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The map label for this gene is gltA [H]

Identifier: 57650566

GI number: 57650566

Start: 1776771

End: 1777892

Strand: Reverse

Name: gltA [H]

Synonym: SACOL1742

Alternate gene names: 57650566

Gene position: 1777892-1776771 (Counterclockwise)

Preceding gene: 57650568

Following gene: 57650565

Centisome position: 63.28

GC content: 36.45

Gene sequence:

>1122_bases
ATGGCAGAATTACAAAGAGGTTTAGAAGGGGTTATCGCAGCGGAGACTAAAATAAGTTCAATTATTGAAAGTCAATTGAC
TTATGCCGGCTATGATATTGATGATCTAGCTGAAAATGCGCAATTTGAAGAAGTTATTTTCCTATTATGGAACTATAGAT
TGCCAAACGAAGAAGAGCTTGCTCATCTAAAAGGGAAATTAAATCAATACATGACATTAAATCCTCGTGTGTATACACAT
TTTGAGGAGTATGTTACAGATCACGTGCATCCAATGACAGCATTACGTACGTCATTATCATATATTGCACATTTCGATCC
TGATGCTGAAAATGAATCAGATGAAAATCGTTATGAAAGAGCAATGCGTATACAGGCTAAAGTAGCATCATTAGTTACAG
CGTTTGCTCGAGTAAGACAAGATAAAGAACCACTTAAGCCTAATCCTGACTTAAGTTATGCGGCAAACTTCCTATATATG
TTACGTGGGGAATTACCAACAGATATAGAAGTAGAAGCCTTCAATAAAGCACTTATTTTACACGCTGATCATGAGTTGAA
CGCATCTGCATTTACGGCACGTTGTGCGGTATCATCATTGTCAGATATGTACTCAGGTATTGTAGCAGCCGTAGGTTCTC
TGAAAGGGCCATTACATGGTGGTGCAAACGAACAAGTTATGACGATGTTATCTGAGATTGGGTCAATTGAAAATGTTGAT
GCTTACTTAGATGAAAAATTTGCTAATAAAGATAAAGTAATGGGCTTCGGTCATCGTGTATATAAAGATGGTGATCCTAG
AGCGAAATATTTAAGAGAAATGAGCCGTCAAATTACGAAAGACGCTGGTCGTGAAGAATTATTTGAAATGTCAGTGAAAA
TGGAAAAACGTATGGCAGAAGAAAAAGGATTAATTCCTAATGTTGATTTTTATAGTGCGAGTGTTTATCACTGTATGGAA
ATACCTCATGACTTATTCACGCCAATCTTTGCTGTAAGTCGTTCTGCAGGATGGATTGCTCATATTTTAGAACAATATAA
AGATAATAGAATTATGCGTCCTAGAGCGAAATATATTGGCGAAACGAATCGTAAGTATATCCCGCTTGAAGAAAGAAAAT
AA

Upstream 100 bases:

>100_bases
ACATATAATGCCAGTTTTTATATTTCACAAACGAAATGCGTTTAGCTATAATATTAGTTGAAAGCCATTTCATAAAGAAA
CAGTAAAGGGGAAATTTATC

Downstream 100 bases:

>100_bases
TCAATACAAATTAAAAATGAAGATGTAAAATTTGGAGGTAAAATAACTATGACTGCAGAAAAAATTACTCAAGGAACTGA
AGGATTAAACGTACCTAATG

Product: citrate synthase

Products: NA

Alternate protein names: Citrate synthase II [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MAELQRGLEGVIAAETKISSIIESQLTYAGYDIDDLAENAQFEEVIFLLWNYRLPNEEELAHLKGKLNQYMTLNPRVYTH
FEEYVTDHVHPMTALRTSLSYIAHFDPDAENESDENRYERAMRIQAKVASLVTAFARVRQDKEPLKPNPDLSYAANFLYM
LRGELPTDIEVEAFNKALILHADHELNASAFTARCAVSSLSDMYSGIVAAVGSLKGPLHGGANEQVMTMLSEIGSIENVD
AYLDEKFANKDKVMGFGHRVYKDGDPRAKYLREMSRQITKDAGREELFEMSVKMEKRMAEEKGLIPNVDFYSASVYHCME
IPHDLFTPIFAVSRSAGWIAHILEQYKDNRIMRPRAKYIGETNRKYIPLEERK

Sequences:

>Translated_373_residues
MAELQRGLEGVIAAETKISSIIESQLTYAGYDIDDLAENAQFEEVIFLLWNYRLPNEEELAHLKGKLNQYMTLNPRVYTH
FEEYVTDHVHPMTALRTSLSYIAHFDPDAENESDENRYERAMRIQAKVASLVTAFARVRQDKEPLKPNPDLSYAANFLYM
LRGELPTDIEVEAFNKALILHADHELNASAFTARCAVSSLSDMYSGIVAAVGSLKGPLHGGANEQVMTMLSEIGSIENVD
AYLDEKFANKDKVMGFGHRVYKDGDPRAKYLREMSRQITKDAGREELFEMSVKMEKRMAEEKGLIPNVDFYSASVYHCME
IPHDLFTPIFAVSRSAGWIAHILEQYKDNRIMRPRAKYIGETNRKYIPLEERK
>Mature_372_residues
AELQRGLEGVIAAETKISSIIESQLTYAGYDIDDLAENAQFEEVIFLLWNYRLPNEEELAHLKGKLNQYMTLNPRVYTHF
EEYVTDHVHPMTALRTSLSYIAHFDPDAENESDENRYERAMRIQAKVASLVTAFARVRQDKEPLKPNPDLSYAANFLYML
RGELPTDIEVEAFNKALILHADHELNASAFTARCAVSSLSDMYSGIVAAVGSLKGPLHGGANEQVMTMLSEIGSIENVDA
YLDEKFANKDKVMGFGHRVYKDGDPRAKYLREMSRQITKDAGREELFEMSVKMEKRMAEEKGLIPNVDFYSASVYHCMEI
PHDLFTPIFAVSRSAGWIAHILEQYKDNRIMRPRAKYIGETNRKYIPLEERK

Specific function: Might regulate the synthesis and function of enzymes involved in later enzymatic steps of Krebs cycle. Loss in activity results in sporulation defect [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=375, Percent_Identity=26.4, Blast_Score=93, Evalue=4e-19,
Organism=Escherichia coli, GI1786527, Length=369, Percent_Identity=36.0433604336043, Blast_Score=252, Evalue=3e-68,
Organism=Escherichia coli, GI1786939, Length=377, Percent_Identity=34.7480106100796, Blast_Score=211, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17555174, Length=373, Percent_Identity=25.201072386059, Blast_Score=94, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324328, Length=337, Percent_Identity=23.7388724035608, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6319850, Length=340, Percent_Identity=24.4117647058824, Blast_Score=76, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6325257, Length=366, Percent_Identity=24.8633879781421, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356863, Length=327, Percent_Identity=26.605504587156, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI24640124, Length=328, Percent_Identity=27.4390243902439, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24640126, Length=328, Percent_Identity=27.4390243902439, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 42594; Mature: 42463

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAELQRGLEGVIAAETKISSIIESQLTYAGYDIDDLAENAQFEEVIFLLWNYRLPNEEEL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCCCCCHHHH
AHLKGKLNQYMTLNPRVYTHFEEYVTDHVHPMTALRTSLSYIAHFDPDAENESDENRYER
HHHHHHHCCEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
AMRIQAKVASLVTAFARVRQDKEPLKPNPDLSYAANFLYMLRGELPTDIEVEAFNKALIL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCEEEE
HADHELNASAFTARCAVSSLSDMYSGIVAAVGSLKGPLHGGANEQVMTMLSEIGSIENVD
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHH
AYLDEKFANKDKVMGFGHRVYKDGDPRAKYLREMSRQITKDAGREELFEMSVKMEKRMAE
HHHHHHHCCCHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
EKGLIPNVDFYSASVYHCMEIPHDLFTPIFAVSRSAGWIAHILEQYKDNRIMRPRAKYIG
HCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHCC
ETNRKYIPLEERK
CCCCEECCCCCCC
>Mature Secondary Structure 
AELQRGLEGVIAAETKISSIIESQLTYAGYDIDDLAENAQFEEVIFLLWNYRLPNEEEL
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHCCCCCCHHHH
AHLKGKLNQYMTLNPRVYTHFEEYVTDHVHPMTALRTSLSYIAHFDPDAENESDENRYER
HHHHHHHCCEEEECCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHH
AMRIQAKVASLVTAFARVRQDKEPLKPNPDLSYAANFLYMLRGELPTDIEVEAFNKALIL
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCEECCCEEEE
HADHELNASAFTARCAVSSLSDMYSGIVAAVGSLKGPLHGGANEQVMTMLSEIGSIENVD
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCHHH
AYLDEKFANKDKVMGFGHRVYKDGDPRAKYLREMSRQITKDAGREELFEMSVKMEKRMAE
HHHHHHHCCCHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
EKGLIPNVDFYSASVYHCMEIPHDLFTPIFAVSRSAGWIAHILEQYKDNRIMRPRAKYIG
HCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCHHHHCC
ETNRKYIPLEERK
CCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8045898; 9387221; 9384377 [H]