTCTTGCCTTGAGGCGGTTGTAACAGGA
CATAACGGCACCTAATTTCC

Product: DNA photolyase

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 479; Mature: 478

Protein sequence:

>479_residues
MSLKTAPVIVWFRKDLRLSDNLALLAAVEHGGPVIPVYIREKSAGPLGGAQEWWLHHSLAALSSSLEKAGGRLVLASGDA
ERILRDLISETGADTVVWNRRYDPTGMATDKALKQKLRDDGLTVRSFSGQLLHEPSRLQTKSGGPYRVYTPFWRALEGSD
EPHAPADPPKSLTAPKVWPKSEKLSNWKLLPTKPDWAKDFSDIWTPGETGALDKLDDFIDGALKGYEEGRDFPAKPATSL
LSPHLAAGEISPAAVWHATKGLSRHIASNDISRFRKEIVWREFCYHLLFHFPELGEKNWNDSFDAFSWRDDEKSFKAWTR
GMTGYPIVDAGMRQLWQHGTMHNRVRMIVASFLIKHLLIDWRKGEKWFRDTLVDADPASNAANWQWVAGSGADASPFFRI
FNPILQGEKFDGDGDYVRRFVPELEKLERKYIHKPFEAPKDALKKAGVELGKTYPLPIVDHGKARERALAAYAAVKKTT

Sequences:

>Translated_479_residues
MSLKTAPVIVWFRKDLRLSDNLALLAAVEHGGPVIPVYIREKSAGPLGGAQEWWLHHSLAALSSSLEKAGGRLVLASGDA
ERILRDLISETGADTVVWNRRYDPTGMATDKALKQKLRDDGLTVRSFSGQLLHEPSRLQTKSGGPYRVYTPFWRALEGSD
EPHAPADPPKSLTAPKVWPKSEKLSNWKLLPTKPDWAKDFSDIWTPGETGALDKLDDFIDGALKGYEEGRDFPAKPATSL
LSPHLAAGEISPAAVWHATKGLSRHIASNDISRFRKEIVWREFCYHLLFHFPELGEKNWNDSFDAFSWRDDEKSFKAWTR
GMTGYPIVDAGMRQLWQHGTMHNRVRMIVASFLIKHLLIDWRKGEKWFRDTLVDADPASNAANWQWVAGSGADASPFFRI
FNPILQGEKFDGDGDYVRRFVPELEKLERKYIHKPFEAPKDALKKAGVELGKTYPLPIVDHGKARERALAAYAAVKKTT
>Mature_478_residues
SLKTAPVIVWFRKDLRLSDNLALLAAVEHGGPVIPVYIREKSAGPLGGAQEWWLHHSLAALSSSLEKAGGRLVLASGDAE
RILRDLISETGADTVVWNRRYDPTGMATDKALKQKLRDDGLTVRSFSGQLLHEPSRLQTKSGGPYRVYTPFWRALEGSDE
PHAPADPPKSLTAPKVWPKSEKLSNWKLLPTKPDWAKDFSDIWTPGETGALDKLDDFIDGALKGYEEGRDFPAKPATSLL
SPHLAAGEISPAAVWHATKGLSRHIASNDISRFRKEIVWREFCYHLLFHFPELGEKNWNDSFDAFSWRDDEKSFKAWTRG
MTGYPIVDAGMRQLWQHGTMHNRVRMIVASFLIKHLLIDWRKGEKWFRDTLVDADPASNAANWQWVAGSGADASPFFRIF
NPILQGEKFDGDGDYVRRFVPELEKLERKYIHKPFEAPKDALKKAGVELGKTYPLPIVDHGKARERALAAYAAVKKTT

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=480, Percent_Identity=30, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI4758072, Length=474, Percent_Identity=28.4810126582279, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI188536103, Length=438, Percent_Identity=28.310502283105, Blast_Score=162, Evalue=6e-40,
Organism=Escherichia coli, GI1786926, Length=489, Percent_Identity=36.40081799591, Blast_Score=275, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6324962, Length=515, Percent_Identity=28.7378640776699, Blast_Score=177, Evalue=5e-45,
Organism=Drosophila melanogaster, GI17137248, Length=505, Percent_Identity=28.1188118811881, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24585455, Length=505, Percent_Identity=28.1188118811881, Blast_Score=172, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24648152, Length=512, Percent_Identity=26.3671875, Blast_Score=162, Evalue=5e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR019947
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 53886; Mature: 53754

Theoretical pI: Translated: 9.53; Mature: 9.53

Prosite motif: PS00394 DNA_PHOTOLYASES_1_1 ; PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLKTAPVIVWFRKDLRLSDNLALLAAVEHGGPVIPVYIREKSAGPLGGAQEWWLHHSLA
CCCCCCCEEEEEECCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHHH
ALSSSLEKAGGRLVLASGDAERILRDLISETGADTVVWNRRYDPTGMATDKALKQKLRDD
HHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHC
GLTVRSFSGQLLHEPSRLQTKSGGPYRVYTPFWRALEGSDEPHAPADPPKSLTAPKVWPK
CCEEEECCCHHHCCCHHHCCCCCCCEEEECHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
SEKLSNWKLLPTKPDWAKDFSDIWTPGETGALDKLDDFIDGALKGYEEGRDFPAKPATSL
CCCCCCCEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
LSPHLAAGEISPAAVWHATKGLSRHIASNDISRFRKEIVWREFCYHLLFHFPELGEKNWN
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCC
DSFDAFSWRDDEKSFKAWTRGMTGYPIVDAGMRQLWQHGTMHNRVRMIVASFLIKHLLID
CCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
WRKGEKWFRDTLVDADPASNAANWQWVAGSGADASPFFRIFNPILQGEKFDGDGDYVRRF
HHCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHH
VPELEKLERKYIHKPFEAPKDALKKAGVELGKTYPLPIVDHGKARERALAAYAAVKKTT
HHHHHHHHHHHHCCCCCCHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLKTAPVIVWFRKDLRLSDNLALLAAVEHGGPVIPVYIREKSAGPLGGAQEWWLHHSLA
CCCCCCEEEEEECCCCCCCCEEEEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHHH
ALSSSLEKAGGRLVLASGDAERILRDLISETGADTVVWNRRYDPTGMATDKALKQKLRDD
HHHHHHHHCCCEEEEECCCHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHHC
GLTVRSFSGQLLHEPSRLQTKSGGPYRVYTPFWRALEGSDEPHAPADPPKSLTAPKVWPK
CCEEEECCCHHHCCCHHHCCCCCCCEEEECHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
SEKLSNWKLLPTKPDWAKDFSDIWTPGETGALDKLDDFIDGALKGYEEGRDFPAKPATSL
CCCCCCCEECCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
LSPHLAAGEISPAAVWHATKGLSRHIASNDISRFRKEIVWREFCYHLLFHFPELGEKNWN
HCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHCCCCCC
DSFDAFSWRDDEKSFKAWTRGMTGYPIVDAGMRQLWQHGTMHNRVRMIVASFLIKHLLID
CCCCCCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
WRKGEKWFRDTLVDADPASNAANWQWVAGSGADASPFFRIFNPILQGEKFDGDGDYVRRF
HHCCHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHH
VPELEKLERKYIHKPFEAPKDALKKAGVELGKTYPLPIVDHGKARERALAAYAAVKKTT
HHHHHHHHHHHHCCCCCCHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2837735; 2110564; 9360600 [H]