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The map label for this gene is uppS

Identifier: 57651830

GI number: 57651830

Start: 1288230

End: 1289000

Strand: Direct

Name: uppS

Synonym: SACOL1279

Alternate gene names: 57651830

Gene position: 1288230-1289000 (Clockwise)

Preceding gene: 57651829

Following gene: 57651831

Centisome position: 45.85

GC content: 30.09

Gene sequence:

>771_bases
ATGTTTAAAAAGCTAATAAATAAAAAGAACACTATAAATAATTATAATGAAGAATTAGACTCGTCTAATATACCTGAACA
TATCGCTATTATTATGGATGGTAATGGGCGATGGGCTAAGAAGCGAAAAATGCCTAGAATTAAAGGTCATTACGAAGGTA
TGCAAACAATAAAAAAAATTACTAGGGTAGCTAGTGATATTGGTGTTAAGTACTTAACTTTATACGCCTTTTCCACTGAA
AATTGGTCAAGACCTGAAAGTGAAGTAAATTATATTATGAATTTGCCTGTCAATTTCTTAAAGACATTCTTACCGGAACT
AATTGAAAAAAATGTCAAAGTTGAAACAATTGGATTTACTGATAAGTTGCCAAAATCAACGATAGAAGCAATTAATAATG
CTAAAGAAAAGACAGCTAATAATACCGGCTTAAAATTAATATTTGCAATTAATTATGGTGGCAGAGCAGAACTTGTTCAT
AGTATTAAAAATATGTTTGACGAGCTTCATCAACAAGGTTTAAATAGTGATATCATAGATGAAACATATATAAACAATCA
TTTAATGACAAAAGACTATCCTGATCCAGAGTTGTTAATTCGTACTTCAGGAGAACAAAGAATAAGTAATTTCTTGATTT
GGCAAGTTTCGTATAGTGAATTTATCTTTAATCAAAAATTATGGCCTGACTTTGACGAAGATGAATTAATTAAATGTATA
AAAATTTATCAGTCACGTCAAAGACGCTTTGGCGGATTGAGTGAGGAGTAG

Upstream 100 bases:

>100_bases
ATTTGCTTATTCAATGCATTAAATGAGTATGATAAAATGATAATGATTGTTTAGTAACTTATACTATATGACAGAGATGA
TCAGGCTCGGAGGAAAGACC

Downstream 100 bases:

>100_bases
TATAGTATGAAAGTTAGAACGCTGACAGCTATTATTGCCTTAATCGTATTCTTGCCTATCTTGTTAAAAGGCGGCCTTGT
GTTAATGATATTTGCTAATA

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MFKKLINKKNTINNYNEELDSSNIPEHIAIIMDGNGRWAKKRKMPRIKGHYEGMQTIKKITRVASDIGVKYLTLYAFSTE
NWSRPESEVNYIMNLPVNFLKTFLPELIEKNVKVETIGFTDKLPKSTIEAINNAKEKTANNTGLKLIFAINYGGRAELVH
SIKNMFDELHQQGLNSDIIDETYINNHLMTKDYPDPELLIRTSGEQRISNFLIWQVSYSEFIFNQKLWPDFDEDELIKCI
KIYQSRQRRFGGLSEE

Sequences:

>Translated_256_residues
MFKKLINKKNTINNYNEELDSSNIPEHIAIIMDGNGRWAKKRKMPRIKGHYEGMQTIKKITRVASDIGVKYLTLYAFSTE
NWSRPESEVNYIMNLPVNFLKTFLPELIEKNVKVETIGFTDKLPKSTIEAINNAKEKTANNTGLKLIFAINYGGRAELVH
SIKNMFDELHQQGLNSDIIDETYINNHLMTKDYPDPELLIRTSGEQRISNFLIWQVSYSEFIFNQKLWPDFDEDELIKCI
KIYQSRQRRFGGLSEE
>Mature_256_residues
MFKKLINKKNTINNYNEELDSSNIPEHIAIIMDGNGRWAKKRKMPRIKGHYEGMQTIKKITRVASDIGVKYLTLYAFSTE
NWSRPESEVNYIMNLPVNFLKTFLPELIEKNVKVETIGFTDKLPKSTIEAINNAKEKTANNTGLKLIFAINYGGRAELVH
SIKNMFDELHQQGLNSDIIDETYINNHLMTKDYPDPELLIRTSGEQRISNFLIWQVSYSEFIFNQKLWPDFDEDELIKCI
KIYQSRQRRFGGLSEE

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580738, Length=224, Percent_Identity=34.8214285714286, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI45580742, Length=224, Percent_Identity=34.8214285714286, Blast_Score=139, Evalue=3e-33,
Organism=Escherichia coli, GI1786371, Length=226, Percent_Identity=43.3628318584071, Blast_Score=208, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71993029, Length=229, Percent_Identity=34.061135371179, Blast_Score=125, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=229, Percent_Identity=37.117903930131, Blast_Score=128, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6323748, Length=214, Percent_Identity=32.7102803738318, Blast_Score=114, Evalue=2e-26,
Organism=Drosophila melanogaster, GI18857969, Length=224, Percent_Identity=33.0357142857143, Blast_Score=134, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_STAAC (Q5HGH1)

Other databases:

- EMBL:   CP000046
- RefSeq:   YP_186136.1
- ProteinModelPortal:   Q5HGH1
- SMR:   Q5HGH1
- STRING:   Q5HGH1
- EnsemblBacteria:   EBSTAT00000010188
- GeneID:   3238385
- GenomeReviews:   CP000046_GR
- KEGG:   sac:SACOL1279
- TIGR:   SACOL1279
- eggNOG:   COG0020
- GeneTree:   EBGT00050000024896
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   PRK14830
- BioCyc:   SAUR93062:SACOL1279-MONOMER
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 29849; Mature: 29849

Theoretical pI: Translated: 8.37; Mature: 8.37

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 33-33

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFKKLINKKNTINNYNEELDSSNIPEHIAIIMDGNGRWAKKRKMPRIKGHYEGMQTIKKI
CCHHHHCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHHHH
TRVASDIGVKYLTLYAFSTENWSRPESEVNYIMNLPVNFLKTFLPELIEKNVKVETIGFT
HHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCC
DKLPKSTIEAINNAKEKTANNTGLKLIFAINYGGRAELVHSIKNMFDELHQQGLNSDIID
CCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
ETYINNHLMTKDYPDPELLIRTSGEQRISNFLIWQVSYSEFIFNQKLWPDFDEDELIKCI
HHHHCCCCCCCCCCCCCEEEECCCHHHHHHEEEEEEEHHHHHHCCCCCCCCCHHHHHHHH
KIYQSRQRRFGGLSEE
HHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFKKLINKKNTINNYNEELDSSNIPEHIAIIMDGNGRWAKKRKMPRIKGHYEGMQTIKKI
CCHHHHCCCCCCCHHHHHCCCCCCCCEEEEEECCCCCCHHHHCCCCHHHHHHHHHHHHHH
TRVASDIGVKYLTLYAFSTENWSRPESEVNYIMNLPVNFLKTFLPELIEKNVKVETIGFT
HHHHHHHCCEEEEEEEECCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCEEEEECCC
DKLPKSTIEAINNAKEKTANNTGLKLIFAINYGGRAELVHSIKNMFDELHQQGLNSDIID
CCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
ETYINNHLMTKDYPDPELLIRTSGEQRISNFLIWQVSYSEFIFNQKLWPDFDEDELIKCI
HHHHCCCCCCCCCCCCCEEEECCCHHHHHHEEEEEEEHHHHHHCCCCCCCCCHHHHHHHH
KIYQSRQRRFGGLSEE
HHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA