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The map label for this gene is hysA

Identifier: 57650790

GI number: 57650790

Start: 2274226

End: 2276649

Strand: Direct

Name: hysA

Synonym: SACOL2194

Alternate gene names: 57650790

Gene position: 2274226-2276649 (Clockwise)

Preceding gene: 57650785

Following gene: 57650793

Centisome position: 80.95

GC content: 33.0

Gene sequence:

>2424_bases
ATGACATATAGAATAAAGAAATGGCAAAAATTATCCACCATTACGTTATTAATGGCTGGTGTGATTACTTTGAATGGTGG
TGAATTCAGAAGTGTTGATAAACATCAAATCGCTGTGGCTGATACGAATGTTCAAACGCCAGATTATGAAAAATTGAGGA
ACACATGGCTGGACGTTAACTATGGTTATGATAAGTATGATGAGAATAATCCAGATATGAAGAAGAAGTTTGATGCTACA
GAGAAAGAGGCGACGAATTTACTCAAGGAAATGAAAACTGAAAGTGGTAGGAAATACTTGTGGTCAGGAGCGGAAACCCT
TGAAACTAATTCTTCTCATATGACTCGTACCTATCGTAATATTGAGAAAATCGCAGAAGCGATGAGGAATCCTAAAACCA
CTTTAAATACTGACGAAAATAAGAAGAAAGTGAAAGATGCCCTTGAGTGGCTGCATAAAAATGCATATGGAAAAGAACCA
GATAAAAAAGTAAAAGAATTAAGTGAGAATTTTACTAAAACAACTGGCAAGAATACCAACTTAAATTGGTGGGATTATGA
AATTGGAACACCTAAATCATTAACAAATACGCTTATATTGCTGAATGATCAATTTTCAAATGAAGAAAAGAAAAAATTCA
CTGCCCCTATTAAAACTTTCGCCCCAGATAGTGACAAAATATTATCTTCTGTAGGAAAAGCTGAACTTGCTAAAGGCGGA
AATCTAGTAGACATTTCTAAGGTGAAACTTTTAGAATGTATTATCGAAGAAGATAAAGATATGATGAAAAAGTCTATAGA
TTCATTTAATAAAGTCTTCACTTACGTTCAAGATTCTGCCACTGGTAAAGAACGTAATGGATTTTATAAAGATGGCTCTT
ACATTGATCATCAAGACGTTCCATACACTGGTGCTTATGGCGTTGTACTCTTAGAGGGGATTTCTCAAATGATGCCGATG
ATAAAAGAAACACCTTTTAATGATAAAACCCAAAATGATACAACCTTAAAGTCATGGATTGACGACGGATTTATGCCACT
CATTTATAAAGGTGAAATGATGGATTTATCACGAGGTAGAGCTATCAGTCGTGAAAATGAAACCAGTCACTCAGCATCTG
CAACAGTAATGAAATCATTGTTGAGATTAAGTGATGCCATGGATGATTCAACAAAAGCTAAGTATAAAAAGATTGTCAAA
TCTTCAGTAGAGTCAGATTCAAGTTATAAACAAAATGATTATTTAAATTCATATTCGGACATAGATAAAATGAAGTCTTT
AATGACAGATAACAGTATTTCTAAAAACGGATTAACACAACAACTTAAAATATATAATGACATGGATCGTGTCACCTATC
ATAACAAAGACTTAGACTTTGCATTTGGTTTAAGTATGACGTCGAAAAACGTAGCACGCTATGAAAGTATCAACGGAGAG
AATTTAAAAGGTTGGCACACTGGTGCTGGAATGTCTTATTTATATAACAGCGATGTCAAACACTATCATGATAACTTCTG
GGTGACAGCCGATATGAAACGTTTATCAGGTACAACAACTTTAGACAATGAAATATTAAAAGATACGGATGATAAAAAGT
CGAGTAAAACTTTTGTTGGCGGAACAAAAGTTGATGACCAACATGCTAGTATCGGAATGGATTTTGAAAATCAGGACAAA
ACTTTAACTGCCAAAAAATCATATTTCATATTAAACGATAAAATTGTCTTCTTAGGAACTGGCATTAAAAGTACTGATTC
ATCAAAGAATCCAGTTACAACGATTGAAAATCGCAAAGCGAATGGGTATACGTTATATACAGACGATAAACAAACAACCA
ATTCTGATAATCAGGAAAACAATTCAGTCTTTTTAGAGTCCACAGATACCAAAAAGAACATCGGTTATCATTTTTTAAAC
AAACCGAAAATAACTGTAAAAAAAGAAAGTCATACTGGTAAGTGGAAAGAAATAAATAAAAGTCAAAAGGATACACAAAA
AACTGATGAGTATTATGAAGTAACTCAAAAGCATTCTAATTCTGACAATAAATATGGATATGTGTTGTATCCAGGCTTAT
CTAAAGATGTCTTTAAGACAAAAAAAGATGAAGTAACTGTCGTTAAGCAAGAAGATGACTTCCACGTTGTGAAAGATAAT
GAATCGGTTTGGGCTGGTGTTAATTATAGTAATAGCACTCAAACTTTTGACATTAACAACACTAAAGTCGAAGTTAAAGC
CAAAGGTATGTTTATACTTAAAAAGAAAGATGATAACACTTATGAATGTAGCTTCTATAATCCTGAATCTACAAATTCCG
CTTCAGATATTGAATCTAAAATTTCAATGACCGGTTACTCTATTACAAACAAAAATACGTCGACTTCTAATGAATCCGGC
GTGCACTTTGAATTAACTAAATAA

Upstream 100 bases:

>100_bases
TAGACAGTCATTTGTATACGTTAACGAATTTTGAAAAATTGAATCATTATTTAATCATAATATTCATTGCGCACGCGCAA
CACAAAAAGGAGACATGTCA

Downstream 100 bases:

>100_bases
GCAAGAAAATCTCGACACTATACCATTTTTATAGTGTCGAGATTTTATAAGTATCGCCATCATTCAGCTTGTAATCCGCA
GACCACATCCCCTTTGATAA

Product: hyaluronate lyase

Products: NA

Alternate protein names: Hyaluronidase; HYase

Number of amino acids: Translated: 807; Mature: 806

Protein sequence:

>807_residues
MTYRIKKWQKLSTITLLMAGVITLNGGEFRSVDKHQIAVADTNVQTPDYEKLRNTWLDVNYGYDKYDENNPDMKKKFDAT
EKEATNLLKEMKTESGRKYLWSGAETLETNSSHMTRTYRNIEKIAEAMRNPKTTLNTDENKKKVKDALEWLHKNAYGKEP
DKKVKELSENFTKTTGKNTNLNWWDYEIGTPKSLTNTLILLNDQFSNEEKKKFTAPIKTFAPDSDKILSSVGKAELAKGG
NLVDISKVKLLECIIEEDKDMMKKSIDSFNKVFTYVQDSATGKERNGFYKDGSYIDHQDVPYTGAYGVVLLEGISQMMPM
IKETPFNDKTQNDTTLKSWIDDGFMPLIYKGEMMDLSRGRAISRENETSHSASATVMKSLLRLSDAMDDSTKAKYKKIVK
SSVESDSSYKQNDYLNSYSDIDKMKSLMTDNSISKNGLTQQLKIYNDMDRVTYHNKDLDFAFGLSMTSKNVARYESINGE
NLKGWHTGAGMSYLYNSDVKHYHDNFWVTADMKRLSGTTTLDNEILKDTDDKKSSKTFVGGTKVDDQHASIGMDFENQDK
TLTAKKSYFILNDKIVFLGTGIKSTDSSKNPVTTIENRKANGYTLYTDDKQTTNSDNQENNSVFLESTDTKKNIGYHFLN
KPKITVKKESHTGKWKEINKSQKDTQKTDEYYEVTQKHSNSDNKYGYVLYPGLSKDVFKTKKDEVTVVKQEDDFHVVKDN
ESVWAGVNYSNSTQTFDINNTKVEVKAKGMFILKKKDDNTYECSFYNPESTNSASDIESKISMTGYSITNKNTSTSNESG
VHFELTK

Sequences:

>Translated_807_residues
MTYRIKKWQKLSTITLLMAGVITLNGGEFRSVDKHQIAVADTNVQTPDYEKLRNTWLDVNYGYDKYDENNPDMKKKFDAT
EKEATNLLKEMKTESGRKYLWSGAETLETNSSHMTRTYRNIEKIAEAMRNPKTTLNTDENKKKVKDALEWLHKNAYGKEP
DKKVKELSENFTKTTGKNTNLNWWDYEIGTPKSLTNTLILLNDQFSNEEKKKFTAPIKTFAPDSDKILSSVGKAELAKGG
NLVDISKVKLLECIIEEDKDMMKKSIDSFNKVFTYVQDSATGKERNGFYKDGSYIDHQDVPYTGAYGVVLLEGISQMMPM
IKETPFNDKTQNDTTLKSWIDDGFMPLIYKGEMMDLSRGRAISRENETSHSASATVMKSLLRLSDAMDDSTKAKYKKIVK
SSVESDSSYKQNDYLNSYSDIDKMKSLMTDNSISKNGLTQQLKIYNDMDRVTYHNKDLDFAFGLSMTSKNVARYESINGE
NLKGWHTGAGMSYLYNSDVKHYHDNFWVTADMKRLSGTTTLDNEILKDTDDKKSSKTFVGGTKVDDQHASIGMDFENQDK
TLTAKKSYFILNDKIVFLGTGIKSTDSSKNPVTTIENRKANGYTLYTDDKQTTNSDNQENNSVFLESTDTKKNIGYHFLN
KPKITVKKESHTGKWKEINKSQKDTQKTDEYYEVTQKHSNSDNKYGYVLYPGLSKDVFKTKKDEVTVVKQEDDFHVVKDN
ESVWAGVNYSNSTQTFDINNTKVEVKAKGMFILKKKDDNTYECSFYNPESTNSASDIESKISMTGYSITNKNTSTSNESG
VHFELTK
>Mature_806_residues
TYRIKKWQKLSTITLLMAGVITLNGGEFRSVDKHQIAVADTNVQTPDYEKLRNTWLDVNYGYDKYDENNPDMKKKFDATE
KEATNLLKEMKTESGRKYLWSGAETLETNSSHMTRTYRNIEKIAEAMRNPKTTLNTDENKKKVKDALEWLHKNAYGKEPD
KKVKELSENFTKTTGKNTNLNWWDYEIGTPKSLTNTLILLNDQFSNEEKKKFTAPIKTFAPDSDKILSSVGKAELAKGGN
LVDISKVKLLECIIEEDKDMMKKSIDSFNKVFTYVQDSATGKERNGFYKDGSYIDHQDVPYTGAYGVVLLEGISQMMPMI
KETPFNDKTQNDTTLKSWIDDGFMPLIYKGEMMDLSRGRAISRENETSHSASATVMKSLLRLSDAMDDSTKAKYKKIVKS
SVESDSSYKQNDYLNSYSDIDKMKSLMTDNSISKNGLTQQLKIYNDMDRVTYHNKDLDFAFGLSMTSKNVARYESINGEN
LKGWHTGAGMSYLYNSDVKHYHDNFWVTADMKRLSGTTTLDNEILKDTDDKKSSKTFVGGTKVDDQHASIGMDFENQDKT
LTAKKSYFILNDKIVFLGTGIKSTDSSKNPVTTIENRKANGYTLYTDDKQTTNSDNQENNSVFLESTDTKKNIGYHFLNK
PKITVKKESHTGKWKEINKSQKDTQKTDEYYEVTQKHSNSDNKYGYVLYPGLSKDVFKTKKDEVTVVKQEDDFHVVKDNE
SVWAGVNYSNSTQTFDINNTKVEVKAKGMFILKKKDDNTYECSFYNPESTNSASDIESKISMTGYSITNKNTSTSNESGV
HFELTK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the polysaccharide lyase 8 family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HYSA_STAA8 (Q59801)

Other databases:

- EMBL:   U21221
- EMBL:   CP000253
- RefSeq:   YP_500931.1
- ProteinModelPortal:   Q59801
- SMR:   Q59801
- STRING:   Q59801
- EnsemblBacteria:   EBSTAT00000027883
- GeneID:   3919026
- GenomeReviews:   CP000253_GR
- KEGG:   sao:SAOUHSC_02463
- eggNOG:   NOG04835
- GeneTree:   EBGT00050000023753
- HOGENOM:   HBG693731
- OMA:   TTIDQRK
- ProtClustDB:   CLSK885824
- BioCyc:   SAUR93061:SAOUHSC_02463-MONOMER
- InterPro:   IPR008929
- InterPro:   IPR011013
- InterPro:   IPR014718
- InterPro:   IPR011071
- InterPro:   IPR012970
- InterPro:   IPR004103
- InterPro:   IPR003159
- InterPro:   IPR012329
- Gene3D:   G3DSA:2.70.98.10
- Gene3D:   G3DSA:2.60.220.10
- Gene3D:   G3DSA:1.50.10.100

Pfam domain/function: PF02278 Lyase_8; PF02884 Lyase_8_C; PF08124 Lyase_8_N; SSF48230 Chondroitin_lyas; SSF74650 Gal_mut_like; SSF49863 Lyase_like_C

EC number: =4.2.2.1

Molecular weight: Translated: 91986; Mature: 91854

Theoretical pI: Translated: 7.79; Mature: 7.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYRIKKWQKLSTITLLMAGVITLNGGEFRSVDKHQIAVADTNVQTPDYEKLRNTWLDVN
CCCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHCEEEEC
YGYDKYDENNPDMKKKFDATEKEATNLLKEMKTESGRKYLWSGAETLETNSSHMTRTYRN
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCHHHHHHHHH
IEKIAEAMRNPKTTLNTDENKKKVKDALEWLHKNAYGKEPDKKVKELSENFTKTTGKNTN
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCC
LNWWDYEIGTPKSLTNTLILLNDQFSNEEKKKFTAPIKTFAPDSDKILSSVGKAELAKGG
CCEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHCCHHHCCCCHHHHHHHHCHHHHHCCC
NLVDISKVKLLECIIEEDKDMMKKSIDSFNKVFTYVQDSATGKERNGFYKDGSYIDHQDV
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
PYTGAYGVVLLEGISQMMPMIKETPFNDKTQNDTTLKSWIDDGFMPLIYKGEMMDLSRGR
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEEEECCEEECCCCC
AISRENETSHSASATVMKSLLRLSDAMDDSTKAKYKKIVKSSVESDSSYKQNDYLNSYSD
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHH
IDKMKSLMTDNSISKNGLTQQLKIYNDMDRVTYHNKDLDFAFGLSMTSKNVARYESINGE
HHHHHHHHCCCCCCCCCCHHHHHHHHCHHHHEECCCCCCEEEECCCCCCCHHHHHCCCCC
NLKGWHTGAGMSYLYNSDVKHYHDNFWVTADMKRLSGTTTLDNEILKDTDDKKSSKTFVG
CCCCEECCCCCCEEECCCCHHCCCCEEEEEEHHHCCCCCCCCHHHHHCCCCCCCCCEEEC
GTKVDDQHASIGMDFENQDKTLTAKKSYFILNDKIVFLGTGIKSTDSSKNPVTTIENRKA
CCCCCCCCCEECCCCCCCCCEEEECCEEEEEECEEEEEECCCCCCCCCCCCCEEECCCCC
NGYTLYTDDKQTTNSDNQENNSVFLESTDTKKNIGYHFLNKPKITVKKESHTGKWKEINK
CCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCEEEEEECCCCCCHHHHCC
SQKDTQKTDEYYEVTQKHSNSDNKYGYVLYPGLSKDVFKTKKDEVTVVKQEDDFHVVKDN
CHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHCCCCCEEEEEECCCEEEEECC
ESVWAGVNYSNSTQTFDINNTKVEVKAKGMFILKKKDDNTYECSFYNPESTNSASDIESK
CCEEEECCCCCCCEEEECCCCEEEEEECCEEEEEECCCCEEEEEEECCCCCCCHHHHHHH
ISMTGYSITNKNTSTSNESGVHFELTK
HEECCEEEECCCCCCCCCCCEEEEECC
>Mature Secondary Structure 
TYRIKKWQKLSTITLLMAGVITLNGGEFRSVDKHQIAVADTNVQTPDYEKLRNTWLDVN
CCCCCHHHHHHHHHHHHHHHEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHCEEEEC
YGYDKYDENNPDMKKKFDATEKEATNLLKEMKTESGRKYLWSGAETLETNSSHMTRTYRN
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCHHHCCCCHHHHHHHHH
IEKIAEAMRNPKTTLNTDENKKKVKDALEWLHKNAYGKEPDKKVKELSENFTKTTGKNTN
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCC
LNWWDYEIGTPKSLTNTLILLNDQFSNEEKKKFTAPIKTFAPDSDKILSSVGKAELAKGG
CCEEEEECCCCCCCCCEEEEEECCCCCCHHHHHHCCHHHCCCCHHHHHHHHCHHHHHCCC
NLVDISKVKLLECIIEEDKDMMKKSIDSFNKVFTYVQDSATGKERNGFYKDGSYIDHQDV
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
PYTGAYGVVLLEGISQMMPMIKETPFNDKTQNDTTLKSWIDDGFMPLIYKGEMMDLSRGR
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCEEEEEECCEEECCCCC
AISRENETSHSASATVMKSLLRLSDAMDDSTKAKYKKIVKSSVESDSSYKQNDYLNSYSD
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHCCHHHH
IDKMKSLMTDNSISKNGLTQQLKIYNDMDRVTYHNKDLDFAFGLSMTSKNVARYESINGE
HHHHHHHHCCCCCCCCCCHHHHHHHHCHHHHEECCCCCCEEEECCCCCCCHHHHHCCCCC
NLKGWHTGAGMSYLYNSDVKHYHDNFWVTADMKRLSGTTTLDNEILKDTDDKKSSKTFVG
CCCCEECCCCCCEEECCCCHHCCCCEEEEEEHHHCCCCCCCCHHHHHCCCCCCCCCEEEC
GTKVDDQHASIGMDFENQDKTLTAKKSYFILNDKIVFLGTGIKSTDSSKNPVTTIENRKA
CCCCCCCCCEECCCCCCCCCEEEECCEEEEEECEEEEEECCCCCCCCCCCCCEEECCCCC
NGYTLYTDDKQTTNSDNQENNSVFLESTDTKKNIGYHFLNKPKITVKKESHTGKWKEINK
CCEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCCEEEECCCEEEEEECCCCCCHHHHCC
SQKDTQKTDEYYEVTQKHSNSDNKYGYVLYPGLSKDVFKTKKDEVTVVKQEDDFHVVKDN
CHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHCCCCCEEEEEECCCEEEEECC
ESVWAGVNYSNSTQTFDINNTKVEVKAKGMFILKKKDDNTYECSFYNPESTNSASDIESK
CCEEEECCCCCCCEEEECCCCEEEEEECCEEEEEECCCCEEEEEEECCCCCCCHHHHHHH
ISMTGYSITNKNTSTSNESGVHFELTK
HEECCEEEECCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7557301