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The map label for this gene is saeS

Identifier: 57651544

GI number: 57651544

Start: 787731

End: 788786

Strand: Reverse

Name: saeS

Synonym: SACOL0765

Alternate gene names: 57651544

Gene position: 788786-787731 (Counterclockwise)

Preceding gene: 57651545

Following gene: 57651534

Centisome position: 28.08

GC content: 30.49

Gene sequence:

>1056_bases
ATGGTGTTATCAATTAGAAGTCAAATCATTATTGGCGTCGTATCGAGTATACTATTAACTTCAACTATTTTAGCAATTGC
ATATATTTTAATGTGGTTTAACGGCCATATGACACTAACTTTGACCTTAACGACAATAATTACAAGCTGTTTAACCTTAT
TAATATGTAGTATTTTTATTAATCCACTTATACAAAAAATTAAGCAGTTTAATATAAAAACTAAGCAATTTGCTAACGGA
AATTACGCAAGCAATGATAAAACGTTTAATTCACCAAAAGAAATTTATGAATTAAATCAATCTTTTAATAAAATGGCTTC
TGAAATTACGCAACAAATGAATCAAATTAAATCCGAACAACAAGAAAAAACAGAACTGATTCAAAACTTAGCCCATGATT
TAAAAACACCTTTAGCAAGCATTATTTCATATTCTGAAGGACTACGTGATGGTATAATCACTAAGGATCATGAGATTAAA
GAGTCATACGACATATTAATTAAACAAGCAAACAGATTATCAACATTATTTGATGATATGACTCATATTATCACTTTAAA
TACAGGTAAAACATATCCCCCAGAATTAATACAACTAGACCAATTACTTGTATCAATATTGCAACCATATGAGCAACGTA
TCAAACATGAAAACCGCACATTAGAAGTGAATTTCTGTAACGAAATTGATGCATTTTATCAATATCGAACGCCACTTGAG
CGTATTTTAACAAACTTACTTGATAATGCGCTAAAATTTTCAAATGTTGGTAGTCGCATTGATATTAATATTAGTGAAAA
CGAAGATCAAGATACTATCGACATTGCTATTAGCGATGAAGGTATTGGCATTATACCAGAACTACAAGAACGTATATTCG
AACGTACATTCAGAGTAGAAAACTCTCGTAATACAAAAACGGGTGGTTCTGGATTAGGCTTATATATAGCTAATGAACTC
GCGCAACAAAATAACGCAAAAATCAGTGTAAGCAGTGATATAGATGTAGGAACTACGATGACTGTAACATTACACAAATT
AGACATTACGTCATAA

Upstream 100 bases:

>100_bases
ATATACACCGTATTAGAGAAAAATTAGAAAAAGAGAGCTTTACAACATATACCATCACAACTGTATGGGGATTAGGATAT
AAATTTGAAAGGAGCCGATA

Downstream 100 bases:

>100_bases
TCCGATTTATTTATAAAATAAAATGCAAAGACTAAAAAGAAGCTCCCATTAATGAGGGCTTCTTTTTTTGTTTATTTAGA
ATAAACTTTATGGGTATCCT

Product: sensor histidine kinase SaeS

Products: NA

Alternate protein names: Sensor protein saeS; Staphylococcus exoprotein expression protein S

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MVLSIRSQIIIGVVSSILLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFINPLIQKIKQFNIKTKQFANG
NYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQQEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIK
ESYDILIKQANRLSTLFDDMTHIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCNEIDAFYQYRTPLE
RILTNLLDNALKFSNVGSRIDINISENEDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANEL
AQQNNAKISVSSDIDVGTTMTVTLHKLDITS

Sequences:

>Translated_351_residues
MVLSIRSQIIIGVVSSILLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFINPLIQKIKQFNIKTKQFANG
NYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQQEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIK
ESYDILIKQANRLSTLFDDMTHIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCNEIDAFYQYRTPLE
RILTNLLDNALKFSNVGSRIDINISENEDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANEL
AQQNNAKISVSSDIDVGTTMTVTLHKLDITS
>Mature_351_residues
MVLSIRSQIIIGVVSSILLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFINPLIQKIKQFNIKTKQFANG
NYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQQEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIK
ESYDILIKQANRLSTLFDDMTHIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCNEIDAFYQYRTPLE
RILTNLLDNALKFSNVGSRIDINISENEDQDTIDIAISDEGIGIIPELQERIFERTFRVENSRNTKTGGSGLGLYIANEL
AQQNNAKISVSSDIDVGTTMTVTLHKLDITS

Specific function: Member of the two-component regulatory system saeR/saeS involved in the regulation of staphylococcal virulence factors in a strain-dependent fashion. Probably functions as a membrane- associated protein kinase that upon sensing the appropriate signal, aut

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain

Homologues:

Organism=Escherichia coli, GI1788393, Length=283, Percent_Identity=26.8551236749117, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1790346, Length=270, Percent_Identity=27.037037037037, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1786783, Length=325, Percent_Identity=23.0769230769231, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI48994928, Length=254, Percent_Identity=26.7716535433071, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1786600, Length=252, Percent_Identity=24.2063492063492, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1789149, Length=266, Percent_Identity=25.5639097744361, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788713, Length=233, Percent_Identity=24.8927038626609, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87081816, Length=241, Percent_Identity=24.896265560166, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790861, Length=269, Percent_Identity=25.6505576208178, Blast_Score=69, Evalue=5e-13,
Organism=Escherichia coli, GI1787374, Length=260, Percent_Identity=25.7692307692308, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1789808, Length=256, Percent_Identity=23.4375, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI145693157, Length=259, Percent_Identity=26.2548262548263, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI87082128, Length=292, Percent_Identity=23.2876712328767, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAES_STAA3 (Q2FIT5)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_493393.1
- ProteinModelPortal:   Q2FIT5
- STRING:   Q2FIT5
- EnsemblBacteria:   EBSTAT00000038071
- GeneID:   3913143
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_0690
- eggNOG:   COG0642
- GeneTree:   EBGT00050000023863
- HOGENOM:   HBG693606
- OMA:   KESLRYV
- ProtClustDB:   CLSK884840
- GO:   GO:0009405
- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- Gene3D:   G3DSA:3.30.565.10
- PRINTS:   PR00344
- SMART:   SM00304
- SMART:   SM00387
- SMART:   SM00388

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; SSF55874 ATP_bd_ATPase; SSF47384 His_kin_homodim

EC number: =2.7.13.3

Molecular weight: Translated: 39742; Mature: 39742

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS50885 HAMP; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd657848)-; HASH(0xd978ad0)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLSIRSQIIIGVVSSILLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFI
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHH
NPLIQKIKQFNIKTKQFANGNYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQ
HHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIKESYDILIKQANRLSTLFDDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
THIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCNEIDAFYQYRTPLE
HHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCHHH
RILTNLLDNALKFSNVGSRIDINISENEDQDTIDIAISDEGIGIIPELQERIFERTFRVE
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCC
NSRNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTLHKLDITS
CCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEECCH
>Mature Secondary Structure
MVLSIRSQIIIGVVSSILLTSTILAIAYILMWFNGHMTLTLTLTTIITSCLTLLICSIFI
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHH
NPLIQKIKQFNIKTKQFANGNYASNDKTFNSPKEIYELNQSFNKMASEITQQMNQIKSEQ
HHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QEKTELIQNLAHDLKTPLASIISYSEGLRDGIITKDHEIKESYDILIKQANRLSTLFDDM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
THIITLNTGKTYPPELIQLDQLLVSILQPYEQRIKHENRTLEVNFCNEIDAFYQYRTPLE
HHEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHCCHHH
RILTNLLDNALKFSNVGSRIDINISENEDQDTIDIAISDEGIGIIPELQERIFERTFRVE
HHHHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHCC
NSRNTKTGGSGLGLYIANELAQQNNAKISVSSDIDVGTTMTVTLHKLDITS
CCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCEEEEEEEEEECCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA