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The map label for this gene is gcvPA [H]

Identifier: 57651930

GI number: 57651930

Start: 1627412

End: 1628758

Strand: Reverse

Name: gcvPA [H]

Synonym: SACOL1594

Alternate gene names: 57651930

Gene position: 1628758-1627412 (Counterclockwise)

Preceding gene: 57651931

Following gene: 57651929

Centisome position: 57.97

GC content: 34.15

Gene sequence:

>1347_bases
GTGAGTCATCGTTATATACCTTTAACTGAAAAAGACAAGCAAGAAATGTTACAAACAATTGGTGCAAAATCTATAGGAGA
ATTATTCGGTGATGTACCAAGTGACATTTTATTAAATAGAGATTTAAATATTGCTGAAGGCGAAGCGGAAACAACGTTAC
TTAGAAGATTAAATCGCATTGCAAGCAAGAATATCACTAAAGAAACGCATACATCATTTTTGGGTGCTGGTGTTTATGAT
CATTACGCGCCATCAGTTGTGGATGCTATGATTTCAAGATCAGAATTTTACACAGCATATACGCCATATCAACCGGAAAT
TTCTCAAGGTGAATTACAAGCCATTTTTGAGTTCCAAACTTTAATTTGTGAATTAACAGATATGGATGTAGCAAATTCTT
CTATGTATGATGGGATGACTAGCTTTGCTGAAGCATGTATCTTAGCATTTAGTCAAACAAAGAAAAATAAAATTGTAGTC
TCAAAAGGTTTACATTATCAAGCATTACAAGTACTTCATACTTATGCTAAGACGCGTAAGGAATTCGAAGTAGTGGAAAT
CGATTTAGATGGCACTGTTACAGATTTGAAAAAATTAGAAGCAGCAGTGGATGATGAAACAGCAGCTGTTGCAGTACAAT
ATCCAAACTTTTACGGTTCAATTGAAGATCTTAAAAAGATTCATAGCTTTATTGAAGATAAAAAAGCATTATTTATCGTA
TATGCAAATCCATTAGCATTGGGATTACTTACACCTCCAGGTTCATTTGGTGCAGATATTGTTGTAGGTGATACTCAGCC
ATTCGGAATTCCTGCTCAATTCGGTGGGCCACATTGTGGATATTTTGCAACGACGAAAAAGTTAATGCGTAAAGTGCCAG
GTAGATTAGTCGGTCAAACACAAGATGATGAAGGTAATCGTGGCTTTGTATTAACATTACAAGCACGTGAACAACATATT
CGACGCGATAAAGCGACATCTAATATTTGTTCTAACCAAGCATTAAATGCTTTAGCGTCATCAATTGCAATGTCAGCACT
TGGTAAACAAGGTATCTATGATATTGCAGTTCAAAATATAGAACATGCTAACTATGCTAAACAACAATTTATTAAAAAAG
GTTTTGAAGTATTAGATGGTACATCTTTCAATGAGTTTGTAGTCAAATTTGACAAACCAATTCAACAAGTTAACGAGGAA
TTAGTGAAGTACAATATTATCGGTGGTTTTGATTTAGGTGTTGTTTCAGACGACTTTAAAAATCACATGTTAATAGCTGT
AACTGAATTAAGAACAAAAGATGAAATCGATACATTTGTAGAAAAGGCTGGTGAGTTAAATGACTAG

Upstream 100 bases:

>100_bases
ATGGGTAGAGAGTTGCTTGTTCAAGTTCGTAAGCGTCAATTAAAAGCGAAAATTGTTAAGAAAAATCAAATTGATAAATA
ATTAAAAAGGGGTGTGCATT

Downstream 100 bases:

>100_bases
TAAATCAAGTCCATTAATTTTTGAAAGATCTCGTGAAGGCAGATATGCATATTCATTACCAAAAAGTGATATTAAAACAA
ATTCTGTTGAGTCATTGTTA

Product: glycine dehydrogenase subunit 1

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 1; Glycine decarboxylase subunit 1 [H]

Number of amino acids: Translated: 448; Mature: 447

Protein sequence:

>448_residues
MSHRYIPLTEKDKQEMLQTIGAKSIGELFGDVPSDILLNRDLNIAEGEAETTLLRRLNRIASKNITKETHTSFLGAGVYD
HYAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMDVANSSMYDGMTSFAEACILAFSQTKKNKIVV
SKGLHYQALQVLHTYAKTRKEFEVVEIDLDGTVTDLKKLEAAVDDETAAVAVQYPNFYGSIEDLKKIHSFIEDKKALFIV
YANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQAREQHI
RRDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNIEHANYAKQQFIKKGFEVLDGTSFNEFVVKFDKPIQQVNEE
LVKYNIIGGFDLGVVSDDFKNHMLIAVTELRTKDEIDTFVEKAGELND

Sequences:

>Translated_448_residues
MSHRYIPLTEKDKQEMLQTIGAKSIGELFGDVPSDILLNRDLNIAEGEAETTLLRRLNRIASKNITKETHTSFLGAGVYD
HYAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMDVANSSMYDGMTSFAEACILAFSQTKKNKIVV
SKGLHYQALQVLHTYAKTRKEFEVVEIDLDGTVTDLKKLEAAVDDETAAVAVQYPNFYGSIEDLKKIHSFIEDKKALFIV
YANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQAREQHI
RRDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNIEHANYAKQQFIKKGFEVLDGTSFNEFVVKFDKPIQQVNEE
LVKYNIIGGFDLGVVSDDFKNHMLIAVTELRTKDEIDTFVEKAGELND
>Mature_447_residues
SHRYIPLTEKDKQEMLQTIGAKSIGELFGDVPSDILLNRDLNIAEGEAETTLLRRLNRIASKNITKETHTSFLGAGVYDH
YAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFEFQTLICELTDMDVANSSMYDGMTSFAEACILAFSQTKKNKIVVS
KGLHYQALQVLHTYAKTRKEFEVVEIDLDGTVTDLKKLEAAVDDETAAVAVQYPNFYGSIEDLKKIHSFIEDKKALFIVY
ANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQTQDDEGNRGFVLTLQAREQHIR
RDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNIEHANYAKQQFIKKGFEVLDGTSFNEFVVKFDKPIQQVNEEL
VKYNIIGGFDLGVVSDDFKNHMLIAVTELRTKDEIDTFVEKAGELND

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG0403

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. N-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=362, Percent_Identity=39.7790055248619, Blast_Score=254, Evalue=1e-67,
Organism=Escherichia coli, GI1789269, Length=392, Percent_Identity=35.7142857142857, Blast_Score=205, Evalue=6e-54,
Organism=Caenorhabditis elegans, GI17535605, Length=394, Percent_Identity=37.5634517766497, Blast_Score=235, Evalue=4e-62,
Organism=Saccharomyces cerevisiae, GI6323843, Length=462, Percent_Identity=35.7142857142857, Blast_Score=259, Evalue=5e-70,
Organism=Drosophila melanogaster, GI24645648, Length=392, Percent_Identity=38.5204081632653, Blast_Score=256, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023010
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 49716; Mature: 49585

Theoretical pI: Translated: 4.95; Mature: 4.95

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHRYIPLTEKDKQEMLQTIGAKSIGELFGDVPSDILLNRDLNIAEGEAETTLLRRLNRI
CCCCCCCCCCHHHHHHHHHHCHHHHHHHHCCCCCHHEECCCCCCCCCHHHHHHHHHHHHH
ASKNITKETHTSFLGAGVYDHYAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFEFQT
HHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHHHH
LICELTDMDVANSSMYDGMTSFAEACILAFSQTKKNKIVVSKGLHYQALQVLHTYAKTRK
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCC
EFEVVEIDLDGTVTDLKKLEAAVDDETAAVAVQYPNFYGSIEDLKKIHSFIEDKKALFIV
CEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEE
YANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQT
EECCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCC
QDDEGNRGFVLTLQAREQHIRRDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNI
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
EHANYAKQQFIKKGFEVLDGTSFNEFVVKFDKPIQQVNEELVKYNIIGGFDLGVVSDDFK
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCC
NHMLIAVTELRTKDEIDTFVEKAGELND
CCEEEEEECCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SHRYIPLTEKDKQEMLQTIGAKSIGELFGDVPSDILLNRDLNIAEGEAETTLLRRLNRI
CCCCCCCCCHHHHHHHHHHCHHHHHHHHCCCCCHHEECCCCCCCCCHHHHHHHHHHHHH
ASKNITKETHTSFLGAGVYDHYAPSVVDAMISRSEFYTAYTPYQPEISQGELQAIFEFQT
HHCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHHHH
LICELTDMDVANSSMYDGMTSFAEACILAFSQTKKNKIVVSKGLHYQALQVLHTYAKTRK
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHCC
EFEVVEIDLDGTVTDLKKLEAAVDDETAAVAVQYPNFYGSIEDLKKIHSFIEDKKALFIV
CEEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEEE
YANPLALGLLTPPGSFGADIVVGDTQPFGIPAQFGGPHCGYFATTKKLMRKVPGRLVGQT
EECCEEEEEECCCCCCCCCEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCHHHCCCC
QDDEGNRGFVLTLQAREQHIRRDKATSNICSNQALNALASSIAMSALGKQGIYDIAVQNI
CCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHC
EHANYAKQQFIKKGFEVLDGTSFNEFVVKFDKPIQQVNEELVKYNIIGGFDLGVVSDDFK
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCC
NHMLIAVTELRTKDEIDTFVEKAGELND
CCEEEEEECCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA