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The map label for this gene is glyA

Identifier: 57652135

GI number: 57652135

Start: 2165590

End: 2166828

Strand: Reverse

Name: glyA

Synonym: SACOL2105

Alternate gene names: 57652135

Gene position: 2166828-2165590 (Counterclockwise)

Preceding gene: 57652136

Following gene: 57652134

Centisome position: 77.13

GC content: 36.88

Gene sequence:

>1239_bases
ATGTCTTATATCACCAAGCAAGATAAAGTTATCGCAGAAGCAATCGAGAGAGAATTTCAGAGACAAAATAGCAACATAGA
GTTAATCGCATCGGAAAATTTTGTATCGGAAGCGGTTATGGAAGCACAAGGTTCAGTGTTGACTAATAAGTATGCTGAAG
GCTATCCAGGACGCCGATATTATGGTGGCTGTGAGTTTGTAGATGTTACTGAAAGCATCGCAATTGATCGTGCTAAAGCA
TTGTTTGGAGCTGAACATGTCAATGTTCAACCACATTCAGGTTCACAAGCGAACATGGCTGTTTACTTAGTTGCATTAGA
AATGGGCGACACAGTTTTAGGTATGAATTTGAGTCATGGTGGTCACTTGACACATGGAGCGCCTGTTAATTTTAGTGGTA
AATTCTACAATTTCGTTGAATATGGAGTAGATAAAGACACAGAACGAATCAATTATGATGAAGTTCGTAAATTAGCGTTA
GAGCATAAGCCTAAGCTTATTGTGGCAGGAGCATCAGCATATTCAAGAACAATTGACTTCAAAAAGTTTAAAGAAATCGC
AGATGAAGTAAACGCTAAGTTAATGGTAGACATGGCACATATTGCAGGATTAGTAGCGGCAGGTTTACATCCAAATCCAG
TAGAATATGCTGATTTTGTAACAACTACAACACACAAAACATTACGCGGACCACGTGGTGGTATGATTTTATGTAAGGAA
GAATATAAAAAAGACATAGATAAAACAATTTTCCCTGGTATTCAAGGTGGACCTCTTGAGCATGTTATTGCAGCAAAAGC
AGTTGCTTTTGGAGAAGCGTTAGAAAATAATTTCAAAACGTATCAACAACAAGTGGTTAAAAACGCAAAAGTTCTTGCAG
AAGCATTAATTAATGAAGGATTTAGAATTGTTTCTGGCGGTACAGATAATCACTTAGTAGCTGTTGATGTAAAAGGGTCT
ATAGGACTTACTGGTAAAGAAGCTGAAGAGACTTTAGATTCAGTTGGTATCACATGTAACAAAAATACCATTCCGTTCGA
TCAAGAAAAACCTTTTGTAACGAGTGGTATACGTTTAGGTACACCTGCTGCAACAACGCGTGGATTTGATGAAAAAGCTT
TTGAGGAAGTTGCAAAAATCATCAGTTTAGCATTGAAAAATAGTAAAGATGAAGAAAAATTACAACAAGCTAAAGAACGC
GTTGCGAAATTAACAGCTGAATATCCTCTATATCAATAA

Upstream 100 bases:

>100_bases
TAGGACAGGCAATTGTAACTATTGCCACATCTAGGCCGAAAAAGATTGGTGGCGAACGTGCTAAATACCAATAAGTTTTT
TTGAAAGAAGGGGAGATTTT

Downstream 100 bases:

>100_bases
ACATACACAAAGATAGGAGTAATTTTTATGAGTAAAGTACACGTTTTCGATCATCCATTAATTCAACACAAACTAAGCTA
TATTAGAGATGTAAATACAG

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MSYITKQDKVIAEAIEREFQRQNSNIELIASENFVSEAVMEAQGSVLTNKYAEGYPGRRYYGGCEFVDVTESIAIDRAKA
LFGAEHVNVQPHSGSQANMAVYLVALEMGDTVLGMNLSHGGHLTHGAPVNFSGKFYNFVEYGVDKDTERINYDEVRKLAL
EHKPKLIVAGASAYSRTIDFKKFKEIADEVNAKLMVDMAHIAGLVAAGLHPNPVEYADFVTTTTHKTLRGPRGGMILCKE
EYKKDIDKTIFPGIQGGPLEHVIAAKAVAFGEALENNFKTYQQQVVKNAKVLAEALINEGFRIVSGGTDNHLVAVDVKGS
IGLTGKEAEETLDSVGITCNKNTIPFDQEKPFVTSGIRLGTPAATTRGFDEKAFEEVAKIISLALKNSKDEEKLQQAKER
VAKLTAEYPLYQ

Sequences:

>Translated_412_residues
MSYITKQDKVIAEAIEREFQRQNSNIELIASENFVSEAVMEAQGSVLTNKYAEGYPGRRYYGGCEFVDVTESIAIDRAKA
LFGAEHVNVQPHSGSQANMAVYLVALEMGDTVLGMNLSHGGHLTHGAPVNFSGKFYNFVEYGVDKDTERINYDEVRKLAL
EHKPKLIVAGASAYSRTIDFKKFKEIADEVNAKLMVDMAHIAGLVAAGLHPNPVEYADFVTTTTHKTLRGPRGGMILCKE
EYKKDIDKTIFPGIQGGPLEHVIAAKAVAFGEALENNFKTYQQQVVKNAKVLAEALINEGFRIVSGGTDNHLVAVDVKGS
IGLTGKEAEETLDSVGITCNKNTIPFDQEKPFVTSGIRLGTPAATTRGFDEKAFEEVAKIISLALKNSKDEEKLQQAKER
VAKLTAEYPLYQ
>Mature_411_residues
SYITKQDKVIAEAIEREFQRQNSNIELIASENFVSEAVMEAQGSVLTNKYAEGYPGRRYYGGCEFVDVTESIAIDRAKAL
FGAEHVNVQPHSGSQANMAVYLVALEMGDTVLGMNLSHGGHLTHGAPVNFSGKFYNFVEYGVDKDTERINYDEVRKLALE
HKPKLIVAGASAYSRTIDFKKFKEIADEVNAKLMVDMAHIAGLVAAGLHPNPVEYADFVTTTTHKTLRGPRGGMILCKEE
YKKDIDKTIFPGIQGGPLEHVIAAKAVAFGEALENNFKTYQQQVVKNAKVLAEALINEGFRIVSGGTDNHLVAVDVKGSI
GLTGKEAEETLDSVGITCNKNTIPFDQEKPFVTSGIRLGTPAATTRGFDEKAFEEVAKIISLALKNSKDEEKLQQAKERV
AKLTAEYPLYQ

Specific function: Interconversion of serine and glycine

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family

Homologues:

Organism=Homo sapiens, GI19923315, Length=452, Percent_Identity=42.0353982300885, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI261862352, Length=452, Percent_Identity=42.0353982300885, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI261862350, Length=452, Percent_Identity=42.0353982300885, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI261862348, Length=452, Percent_Identity=42.0353982300885, Blast_Score=352, Evalue=5e-97,
Organism=Homo sapiens, GI261862346, Length=452, Percent_Identity=41.5929203539823, Blast_Score=340, Evalue=2e-93,
Organism=Homo sapiens, GI22547186, Length=430, Percent_Identity=45.8139534883721, Blast_Score=339, Evalue=3e-93,
Organism=Homo sapiens, GI22547189, Length=415, Percent_Identity=45.0602409638554, Blast_Score=313, Evalue=2e-85,
Organism=Escherichia coli, GI1788902, Length=411, Percent_Identity=59.8540145985402, Blast_Score=479, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI25144732, Length=404, Percent_Identity=46.2871287128713, Blast_Score=357, Evalue=5e-99,
Organism=Caenorhabditis elegans, GI25144729, Length=404, Percent_Identity=46.2871287128713, Blast_Score=356, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6319739, Length=416, Percent_Identity=45.9134615384615, Blast_Score=369, Evalue=1e-103,
Organism=Saccharomyces cerevisiae, GI6323087, Length=426, Percent_Identity=42.4882629107981, Blast_Score=328, Evalue=9e-91,
Organism=Drosophila melanogaster, GI24640005, Length=406, Percent_Identity=47.2906403940887, Blast_Score=375, Evalue=1e-104,
Organism=Drosophila melanogaster, GI221329721, Length=414, Percent_Identity=46.8599033816425, Blast_Score=375, Evalue=1e-104,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): GLYA_STAA1 (A7X4V7)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442687.1
- ProteinModelPortal:   A7X4V7
- SMR:   A7X4V7
- STRING:   A7X4V7
- EnsemblBacteria:   EBSTAT00000005273
- GeneID:   5561198
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_2097
- eggNOG:   COG0112
- GeneTree:   EBGT00050000024772
- HOGENOM:   HBG301263
- OMA:   MILTNHE
- ProtClustDB:   PRK00011
- BioCyc:   SAUR418127:SAHV_2097-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00051_B
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11680
- PIRSF:   PIRSF000412

Pfam domain/function: PF00464 SHMT; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.1.2.1

Molecular weight: Translated: 45173; Mature: 45042

Theoretical pI: Translated: 5.99; Mature: 5.99

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYITKQDKVIAEAIEREFQRQNSNIELIASENFVSEAVMEAQGSVLTNKYAEGYPGRRY
CCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCHHHHHHHCCCCCCEE
YGGCEFVDVTESIAIDRAKALFGAEHVNVQPHSGSQANMAVYLVALEMGDTVLGMNLSHG
CCCCCEEEHHHHHHHHHHHHHHCHHHCEECCCCCCCCCEEEEEEEEECCCEEEEEEECCC
GHLTHGAPVNFSGKFYNFVEYGVDKDTERINYDEVRKLALEHKPKLIVAGASAYSRTIDF
CCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHCCH
KKFKEIADEVNAKLMVDMAHIAGLVAAGLHPNPVEYADFVTTTTHKTLRGPRGGMILCKE
HHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHCCCCCCEEEEHH
EYKKDIDKTIFPGIQGGPLEHVIAAKAVAFGEALENNFKTYQQQVVKNAKVLAEALINEG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FRIVSGGTDNHLVAVDVKGSIGLTGKEAEETLDSVGITCNKNTIPFDQEKPFVTSGIRLG
CEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCCEEEC
TPAATTRGFDEKAFEEVAKIISLALKNSKDEEKLQQAKERVAKLTAEYPLYQ
CCCHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SYITKQDKVIAEAIEREFQRQNSNIELIASENFVSEAVMEAQGSVLTNKYAEGYPGRRY
CCCCCHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHCCCHHHHHHHCCCCCCEE
YGGCEFVDVTESIAIDRAKALFGAEHVNVQPHSGSQANMAVYLVALEMGDTVLGMNLSHG
CCCCCEEEHHHHHHHHHHHHHHCHHHCEECCCCCCCCCEEEEEEEEECCCEEEEEEECCC
GHLTHGAPVNFSGKFYNFVEYGVDKDTERINYDEVRKLALEHKPKLIVAGASAYSRTIDF
CCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCHHHHHCCH
KKFKEIADEVNAKLMVDMAHIAGLVAAGLHPNPVEYADFVTTTTHKTLRGPRGGMILCKE
HHHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHCCCCCCEEEEHH
EYKKDIDKTIFPGIQGGPLEHVIAAKAVAFGEALENNFKTYQQQVVKNAKVLAEALINEG
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FRIVSGGTDNHLVAVDVKGSIGLTGKEAEETLDSVGITCNKNTIPFDQEKPFVTSGIRLG
CEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHCCCEECCCCCCCCCCCCCCCCCEEEC
TPAATTRGFDEKAFEEVAKIISLALKNSKDEEKLQQAKERVAKLTAEYPLYQ
CCCHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA