Click here to switch to the map view.

The map label for this gene is cysK [H]

Identifier: 15888553

GI number: 15888553

Start: 1210953

End: 1211990

Strand: Reverse

Name: cysK [H]

Synonym: Atu1217

Alternate gene names: 15888553

Gene position: 1211990-1210953 (Counterclockwise)

Preceding gene: 15888554

Following gene: 15888552

Centisome position: 42.65

GC content: 60.12

Gene sequence:

>1038_bases
ATGACCATTCATTCCTCTGCGCTCAGTGCAATCGGCAACACGCCGCTCATCCGTCTGAAGGCTGCCTCTGAAGCGACGGG
GTGTGAAATCCTCGGCAAGGCGGAATTCCTCAATCCCGGCCAGTCGGTGAAGGATCGTGCAGCGCTCTACATCATCCGCG
ACGCCGAACGGCGCGGCCAATTGCGCCCGGGCGGCACCATCGTGGAAGGCACGGCCGGAAATACCGGCATCGGCCTGTCG
CTGGTCGCCAATGCGCTCGGCTACAAGACGGTGATCGTCATTCCCGAGACGCAGAGCCAGGAGAAGAAGGACGCGCTGAA
GCTTCTCGGCGCCAAGCTGGTCGAAGTACCGGCCGCGCCTTATTCCAATCCGAACAATTACGTAAAGGTCTCCGGCCGGC
TTGCAAAACAGCTCGCCGCCACGGATGAAAACGGCGCGATCTGGGCCAACCAGTTCGACAATATCGCCAACCGTCAGGCG
CATATCGAGACGACCGCGCCTGAGATCTGGGACCAGACGGACGGCAAGGTCGATGGCTTCATATGCTCGGTCGGTTCCGG
CGGAACACTGGCCGGCGTCGCCGACGGCCTGCGCGATTTCAATCCCGACATCAAGATCGGTCTTGCCGACCCTGAAGGTG
CCGCCCTTTATGAATTTTACAAACACGGCGTCCTGAAGTCCGAAGGCTCCTCCATTACCGAAGGCATCGGACAGGGGCGC
ATCACCGCCAATCTGGAAGGGTTCGCACCGGATTTCTCCTATCGTATTTCGGACGCGGAAGCGCTGCCGGTGCTGTTCGA
TCTGGTCACGAAAGAAGGCCTGTGCCTCGGCGGTTCTTCCGGCATCAACATTGCCGGCGCAATCCGCCTTGCCCGTGAGC
TCGGTCCGGGGCATACAATCGTGACGATACTGTGCGACTACGGTAATCGTTATCAGTCGAAGCTCTTCAATCCGGATTTC
CTGCGCTCCAAGGGGCTTCCCGTGCCGCAGTGGCTGGCGACCAAGAGCGAGATTCCGGTTCCCTACGAAACCGTTTGA

Upstream 100 bases:

>100_bases
GCGTGGCTAAGCCCGAGCCGGGAAGATAATTTCTTGCCTTGAGGCGGTTGTAACAGGACATAACGGCACCTAATTTCCGC
TCAGACAAGAAGGCTCGATC

Downstream 100 bases:

>100_bases
GGACATGCCGAAATGCCTGTGAATGCCCTGTTCCGTGACGATTTTTATCTTTCTACCGCAGAAGCGATCGTCACGGCGGT
GCATGAGGATGGCGGCATCG

Product: cysteine synthase A

Products: NA

Alternate protein names: CSase; O-acetylserine (thiol)-lyase; OAS-TL; O-acetylserine sulfhydrylase [H]

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTIHSSALSAIGNTPLIRLKAASEATGCEILGKAEFLNPGQSVKDRAALYIIRDAERRGQLRPGGTIVEGTAGNTGIGLS
LVANALGYKTVIVIPETQSQEKKDALKLLGAKLVEVPAAPYSNPNNYVKVSGRLAKQLAATDENGAIWANQFDNIANRQA
HIETTAPEIWDQTDGKVDGFICSVGSGGTLAGVADGLRDFNPDIKIGLADPEGAALYEFYKHGVLKSEGSSITEGIGQGR
ITANLEGFAPDFSYRISDAEALPVLFDLVTKEGLCLGGSSGINIAGAIRLARELGPGHTIVTILCDYGNRYQSKLFNPDF
LRSKGLPVPQWLATKSEIPVPYETV

Sequences:

>Translated_345_residues
MTIHSSALSAIGNTPLIRLKAASEATGCEILGKAEFLNPGQSVKDRAALYIIRDAERRGQLRPGGTIVEGTAGNTGIGLS
LVANALGYKTVIVIPETQSQEKKDALKLLGAKLVEVPAAPYSNPNNYVKVSGRLAKQLAATDENGAIWANQFDNIANRQA
HIETTAPEIWDQTDGKVDGFICSVGSGGTLAGVADGLRDFNPDIKIGLADPEGAALYEFYKHGVLKSEGSSITEGIGQGR
ITANLEGFAPDFSYRISDAEALPVLFDLVTKEGLCLGGSSGINIAGAIRLARELGPGHTIVTILCDYGNRYQSKLFNPDF
LRSKGLPVPQWLATKSEIPVPYETV
>Mature_344_residues
TIHSSALSAIGNTPLIRLKAASEATGCEILGKAEFLNPGQSVKDRAALYIIRDAERRGQLRPGGTIVEGTAGNTGIGLSL
VANALGYKTVIVIPETQSQEKKDALKLLGAKLVEVPAAPYSNPNNYVKVSGRLAKQLAATDENGAIWANQFDNIANRQAH
IETTAPEIWDQTDGKVDGFICSVGSGGTLAGVADGLRDFNPDIKIGLADPEGAALYEFYKHGVLKSEGSSITEGIGQGRI
TANLEGFAPDFSYRISDAEALPVLFDLVTKEGLCLGGSSGINIAGAIRLARELGPGHTIVTILCDYGNRYQSKLFNPDFL
RSKGLPVPQWLATKSEIPVPYETV

Specific function: Two Cysteine Synthase Enzymes Are Found. Both Catalyze The Same Reaction. Cysteine Synthase B Can Also Use Thiosulfate In Place Of Sulfide To Give Cysteine Thiosulfonate As A Product. [C]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=323, Percent_Identity=40.8668730650155, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI295821200, Length=323, Percent_Identity=40.8668730650155, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI4557415, Length=323, Percent_Identity=40.8668730650155, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI11345492, Length=211, Percent_Identity=27.9620853080569, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI2367138, Length=316, Percent_Identity=36.3924050632911, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1788754, Length=319, Percent_Identity=38.2445141065831, Blast_Score=151, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17535051, Length=305, Percent_Identity=36.0655737704918, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17562970, Length=315, Percent_Identity=36.5079365079365, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI32566674, Length=305, Percent_Identity=37.0491803278689, Blast_Score=164, Evalue=5e-41,
Organism=Caenorhabditis elegans, GI17534315, Length=339, Percent_Identity=34.5132743362832, Blast_Score=161, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI115535073, Length=326, Percent_Identity=35.5828220858896, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25147552, Length=335, Percent_Identity=32.5373134328358, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17561720, Length=331, Percent_Identity=33.5347432024169, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI32566672, Length=231, Percent_Identity=32.9004329004329, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71996324, Length=333, Percent_Identity=26.7267267267267, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6321449, Length=325, Percent_Identity=40.9230769230769, Blast_Score=202, Evalue=8e-53,
Organism=Saccharomyces cerevisiae, GI6321594, Length=334, Percent_Identity=32.6347305389222, Blast_Score=165, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24643623, Length=333, Percent_Identity=36.9369369369369, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI20129101, Length=333, Percent_Identity=36.9369369369369, Blast_Score=180, Evalue=1e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005859
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 36566; Mature: 36435

Theoretical pI: Translated: 5.46; Mature: 5.46

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.3 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.0 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIHSSALSAIGNTPLIRLKAASEATGCEILGKAEFLNPGQSVKDRAALYIIRDAERRGQ
CCCCHHHHHHHCCCCEEEEEECCCCCCCEEEECHHHCCCCCCCCCCEEEEEEEEHHHCCC
LRPGGTIVEGTAGNTGIGLSLVANALGYKTVIVIPETQSQEKKDALKLLGAKLVEVPAAP
CCCCCEEEECCCCCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCC
YSNPNNYVKVSGRLAKQLAATDENGAIWANQFDNIANRQAHIETTAPEIWDQTDGKVDGF
CCCCCCEEEECHHHHHHHHCCCCCCCEEHHHHHHHHCCEEEEECCCCHHHCCCCCCCCEE
ICSVGSGGTLAGVADGLRDFNPDIKIGLADPEGAALYEFYKHGVLKSEGSSITEGIGQGR
EEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCE
ITANLEGFAPDFSYRISDAEALPVLFDLVTKEGLCLGGSSGINIAGAIRLARELGPGHTI
EEEECCCCCCCCEEEECCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHCCCCCEE
VTILCDYGNRYQSKLFNPDFLRSKGLPVPQWLATKSEIPVPYETV
EEEEECCCCHHHHHCCCCHHHHHCCCCCCHHHCCCCCCCCCCCCC
>Mature Secondary Structure 
TIHSSALSAIGNTPLIRLKAASEATGCEILGKAEFLNPGQSVKDRAALYIIRDAERRGQ
CCCHHHHHHHCCCCEEEEEECCCCCCCEEEECHHHCCCCCCCCCCEEEEEEEEHHHCCC
LRPGGTIVEGTAGNTGIGLSLVANALGYKTVIVIPETQSQEKKDALKLLGAKLVEVPAAP
CCCCCEEEECCCCCCCCHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCC
YSNPNNYVKVSGRLAKQLAATDENGAIWANQFDNIANRQAHIETTAPEIWDQTDGKVDGF
CCCCCCEEEECHHHHHHHHCCCCCCCEEHHHHHHHHCCEEEEECCCCHHHCCCCCCCCEE
ICSVGSGGTLAGVADGLRDFNPDIKIGLADPEGAALYEFYKHGVLKSEGSSITEGIGQGR
EEECCCCCCHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCE
ITANLEGFAPDFSYRISDAEALPVLFDLVTKEGLCLGGSSGINIAGAIRLARELGPGHTI
EEEECCCCCCCCEEEECCCCHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHCCCCCEE
VTILCDYGNRYQSKLFNPDFLRSKGLPVPQWLATKSEIPVPYETV
EEEEECCCCHHHHHCCCCHHHHHCCCCCCHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA