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The map label for this gene is gcvPB [H]

Identifier: 57651929

GI number: 57651929

Start: 1625947

End: 1627419

Strand: Reverse

Name: gcvPB [H]

Synonym: SACOL1593

Alternate gene names: 57651929

Gene position: 1627419-1625947 (Counterclockwise)

Preceding gene: 57651930

Following gene: 57651927

Centisome position: 57.93

GC content: 34.49

Gene sequence:

>1473_bases
ATGACTAGTAAATCAAGTCCATTAATTTTTGAAAGATCTCGTGAAGGCAGATATGCATATTCATTACCAAAAAGTGATAT
TAAAACAAATTCTGTTGAGTCATTGTTAGATGATAAATTTATTCGTAAAAACAAAGCGGAGTTTCCTGAAGTTGCTGAAC
TAGACTTAGTACGTCATTATACTGAACTTTCAAATAAAAATTTCGGTGTAGACAACGGATTTTATCCATTGGGTTCATGT
ACGATGAAGTATAACCCTAAAATTAATGAAAAGGTTGCTAGAATACCAGGATTTAGTGAATCACATCCATTACAAGATGA
AGATCAAGTTCAAGGTTCATTAGAAATTATTTATAGTTTGCAAGAAGAATTAAAAGAAATTACTGGTATGGATGAGGTGA
CATTACAACCAGCTGCTGGCGCACATGGTGAATGGACTGCATTGATGATATTTAAAGCTTACCATGAGAATAATGGTGAA
GGTCATCGTGATGAAGTCATTGTGCCAGATTCTGCGCATGGTACGAATCCAGCCTCAGCTTCATTTGCAGGATTTAAATC
AGTTACTGTAAAATCAAACGAACGTGGCGAAGTTAATATTGATGACTTGAAACGTGTTGTAAATGAAAATACAGCAGCTA
TTATGTTAACTAATCCAAACACTTTAGGTATTTTCGAAAAAAATATTATGGAAATCCGTGAAATCGTCCATAATGCTGGT
GGTCTATTATATTATGATGGTGCGAATTTAAACGCTATTATGGACAAAGTTCGCCCAGGAGATATGGGATTTGATGCTGT
TCATTTAAACTTGCATAAAACATTTACTGGTCCACATGGTGGTGGCGGTCCTGGTTCAGGTCCAGTCGGTGTAGTAAAAG
AACTAGCAAGTTACTTACCAAAGCCAATGGTTATTAAAGATGGCGACAAATTTAAATATGATAATGACATTAAAAATTCT
ATCGGACGTGTAAAACCATTTTATGGTAACTTTGGTATTTACTTAAGAGCTTATACGTATATTCGAACTATGGGAGCAAC
TGGACTTAAAGAGGTTTCTGAAGCAGCGGTTCTTAATGCGAATTATATTAAAGCACGTTTATCTAAACACTTTGAAATAC
CTTATAAACAATATTGTAAACACGAGTTTGTGTTAAGTGGTGTGCGTCAAAAAGAATTTGGTGTACGTACTTTAGACATG
GCTAAGCGATTATTAGATTTCGGTGTACATCCACCAACAATATACTTCCCATTAAATGTTGAAGAAGGTATGATGATTGA
ACCGACTGAGACAGAGTCTAAAGAAACACTTGATTATTTTATCGATACATTAATTAGTATTGCTGAAGAAGCTAAAAATG
ATCCTGATAAAGTGCTAGAAGCACCACATACAACTGTGATTGATCGATTAGACGAAGCTACAGCTGCTCGTAAACCAATA
TTAAAGTTTGAAAATCTTAAACAGGAAAAATAA

Upstream 100 bases:

>100_bases
GTTGTTTCAGACGACTTTAAAAATCACATGTTAATAGCTGTAACTGAATTAAGAACAAAAGATGAAATCGATACATTTGT
AGAAAAGGCTGGTGAGTTAA

Downstream 100 bases:

>100_bases
AGTATTAAACACATATTCCGAGAATTATTATTCTAACTTTGTATGAAGATTTAAGGATAATGGTTTCAAAATCAATTGAA
AAAGACAATTTCTATTTAAA

Product: glycine dehydrogenase subunit 2

Products: NA

Alternate protein names: Glycine cleavage system P-protein subunit 2; Glycine decarboxylase subunit 2 [H]

Number of amino acids: Translated: 490; Mature: 489

Protein sequence:

>490_residues
MTSKSSPLIFERSREGRYAYSLPKSDIKTNSVESLLDDKFIRKNKAEFPEVAELDLVRHYTELSNKNFGVDNGFYPLGSC
TMKYNPKINEKVARIPGFSESHPLQDEDQVQGSLEIIYSLQEELKEITGMDEVTLQPAAGAHGEWTALMIFKAYHENNGE
GHRDEVIVPDSAHGTNPASASFAGFKSVTVKSNERGEVNIDDLKRVVNENTAAIMLTNPNTLGIFEKNIMEIREIVHNAG
GLLYYDGANLNAIMDKVRPGDMGFDAVHLNLHKTFTGPHGGGGPGSGPVGVVKELASYLPKPMVIKDGDKFKYDNDIKNS
IGRVKPFYGNFGIYLRAYTYIRTMGATGLKEVSEAAVLNANYIKARLSKHFEIPYKQYCKHEFVLSGVRQKEFGVRTLDM
AKRLLDFGVHPPTIYFPLNVEEGMMIEPTETESKETLDYFIDTLISIAEEAKNDPDKVLEAPHTTVIDRLDEATAARKPI
LKFENLKQEK

Sequences:

>Translated_490_residues
MTSKSSPLIFERSREGRYAYSLPKSDIKTNSVESLLDDKFIRKNKAEFPEVAELDLVRHYTELSNKNFGVDNGFYPLGSC
TMKYNPKINEKVARIPGFSESHPLQDEDQVQGSLEIIYSLQEELKEITGMDEVTLQPAAGAHGEWTALMIFKAYHENNGE
GHRDEVIVPDSAHGTNPASASFAGFKSVTVKSNERGEVNIDDLKRVVNENTAAIMLTNPNTLGIFEKNIMEIREIVHNAG
GLLYYDGANLNAIMDKVRPGDMGFDAVHLNLHKTFTGPHGGGGPGSGPVGVVKELASYLPKPMVIKDGDKFKYDNDIKNS
IGRVKPFYGNFGIYLRAYTYIRTMGATGLKEVSEAAVLNANYIKARLSKHFEIPYKQYCKHEFVLSGVRQKEFGVRTLDM
AKRLLDFGVHPPTIYFPLNVEEGMMIEPTETESKETLDYFIDTLISIAEEAKNDPDKVLEAPHTTVIDRLDEATAARKPI
LKFENLKQEK
>Mature_489_residues
TSKSSPLIFERSREGRYAYSLPKSDIKTNSVESLLDDKFIRKNKAEFPEVAELDLVRHYTELSNKNFGVDNGFYPLGSCT
MKYNPKINEKVARIPGFSESHPLQDEDQVQGSLEIIYSLQEELKEITGMDEVTLQPAAGAHGEWTALMIFKAYHENNGEG
HRDEVIVPDSAHGTNPASASFAGFKSVTVKSNERGEVNIDDLKRVVNENTAAIMLTNPNTLGIFEKNIMEIREIVHNAGG
LLYYDGANLNAIMDKVRPGDMGFDAVHLNLHKTFTGPHGGGGPGSGPVGVVKELASYLPKPMVIKDGDKFKYDNDIKNSI
GRVKPFYGNFGIYLRAYTYIRTMGATGLKEVSEAAVLNANYIKARLSKHFEIPYKQYCKHEFVLSGVRQKEFGVRTLDMA
KRLLDFGVHPPTIYFPLNVEEGMMIEPTETESKETLDYFIDTLISIAEEAKNDPDKVLEAPHTTVIDRLDEATAARKPIL
KFENLKQEK

Specific function: The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide co

COG id: COG1003

COG function: function code E; Glycine cleavage system protein P (pyridoxal-binding), C-terminal domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvP family. C-terminal subunit subfamily [H]

Homologues:

Organism=Homo sapiens, GI108773801, Length=407, Percent_Identity=43.2432432432432, Blast_Score=294, Evalue=1e-79,
Organism=Escherichia coli, GI1789269, Length=407, Percent_Identity=41.7690417690418, Blast_Score=290, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17535605, Length=429, Percent_Identity=41.958041958042, Blast_Score=285, Evalue=6e-77,
Organism=Caenorhabditis elegans, GI32564013, Length=385, Percent_Identity=42.5974025974026, Blast_Score=258, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6323843, Length=426, Percent_Identity=42.018779342723, Blast_Score=311, Evalue=1e-85,
Organism=Drosophila melanogaster, GI24645648, Length=457, Percent_Identity=39.1684901531729, Blast_Score=294, Evalue=1e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020580
- InterPro:   IPR020581
- InterPro:   IPR023012
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF02347 GDC-P [H]

EC number: =1.4.4.2 [H]

Molecular weight: Translated: 54782; Mature: 54651

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSKSSPLIFERSREGRYAYSLPKSDIKTNSVESLLDDKFIRKNKAEFPEVAELDLVRHY
CCCCCCCEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
TELSNKNFGVDNGFYPLGSCTMKYNPKINEKVARIPGFSESHPLQDEDQVQGSLEIIYSL
HHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
QEELKEITGMDEVTLQPAAGAHGEWTALMIFKAYHENNGEGHRDEVIVPDSAHGTNPASA
HHHHHHHCCCCCEEECCCCCCCCCEEEEEEEEEECCCCCCCCCCCEEECCCCCCCCCCCC
SFAGFKSVTVKSNERGEVNIDDLKRVVNENTAAIMLTNPNTLGIFEKNIMEIREIVHNAG
CCCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCC
GLLYYDGANLNAIMDKVRPGDMGFDAVHLNLHKTFTGPHGGGGPGSGPVGVVKELASYLP
CEEEECCCCHHHHHHHCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCC
KPMVIKDGDKFKYDNDIKNSIGRVKPFYGNFGIYLRAYTYIRTMGATGLKEVSEAAVLNA
CCEEEECCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCH
NYIKARLSKHFEIPYKQYCKHEFVLSGVRQKEFGVRTLDMAKRLLDFGVHPPTIYFPLNV
HHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHCCCCCCEEEEEECC
EEGMMIEPTETESKETLDYFIDTLISIAEEAKNDPDKVLEAPHTTVIDRLDEATAARKPI
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHCCC
LKFENLKQEK
HHHHHCCCCC
>Mature Secondary Structure 
TSKSSPLIFERSREGRYAYSLPKSDIKTNSVESLLDDKFIRKNKAEFPEVAELDLVRHY
CCCCCCEEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
TELSNKNFGVDNGFYPLGSCTMKYNPKINEKVARIPGFSESHPLQDEDQVQGSLEIIYSL
HHHCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
QEELKEITGMDEVTLQPAAGAHGEWTALMIFKAYHENNGEGHRDEVIVPDSAHGTNPASA
HHHHHHHCCCCCEEECCCCCCCCCEEEEEEEEEECCCCCCCCCCCEEECCCCCCCCCCCC
SFAGFKSVTVKSNERGEVNIDDLKRVVNENTAAIMLTNPNTLGIFEKNIMEIREIVHNAG
CCCCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCC
GLLYYDGANLNAIMDKVRPGDMGFDAVHLNLHKTFTGPHGGGGPGSGPVGVVKELASYLP
CEEEECCCCHHHHHHHCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHCC
KPMVIKDGDKFKYDNDIKNSIGRVKPFYGNFGIYLRAYTYIRTMGATGLKEVSEAAVLNA
CCEEEECCCCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHCH
NYIKARLSKHFEIPYKQYCKHEFVLSGVRQKEFGVRTLDMAKRLLDFGVHPPTIYFPLNV
HHHHHHHHHCCCCCHHHHHHHHHHHHCCHHHHCCCHHHHHHHHHHHCCCCCCEEEEEECC
EEGMMIEPTETESKETLDYFIDTLISIAEEAKNDPDKVLEAPHTTVIDRLDEATAARKPI
CCCEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCHHHHHHHHHHHHHHCCC
LKFENLKQEK
HHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA