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The map label for this gene is cobB [H]

Identifier: 57650785

GI number: 57650785

Start: 2270247

End: 2270978

Strand: Direct

Name: cobB [H]

Synonym: SACOL2189

Alternate gene names: 57650785

Gene position: 2270247-2270978 (Clockwise)

Preceding gene: 57652198

Following gene: 57650790

Centisome position: 80.81

GC content: 36.07

Gene sequence:

>732_bases
TTGAAACATGATTTAGAGACACTAAAACATATTATAGATAGTTCGAATCGTATTACATTTTTTACAGGTGCTGGTGTATC
TGTCGCAAGTGGCGTTCCAGATTTCCGTTCAATGGGTGGCTTATTTGATGAAATTTCAAAAGATGGGCTTTCGCCAGAAT
ACTTGTTAAGCCGTGATTATTTAGAAGATGATCCTGAAGGTTTTATCAATTTCTGCCATAAGCGCTTACTATTTGTCGAT
ACGATGCCCAATATCGTTCATGATTGGATTGCAAAATTAGAACGTAATCAACAATCTTTAGGTATCATCACGCAAAATAT
CGATGGTTTGCACTCAGACGCTGGAAGTCAACATGTTGATGAATTACATGGCACGTTAAATCGTTTTTATTGTAATGTAT
GTCATAAATCTTATACGAAGTCAGATGTTATTGATAGAACTTTGAAACATTGTGATAATTGTGGTGGTGCCATTCGACCG
GACATCGTATTATACGGTGAAATGTTAGATCAACCTACCATCATAAGGGCATTAAATAAAATTGAACATGCTGACACCCT
TGTTGTACTAGGTTCATCACTCGTTGTACAACCTGCCGCAGGATTAATATCACATTTTAAAGGCGACAATTTAATTATTA
TCAATAAAGATCGAACACCTTATGATAGCGACGCTACTTTGGTCATACATGACGACATGGTTTCCGTTGTAAAATCATTA
ATGACAGAGTAA

Upstream 100 bases:

>100_bases
GAACTGTTTAAACTGCGCTTTTGATAATCGTAAAATGAATATACTATAATAAAAGTAAAAGACGTTATAAATCATTCATT
ATTTTGATGGGGTGTTTAAC

Downstream 100 bases:

>100_bases
TCAGTATGTAAAAAGCATTTCCCGAATGGTAGGGAAATGCTTTTAATTTTGGAGTTGCGTTTTTGGAATTTGGAGTTTGG
TTTTCGGAATTCGACATTTG

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MKHDLETLKHIIDSSNRITFFTGAGVSVASGVPDFRSMGGLFDEISKDGLSPEYLLSRDYLEDDPEGFINFCHKRLLFVD
TMPNIVHDWIAKLERNQQSLGIITQNIDGLHSDAGSQHVDELHGTLNRFYCNVCHKSYTKSDVIDRTLKHCDNCGGAIRP
DIVLYGEMLDQPTIIRALNKIEHADTLVVLGSSLVVQPAAGLISHFKGDNLIIINKDRTPYDSDATLVIHDDMVSVVKSL
MTE

Sequences:

>Translated_243_residues
MKHDLETLKHIIDSSNRITFFTGAGVSVASGVPDFRSMGGLFDEISKDGLSPEYLLSRDYLEDDPEGFINFCHKRLLFVD
TMPNIVHDWIAKLERNQQSLGIITQNIDGLHSDAGSQHVDELHGTLNRFYCNVCHKSYTKSDVIDRTLKHCDNCGGAIRP
DIVLYGEMLDQPTIIRALNKIEHADTLVVLGSSLVVQPAAGLISHFKGDNLIIINKDRTPYDSDATLVIHDDMVSVVKSL
MTE
>Mature_243_residues
MKHDLETLKHIIDSSNRITFFTGAGVSVASGVPDFRSMGGLFDEISKDGLSPEYLLSRDYLEDDPEGFINFCHKRLLFVD
TMPNIVHDWIAKLERNQQSLGIITQNIDGLHSDAGSQHVDELHGTLNRFYCNVCHKSYTKSDVIDRTLKHCDNCGGAIRP
DIVLYGEMLDQPTIIRALNKIEHADTLVVLGSSLVVQPAAGLISHFKGDNLIIINKDRTPYDSDATLVIHDDMVSVVKSL
MTE

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI6912660, Length=227, Percent_Identity=31.7180616740088, Blast_Score=110, Evalue=8e-25,
Organism=Homo sapiens, GI63054862, Length=205, Percent_Identity=33.1707317073171, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI7657575, Length=237, Percent_Identity=29.1139240506329, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI300795542, Length=226, Percent_Identity=30.9734513274336, Blast_Score=102, Evalue=2e-22,
Organism=Homo sapiens, GI13775602, Length=218, Percent_Identity=32.5688073394495, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI13775600, Length=218, Percent_Identity=32.5688073394495, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI13787215, Length=244, Percent_Identity=29.0983606557377, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI6912664, Length=244, Percent_Identity=29.0983606557377, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI300797705, Length=199, Percent_Identity=31.6582914572864, Blast_Score=89, Evalue=5e-18,
Organism=Homo sapiens, GI300797577, Length=258, Percent_Identity=26.7441860465116, Blast_Score=88, Evalue=7e-18,
Organism=Homo sapiens, GI7706712, Length=263, Percent_Identity=27.3764258555133, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI300797597, Length=245, Percent_Identity=26.530612244898, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI215982798, Length=174, Percent_Identity=28.735632183908, Blast_Score=72, Evalue=3e-13,
Organism=Escherichia coli, GI308199517, Length=201, Percent_Identity=34.3283582089552, Blast_Score=89, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17541892, Length=234, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17567771, Length=285, Percent_Identity=25.9649122807018, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71990482, Length=285, Percent_Identity=25.9649122807018, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71990487, Length=287, Percent_Identity=25.7839721254355, Blast_Score=92, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6325242, Length=219, Percent_Identity=31.5068493150685, Blast_Score=86, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6324599, Length=278, Percent_Identity=29.136690647482, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6324504, Length=269, Percent_Identity=27.5092936802974, Blast_Score=79, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320163, Length=257, Percent_Identity=25.2918287937743, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6320397, Length=252, Percent_Identity=24.2063492063492, Blast_Score=69, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17137536, Length=241, Percent_Identity=29.8755186721992, Blast_Score=100, Evalue=8e-22,
Organism=Drosophila melanogaster, GI24648389, Length=212, Percent_Identity=32.5471698113208, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI28571445, Length=213, Percent_Identity=24.8826291079812, Blast_Score=81, Evalue=7e-16,
Organism=Drosophila melanogaster, GI24645650, Length=244, Percent_Identity=26.2295081967213, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 27066; Mature: 27066

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKHDLETLKHIIDSSNRITFFTGAGVSVASGVPDFRSMGGLFDEISKDGLSPEYLLSRDY
CCCHHHHHHHHHCCCCCEEEEECCCCHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHC
LEDDPEGFINFCHKRLLFVDTMPNIVHDWIAKLERNQQSLGIITQNIDGLHSDAGSQHVD
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHCCCCHHCCCCHHHHH
ELHGTLNRFYCNVCHKSYTKSDVIDRTLKHCDNCGGAIRPDIVLYGEMLDQPTIIRALNK
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHCCCHHHHHHHH
IEHADTLVVLGSSLVVQPAAGLISHFKGDNLIIINKDRTPYDSDATLVIHDDMVSVVKSL
HHHHHHEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHH
MTE
HCC
>Mature Secondary Structure
MKHDLETLKHIIDSSNRITFFTGAGVSVASGVPDFRSMGGLFDEISKDGLSPEYLLSRDY
CCCHHHHHHHHHCCCCCEEEEECCCCHHHCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHC
LEDDPEGFINFCHKRLLFVDTMPNIVHDWIAKLERNQQSLGIITQNIDGLHSDAGSQHVD
CCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHCCCCHHCCCCHHHHH
ELHGTLNRFYCNVCHKSYTKSDVIDRTLKHCDNCGGAIRPDIVLYGEMLDQPTIIRALNK
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHCCCHHHHHHHH
IEHADTLVVLGSSLVVQPAAGLISHFKGDNLIIINKDRTPYDSDATLVIHDDMVSVVKSL
HHHHHHEEEECCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCEEEEEHHHHHHHHHH
MTE
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2163387 [H]