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Identifier: 57652134

GI number: 57652134

Start: 2164933

End: 2165562

Strand: Reverse

Name: upp

Synonym: SACOL2104

Alternate gene names: 57652134

Gene position: 2165562-2164933 (Counterclockwise)

Preceding gene: 57652135

Following gene: 57652133

Centisome position: 77.08

GC content: 36.51

Gene sequence:

>630_bases
ATGAGTAAAGTACACGTTTTCGATCATCCATTAATTCAACACAAACTAAGCTATATTAGAGATGTAAATACAGGTACTAA
AGAATTTAGAGAACTTGTAGACGAAGTTGGTATGTTGATGGCATATGAAGTAACTAGAGACTTAGAGCTTCAGGATGTTG
ATATTGAAACGCCTGTAACTAAAATGACGGCTAAACGATTAGCTGGTAAAAAATTAGCTATCGTTCCAATTTTAAGAGCT
GGTTTAGGTATGACTGATGGTATTTTAAGTTTAGTACCTGCAGCCAGAGTTGGACATATCGGTTTATATCGAGATCCCGA
AACATTAAAGGCTGTAGAGTATTTTGCTAAGTTACCTCAAGATATTACTGAAAGACAAATCATTGTTGTTGATCCTATGT
TAGCAACAGGCGCATCAGCAATTGAAGCTATTACTTCATTGAAGAAACGTGGCGCTAAAAATATTCGCTTCATGTGTTTA
ATTGCAGCACCAGAAGGCGTAGAAAAGATGCATGAAGCACATCCAGATGTAGATATTTATATTGCTGCACTTGATGAAAA
GCTAAATGACAAAGCATATATCACACCAGGGTTAGGCGACGCTGGAGATAGATTGTTTGGTACTAAATAG

Upstream 100 bases:

>100_bases
AGATGAAGAAAAATTACAACAAGCTAAAGAACGCGTTGCGAAATTAACAGCTGAATATCCTCTATATCAATAAACATACA
CAAAGATAGGAGTAATTTTT

Downstream 100 bases:

>100_bases
AAGAATCGGAGATAAGTAGTTTGATGAAAAAGATTATGACCATATTTGGAACAAGACCCGAAGCCATAAAGATGGCTCCT
TTAGTTAAAGCTTTGGAACA

Product: uracil phosphoribosyltransferase

Products: NA

Alternate protein names: UMP pyrophosphorylase; UPRTase

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSKVHVFDHPLIQHKLSYIRDVNTGTKEFRELVDEVGMLMAYEVTRDLELQDVDIETPVTKMTAKRLAGKKLAIVPILRA
GLGMTDGILSLVPAARVGHIGLYRDPETLKAVEYFAKLPQDITERQIIVVDPMLATGASAIEAITSLKKRGAKNIRFMCL
IAAPEGVEKMHEAHPDVDIYIAALDEKLNDKAYITPGLGDAGDRLFGTK

Sequences:

>Translated_209_residues
MSKVHVFDHPLIQHKLSYIRDVNTGTKEFRELVDEVGMLMAYEVTRDLELQDVDIETPVTKMTAKRLAGKKLAIVPILRA
GLGMTDGILSLVPAARVGHIGLYRDPETLKAVEYFAKLPQDITERQIIVVDPMLATGASAIEAITSLKKRGAKNIRFMCL
IAAPEGVEKMHEAHPDVDIYIAALDEKLNDKAYITPGLGDAGDRLFGTK
>Mature_208_residues
SKVHVFDHPLIQHKLSYIRDVNTGTKEFRELVDEVGMLMAYEVTRDLELQDVDIETPVTKMTAKRLAGKKLAIVPILRAG
LGMTDGILSLVPAARVGHIGLYRDPETLKAVEYFAKLPQDITERQIIVVDPMLATGASAIEAITSLKKRGAKNIRFMCLI
AAPEGVEKMHEAHPDVDIYIAALDEKLNDKAYITPGLGDAGDRLFGTK

Specific function: Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate

COG id: COG0035

COG function: function code F; Uracil phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPRTase family

Homologues:

Organism=Homo sapiens, GI301129207, Length=202, Percent_Identity=31.1881188118812, Blast_Score=91, Evalue=8e-19,
Organism=Homo sapiens, GI57863312, Length=202, Percent_Identity=31.1881188118812, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI21450816, Length=167, Percent_Identity=28.7425149700599, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI87082118, Length=201, Percent_Identity=52.7363184079602, Blast_Score=224, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17539892, Length=201, Percent_Identity=25.8706467661692, Blast_Score=87, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI17539894, Length=201, Percent_Identity=25.8706467661692, Blast_Score=87, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6321920, Length=190, Percent_Identity=40, Blast_Score=128, Evalue=7e-31,
Organism=Drosophila melanogaster, GI45550449, Length=203, Percent_Identity=32.512315270936, Blast_Score=98, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28573516, Length=203, Percent_Identity=32.512315270936, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28573514, Length=203, Percent_Identity=32.512315270936, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28573512, Length=203, Percent_Identity=32.512315270936, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21358379, Length=171, Percent_Identity=26.3157894736842, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: 2580 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): UPP_STAA1 (A7X4V6)

Other databases:

- EMBL:   AP009324
- RefSeq:   YP_001442686.1
- ProteinModelPortal:   A7X4V6
- SMR:   A7X4V6
- STRING:   A7X4V6
- EnsemblBacteria:   EBSTAT00000004465
- GeneID:   5560280
- GenomeReviews:   AP009324_GR
- KEGG:   saw:SAHV_2096
- eggNOG:   COG0035
- GeneTree:   EBGT00050000024653
- HOGENOM:   HBG326432
- OMA:   IQHKLSH
- ProtClustDB:   PRK00129
- BioCyc:   SAUR418127:SAHV_2096-MONOMER
- HAMAP:   MF_01218_B
- InterPro:   IPR000836
- InterPro:   IPR005765
- TIGRFAMs:   TIGR01091

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.9

Molecular weight: Translated: 23050; Mature: 22919

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: BINDING 79-79 BINDING 104-104 BINDING 194-194 BINDING 200-200

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVHVFDHPLIQHKLSYIRDVNTGTKEFRELVDEVGMLMAYEVTRDLELQDVDIETPVT
CCCEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHH
KMTAKRLAGKKLAIVPILRAGLGMTDGILSLVPAARVGHIGLYRDPETLKAVEYFAKLPQ
HHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHCCH
DITERQIIVVDPMLATGASAIEAITSLKKRGAKNIRFMCLIAAPEGVEKMHEAHPDVDIY
HHHHCEEEEECCHHHCCHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCCEEE
IAALDEKLNDKAYITPGLGDAGDRLFGTK
EEEECCCCCCCEEECCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKVHVFDHPLIQHKLSYIRDVNTGTKEFRELVDEVGMLMAYEVTRDLELQDVDIETPVT
CCEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCHH
KMTAKRLAGKKLAIVPILRAGLGMTDGILSLVPAARVGHIGLYRDPETLKAVEYFAKLPQ
HHHHHHHCCCCCHHHHHHHHCCCCCHHHHHHHCHHHHCCCCCCCCHHHHHHHHHHHHCCH
DITERQIIVVDPMLATGASAIEAITSLKKRGAKNIRFMCLIAAPEGVEKMHEAHPDVDIY
HHHHCEEEEECCHHHCCHHHHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCCEEE
IAALDEKLNDKAYITPGLGDAGDRLFGTK
EEEECCCCCCCEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA