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The map label for this gene is panE [C]

Identifier: 57652335

GI number: 57652335

Start: 2672486

End: 2673346

Strand: Direct

Name: panE [C]

Synonym: SACOL2616

Alternate gene names: 57652335

Gene position: 2672486-2673346 (Clockwise)

Preceding gene: 57652331

Following gene: 57652338

Centisome position: 95.13

GC content: 37.86

Gene sequence:

>861_bases
ATGTTATCAGTTGCGATTATCGGCCCAGGCGCTGTCGGTACAACTATTGCCTATGAATTACAACAATCATTGCCTCATAC
AACGCTTATCGGGAGACACGCCAAAACAATAACATATTATACTGTACCACATGCACCTGCACAAGATATTGTTGTGAAAG
GTTATGAAGATGTCACAAACACATTTGATGTTATTATTATTGCAGTCAAAACACATCAACTTGATGCAGTTATTCCTCAT
TTAACTCATCTTGCACATGAGGACACGCTCATCATTTTAGCCCAAAATGGTTATGGTCAACTCGAACATATTTCATTTAA
AAACGTATGCCAAGCAGTTGTCTATATAAGTGGTCAAAAGAAAGGCGATGTTGTTACGCACTTCAGAGATTATCAATTAC
GTATACAAGATAATGCATTAACTCGACAATTTAGAGATTTGGTCCAAGACAGTCAAATCGACATTGTATTAGAAGCAAAT
ATTCAACAAGCTATTTGGTATAAATTGTTAGTTAACTTGGGCATTAATTCTATCACAGCACTCGGTAGACAGACCGTTGC
AATCATGCATAATCCTGAAATACGTACACTGTGTAGACAGCTATTACTAGATGGTTGTCGTGTTGCACAGGCAGAGGGGT
TAAACTTTTCAGAACAAACTGTCGATACTATTATGACTATATATCAAGGTTATCCCGACGAAATGGGAACGAGCATGTAT
TACGACATTGCGCATCAGCAACCTCTTGAAGTCGAAGCGATTCAAGGCTTTATTTATCGACGTGCACGTGAACACAATCT
TGACACCCCATATCTTGATACTATTTATAGCTTTTTACGCGCGTATCAACAAAATATGTAA

Upstream 100 bases:

>100_bases
TATCTATTAATTGACTTACTGTTTTCAATGTTATTCAACCTCTTTTTGCAGTATTATTAGAAATAGTATAATGAATCTTT
TATAGAAAGGAAAGAAGAAG

Downstream 100 bases:

>100_bases
GCACATATATAATATAAAAAGACCTTAACGATGCATTTAGAACCACCTGTTCCTAATATCGCTAAGGTCTTTTAATTATA
TTAGACTATTCAGCTTCTCT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MLSVAIIGPGAVGTTIAYELQQSLPHTTLIGRHAKTITYYTVPHAPAQDIVVKGYEDVTNTFDVIIIAVKTHQLDAVIPH
LTHLAHEDTLIILAQNGYGQLEHISFKNVCQAVVYISGQKKGDVVTHFRDYQLRIQDNALTRQFRDLVQDSQIDIVLEAN
IQQAIWYKLLVNLGINSITALGRQTVAIMHNPEIRTLCRQLLLDGCRVAQAEGLNFSEQTVDTIMTIYQGYPDEMGTSMY
YDIAHQQPLEVEAIQGFIYRRAREHNLDTPYLDTIYSFLRAYQQNM

Sequences:

>Translated_286_residues
MLSVAIIGPGAVGTTIAYELQQSLPHTTLIGRHAKTITYYTVPHAPAQDIVVKGYEDVTNTFDVIIIAVKTHQLDAVIPH
LTHLAHEDTLIILAQNGYGQLEHISFKNVCQAVVYISGQKKGDVVTHFRDYQLRIQDNALTRQFRDLVQDSQIDIVLEAN
IQQAIWYKLLVNLGINSITALGRQTVAIMHNPEIRTLCRQLLLDGCRVAQAEGLNFSEQTVDTIMTIYQGYPDEMGTSMY
YDIAHQQPLEVEAIQGFIYRRAREHNLDTPYLDTIYSFLRAYQQNM
>Mature_286_residues
MLSVAIIGPGAVGTTIAYELQQSLPHTTLIGRHAKTITYYTVPHAPAQDIVVKGYEDVTNTFDVIIIAVKTHQLDAVIPH
LTHLAHEDTLIILAQNGYGQLEHISFKNVCQAVVYISGQKKGDVVTHFRDYQLRIQDNALTRQFRDLVQDSQIDIVLEAN
IQQAIWYKLLVNLGINSITALGRQTVAIMHNPEIRTLCRQLLLDGCRVAQAEGLNFSEQTVDTIMTIYQGYPDEMGTSMY
YDIAHQQPLEVEAIQGFIYRRAREHNLDTPYLDTIYSFLRAYQQNM

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=235, Percent_Identity=25.531914893617, Blast_Score=68, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 32358; Mature: 32358

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLSVAIIGPGAVGTTIAYELQQSLPHTTLIGRHAKTITYYTVPHAPAQDIVVKGYEDVTN
CEEEEEECCCCHHHHHHHHHHHHCCCHHEECCCCEEEEEEECCCCCCCHHEEECHHHHCC
TFDVIIIAVKTHQLDAVIPHLTHLAHEDTLIILAQNGYGQLEHISFKNVCQAVVYISGQK
CEEEEEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCHHHHHHHHHEECCCC
KGDVVTHFRDYQLRIQDNALTRQFRDLVQDSQIDIVLEANIQQAIWYKLLVNLGINSITA
CCCEEEEEEEEEEEECCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCHHHHH
LGRQTVAIMHNPEIRTLCRQLLLDGCRVAQAEGLNFSEQTVDTIMTIYQGYPDEMGTSMY
HCCCEEEEEECCCHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHCCCEE
YDIAHQQPLEVEAIQGFIYRRAREHNLDTPYLDTIYSFLRAYQQNM
EECCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLSVAIIGPGAVGTTIAYELQQSLPHTTLIGRHAKTITYYTVPHAPAQDIVVKGYEDVTN
CEEEEEECCCCHHHHHHHHHHHHCCCHHEECCCCEEEEEEECCCCCCCHHEEECHHHHCC
TFDVIIIAVKTHQLDAVIPHLTHLAHEDTLIILAQNGYGQLEHISFKNVCQAVVYISGQK
CEEEEEEEEECCCHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCHHHHHHHHHEECCCC
KGDVVTHFRDYQLRIQDNALTRQFRDLVQDSQIDIVLEANIQQAIWYKLLVNLGINSITA
CCCEEEEEEEEEEEECCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHCCCHHHHH
LGRQTVAIMHNPEIRTLCRQLLLDGCRVAQAEGLNFSEQTVDTIMTIYQGYPDEMGTSMY
HCCCEEEEEECCCHHHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHCCCEE
YDIAHQQPLEVEAIQGFIYRRAREHNLDTPYLDTIYSFLRAYQQNM
EECCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]