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The map label for this gene is pyrG

Identifier: 57652149

GI number: 57652149

Start: 2179335

End: 2180945

Strand: Reverse

Name: pyrG

Synonym: SACOL2119

Alternate gene names: 57652149

Gene position: 2180945-2179335 (Counterclockwise)

Preceding gene: 57652150

Following gene: 57652147

Centisome position: 77.63

GC content: 33.89

Gene sequence:

>1611_bases
ATGACAAAATTTATTTTTGTAACAGGTGGCGTAGTTTCATCATTAGGGAAGGGTATTACAGCATCTTCTCTAGGTAGATT
ATTAAAAGATAGAGGTCTAAATGTAACAATTCAAAAATTCGATCCATACTTAAATGTTGACCCAGGTACAATGAGTCCTT
ATCAACATGGTGAAGTATTCGTAACGGATGATGGTGCAGAAACTGACCTAGACTTAGGACATTACGAAAGATTTATTGAT
ATTAATTTAAACAAGTTTTCAAATGTGACAGCCGGTAAAGTGTATTCACACGTATTGAAAAAAGAACGTCGTGGTGATTA
CTTAGGCGGAACAGTTCAAGTTATTCCGCATATTACAAATGAAATTAAAGAACGTTTATTACTTGCAGGGGAAAGTACGA
ATGCAGACGTTGTTATCACTGAAATTGGCGGTACAACAGGTGATATTGAGTCATTACCGTTTATTGAAGCGATTCGTCAA
ATTCGTAGCGATTTAGGTAGAGAAAATGTTATGTATGTTCACTGTACATTACTGCCTTATATTAAAGCTGCTGGAGAAAT
GAAAACGAAGCCAACACAACATAGTGTTAAAGAATTACGAGGCTTAGGTATTCAACCAGACTTAATCGTTGTAAGAACTG
AATATGAAATGACACAAGATTTAAAAGATAAAATTGCATTATTCTGTGACATTAATAAAGAAAGTGTTATTGAATGTCGT
GATGCAGACTCTTTATACGAAATTCCATTACAATTAAGCCAACAAAATATGGATGATATCGTTATTAAACGTTTACAATT
AAACGCGAAATATGAAACACAGCTTGATGAATGGAAACAGTTGTTAGATATCGTTAATAATTTAGATGGTAAAATTACAA
TTGGTTTAGTAGGTAAATATGTTAGCTTACAAGATGCATATTTATCAGTTGTTGAATCATTGAAACATGCTGGATATCCT
TTTGCCAAAGATATTGACATTAGATGGATTGATTCAAGTGAAGTAACAGATGAAAATGCAGCCGAATACCTTGCAGATGT
CGACGGTATTTTAGTACCAGGTGGATTTGGTTTCCGTGCAAGTGAAGGTAAAATTAGTGCAATTAAGTATGCTAGAGAAA
ACAATGTACCATTCTTTGGTATTTGTTTAGGAATGCAACTTGCAACAGTTGAATTTTCAAGAAACGTATTAGGCCTTGAA
GGCGCACATTCAGCTGAATTAGACCCAGCAACACCATACCCAATTATAGATTTATTACCAGAACAAAAAGATATCGAAGA
TTTAGGTGGTACATTACGCTTAGGCTTATATCCATGTTCAATTAAAGAAGGCACATTGGCACAAGATGTTTATGGTAAAG
CGGAAATTGAAGAAAGACATCGTCATCGTTATGAATTTAATAATGACTATAGAGAACAATTAGAAGCAAATGGTATGGTG
ATTTCTGGTACAAGTCCAGATGGACGTTTAGTAGAAATGGTAGAGATTCCGACAAATGATTTCTTTATTGCTTGTCAATT
CCACCCAGAATTCTTATCTAGACCAAATCGTCCGCACCCGATTTTTAAATCATTTATTGAAGCTTCATTAAAATATCAAC
AAAATAAATAA

Upstream 100 bases:

>100_bases
ACAAATAAACAACTTGAATGAGCTTGCTTTAATGTTATGTTTTACGTAATTTTTACAATTGATGAGGAAGCATTCCCTTT
AATAATTAGGAGGTCAAGAC

Downstream 100 bases:

>100_bases
ATTTGCTAATAAAACCGGTACTTTCATTGTTAAACATTGAAAGTACCGGTTTTTCGTATAATTTTAATATTATGTTAGTG
ACAAGGTATGAAATAACAAT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MTKFIFVTGGVVSSLGKGITASSLGRLLKDRGLNVTIQKFDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFID
INLNKFSNVTAGKVYSHVLKKERRGDYLGGTVQVIPHITNEIKERLLLAGESTNADVVITEIGGTTGDIESLPFIEAIRQ
IRSDLGRENVMYVHCTLLPYIKAAGEMKTKPTQHSVKELRGLGIQPDLIVVRTEYEMTQDLKDKIALFCDINKESVIECR
DADSLYEIPLQLSQQNMDDIVIKRLQLNAKYETQLDEWKQLLDIVNNLDGKITIGLVGKYVSLQDAYLSVVESLKHAGYP
FAKDIDIRWIDSSEVTDENAAEYLADVDGILVPGGFGFRASEGKISAIKYARENNVPFFGICLGMQLATVEFSRNVLGLE
GAHSAELDPATPYPIIDLLPEQKDIEDLGGTLRLGLYPCSIKEGTLAQDVYGKAEIEERHRHRYEFNNDYREQLEANGMV
ISGTSPDGRLVEMVEIPTNDFFIACQFHPEFLSRPNRPHPIFKSFIEASLKYQQNK

Sequences:

>Translated_536_residues
MTKFIFVTGGVVSSLGKGITASSLGRLLKDRGLNVTIQKFDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFID
INLNKFSNVTAGKVYSHVLKKERRGDYLGGTVQVIPHITNEIKERLLLAGESTNADVVITEIGGTTGDIESLPFIEAIRQ
IRSDLGRENVMYVHCTLLPYIKAAGEMKTKPTQHSVKELRGLGIQPDLIVVRTEYEMTQDLKDKIALFCDINKESVIECR
DADSLYEIPLQLSQQNMDDIVIKRLQLNAKYETQLDEWKQLLDIVNNLDGKITIGLVGKYVSLQDAYLSVVESLKHAGYP
FAKDIDIRWIDSSEVTDENAAEYLADVDGILVPGGFGFRASEGKISAIKYARENNVPFFGICLGMQLATVEFSRNVLGLE
GAHSAELDPATPYPIIDLLPEQKDIEDLGGTLRLGLYPCSIKEGTLAQDVYGKAEIEERHRHRYEFNNDYREQLEANGMV
ISGTSPDGRLVEMVEIPTNDFFIACQFHPEFLSRPNRPHPIFKSFIEASLKYQQNK
>Mature_535_residues
TKFIFVTGGVVSSLGKGITASSLGRLLKDRGLNVTIQKFDPYLNVDPGTMSPYQHGEVFVTDDGAETDLDLGHYERFIDI
NLNKFSNVTAGKVYSHVLKKERRGDYLGGTVQVIPHITNEIKERLLLAGESTNADVVITEIGGTTGDIESLPFIEAIRQI
RSDLGRENVMYVHCTLLPYIKAAGEMKTKPTQHSVKELRGLGIQPDLIVVRTEYEMTQDLKDKIALFCDINKESVIECRD
ADSLYEIPLQLSQQNMDDIVIKRLQLNAKYETQLDEWKQLLDIVNNLDGKITIGLVGKYVSLQDAYLSVVESLKHAGYPF
AKDIDIRWIDSSEVTDENAAEYLADVDGILVPGGFGFRASEGKISAIKYARENNVPFFGICLGMQLATVEFSRNVLGLEG
AHSAELDPATPYPIIDLLPEQKDIEDLGGTLRLGLYPCSIKEGTLAQDVYGKAEIEERHRHRYEFNNDYREQLEANGMVI
SGTSPDGRLVEMVEIPTNDFFIACQFHPEFLSRPNRPHPIFKSFIEASLKYQQNK

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=548, Percent_Identity=46.1678832116788, Blast_Score=504, Evalue=1e-142,
Organism=Homo sapiens, GI28559085, Length=547, Percent_Identity=45.5210237659963, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI28559083, Length=547, Percent_Identity=45.5210237659963, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI221316689, Length=547, Percent_Identity=45.5210237659963, Blast_Score=493, Evalue=1e-139,
Organism=Escherichia coli, GI1789142, Length=545, Percent_Identity=53.0275229357798, Blast_Score=591, Evalue=1e-170,
Organism=Caenorhabditis elegans, GI25148299, Length=603, Percent_Identity=37.9767827529022, Blast_Score=417, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6319432, Length=569, Percent_Identity=42.7065026362039, Blast_Score=475, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6322563, Length=560, Percent_Identity=43.0357142857143, Blast_Score=465, Evalue=1e-132,
Organism=Drosophila melanogaster, GI24664469, Length=548, Percent_Identity=45.6204379562044, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI21357815, Length=493, Percent_Identity=43.6105476673428, Blast_Score=413, Evalue=1e-115,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_STAA1 (A7X4X7)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442701.1
- ProteinModelPortal:   A7X4X7
- SMR:   A7X4X7
- STRING:   A7X4X7
- EnsemblBacteria:   EBSTAT00000003268
- GeneID:   5560100
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_2111
- eggNOG:   COG0504
- GeneTree:   EBGT00050000025253
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- BioCyc:   SAUR418127:SAHV_2111-MONOMER
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 59993; Mature: 59862

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 382-382 ACT_SITE 508-508 ACT_SITE 510-510

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKFIFVTGGVVSSLGKGITASSLGRLLKDRGLNVTIQKFDPYLNVDPGTMSPYQHGEVF
CCEEEEEECHHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDINLNKFSNVTAGKVYSHVLKKERRGDYLGGTVQVIPHITN
EECCCCCCCCCCCCCEEEEEEECHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHH
EIKERLLLAGESTNADVVITEIGGTTGDIESLPFIEAIRQIRSDLGRENVMYVHCTLLPY
HHHHHHEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEHHHH
IKAAGEMKTKPTQHSVKELRGLGIQPDLIVVRTEYEMTQDLKDKIALFCDINKESVIECR
HHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHCEEEEEECCCCCEEEEC
DADSLYEIPLQLSQQNMDDIVIKRLQLNAKYETQLDEWKQLLDIVNNLDGKITIGLVGKY
CCCCHHHCCHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCH
VSLQDAYLSVVESLKHAGYPFAKDIDIRWIDSSEVTDENAAEYLADVDGILVPGGFGFRA
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEECCCCCCCC
SEGKISAIKYARENNVPFFGICLGMQLATVEFSRNVLGLEGAHSAELDPATPYPIIDLLP
CCCCEEEEEEHHCCCCCEEEEECCCEEEEEECCCCEECCCCCCCCCCCCCCCCCHHHCCC
EQKDIEDLGGTLRLGLYPCSIKEGTLAQDVYGKAEIEERHRHRYEFNNDYREQLEANGMV
CCCCHHHCCCEEEEEEEECCCCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHCCCEE
ISGTSPDGRLVEMVEIPTNDFFIACQFHPEFLSRPNRPHPIFKSFIEASLKYQQNK
EECCCCCCCEEEEEEECCCCEEEEEEECHHHHCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKFIFVTGGVVSSLGKGITASSLGRLLKDRGLNVTIQKFDPYLNVDPGTMSPYQHGEVF
CEEEEEECHHHHHHCCCCCHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFIDINLNKFSNVTAGKVYSHVLKKERRGDYLGGTVQVIPHITN
EECCCCCCCCCCCCCEEEEEEECHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEEHHHHHH
EIKERLLLAGESTNADVVITEIGGTTGDIESLPFIEAIRQIRSDLGRENVMYVHCTLLPY
HHHHHHEEECCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEEHHHH
IKAAGEMKTKPTQHSVKELRGLGIQPDLIVVRTEYEMTQDLKDKIALFCDINKESVIECR
HHHCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHCEEEEEECCCCCEEEEC
DADSLYEIPLQLSQQNMDDIVIKRLQLNAKYETQLDEWKQLLDIVNNLDGKITIGLVGKY
CCCCHHHCCHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCH
VSLQDAYLSVVESLKHAGYPFAKDIDIRWIDSSEVTDENAAEYLADVDGILVPGGFGFRA
HHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEECCCCCCCC
SEGKISAIKYARENNVPFFGICLGMQLATVEFSRNVLGLEGAHSAELDPATPYPIIDLLP
CCCCEEEEEEHHCCCCCEEEEECCCEEEEEECCCCEECCCCCCCCCCCCCCCCCHHHCCC
EQKDIEDLGGTLRLGLYPCSIKEGTLAQDVYGKAEIEERHRHRYEFNNDYREQLEANGMV
CCCCHHHCCCEEEEEEEECCCCCCCCHHHHCCCHHHHHHHHHCCCCCCHHHHHHHCCCEE
ISGTSPDGRLVEMVEIPTNDFFIACQFHPEFLSRPNRPHPIFKSFIEASLKYQQNK
EECCCCCCCEEEEEEECCCCEEEEEEECHHHHCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA