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The map label for this gene is saeR

Identifier: 57651545

GI number: 57651545

Start: 788786

End: 789472

Strand: Reverse

Name: saeR

Synonym: SACOL0766

Alternate gene names: 57651545

Gene position: 789472-788786 (Counterclockwise)

Preceding gene: 57651546

Following gene: 57651544

Centisome position: 28.1

GC content: 32.75

Gene sequence:

>687_bases
ATGACCCACTTACTGATCGTGGATGATGAACAAGACATTGTAGACATTTGTCAAACCTATTTTGAATATGAAGGTTACAA
AGTAACAACGACAACTAGCGGTAAAGAAGCAATTTCTTTACTATCAAATGATATTGATATCATGGTACTTGATATCATGA
TGCCAGAAGTTAATGGTTACGACATTGTCAAAGAAATGAAAAGGCAAAAATTAGATATCCCCTTTATCTATTTAACTGCC
AAAACACAAGAACATGATACCATTTACGCCTTAACTTTAGGTGCAGATGACTATGTCAAAAAACCATTTAGTCCAAGGGA
ACTCGTTTTACGTATTAATAATTTACTTACAAGAATGAAGAAATACCATCATCAACCAGTTGAACAACTGTCGTTTGATG
AATTAACACTTATTAACTTAAGTAAAGTTGTGACTGTAAATGGTCACGAAGTCCCTATGCGTATTAAGGAATTTGAGTTA
TTGTGGTATTTAGCTTCTAGAGAAAATGAAGTTATTTCTAAATCAGAATTACTTGAAAAAGTTTGGGGATATGACTATTA
CGAAGATGCTAATACCGTGAATGTCCATATACACCGTATTAGAGAAAAATTAGAAAAAGAGAGCTTTACAACATATACCA
TCACAACTGTATGGGGATTAGGATATAAATTTGAAAGGAGCCGATAA

Upstream 100 bases:

>100_bases
TTTATCCTTTTACTAATGAGTCACTCATTGTTAAAACAGATTTCACTTAAAGAAATCATTAATTACTTTAGAGGTCGTAA
GAACAGAGGTGAAAAAATAG

Downstream 100 bases:

>100_bases
TGGTGTTATCAATTAGAAGTCAAATCATTATTGGCGTCGTATCGAGTATACTATTAACTTCAACTATTTTAGCAATTGCA
TATATTTTAATGTGGTTTAA

Product: DNA-binding response regulator SaeR

Products: NA

Alternate protein names: Staphylococcus exoprotein expression protein R

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MTHLLIVDDEQDIVDICQTYFEYEGYKVTTTTSGKEAISLLSNDIDIMVLDIMMPEVNGYDIVKEMKRQKLDIPFIYLTA
KTQEHDTIYALTLGADDYVKKPFSPRELVLRINNLLTRMKKYHHQPVEQLSFDELTLINLSKVVTVNGHEVPMRIKEFEL
LWYLASRENEVISKSELLEKVWGYDYYEDANTVNVHIHRIREKLEKESFTTYTITTVWGLGYKFERSR

Sequences:

>Translated_228_residues
MTHLLIVDDEQDIVDICQTYFEYEGYKVTTTTSGKEAISLLSNDIDIMVLDIMMPEVNGYDIVKEMKRQKLDIPFIYLTA
KTQEHDTIYALTLGADDYVKKPFSPRELVLRINNLLTRMKKYHHQPVEQLSFDELTLINLSKVVTVNGHEVPMRIKEFEL
LWYLASRENEVISKSELLEKVWGYDYYEDANTVNVHIHRIREKLEKESFTTYTITTVWGLGYKFERSR
>Mature_227_residues
THLLIVDDEQDIVDICQTYFEYEGYKVTTTTSGKEAISLLSNDIDIMVLDIMMPEVNGYDIVKEMKRQKLDIPFIYLTAK
TQEHDTIYALTLGADDYVKKPFSPRELVLRINNLLTRMKKYHHQPVEQLSFDELTLINLSKVVTVNGHEVPMRIKEFELL
WYLASRENEVISKSELLEKVWGYDYYEDANTVNVHIHRIREKLEKESFTTYTITTVWGLGYKFERSR

Specific function: Member of the two-component regulatory system saeR/saeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a transcriptional regulator via a specific DNA-binding domain, recognizing motifs n

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain

Homologues:

Organism=Escherichia coli, GI1790863, Length=229, Percent_Identity=34.4978165938865, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI87082012, Length=222, Percent_Identity=32.4324324324324, Blast_Score=131, Evalue=3e-32,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=31.4159292035398, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1786599, Length=224, Percent_Identity=33.9285714285714, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=33.9285714285714, Blast_Score=122, Evalue=1e-29,
Organism=Escherichia coli, GI1790860, Length=225, Percent_Identity=31.5555555555556, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=225, Percent_Identity=31.1111111111111, Blast_Score=117, Evalue=5e-28,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=33.4801762114537, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1788394, Length=227, Percent_Identity=30.8370044052863, Blast_Score=110, Evalue=6e-26,
Organism=Escherichia coli, GI1789402, Length=221, Percent_Identity=30.316742081448, Blast_Score=108, Evalue=4e-25,
Organism=Escherichia coli, GI1787229, Length=215, Percent_Identity=32.093023255814, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=30.9090909090909, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=29.0598290598291, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=26.3392857142857, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI1788550, Length=125, Percent_Identity=36, Blast_Score=76, Evalue=2e-15,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SAER_STAA3 (Q2FIT4)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_493394.1
- ProteinModelPortal:   Q2FIT4
- SMR:   Q2FIT4
- STRING:   Q2FIT4
- EnsemblBacteria:   EBSTAT00000037290
- GeneID:   3913605
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_0691
- eggNOG:   COG0745
- GeneTree:   EBGT00050000024053
- HOGENOM:   HBG753323
- ProtClustDB:   CLSK883907
- GO:   GO:0005737
- GO:   GO:0009405
- GO:   GO:0006350
- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- SMART:   SM00448
- SMART:   SM00862

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C; SSF52172 CheY_like

EC number: NA

Molecular weight: Translated: 26858; Mature: 26727

Theoretical pI: Translated: 5.05; Mature: 5.05

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHLLIVDDEQDIVDICQTYFEYEGYKVTTTTSGKEAISLLSNDIDIMVLDIMMPEVNGY
CCEEEEEECCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCEEEEEEECCCCCCH
DIVKEMKRQKLDIPFIYLTAKTQEHDTIYALTLGADDYVKKPFSPRELVLRINNLLTRMK
HHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHH
KYHHQPVEQLSFDELTLINLSKVVTVNGHEVPMRIKEFELLWYLASRENEVISKSELLEK
HHCCCCHHHCCCCCEEEEEEEEEEEECCCCCCCCHHHEEEEEEEECCCCCHHHHHHHHHH
VWGYDYYEDANTVNVHIHRIREKLEKESFTTYTITTVWGLGYKFERSR
HHCCCCCCCCCEEEEHHHHHHHHHHHCCCEEEEEEEEECCCEEEECCC
>Mature Secondary Structure 
THLLIVDDEQDIVDICQTYFEYEGYKVTTTTSGKEAISLLSNDIDIMVLDIMMPEVNGY
CEEEEEECCCHHHHHHHHHHHCCCEEEEEECCHHHHHHHHCCCCCEEEEEEECCCCCCH
DIVKEMKRQKLDIPFIYLTAKTQEHDTIYALTLGADDYVKKPFSPRELVLRINNLLTRMK
HHHHHHHHHCCCCCEEEEEECCCCCCEEEEEEECCCHHHHCCCCHHHHHHHHHHHHHHHH
KYHHQPVEQLSFDELTLINLSKVVTVNGHEVPMRIKEFELLWYLASRENEVISKSELLEK
HHCCCCHHHCCCCCEEEEEEEEEEEECCCCCCCCHHHEEEEEEEECCCCCHHHHHHHHHH
VWGYDYYEDANTVNVHIHRIREKLEKESFTTYTITTVWGLGYKFERSR
HHCCCCCCCCCEEEEHHHHHHHHHHHCCCEEEEEEEEECCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA