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The map label for this gene is fbaA

Identifier: 57652147

GI number: 57652147

Start: 2177627

End: 2178487

Strand: Reverse

Name: fbaA

Synonym: SACOL2117

Alternate gene names: 57652147

Gene position: 2178487-2177627 (Counterclockwise)

Preceding gene: 57652149

Following gene: 57652146

Centisome position: 77.54

GC content: 36.59

Gene sequence:

>861_bases
ATGCCTTTAGTTTCAATGAAAGAAATGTTAATTGATGCAAAAGAAAATGGTTATGCGGTAGGTCAATACAATATTAATAA
CCTAGAATTCACTCAAGCAATTTTAGAAGCGTCACAAGAAGAAAATGCACCTGTAATTTTAGGTGTTTCTGAAGGTGCTG
CTCGTTACATGAGCGGTTTCTACACAATTGTTAAAATGGTTGAAGGGTTAATGCATGACTTAAACATCACTATTCCTGTA
GCAATCCATTTAGACCATGGTTCAAGCTTTGAAAAATGTAAAGAAGCTATCGATGCTGGTTTCACATCAGTAATGATCGA
TGCTTCACACAGCCCATTCGAAGAAAACGTAGCAACAACTAAAAAAGTTGTTGAATACGCTCATGAAAAAGGTGTTTCTG
TAGAAGCTGAATTAGGTACTGTTGGTGGACAAGAAGATGATGTTGTAGCAGACGGCATCATTTATGCTGATCCTAAAGAA
TGTCAAGAACTAGTTGAAAAAACTGGTATTGATGCATTAGCGCCAGCATTAGGTTCAGTTCATGGTCCATACAAAGGTGA
ACCAAAATTAGGATTTAAAGAAATGGAAGAAATCGGTTTATCTACAGGTTTACCATTAGTATTACACGGTGGTACTGGTA
TCCCGACTAAAGATATCCAAAAAGCAATTCCATTTGGTACAGCTAAAATTAACGTAAACACTGAAAACCAAATCGCTTCA
GCAAAAGCAGTTCGTGACGTTTTAAATAACGACAAAGAAGTTTACGATCCTCGTAAATACTTAGGACCTGCACGTGAAGC
CATCAAAGAAACAGTTAAAGGTAAAATTAAAGAGTTCGGTACTTCTAACCGCGCTAAATAA

Upstream 100 bases:

>100_bases
AAATACACATTTAATCTGCAGTATTTCAATGCATTGACGCTATTTTTTTGATATAATTACTTTGAAAAATACGTGCGTAA
GCACTCAAGGAGGAACTTTC

Downstream 100 bases:

>100_bases
TTAATATTTAGTCTTTAAGTTATTAATAACGTAGGGATATTAATTTTAAAAGAAGCAGACAAAATGGTGTTTGCTTCTTT
TTTATGTCGTATAAGTAATA

Product: fructose-bisphosphate aldolase

Products: NA

Alternate protein names: FBP aldolase; FBPA; Fructose-1,6-bisphosphate aldolase

Number of amino acids: Translated: 286; Mature: 285

Protein sequence:

>286_residues
MPLVSMKEMLIDAKENGYAVGQYNINNLEFTQAILEASQEENAPVILGVSEGAARYMSGFYTIVKMVEGLMHDLNITIPV
AIHLDHGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVGGQEDDVVADGIIYADPKE
CQELVEKTGIDALAPALGSVHGPYKGEPKLGFKEMEEIGLSTGLPLVLHGGTGIPTKDIQKAIPFGTAKINVNTENQIAS
AKAVRDVLNNDKEVYDPRKYLGPAREAIKETVKGKIKEFGTSNRAK

Sequences:

>Translated_286_residues
MPLVSMKEMLIDAKENGYAVGQYNINNLEFTQAILEASQEENAPVILGVSEGAARYMSGFYTIVKMVEGLMHDLNITIPV
AIHLDHGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVGGQEDDVVADGIIYADPKE
CQELVEKTGIDALAPALGSVHGPYKGEPKLGFKEMEEIGLSTGLPLVLHGGTGIPTKDIQKAIPFGTAKINVNTENQIAS
AKAVRDVLNNDKEVYDPRKYLGPAREAIKETVKGKIKEFGTSNRAK
>Mature_285_residues
PLVSMKEMLIDAKENGYAVGQYNINNLEFTQAILEASQEENAPVILGVSEGAARYMSGFYTIVKMVEGLMHDLNITIPVA
IHLDHGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVGGQEDDVVADGIIYADPKEC
QELVEKTGIDALAPALGSVHGPYKGEPKLGFKEMEEIGLSTGLPLVLHGGTGIPTKDIQKAIPFGTAKINVNTENQIASA
KAVRDVLNNDKEVYDPRKYLGPAREAIKETVKGKIKEFGTSNRAK

Specific function: Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3- phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis

COG id: COG0191

COG function: function code G; Fructose/tagatose bisphosphate aldolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class II fructose-bisphosphate aldolase family

Homologues:

Organism=Escherichia coli, GI87082041, Length=287, Percent_Identity=42.1602787456446, Blast_Score=231, Evalue=5e-62,
Organism=Escherichia coli, GI1789526, Length=286, Percent_Identity=41.2587412587413, Blast_Score=220, Evalue=8e-59,
Organism=Escherichia coli, GI1788072, Length=278, Percent_Identity=38.4892086330935, Blast_Score=174, Evalue=7e-45,
Organism=Escherichia coli, GI1789293, Length=329, Percent_Identity=25.8358662613982, Blast_Score=97, Evalue=9e-22,
Organism=Saccharomyces cerevisiae, GI6322790, Length=336, Percent_Identity=25.297619047619, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALF2_STAAC (Q5HE75)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_186932.1
- ProteinModelPortal:   Q5HE75
- SMR:   Q5HE75
- STRING:   Q5HE75
- EnsemblBacteria:   EBSTAT00000009224
- GeneID:   3237468
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL2117
- TIGR:   SACOL2117
- eggNOG:   COG0191
- GeneTree:   EBGT00050000024357
- HOGENOM:   HBG327581
- OMA:   IGKMREF
- ProtClustDB:   PRK08610
- BioCyc:   SAUR93062:SACOL2117-MONOMER
- GO:   GO:0006096
- InterPro:   IPR013785
- InterPro:   IPR011289
- InterPro:   IPR000771
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF001359
- TIGRFAMs:   TIGR00167
- TIGRFAMs:   TIGR01859

Pfam domain/function: PF01116 F_bP_aldolase

EC number: =4.1.2.13

Molecular weight: Translated: 30836; Mature: 30705

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00602 ALDOLASE_CLASS_II_1; PS00806 ALDOLASE_CLASS_II_2

Important sites: ACT_SITE 85-85 BINDING 50-50 BINDING 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLVSMKEMLIDAKENGYAVGQYNINNLEFTQAILEASQEENAPVILGVSEGAARYMSGF
CCCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHH
YTIVKMVEGLMHDLNITIPVAIHLDHGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATT
HHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
KKVVEYAHEKGVSVEAELGTVGGQEDDVVADGIIYADPKECQELVEKTGIDALAPALGSV
HHHHHHHHHCCCEEEEECCCCCCCCCCEEECCEEECCHHHHHHHHHHCCCHHHHHHHHCC
HGPYKGEPKLGFKEMEEIGLSTGLPLVLHGGTGIPTKDIQKAIPFGTAKINVNTENQIAS
CCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCCCEEEEEECCHHHHHH
AKAVRDVLNNDKEVYDPRKYLGPAREAIKETVKGKIKEFGTSNRAK
HHHHHHHHCCCHHHCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PLVSMKEMLIDAKENGYAVGQYNINNLEFTQAILEASQEENAPVILGVSEGAARYMSGF
CCHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHH
YTIVKMVEGLMHDLNITIPVAIHLDHGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATT
HHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHCCCCEEEEECCCCCHHHHHHHH
KKVVEYAHEKGVSVEAELGTVGGQEDDVVADGIIYADPKECQELVEKTGIDALAPALGSV
HHHHHHHHHCCCEEEEECCCCCCCCCCEEECCEEECCHHHHHHHHHHCCCHHHHHHHHCC
HGPYKGEPKLGFKEMEEIGLSTGLPLVLHGGTGIPTKDIQKAIPFGTAKINVNTENQIAS
CCCCCCCCCCCHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHCCCCEEEEEECCHHHHHH
AKAVRDVLNNDKEVYDPRKYLGPAREAIKETVKGKIKEFGTSNRAK
HHHHHHHHCCCHHHCCCHHHCCHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA