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The map label for this gene is metC [H]

Identifier: 57652618

GI number: 57652618

Start: 436024

End: 437184

Strand: Reverse

Name: metC [H]

Synonym: SACOL0430

Alternate gene names: 57652618

Gene position: 437184-436024 (Counterclockwise)

Preceding gene: 57652619

Following gene: 57652617

Centisome position: 15.56

GC content: 37.9

Gene sequence:

>1161_bases
ATGACACTTTCAAAAGAGACAGAAGTGATATTCGATTGGCGTAGAGGTGTGGAATATCATTCAGCTAACCCACCACTCTA
TGATTCTTCAACATTCCATCAAACAAGTCTTGGTGGCGATGTTAAATATGATTATGCACGAAGTGGCAACCCTAACCGTG
AACTTTTAGAAGAGAAGTTAGCACGATTAGAACAGGGAAAATTCGCTTTTGCTTTTGCATCAGGTATTGCTGCTATTTCA
GCAGTACTTTTGACTTTCAAATCTGGTGATCATGTCATCTTACCCGATGATGTATATGGCGGTACTTTTCGCCTCACTGA
GCAAATTTTGAATCGATTTAATATTGAATTTACAACCGTAGATACTACAAAGCTCGAACAAATCGAGGGTGCCATTCAAT
CAAACACAAAATTAATTTATATCGAAACACCATCGAATCCCTGTTTTAAAATTACTGATATCAAAGCTGTTTCTAAAATA
GCCGAAAAGCATGAACTACTGGTAGCTGTGGACAATACATTTATGACACCGTTAGGTCAATCACCTTTATTACTTGGCGC
TGATATTGTCATTCATAGTGCTACAAAATTTTTAAGTGGACATAGCGATTTAATTGCTGGTGCTGTCATAACTAATAATG
AGGCAATTAGTGACGCTCTTTATTTAATACAAAATGGTACAGGCAATATGTTATCTGCTCAGGATAGCTGGACACTTGCT
AAACATTTAAAAACTTTTCCAATCAGATTTAAACAATCTGTCGAAAACGCTCAAAAAATCGTGTCATTTTTAATAAAGCA
AGATGAAATTTCAGAAGTTTATTATCCGGGACTCACTACTGCTCATTTAGAACAAGCTAAAAATGGCGGTGCCGTTATTG
GCTTTCGTTTAGCTGATGAGTCTAAAGCACAACAATTTGTCGATGCACTGACATTACCACTCGTTTCAGTGAGTCTGGGC
GGTGTTGAAACGATCCTTTCACATCCAGCAACAATGTCTCACGCTGCACTACCTGAAGAAGTGAGACAAGAACGTGGTAT
CACTTTCGGTCTATTCCGATTAAGTGTTGGTCTCGAAGATCCTGATGAACTCATTGCAGACATCAAATACGCATTAAAGG
AGGCATTCAATGAGTCAATTCCTCACACAATTGAAAGATAA

Upstream 100 bases:

>100_bases
ATGAGTATTTAATCCGCTTATCACTAGGTGTTGAAAATTATGAAGACATCGAACGCGATATCATCCAAGCATTAGATAAA
GCTCAGATTGGAGAGATTGT

Downstream 100 bases:

>100_bases
TGTTTTAGTAGCTGATGGCGCTATAGGAACCATTTTATACTCTGAAGGATTAGACACCTGTCCAGAAGCATATAATCTTA
GCCATCCAGATAAAGTTGAA

Product: trans-sulfuration enzyme family protein

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 386; Mature: 385

Protein sequence:

>386_residues
MTLSKETEVIFDWRRGVEYHSANPPLYDSSTFHQTSLGGDVKYDYARSGNPNRELLEEKLARLEQGKFAFAFASGIAAIS
AVLLTFKSGDHVILPDDVYGGTFRLTEQILNRFNIEFTTVDTTKLEQIEGAIQSNTKLIYIETPSNPCFKITDIKAVSKI
AEKHELLVAVDNTFMTPLGQSPLLLGADIVIHSATKFLSGHSDLIAGAVITNNEAISDALYLIQNGTGNMLSAQDSWTLA
KHLKTFPIRFKQSVENAQKIVSFLIKQDEISEVYYPGLTTAHLEQAKNGGAVIGFRLADESKAQQFVDALTLPLVSVSLG
GVETILSHPATMSHAALPEEVRQERGITFGLFRLSVGLEDPDELIADIKYALKEAFNESIPHTIER

Sequences:

>Translated_386_residues
MTLSKETEVIFDWRRGVEYHSANPPLYDSSTFHQTSLGGDVKYDYARSGNPNRELLEEKLARLEQGKFAFAFASGIAAIS
AVLLTFKSGDHVILPDDVYGGTFRLTEQILNRFNIEFTTVDTTKLEQIEGAIQSNTKLIYIETPSNPCFKITDIKAVSKI
AEKHELLVAVDNTFMTPLGQSPLLLGADIVIHSATKFLSGHSDLIAGAVITNNEAISDALYLIQNGTGNMLSAQDSWTLA
KHLKTFPIRFKQSVENAQKIVSFLIKQDEISEVYYPGLTTAHLEQAKNGGAVIGFRLADESKAQQFVDALTLPLVSVSLG
GVETILSHPATMSHAALPEEVRQERGITFGLFRLSVGLEDPDELIADIKYALKEAFNESIPHTIER
>Mature_385_residues
TLSKETEVIFDWRRGVEYHSANPPLYDSSTFHQTSLGGDVKYDYARSGNPNRELLEEKLARLEQGKFAFAFASGIAAISA
VLLTFKSGDHVILPDDVYGGTFRLTEQILNRFNIEFTTVDTTKLEQIEGAIQSNTKLIYIETPSNPCFKITDIKAVSKIA
EKHELLVAVDNTFMTPLGQSPLLLGADIVIHSATKFLSGHSDLIAGAVITNNEAISDALYLIQNGTGNMLSAQDSWTLAK
HLKTFPIRFKQSVENAQKIVSFLIKQDEISEVYYPGLTTAHLEQAKNGGAVIGFRLADESKAQQFVDALTLPLVSVSLGG
VETILSHPATMSHAALPEEVRQERGITFGLFRLSVGLEDPDELIADIKYALKEAFNESIPHTIER

Specific function: Catalyzes the transformation of cystathionine into homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=368, Percent_Identity=38.8586956521739, Blast_Score=247, Evalue=1e-65,
Organism=Homo sapiens, GI299473759, Length=368, Percent_Identity=34.2391304347826, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI25453487, Length=367, Percent_Identity=33.2425068119891, Blast_Score=182, Evalue=6e-46,
Organism=Escherichia coli, GI1790375, Length=365, Percent_Identity=37.2602739726027, Blast_Score=247, Evalue=7e-67,
Organism=Escherichia coli, GI1789383, Length=344, Percent_Identity=27.0348837209302, Blast_Score=124, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17560056, Length=362, Percent_Identity=44.475138121547, Blast_Score=289, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17538055, Length=345, Percent_Identity=41.1594202898551, Blast_Score=269, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI71980708, Length=368, Percent_Identity=36.1413043478261, Blast_Score=220, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6319307, Length=367, Percent_Identity=40.3269754768392, Blast_Score=271, Evalue=1e-73,
Organism=Saccharomyces cerevisiae, GI6321254, Length=407, Percent_Identity=32.4324324324324, Blast_Score=190, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6323333, Length=393, Percent_Identity=30.2798982188295, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6321170, Length=259, Percent_Identity=31.2741312741313, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6321904, Length=338, Percent_Identity=30.1775147928994, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6322590, Length=301, Percent_Identity=25.9136212624585, Blast_Score=84, Evalue=5e-17,
Organism=Saccharomyces cerevisiae, GI6322970, Length=344, Percent_Identity=26.1627906976744, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323557, Length=310, Percent_Identity=25.1612903225806, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI19922554, Length=360, Percent_Identity=41.1111111111111, Blast_Score=281, Evalue=7e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42489; Mature: 42357

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLSKETEVIFDWRRGVEYHSANPPLYDSSTFHQTSLGGDVKYDYARSGNPNRELLEEKL
CCCCCCCCEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHH
ARLEQGKFAFAFASGIAAISAVLLTFKSGDHVILPDDVYGGTFRLTEQILNRFNIEFTTV
HHHHCCCEEEHHHHHHHHHHHHHHEECCCCEEEECCCCCCCHHHHHHHHHHHHCCEEEEE
DTTKLEQIEGAIQSNTKLIYIETPSNPCFKITDIKAVSKIAEKHELLVAVDNTFMTPLGQ
CHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEHHHHHHHHHHHCCEEEEECCCCCCCCCC
SPLLLGADIVIHSATKFLSGHSDLIAGAVITNNEAISDALYLIQNGTGNMLSAQDSWTLA
CCCEEECHHHHHHHHHHHCCCCHHEEEEEEECCHHHHHHEEEEECCCCCEECCCCCHHHH
KHLKTFPIRFKQSVENAQKIVSFLIKQDEISEVYYPGLTTAHLEQAKNGGAVIGFRLADE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEEECCH
SKAQQFVDALTLPLVSVSLGGVETILSHPATMSHAALPEEVRQERGITFGLFRLSVGLED
HHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHCCCHHHHHHCCCEEEEEEEEECCCC
PDELIADIKYALKEAFNESIPHTIER
HHHHHHHHHHHHHHHHHCCCCHHHCC
>Mature Secondary Structure 
TLSKETEVIFDWRRGVEYHSANPPLYDSSTFHQTSLGGDVKYDYARSGNPNRELLEEKL
CCCCCCCEEEEHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHH
ARLEQGKFAFAFASGIAAISAVLLTFKSGDHVILPDDVYGGTFRLTEQILNRFNIEFTTV
HHHHCCCEEEHHHHHHHHHHHHHHEECCCCEEEECCCCCCCHHHHHHHHHHHHCCEEEEE
DTTKLEQIEGAIQSNTKLIYIETPSNPCFKITDIKAVSKIAEKHELLVAVDNTFMTPLGQ
CHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEHHHHHHHHHHHCCEEEEECCCCCCCCCC
SPLLLGADIVIHSATKFLSGHSDLIAGAVITNNEAISDALYLIQNGTGNMLSAQDSWTLA
CCCEEECHHHHHHHHHHHCCCCHHEEEEEEECCHHHHHHEEEEECCCCCEECCCCCHHHH
KHLKTFPIRFKQSVENAQKIVSFLIKQDEISEVYYPGLTTAHLEQAKNGGAVIGFRLADE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCEEEEEEECCH
SKAQQFVDALTLPLVSVSLGGVETILSHPATMSHAALPEEVRQERGITFGLFRLSVGLED
HHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCHHHHCCCHHHHHHCCCEEEEEEEEECCCC
PDELIADIKYALKEAFNESIPHTIER
HHHHHHHHHHHHHHHHHCCCCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]