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The map label for this gene is hisD

Identifier: 15887885

GI number: 15887885

Start: 527870

End: 529168

Strand: Reverse

Name: hisD

Synonym: Atu0537

Alternate gene names: 15887885

Gene position: 529168-527870 (Counterclockwise)

Preceding gene: 159184360

Following gene: 15887884

Centisome position: 18.62

GC content: 62.43

Gene sequence:

>1299_bases
GTGGCAATCTGGCTGGAGCGGGCATCGGCTGATTTCGAACAGAAATTCGCTGCCTTCCTGACAACCAAGAGAGAAGTTTC
CGAAGACGTCAACGCGACGGTTCGCGACATCATCAACGATGTCCGTCATCGCGGCGATGCGGCCCTTGCCCATTATTCCC
AGAAATTCGACGGCATTGATTTTACCAGGGTTTCGATGCGCGTGACGGCGGATGAAATCGACGCCGCGTTTTCGGCAGTC
GACAGGGCCGTCATCGAGGCGCTTGAACTCGCAGCCCGGCGTATCGAAAAACACCATGCGCGGCAGATGCCGAAGGATGA
CATCTACGAGGACGATATCGGCGTGGGCCTCGGCTCGCGCTGGACCGCCATCGAGGCCGTGGGGCTTTATGTACCCGGCG
GCACGGCGAGCTACCCGAGCTCGGTGCTGATGAATGCCGTACCGGCAAAGGTCGCCGGCGTGGAGCGTATCGTCATGGTC
GTGCCGGCCAATGGCGGTGCGGTCAATCCCGCGGTACTCGCTGCGGCACGTATTGCAGGCGTCGAGGAAATCTACCGTAT
TGGTGGCGCACAGGCTGTCGCCGCACTTGCCTATGGCACGGAGACCATCGCGCCGGTCGCCAAGATCGTCGGCCCGGGCA
ATGCCTATGTGGCGGCCGCCAAGCGGCAGGTCTTCGGCACTGTCGGTATCGATATGATCGCCGGACCTTCCGAAGTGCTT
GTTATTGCCGACAAGGACAATGATCCCGACTGGCTGGCCGCCGATCTTCTGGCGCAGGCGGAGCATGATCGCGGTGCCCA
ATCCATTCTCATCACCGATAATGCCGACCTCGGCAAGGCGGTGGGGGCAGCCGTCGAGCGGCAGCTGAAGCTTCTTTCGC
GTTCCGAGACGGCGGCGGCCAGCTGGGCCGATTTCGGCGCGATCATTCTGGTCGAAAAACTCACCGACGCCATTCCGCTC
GCCAACCGCATTGCCGCCGAGCATCTGGAGCTTGCCGTCGATGACCCGGATGCCTTGATGGCCCACATCCGCAATGCCGG
GGCGATTTTCGTCGGGCGTCATACCCCTGAGGTGATCGGCGATTATGTCGGCGGTTCCAACCACGTTTTGCCGACGGCAC
GCTCGGCTCGCTTCTCCTCCGGCCTTTCGGTGCTGGATTTCGTCAAGCGCACGTCGATCCTGCGGCTCGGGCCCGAGCAG
TTGCGCCAGCTTGCGCCGGCGGCGATCACCCTTGCCCACTCGGAGGGGCTGGACGCGCATGCGCGCTCGGTCTCCATTCG
CCTCAATCCGGAAAGTTAA

Upstream 100 bases:

>100_bases
TGCCGTTTCGATTTATGCCACTTACCAGAGCCGTGATTATTGCGCGGCAAGTTCGTATACCTCGCGGGATCGCCCGCGGG
GACAATGAAAGGGTAATGGC

Downstream 100 bases:

>100_bases
GCGATGGCTTCAGGCGATTTCCGGCTCTGCGACGTGGTACTGGACGACAGCATCGGCCGGTCCACGCCTGATGTGGAGCA
TGAACGCGCCGTCGCCATTT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MAIWLERASADFEQKFAAFLTTKREVSEDVNATVRDIINDVRHRGDAALAHYSQKFDGIDFTRVSMRVTADEIDAAFSAV
DRAVIEALELAARRIEKHHARQMPKDDIYEDDIGVGLGSRWTAIEAVGLYVPGGTASYPSSVLMNAVPAKVAGVERIVMV
VPANGGAVNPAVLAAARIAGVEEIYRIGGAQAVAALAYGTETIAPVAKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEVL
VIADKDNDPDWLAADLLAQAEHDRGAQSILITDNADLGKAVGAAVERQLKLLSRSETAAASWADFGAIILVEKLTDAIPL
ANRIAAEHLELAVDDPDALMAHIRNAGAIFVGRHTPEVIGDYVGGSNHVLPTARSARFSSGLSVLDFVKRTSILRLGPEQ
LRQLAPAAITLAHSEGLDAHARSVSIRLNPES

Sequences:

>Translated_432_residues
MAIWLERASADFEQKFAAFLTTKREVSEDVNATVRDIINDVRHRGDAALAHYSQKFDGIDFTRVSMRVTADEIDAAFSAV
DRAVIEALELAARRIEKHHARQMPKDDIYEDDIGVGLGSRWTAIEAVGLYVPGGTASYPSSVLMNAVPAKVAGVERIVMV
VPANGGAVNPAVLAAARIAGVEEIYRIGGAQAVAALAYGTETIAPVAKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEVL
VIADKDNDPDWLAADLLAQAEHDRGAQSILITDNADLGKAVGAAVERQLKLLSRSETAAASWADFGAIILVEKLTDAIPL
ANRIAAEHLELAVDDPDALMAHIRNAGAIFVGRHTPEVIGDYVGGSNHVLPTARSARFSSGLSVLDFVKRTSILRLGPEQ
LRQLAPAAITLAHSEGLDAHARSVSIRLNPES
>Mature_431_residues
AIWLERASADFEQKFAAFLTTKREVSEDVNATVRDIINDVRHRGDAALAHYSQKFDGIDFTRVSMRVTADEIDAAFSAVD
RAVIEALELAARRIEKHHARQMPKDDIYEDDIGVGLGSRWTAIEAVGLYVPGGTASYPSSVLMNAVPAKVAGVERIVMVV
PANGGAVNPAVLAAARIAGVEEIYRIGGAQAVAALAYGTETIAPVAKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEVLV
IADKDNDPDWLAADLLAQAEHDRGAQSILITDNADLGKAVGAAVERQLKLLSRSETAAASWADFGAIILVEKLTDAIPLA
NRIAAEHLELAVDDPDALMAHIRNAGAIFVGRHTPEVIGDYVGGSNHVLPTARSARFSSGLSVLDFVKRTSILRLGPEQL
RQLAPAAITLAHSEGLDAHARSVSIRLNPES

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=425, Percent_Identity=40.9411764705882, Blast_Score=298, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6319819, Length=406, Percent_Identity=41.6256157635468, Blast_Score=273, Evalue=5e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_AGRT5 (Q8UHX1)

Other databases:

- EMBL:   AE007869
- PIR:   AE2642
- PIR:   F97424
- RefSeq:   NP_353566.1
- ProteinModelPortal:   Q8UHX1
- SMR:   Q8UHX1
- STRING:   Q8UHX1
- GeneID:   1132575
- GenomeReviews:   AE007869_GR
- KEGG:   atu:Atu0537
- eggNOG:   COG0141
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- PhylomeDB:   Q8UHX1
- ProtClustDB:   PRK00877
- BioCyc:   ATUM176299-1:ATU0537-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 45806; Mature: 45675

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 327-327 ACT_SITE 328-328 BINDING 130-130 BINDING 191-191 BINDING 214-214 BINDING 237-237 BINDING 259-259 BINDING 262-262 BINDING 328-328 BINDING 361-361 BINDING 415-415 BINDING 420-420

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIWLERASADFEQKFAAFLTTKREVSEDVNATVRDIINDVRHRGDAALAHYSQKFDGID
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
FTRVSMRVTADEIDAAFSAVDRAVIEALELAARRIEKHHARQMPKDDIYEDDIGVGLGSR
EEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
WTAIEAVGLYVPGGTASYPSSVLMNAVPAKVAGVERIVMVVPANGGAVNPAVLAAARIAG
CEEEEEEEEEECCCCCCCCHHHHHHHCCHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHH
VEEIYRIGGAQAVAALAYGTETIAPVAKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEVL
HHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCEECCCCEEE
VIADKDNDPDWLAADLLAQAEHDRGAQSILITDNADLGKAVGAAVERQLKLLSRSETAAA
EEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHH
SWADFGAIILVEKLTDAIPLANRIAAEHLELAVDDPDALMAHIRNAGAIFVGRHTPEVIG
HHHHCCHHEEHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHCCCEEEEECCCHHHHH
DYVGGSNHVLPTARSARFSSGLSVLDFVKRTSILRLGPEQLRQLAPAAITLAHSEGLDAH
HHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCHHEEEECCCCCCCC
ARSVSIRLNPES
CEEEEEEECCCC
>Mature Secondary Structure 
AIWLERASADFEQKFAAFLTTKREVSEDVNATVRDIINDVRHRGDAALAHYSQKFDGID
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCC
FTRVSMRVTADEIDAAFSAVDRAVIEALELAARRIEKHHARQMPKDDIYEDDIGVGLGSR
EEEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
WTAIEAVGLYVPGGTASYPSSVLMNAVPAKVAGVERIVMVVPANGGAVNPAVLAAARIAG
CEEEEEEEEEECCCCCCCCHHHHHHHCCHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHH
VEEIYRIGGAQAVAALAYGTETIAPVAKIVGPGNAYVAAAKRQVFGTVGIDMIAGPSEVL
HHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCCCEEHHHHHHHHHHCCCCEECCCCEEE
VIADKDNDPDWLAADLLAQAEHDRGAQSILITDNADLGKAVGAAVERQLKLLSRSETAAA
EEEECCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCHHHH
SWADFGAIILVEKLTDAIPLANRIAAEHLELAVDDPDALMAHIRNAGAIFVGRHTPEVIG
HHHHCCHHEEHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHCCCEEEEECCCHHHHH
DYVGGSNHVLPTARSARFSSGLSVLDFVKRTSILRLGPEQLRQLAPAAITLAHSEGLDAH
HHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHCCHHEEEECCCCCCCC
ARSVSIRLNPES
CEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11743193; 11743194